Rahmi Sinan Karadeniz - Academia.edu (original) (raw)

Papers by Rahmi Sinan Karadeniz

Research paper thumbnail of Risk Factors in Prediction of Shoulder Distocia

Research Square (Research Square), Jun 29, 2022

The aim of this study was to evaluate the maternal, obstetric, and fetal risk factors, shoulder d... more The aim of this study was to evaluate the maternal, obstetric, and fetal risk factors, shoulder dystocia maneuvers, and perinatal outcomes of shoulder dystocia cases. Methods In this descriptive retrospective cross-sectional study, 66 documented shoulder dystocia (incidence 0.18%) groups from 36390 singleton vaginal deliveries between 2017 and 2022 in a gynecology&obstetrics hospital and 201 control groups selected from the computer-assisted randomization program on pregnancy, delivery, fetal and newborn outcomes data were evaluated and compared. Regression analysis were used to explain the relationship between the shoulder dystocia and risk factors. Results Mean age was signi cantly higher in the shoulder dystocia group (p < 0.05). In the stepwise binary logistic regression model analysis, hemoglobin level, abdominal circumference, femur length, estimated fetal weight, birth weight and second stage of labor were found to be signi cant risk factors for shoulder dystocia (p < 0.05). Measurement of abdominal circumference (sensitivity 81.8%, speci city 91.0%) and birth weight (sensitivity 62.4%, speci city 91.5%) were found to be the most signi cant risk factors for shoulder dystocia, while the other risk factors had low sensitivity (< 60.0%). Conclusion The low sensitivity of shoulder dystocia risk factors other than birth weight and abdominal circumference measurement indicates that the unpredictable feature of shoulder dystocia is preserved.

Research paper thumbnail of Evaluation of The Effects of Different Progesterone Treatment Methods on Fetal Aneuploidy Screening Tests

Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi

In this study, the effect of progesterone use on biomarkers due to abortion complaints in aneuplo... more In this study, the effect of progesterone use on biomarkers due to abortion complaints in aneuploidy screenings was investigated. Two hundred seventy-six singleton pregnant patients with threatened abortion were enrolled in this retrospective study. The treatment group consisted of patients who received oral, vaginal, or intramuscular progesterone (n=137) while the control group received no progesterone (n=139). The results of the double and triple screening tests of the study groups were compared. Nuchal translucency measurements and pregnancy-associated plasma protein-A (PAPP-A), (MoM) values were significantly lower in the group that received treatment with progesterone compared to the control group (p=0.009 and p<0.001, respectively). Beta-human chorionic gonadotropin (βhCG), (MoM) and alpha-fetoprotein (MoM) were found to be statistically significantly higher in the group receiving oral progesterone treatment compared to the group receiving other types of progesterone treatm...

Research paper thumbnail of Maternal and Perinatal Outcomes of Pregnancies with Uterine Leiomyomas

Gynecology obstetrics & reproductive medicine, Mar 29, 2023

Research paper thumbnail of Risk Factors in Prediction of Shoulder Distocia

Purpose The aim of this study was to evaluate the maternal, obstetric, and fetal risk factors, sh... more Purpose The aim of this study was to evaluate the maternal, obstetric, and fetal risk factors, shoulder dystocia maneuvers, and perinatal outcomes of shoulder dystocia cases. Methods In this descriptive retrospective cross-sectional study, 66 documented shoulder dystocia (incidence 0.18%) groups from 36390 singleton vaginal deliveries between 2017 and 2022 in a gynecology&obstetrics hospital and 201 control groups selected from the computer-assisted randomization program on pregnancy, delivery, fetal and newborn outcomes data were evaluated and compared. Regression analysis were used to explain the relationship between the shoulder dystocia and risk factors. Results Mean age was significantly higher in the shoulder dystocia group (p < 0.05). In the stepwise binary logistic regression model analysis, hemoglobin level, abdominal circumference, femur length, estimated fetal weight, birth weight and second stage of labor were found to be significant risk factors for shoulder dystocia...

Research paper thumbnail of 3c-2 ハイブリッドカーの静粛性が視覚障害者の歩行の安全性に及ぼす影響 : 路地横断時の事故の可能性に関する事例検討とガソリン車との音響比較(セッション3-C「歩行者・歩行環境2」,研究発表座長報告,日本福祉のまちづくり学会 第8回全国大会)

Research paper thumbnail of 視覚障害児 者の知覚 行動特性と環境の相互依存性を考慮した歩行支援手法の開発

Research paper thumbnail of Asymmetric Small for Gestational Age

leptin and soluble leptin receptor levels in full-term

Research paper thumbnail of Comparison of Triple and Qadrupple Test in Second Trimester Down Syndrome Screening

OBJECTIVE: To compare the Down syndrome detection ratio of triple test and qaudruple test in the ... more OBJECTIVE: To compare the Down syndrome detection ratio of triple test and qaudruple test in the second trimester of pregnancy. STUDY DESIGN: 148 patients whose were admitted to our clinic in the second trimester of their pregnancy were included in this study. All the patients were screened for trisomy 21, trisomy 18 and neural tube defects (NTD) with both triple and quadruple tests. Each patient gave one blood sample and both triple and quadruple tests were studied within the same sample. Any sign of down syndrome, trisomy 18 and NTD was not detected by ultrasound examination. Treshold value for down syndrome is 1/300, for trisomy 18 is 1/300 and for NTD is 1/1000. Amniocentesis was performed to the patients with high test results for trisomy 21 and 18. RESULTS: There were 6 patients (4.05%) in triple test and 5 patients (3.37%) in quadruple test with high risk results for Down syndrome. In three patient both triple and quadruple tests were reported as high risk. There were 12 pati...

