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Papers by Vandana Raghunath
Journal of Oral Pathology and Medicine, 2004
Primary intraosseous carcinoma/odontogenic carcinomas are extremely rare malignant odontogenic tu... more Primary intraosseous carcinoma/odontogenic carcinomas are extremely rare malignant odontogenic tumours that are thought to arise from residues of odontogenic epithelium. An unusual case of primary intraosseous carcinoma arising de novo in a previously unreported site of posterior maxilla is described. The tumour was characterized by sheets of pleomorphic round-to-ovoid cells and marked osteoid/dentinoid formation with foci of globular mineralization.
Asia-Pacific Journal of Public Health, 2011
To assess the prevalence and severity of developmental defects and their relationship to fluoride... more To assess the prevalence and severity of developmental defects and their relationship to fluoride levels in drinking water. 739 (406 male and 333 female) schoolchildren aged 13 years formed the study population. We used the ion selective electrode method to estimate the fluoride concentration in drinking water. A modified developmental defects of enamel index was used for recording the developmental defects. The Karl Pearson coefficient for correlation and the chi-square test were used for statistical estimation. The fluoride concentration ranged from 0.64 to 2.64 ppm. The prevalence of developmental defects was 88.5%. The most common type of defect was diffuse opacity in 61.2% of the children. There was a significant positive correlation between the type (r=0.85; P<.001) and extent (r=0.92; P<.001) of developmental defects in relation to fluoride levels in drinking water. The observed prevalence demonstrates the need to ascertain factors other than fluoride levels in drinking water that could contribute to its occurrence.
Journal of Oral and Maxillofacial Pathology
Journal of Oral and Maxillofacial Pathology
SRM Journal of Research in Dental Sciences
SRM Journal of Research in Dental Sciences
BMJ Case Reports, 2016
Hamartoma is a tumour-like malformation appearing as a focal overgrowth of normal cells. Leiomyom... more Hamartoma is a tumour-like malformation appearing as a focal overgrowth of normal cells. Leiomyomatous hamartomas (LHs) are rare in the oral cavity and commonly seen in the Japanese and less than 40 cases have been reported in the Japanese and English literature. The clinical differential diagnoses are irritational (traumatic) fibroma and congenital epulis. It has to be differentiated histopathologically from its neoplastic counterparts and mesenchymomas. Hence, we report such a case of LHs, which presented as a sessile gingival growth occurring in the midline in a 15-year-old girl. The final diagnosis was based on the histopathological appearance which was confirmed by immunohistochemical staining of various markers. A review of the literature of previous cases was also carried out.
Journal of clinical and diagnostic research : JCDR, 2016
White, non scrapable lesions are commonly seen in the oral cavity. Based on their history and cli... more White, non scrapable lesions are commonly seen in the oral cavity. Based on their history and clinical appearance, most of these lesions can be easily diagnosed, but sometimes diagnosis may go wrong. In order to arrive to a confirmative diagnosis, histopathological assessment is needed in many cases, if not all. 1) To find out the prevalence of clinically diagnosed oral white, non scrapable lesions. 2) To find out the prevalence of histopathologically diagnosed oral white, non scrapable lesions. 3) To correlate the clinical and histopathological diagnosis in the above lesions. A total of 100 cases of oral white, non scrapable lesions were included in the study. Based on their history and clinical presentation, clinical provisional diagnosis was made. Then biopsy was done and confirmatory histopathological diagnosis was given and both were correlated. In order to correlate clinical and histopathological diagnosis Discrepancy Index (DI) was calculated for all the cases. Based on clini...
BMJ Case Reports, 2015
Lipomas are benign soft tissue tumours composed mainly of mature adipose tissue. Histological var... more Lipomas are benign soft tissue tumours composed mainly of mature adipose tissue. Histological variants of lipomas have been named according to the type of tissue present and they include fibrolipoma, angiolipoma, osteolipoma, chondrolipoma and others. Osteolipoma, a classic lipoma with osseous metaplasia, is a very rare histological variant. Owing to the rarity of oral osteolipomas, we report an uncommon case of osteolipoma located on the floor of the mouth of a 20-year-old female patient and include a review of the literature.
