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Papers by Raghavendra Kulkarni

Journal of Drug Delivery and Therapeutics

The aim of present study is to formulate and evaluate extended release matrix tablet of Nateglini... more The aim of present study is to formulate and evaluate extended release matrix tablet of Nateglinide by direct compression method using different polymer like HPMC K4 and HPMC K15. Matrix tablet of nateglidine were prepared in combination with the polymer HPMC K4, HPMC K15, along with the excipients and the formulations were evaluated for tablet properties and in vitro drug release studies. Nateglinide matrix tablet prepared by using polymer such as HPMC K4 and HPMC K15, it was found that HPMC K15 having higher viscosity as compare to HPMC K4 therefore different concentration of polymer were studied to extend the drug release up to 12 h. The tablets of Nateglinide prepared by direct compression had acceptable physical characteristics and satisfactory drug release. The study demonstrated that as far as the formulations were concerned, the selected polymers proved to have an acceptable flexibility in terms of in-vitro release profile. In present the study the percent drug release for ...

Journal of biomaterials science. Polymer edition, 2017

Unique pH-sensitive spray dried microspheres were formulated employing hydrolyzed polyacrylamide-... more Unique pH-sensitive spray dried microspheres were formulated employing hydrolyzed polyacrylamide-g-carboxymethylcellulose sodium (PAAm-g-NaCMC) co-polymer for colon targeted delivery of an anticancer drug, capecitabine. Synthesis of PAAm-g-NaCMC was carried out through free radical polymerization, which was supported with an inert atmosphere and then the alkaline hydrolysis was performed and subjected for characterization including FTIR spectroscopic analysis, (1)H NMR spectroscopic analysis, elemental analysis, viscosity measurement, neutralization equivalent and thermo-gravimetric investigation. The swelling data suggested that the PAAm-g-NaCMC possesses significant pH-sensitive property. The microspheres were in the range of 1.00 to 7.34 μ and the drug entrapment efficiency ranged between 70.98 and 94.41%. In vitro drug release suggested the failure of microspheres formulated using native NaCMC which failed to impede drug release in stomach and small intestine, while those prepar...

Acta Pharmaceutica Sciencia, 2010

Page 1. 137 Acta Pharmaceutica Sciencia 52: 137-143 (2010) Carboxymethylcellulose ̶ aluminum hydr... more Page 1. 137 Acta Pharmaceutica Sciencia 52: 137-143 (2010) Carboxymethylcellulose ̶ aluminum hydrogel microbeads for prolonged release of simvastatin Rashmi Boppana 1 , Raghavendra V. Kulkarni 1 *, Chitrali Mallikarjun Setty 2 and Navanath V. Kalyane 1 ...

Http Dx Doi Org 10 1080 003239104909811164, Jun 3, 2010

ABSTRACT

Research Journal of Pharmacy and Technology, 2013

In the present study, an attempt was made to prepare and evaluate the natural polymers based comp... more In the present study, an attempt was made to prepare and evaluate the natural polymers based compression coated tablets for controlled release of an antibiotic, cefadroxil monohydrate. The core tablets were prepared by direct compression method and compression coating granules were prepared by wet granulation method using sodium alginate and xanthan gum. The weight and drug content of all the tablets were found to be uniform. The hardness and friability were found within specified range. The core tablets released 99% drug within 1 h, while the compression coated tablets were capable of releasing the drug for 24 h. The coating formula containing more amount of aluminum chloride released the drug slowly as compared to barium chloride. Drug release mechanism was found to be non-Fickian transport type.

Indian Journal of Pharmaceutical Sciences

The present investigation was taken up to prepare and evaluate Eudragit RS100 films as rate contr... more The present investigation was taken up to prepare and evaluate Eudragit RS100 films as rate controlling membrane for transdermal use and to study the effect of different concentrations of various plasticizers on the permeability and mechanical properties. Drug free films of Eudragit RS100 were prepared by the casting method on mercury surface employing chloroform as a solvent and dibutyl phthalate (DBP) and polyethylene glycol-400 (PEG) as plasticizers. These films were evaluated for thickness uniformity, tensile strength, percentage of elongation and water vapor transmission. Permeability characters of these films were studied using verapamil hydrochloride (VPH) as a model drug. The thickness of the films was found to be uniform. Tensile strength of the films prepared using DBP as plasticizer was high compared to the films plasticized with PEG. Water vapor transmission and drug diffusion through films followed a pattern closed to zero order type and it was decreased with increase in the film thickness. Films plasticized with PEG showed higher permeability to verapamil hydrochloride. The permeability of the drug was decreased as the concentration of dibutyl phthalate was increased. Whereas increase in the concentration of PEG enhanced the permeability characteristics of the films.