Quintessence international (Berlin, Germany : 1985), 2003
Impaction of the permanent maxillary central incisor is rare. Trauma to the primary maxillary ant... more Impaction of the permanent maxillary central incisor is rare. Trauma to the primary maxillary anterior teeth is the most common cause. Two case reports of impacted permanent maxillary central incisors with a history of trauma to the primary maxillary anterior teeth are presented. In one case there was radiographic evidence of complete arrest of root formation, and in the other case the root was dilacerated from the cervical third and the enamel surface was rough.
Contemporary Clinical Dentistry, 2014
Ameloblastomas are rare histologically benign, locally aggressive tumors arising from the oral ec... more Ameloblastomas are rare histologically benign, locally aggressive tumors arising from the oral ectoderm that occasionally reach a gigantic size. Giant ameloblastomas are a rarity these days with the advent of panoramic radiography in routine dental practice. Furthermore, the granular cell variant is an uncommon histological subtype of ameloblastoma where the central stellate reticulum like cells in tumor follicles is replaced by granular cells. Although granular cell ameloblastoma (GCA) is considered to be a destructive tumor with a high recurrence rate, the significance of granular cells in predicting its biologic behavior is debatable. However, we present a rare case of giant GCA of remarkable histomorphology showing extensive craniofacial involvement and dural extension that rendered a good prognosis following treatment.
Mukoepidermoidni karcinom rijedak je u čeljusti i histološki je jako varijabilan. Točna patogenez... more Mukoepidermoidni karcinom rijedak je u čeljusti i histološki je jako varijabilan. Točna patogeneza nije poznata-hipoteza je da epitelna ovojnica odontogene ciste ima najvažniju zadaću. Budući da je malo oralnih patologa i kliničara vidjelo tu leziju, potrebno je odrediti kliničko-patološke parametre i kriterije za postavljanje dijagnoze. U ovom radu izvještavamo o centralnom mukoepidermoidnom karcinomu niskog stupnja kod 46-godišnjeg muškarca te opisujemo kliničko-patološka svojstva i raspravljamo o sličnosti sa žljezdanom odontogenom cistom (GOC-om). Svjetska zdravstvena organizacija proglasila je GOC neovisnim patološkim entitetom i klasificirala ga kao razvojnu odontogenu epitelnu cistu. Ključne riječi Odontogene ciste; karcinom, mukoepidermoidni 1 Zavod za oralnu patologiju i mikrobiologiju, K M Shah Stomatološki fakultet, Pipariya-391760, Waghodia (T), Vadodara (D),
Medicina Oral Patología Oral y Cirugia Bucal, 2011
Objectives: The present study was undertaken to assess and compare the immunohistochemical expres... more Objectives: The present study was undertaken to assess and compare the immunohistochemical expression of Bcl-2 in selected benign and malignant salivary gland tumors. Study Design: A total of 50 cases of buffered formalin-fixed, paraffin embedded tissues of previously diagnosed cases of benign and malignant salivary gland tumors from the archives of
The Journal of Contemporary Dental Practice, 2012
Aims and objectives: To study the clinical, histological features of peripheral and central ossif... more Aims and objectives: To study the clinical, histological features of peripheral and central ossifying fibromas and also to compare between them. Materials and methods: The sample comprised a total 50 cases of ossifying fibromas [25 central ossifying fibromas (COF) and 25 peripheral ossifying fibromas (POF)] inclusive of cemento-ossifying fibromas. Results: The mean age is 28.2 years in POF and 24.7 years in COF. The male: female ratio was 1:1.5 in POF and 1:1.8 in COF. The size of the lesions varied from 0.45 to 2.75 cm in cases of POF and in COF, it ranged from 1.25 to 13.5 cm. COF showed more duration (1-8 years) when compared with POF (1-3). Majority of cases of COF showed radiolucent, mixed radiolucent and radiopaque unilocular lesions. The predominant cell type in both POF and COF was a combination of both ovoid and spindle cells. Regarding vascularity it showed mild, moderate and intense vascularity. On comparison of all stromal changes between POF and COF showed no statistically significant difference. Conclusion: The clinical parameters and radiographic changes of POF and COF in our study were similar to the previous studies. Histopathological features like type of cells, cellularity and vascularity in POF and COF were similar to previous studies. However, when clinical and histopathological features were compared between POF and COF showed no statistical significance except for site of the lesion. These features signify the behavior of two lesions. Further research on larger sample might give more insights into these lesions.
Indian Journal of Dental Research, 2008
Vegetable granuloma (VG) or pulse granuloma (PG) results from the implantation of food particles ... more Vegetable granuloma (VG) or pulse granuloma (PG) results from the implantation of food particles of plant or vegetable origin. It is usually seen in the periapical or in the sulcus areas. These lesions have been described as a distinct entity and classified into central and peripheral lesions according to the location. Central lesions are asymptomatic, whereas peripheral lesions present as painless sub-mucosal swellings. Many authors have postulated that food particles in VG or PG get implanted and are rapidly digested, and sometimes partly get altered by host responses. The cellulose part of plant foods being indigestible persists in the form of hyaline material, whereas the starch matter gets digested. This cellulose moiety invokes chronic granulomatous response.
Dental Research Journal, 2010
Vascular neoplasms, other than benign are characterized as intermediate or malignant. They are of... more Vascular neoplasms, other than benign are characterized as intermediate or malignant. They are often enshrouded in controversy, because the same neoplasm could show variability in biologic behavior that may not be correlated with microscopic features. The intermediate grade vascular neoplasm is named as epithelioid hemangioendothelioma (EHE). Epithelioid hemangioendothelioma of the oral cavity has been infrequently reported. To the best of our knowledge, the review of the English literature revealed a total of 30 cases of intraoral EHE reported till today. We report such a rare case in a 20 year old male, presented with a growth in lower anterior lingual gingiva since five months before the diagnosis with a history of similar swelling, twice in the same area. The differential diagnosis and brief review of literature is also discussed in the current article.
Journal of Oral Pathology and Medicine, 2004
Primary intraosseous carcinoma/odontogenic carcinomas are extremely rare malignant odontogenic tu... more Primary intraosseous carcinoma/odontogenic carcinomas are extremely rare malignant odontogenic tumours that are thought to arise from residues of odontogenic epithelium. An unusual case of primary intraosseous carcinoma arising de novo in a previously unreported site of posterior maxilla is described. The tumour was characterized by sheets of pleomorphic round-to-ovoid cells and marked osteoid/dentinoid formation with foci of globular mineralization.
Asia-Pacific Journal of Public Health, 2011
To assess the prevalence and severity of developmental defects and their relationship to fluoride... more To assess the prevalence and severity of developmental defects and their relationship to fluoride levels in drinking water. 739 (406 male and 333 female) schoolchildren aged 13 years formed the study population. We used the ion selective electrode method to estimate the fluoride concentration in drinking water. A modified developmental defects of enamel index was used for recording the developmental defects. The Karl Pearson coefficient for correlation and the chi-square test were used for statistical estimation. The fluoride concentration ranged from 0.64 to 2.64 ppm. The prevalence of developmental defects was 88.5%. The most common type of defect was diffuse opacity in 61.2% of the children. There was a significant positive correlation between the type (r=0.85; P<.001) and extent (r=0.92; P<.001) of developmental defects in relation to fluoride levels in drinking water. The observed prevalence demonstrates the need to ascertain factors other than fluoride levels in drinking water that could contribute to its occurrence.