Indian Journal of Pharmaceutical Sciences

In this article various polymeric membrane systems of poly vinyl pyrrolidone, ethyl cellulose, Eu... more In this article various polymeric membrane systems of poly vinyl pyrrolidone, ethyl cellulose, Eudragit RS100 and ethylene vinyl acetate, containing verapamil hydrochloride, along with glycerol and dibutyl phthalate as plasticizers have been fabricated for transdermal use. Both monolithic and membrane controlled systems were prepared by the method of casting on mercury surface and evaluated for thickness uniformity, drug content uniformity, tensile strength, Percentage of elongation and skin irritation. In vitro drug permeation through rat abdominal skin and human cadaver skin was performed using Keshary-Chien diffusion cells. Results indicated that, the order of permeation of the drug from different polymeric membranes was poly vinyl pyrrolidone>ethyl cellulose>Eudragit RS100>ethylene vinyl acetate. The drug release mechanism from all monolithic systems was diffusion controlled, where as membrane controlled systems followed nearly zero order kinetics, as the thickness of rate controlling membrane was increased from 100 to 200µ, the drug release was decreased. Compared to rat skin, a low permeation rate of the drug was observed through human cadaver skin, this indicates meeting the target flux in rat skin does not guarantee it's good permeability in human skin.

Indian Drugs

Preliminary phytochemical investigation of different extracts of Hedychium spicatum showed the pr... more Preliminary phytochemical investigation of different extracts of Hedychium spicatum showed the presence of steroids, glycosides and carbohydrates. The ethyl acetate and alcohol extracts of dried rhizomes were shown significant hepatoprotective activity, lowering the enzymes like Serum Glutamate Oxalocaetate Transaminase (SGOT) and Serum Glutamate Pyruvate Transaminase (SGPT) in albino rats intoxicated with Carbon tetra chloride (CCI 4 ) and also were comparable to marketed product.

Indian journal of pharmaceutical education

Article history: Received on 31August 2009 Modified on 8 September 2009 Accepted on 11 September ... more Article history: Received on 31August 2009 Modified on 8 September 2009 Accepted on 11 September 2009 Compared to single unit-dosage forms, multi-unit controlled release dosage forms like microbeads and microparticles are advantageous as they prevent the exposure of absorbing site to high drug concentration on chronic dosing. Gellan gum based hydrogel microbeads loaded with ketoprofen were prepared by ionotropic gelation method and evaluated for size analysis, surface morphology, dynamic swelling and drug release behavior. The scanning electron microscopy (SEM) revealed that the prepared beads were spherical in nature. The effects of crosslinking agent and polymer concentrations on the release of drug were studied. With increase in concentrations of crosslinking agent and polymers, a decreased drug release was observed. The release data were fitted to an empirical equation to calculate the release mechanism. Drug release followed non-Fickian mechanism. Thus the prepared microbeads are useful carriers for controlled release of ketoprofen © KESS All rights reserved

Farmacia

In the present investigation, hydrogel based interpenetrating network (IPN) discs of poly(vinyl a... more In the present investigation, hydrogel based interpenetrating network (IPN) discs of poly(vinyl alcohol) and poly(vinyl pyrrolidone) loaded with an anti-diabetic drug, glipizide were prepared by chemical crosslinking method. The prepared discs were characterized by thermogravimetric analysis (TGA), differential scanning calorimetric analysis (DSC) and X-ray diffractometry (XRD). The swelling behavior and drug release were dependent upon the crosslink density. The IPN hydrogel discs were capable of releasing drug up to 24 h. The discs which were prepared with higher concentration of glutaraldehyde released the drug more slowly. The release data were fitted to an empirical equation to determine the transport mechanism, which indicated the non-Fickian trend for drug transport.

In the present work a simple, precise and economical procedure for the simultaneous estimation of... more In the present work a simple, precise and economical procedure for the simultaneous estimation of Ramipril and Olmesartan Medoxomil in tablet formulation has been developed using Elico SL- 160 UV spectrophotometer. Results from the present study indicate that Olmesartan Medoxomil has zero crossing point at 243.4 nm, where Ramipril zero crossing point at 237.4 nm in methanol. Both these drugs obey Beer’s law in the concentration range employed (5-35 microgram/ml) for the present method. The result of analysis has been validated statistically by recovery studies. The outcome of the present study conclude that the developed method is a sensitive, accurate, precise and simple, which can be successfully employed for the routine estimation of both these drugs in bulk drugs and formulations without the interference of common excipients.

Journal of Drug Delivery and Therapeutics

The aim of present study is to formulate and evaluate extended release matrix tablet of Nateglini... more The aim of present study is to formulate and evaluate extended release matrix tablet of Nateglinide by direct compression method using different polymer like HPMC K4 and HPMC K15. Matrix tablet of nateglidine were prepared in combination with the polymer HPMC K4, HPMC K15, along with the excipients and the formulations were evaluated for tablet properties and in vitro drug release studies. Nateglinide matrix tablet prepared by using polymer such as HPMC K4 and HPMC K15, it was found that HPMC K15 having higher viscosity as compare to HPMC K4 therefore different concentration of polymer were studied to extend the drug release up to 12 h. The tablets of Nateglinide prepared by direct compression had acceptable physical characteristics and satisfactory drug release. The study demonstrated that as far as the formulations were concerned, the selected polymers proved to have an acceptable flexibility in terms of in-vitro release profile. In present the study the percent drug release for ...

Journal of biomaterials science. Polymer edition, 2017

Unique pH-sensitive spray dried microspheres were formulated employing hydrolyzed polyacrylamide-... more Unique pH-sensitive spray dried microspheres were formulated employing hydrolyzed polyacrylamide-g-carboxymethylcellulose sodium (PAAm-g-NaCMC) co-polymer for colon targeted delivery of an anticancer drug, capecitabine. Synthesis of PAAm-g-NaCMC was carried out through free radical polymerization, which was supported with an inert atmosphere and then the alkaline hydrolysis was performed and subjected for characterization including FTIR spectroscopic analysis, (1)H NMR spectroscopic analysis, elemental analysis, viscosity measurement, neutralization equivalent and thermo-gravimetric investigation. The swelling data suggested that the PAAm-g-NaCMC possesses significant pH-sensitive property. The microspheres were in the range of 1.00 to 7.34 μ and the drug entrapment efficiency ranged between 70.98 and 94.41%. In vitro drug release suggested the failure of microspheres formulated using native NaCMC which failed to impede drug release in stomach and small intestine, while those prepar...

Acta Pharmaceutica Sciencia, 2010

Page 1. 137 Acta Pharmaceutica Sciencia 52: 137-143 (2010) Carboxymethylcellulose ̶ aluminum hydr... more Page 1. 137 Acta Pharmaceutica Sciencia 52: 137-143 (2010) Carboxymethylcellulose ̶ aluminum hydrogel microbeads for prolonged release of simvastatin Rashmi Boppana 1 , Raghavendra V. Kulkarni 1 *, Chitrali Mallikarjun Setty 2 and Navanath V. Kalyane 1 ...

Http Dx Doi Org 10 1080 003239104909811164, Jun 3, 2010

ABSTRACT

Research Journal of Pharmacy and Technology, 2013

In the present study, an attempt was made to prepare and evaluate the natural polymers based comp... more In the present study, an attempt was made to prepare and evaluate the natural polymers based compression coated tablets for controlled release of an antibiotic, cefadroxil monohydrate. The core tablets were prepared by direct compression method and compression coating granules were prepared by wet granulation method using sodium alginate and xanthan gum. The weight and drug content of all the tablets were found to be uniform. The hardness and friability were found within specified range. The core tablets released 99% drug within 1 h, while the compression coated tablets were capable of releasing the drug for 24 h. The coating formula containing more amount of aluminum chloride released the drug slowly as compared to barium chloride. Drug release mechanism was found to be non-Fickian transport type.

Indian Journal of Pharmaceutical Sciences

The present investigation was taken up to prepare and evaluate Eudragit RS100 films as rate contr... more The present investigation was taken up to prepare and evaluate Eudragit RS100 films as rate controlling membrane for transdermal use and to study the effect of different concentrations of various plasticizers on the permeability and mechanical properties. Drug free films of Eudragit RS100 were prepared by the casting method on mercury surface employing chloroform as a solvent and dibutyl phthalate (DBP) and polyethylene glycol-400 (PEG) as plasticizers. These films were evaluated for thickness uniformity, tensile strength, percentage of elongation and water vapor transmission. Permeability characters of these films were studied using verapamil hydrochloride (VPH) as a model drug. The thickness of the films was found to be uniform. Tensile strength of the films prepared using DBP as plasticizer was high compared to the films plasticized with PEG. Water vapor transmission and drug diffusion through films followed a pattern closed to zero order type and it was decreased with increase in the film thickness. Films plasticized with PEG showed higher permeability to verapamil hydrochloride. The permeability of the drug was decreased as the concentration of dibutyl phthalate was increased. Whereas increase in the concentration of PEG enhanced the permeability characteristics of the films.