Journal of Oral and Maxillofacial Pathology
Journal of Oral and Maxillofacial Pathology
SRM Journal of Research in Dental Sciences
SRM Journal of Research in Dental Sciences
BMJ Case Reports, 2016
Hamartoma is a tumour-like malformation appearing as a focal overgrowth of normal cells. Leiomyom... more Hamartoma is a tumour-like malformation appearing as a focal overgrowth of normal cells. Leiomyomatous hamartomas (LHs) are rare in the oral cavity and commonly seen in the Japanese and less than 40 cases have been reported in the Japanese and English literature. The clinical differential diagnoses are irritational (traumatic) fibroma and congenital epulis. It has to be differentiated histopathologically from its neoplastic counterparts and mesenchymomas. Hence, we report such a case of LHs, which presented as a sessile gingival growth occurring in the midline in a 15-year-old girl. The final diagnosis was based on the histopathological appearance which was confirmed by immunohistochemical staining of various markers. A review of the literature of previous cases was also carried out.
Journal of clinical and diagnostic research : JCDR, 2016
White, non scrapable lesions are commonly seen in the oral cavity. Based on their history and cli... more White, non scrapable lesions are commonly seen in the oral cavity. Based on their history and clinical appearance, most of these lesions can be easily diagnosed, but sometimes diagnosis may go wrong. In order to arrive to a confirmative diagnosis, histopathological assessment is needed in many cases, if not all. 1) To find out the prevalence of clinically diagnosed oral white, non scrapable lesions. 2) To find out the prevalence of histopathologically diagnosed oral white, non scrapable lesions. 3) To correlate the clinical and histopathological diagnosis in the above lesions. A total of 100 cases of oral white, non scrapable lesions were included in the study. Based on their history and clinical presentation, clinical provisional diagnosis was made. Then biopsy was done and confirmatory histopathological diagnosis was given and both were correlated. In order to correlate clinical and histopathological diagnosis Discrepancy Index (DI) was calculated for all the cases. Based on clini...
BMJ Case Reports, 2015
Lipomas are benign soft tissue tumours composed mainly of mature adipose tissue. Histological var... more Lipomas are benign soft tissue tumours composed mainly of mature adipose tissue. Histological variants of lipomas have been named according to the type of tissue present and they include fibrolipoma, angiolipoma, osteolipoma, chondrolipoma and others. Osteolipoma, a classic lipoma with osseous metaplasia, is a very rare histological variant. Owing to the rarity of oral osteolipomas, we report an uncommon case of osteolipoma located on the floor of the mouth of a 20-year-old female patient and include a review of the literature.
Quintessence international (Berlin, Germany : 1985), 2003
Impaction of the permanent maxillary central incisor is rare. Trauma to the primary maxillary ant... more Impaction of the permanent maxillary central incisor is rare. Trauma to the primary maxillary anterior teeth is the most common cause. Two case reports of impacted permanent maxillary central incisors with a history of trauma to the primary maxillary anterior teeth are presented. In one case there was radiographic evidence of complete arrest of root formation, and in the other case the root was dilacerated from the cervical third and the enamel surface was rough.
Contemporary Clinical Dentistry, 2014
Ameloblastomas are rare histologically benign, locally aggressive tumors arising from the oral ec... more Ameloblastomas are rare histologically benign, locally aggressive tumors arising from the oral ectoderm that occasionally reach a gigantic size. Giant ameloblastomas are a rarity these days with the advent of panoramic radiography in routine dental practice. Furthermore, the granular cell variant is an uncommon histological subtype of ameloblastoma where the central stellate reticulum like cells in tumor follicles is replaced by granular cells. Although granular cell ameloblastoma (GCA) is considered to be a destructive tumor with a high recurrence rate, the significance of granular cells in predicting its biologic behavior is debatable. However, we present a rare case of giant GCA of remarkable histomorphology showing extensive craniofacial involvement and dural extension that rendered a good prognosis following treatment.