Indian Journal of Pharmaceutical Sciences

In this article various polymeric membrane systems of poly vinyl pyrrolidone, ethyl cellulose, Eu... more In this article various polymeric membrane systems of poly vinyl pyrrolidone, ethyl cellulose, Eudragit RS100 and ethylene vinyl acetate, containing verapamil hydrochloride, along with glycerol and dibutyl phthalate as plasticizers have been fabricated for transdermal use. Both monolithic and membrane controlled systems were prepared by the method of casting on mercury surface and evaluated for thickness uniformity, drug content uniformity, tensile strength, Percentage of elongation and skin irritation. In vitro drug permeation through rat abdominal skin and human cadaver skin was performed using Keshary-Chien diffusion cells. Results indicated that, the order of permeation of the drug from different polymeric membranes was poly vinyl pyrrolidone>ethyl cellulose>Eudragit RS100>ethylene vinyl acetate. The drug release mechanism from all monolithic systems was diffusion controlled, where as membrane controlled systems followed nearly zero order kinetics, as the thickness of rate controlling membrane was increased from 100 to 200µ, the drug release was decreased. Compared to rat skin, a low permeation rate of the drug was observed through human cadaver skin, this indicates meeting the target flux in rat skin does not guarantee it's good permeability in human skin.

Indian Drugs

Preliminary phytochemical investigation of different extracts of Hedychium spicatum showed the pr... more Preliminary phytochemical investigation of different extracts of Hedychium spicatum showed the presence of steroids, glycosides and carbohydrates. The ethyl acetate and alcohol extracts of dried rhizomes were shown significant hepatoprotective activity, lowering the enzymes like Serum Glutamate Oxalocaetate Transaminase (SGOT) and Serum Glutamate Pyruvate Transaminase (SGPT) in albino rats intoxicated with Carbon tetra chloride (CCI 4 ) and also were comparable to marketed product.

Indian journal of pharmaceutical education

Article history: Received on 31August 2009 Modified on 8 September 2009 Accepted on 11 September ... more Article history: Received on 31August 2009 Modified on 8 September 2009 Accepted on 11 September 2009 Compared to single unit-dosage forms, multi-unit controlled release dosage forms like microbeads and microparticles are advantageous as they prevent the exposure of absorbing site to high drug concentration on chronic dosing. Gellan gum based hydrogel microbeads loaded with ketoprofen were prepared by ionotropic gelation method and evaluated for size analysis, surface morphology, dynamic swelling and drug release behavior. The scanning electron microscopy (SEM) revealed that the prepared beads were spherical in nature. The effects of crosslinking agent and polymer concentrations on the release of drug were studied. With increase in concentrations of crosslinking agent and polymers, a decreased drug release was observed. The release data were fitted to an empirical equation to calculate the release mechanism. Drug release followed non-Fickian mechanism. Thus the prepared microbeads are useful carriers for controlled release of ketoprofen © KESS All rights reserved

Farmacia

In the present investigation, hydrogel based interpenetrating network (IPN) discs of poly(vinyl a... more In the present investigation, hydrogel based interpenetrating network (IPN) discs of poly(vinyl alcohol) and poly(vinyl pyrrolidone) loaded with an anti-diabetic drug, glipizide were prepared by chemical crosslinking method. The prepared discs were characterized by thermogravimetric analysis (TGA), differential scanning calorimetric analysis (DSC) and X-ray diffractometry (XRD). The swelling behavior and drug release were dependent upon the crosslink density. The IPN hydrogel discs were capable of releasing drug up to 24 h. The discs which were prepared with higher concentration of glutaraldehyde released the drug more slowly. The release data were fitted to an empirical equation to determine the transport mechanism, which indicated the non-Fickian trend for drug transport.

In the present work a simple, precise and economical procedure for the simultaneous estimation of... more In the present work a simple, precise and economical procedure for the simultaneous estimation of Ramipril and Olmesartan Medoxomil in tablet formulation has been developed using Elico SL- 160 UV spectrophotometer. Results from the present study indicate that Olmesartan Medoxomil has zero crossing point at 243.4 nm, where Ramipril zero crossing point at 237.4 nm in methanol. Both these drugs obey Beer’s law in the concentration range employed (5-35 microgram/ml) for the present method. The result of analysis has been validated statistically by recovery studies. The outcome of the present study conclude that the developed method is a sensitive, accurate, precise and simple, which can be successfully employed for the routine estimation of both these drugs in bulk drugs and formulations without the interference of common excipients.