Mukoepidermoidni karcinom rijedak je u čeljusti i histološki je jako varijabilan. Točna patogenez... more Mukoepidermoidni karcinom rijedak je u čeljusti i histološki je jako varijabilan. Točna patogeneza nije poznata-hipoteza je da epitelna ovojnica odontogene ciste ima najvažniju zadaću. Budući da je malo oralnih patologa i kliničara vidjelo tu leziju, potrebno je odrediti kliničko-patološke parametre i kriterije za postavljanje dijagnoze. U ovom radu izvještavamo o centralnom mukoepidermoidnom karcinomu niskog stupnja kod 46-godišnjeg muškarca te opisujemo kliničko-patološka svojstva i raspravljamo o sličnosti sa žljezdanom odontogenom cistom (GOC-om). Svjetska zdravstvena organizacija proglasila je GOC neovisnim patološkim entitetom i klasificirala ga kao razvojnu odontogenu epitelnu cistu. Ključne riječi Odontogene ciste; karcinom, mukoepidermoidni 1 Zavod za oralnu patologiju i mikrobiologiju, K M Shah Stomatološki fakultet, Pipariya-391760, Waghodia (T), Vadodara (D),
Medicina Oral Patología Oral y Cirugia Bucal, 2011
Objectives: The present study was undertaken to assess and compare the immunohistochemical expres... more Objectives: The present study was undertaken to assess and compare the immunohistochemical expression of Bcl-2 in selected benign and malignant salivary gland tumors. Study Design: A total of 50 cases of buffered formalin-fixed, paraffin embedded tissues of previously diagnosed cases of benign and malignant salivary gland tumors from the archives of
The Journal of Contemporary Dental Practice, 2012
Aims and objectives: To study the clinical, histological features of peripheral and central ossif... more Aims and objectives: To study the clinical, histological features of peripheral and central ossifying fibromas and also to compare between them. Materials and methods: The sample comprised a total 50 cases of ossifying fibromas [25 central ossifying fibromas (COF) and 25 peripheral ossifying fibromas (POF)] inclusive of cemento-ossifying fibromas. Results: The mean age is 28.2 years in POF and 24.7 years in COF. The male: female ratio was 1:1.5 in POF and 1:1.8 in COF. The size of the lesions varied from 0.45 to 2.75 cm in cases of POF and in COF, it ranged from 1.25 to 13.5 cm. COF showed more duration (1-8 years) when compared with POF (1-3). Majority of cases of COF showed radiolucent, mixed radiolucent and radiopaque unilocular lesions. The predominant cell type in both POF and COF was a combination of both ovoid and spindle cells. Regarding vascularity it showed mild, moderate and intense vascularity. On comparison of all stromal changes between POF and COF showed no statistically significant difference. Conclusion: The clinical parameters and radiographic changes of POF and COF in our study were similar to the previous studies. Histopathological features like type of cells, cellularity and vascularity in POF and COF were similar to previous studies. However, when clinical and histopathological features were compared between POF and COF showed no statistical significance except for site of the lesion. These features signify the behavior of two lesions. Further research on larger sample might give more insights into these lesions.
Indian Journal of Dental Research, 2008
Vegetable granuloma (VG) or pulse granuloma (PG) results from the implantation of food particles ... more Vegetable granuloma (VG) or pulse granuloma (PG) results from the implantation of food particles of plant or vegetable origin. It is usually seen in the periapical or in the sulcus areas. These lesions have been described as a distinct entity and classified into central and peripheral lesions according to the location. Central lesions are asymptomatic, whereas peripheral lesions present as painless sub-mucosal swellings. Many authors have postulated that food particles in VG or PG get implanted and are rapidly digested, and sometimes partly get altered by host responses. The cellulose part of plant foods being indigestible persists in the form of hyaline material, whereas the starch matter gets digested. This cellulose moiety invokes chronic granulomatous response.
Dental Research Journal, 2010
Vascular neoplasms, other than benign are characterized as intermediate or malignant. They are of... more Vascular neoplasms, other than benign are characterized as intermediate or malignant. They are often enshrouded in controversy, because the same neoplasm could show variability in biologic behavior that may not be correlated with microscopic features. The intermediate grade vascular neoplasm is named as epithelioid hemangioendothelioma (EHE). Epithelioid hemangioendothelioma of the oral cavity has been infrequently reported. To the best of our knowledge, the review of the English literature revealed a total of 30 cases of intraoral EHE reported till today. We report such a rare case in a 20 year old male, presented with a growth in lower anterior lingual gingiva since five months before the diagnosis with a history of similar swelling, twice in the same area. The differential diagnosis and brief review of literature is also discussed in the current article.