Research paper thumbnail of Unilateral twin tubal pregnancy successfully treated with methotrexate

International Journal of Gynecology & Obstetrics, 2008

Research paper thumbnail of Hyperemesis Gravidarum and Helicobacter pylori Infection

Obstetrics & Gynecology, 2007

To systematically review studies examining the relationship between hyperemesis gravidarum and He... more To systematically review studies examining the relationship between hyperemesis gravidarum and Helicobacter pylori (H pylori) infection. A 1966 to January 2007 search using MEDLINE/PubMed, EMBASE, and Web of Science included MeSH terms: &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;Helicobacter pylori,&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;Helicobacter infections,&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;hyperemesis gravidarum,&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; and the text words &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;nausea,&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;vomit,&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;pregnancy,&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; and &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;Helicobacter.&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; References of selected papers were examined for additional relevant studies. We evaluated studies investigating a relationship between hyperemesis gravidarum and H pylori infection. Studies were included in which the diagnosis of hyperemesis gravidarum was made at or before entry into the study, and H pylori diagnosis was made by serum antibody sample, gastric biopsy, saliva test, or stool sample. The search produced 169 titles; 22 were reviewed in further detail. Fourteen case-control studies met established criteria, involving 1,732 participants and controls tested for H pylori infection. Studies were evaluated according to patient demographics and study methodology (case definition, exclusion criteria, H pylori testing). An estimate of the odds ratios with 95% confidence intervals was calculated by using a random effects model for dichotomous variables with review article software. Ten studies showed a significant association between hyperemesis gravidarum and H pylori infection. Odds ratios varied from 0.55 to 109.33; three results were less than 1.0. Tests for heterogeneity applied to several subgroups were considerable with values above 75% for all groups. An association between hyperemesis gravidarum and H pylori infection is suggested by this systematic review. However, the considerable heterogeneity among studies highlights study limitations.

Research paper thumbnail of Successfull treatment of cervical pregnancy with methotrexate administration: A case report

A case of cervical pregnancy which was successfully treated by intramuscular methotrexate therapy... more A case of cervical pregnancy which was successfully treated by intramuscular methotrexate therapy is presented. It is suggested that, in cervical pregnancies in which fertility preservation is desired, medical treatment would be applied if the patient condition is proper.

Research paper thumbnail of Asymmetric Small for Gestational Age

leptin and soluble leptin receptor levels in full-term

Research paper thumbnail of Assessing leptin and soluble leptin receptor levels in full-term asymmetric small for gestational age and healthy neonates

The aim in this study was to determine the factors affecting leptin and soluble leptin receptor (... more The aim in this study was to determine the factors affecting leptin and soluble leptin receptor (sOB-R) levels in term small for gestational age (SGA) and appropriate for gestational age (AGA) newborns. The study group consisted of SGA (n=20) and AGA (n=20) newborns and their mothers. The leptin and sOB-R levels were tested using the ELISA method. The cord blood leptin concentrations were found significantly higher in the AGA group than in the SGA group (p=0.048). It was observed that cord blood leptin levels increased as body weight increased in the AGA group (r=0.681, p=0.001). The cord blood leptin levels were found higher in female infants than male infants (p=0.021). The plasma leptin levels were higher in the mothers of SGA neonates than those of AGA neonates (p=0.014). A positive correlation was detected between cord blood and amniotic fluid sOB-R concentrations in the AGA group (AGA: r=0.492, p=0.028). We conclude that the main determinants of leptin in SGA and AGA newborns ...

Research paper thumbnail of Chitotriosidase Activity in Normal Pregnancies and in Abortions

Turkiye Klinikleri Journal of Medical Sciences, 2013

C hitin is the most abundant polysaccharide in the world following cellulose. Chitotriosidase (CH... more C hitin is the most abundant polysaccharide in the world following cellulose. Chitotriosidase (CHIT) is an enzyme of the chitinase class, which can hydrolyze chitin and various artificial substrates. The human CHIT gene is located on 1q31-q32, and contains a sequence of 20 kb, consisting of 12 exons. 1 CHIT enzymes are synthesized selectively in re-Chitotriosidase Activity in Normal Pregnancies and in Abortions A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : The aim of this study was to gather data on the importance of chitotriosidase in the prediction of abortion by comparing maternal serum chitotriosidase activity in normal pregnancies and in abortions. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : This study was designed as a prospective case-control study and included 142 pregnancies; 81 ended with abortion before 10 weeks of gestation, and 61 normal pregnancies. Five women in the spontaneous abortion group and one woman in the normal pregnancy group were excluded from the study. Peripheral blood samples were obtained from all pregnant women. Chitotriosidase activity was studied in these samples using the fluorometric method. R Re es su ul lt ts s: : Chitotriosidase activity was significantly higher in the spontaneous abortion group compared to the control group (p<0.01). A threshold of 46 nmol/mL/hour for maternal chitotriosidase activity yielded 53.9% sensitivity and 85% specificity. There was no significant difference between the type of abortion and chitotriosidase activity (p>0.05). C Co on nc cl lu us si io on n: : Activated macrophages may play a role in the pathogenesis of abortion. Further studies are warranted on this subject. This is the first study evaluating macrophage activation in spontaneous abortion. K Ke ey y W Wo or rd ds s: : Chitotriosidase; abortion, spontaneous Ö ÖZ ZE ET T A Am ma aç ç: : Çalışmamızda normal ve abortus tanısı almış gebelerde maternal serum kitotriosidaz aktivitesini karşılaştırarak abortus öngörüsünde kitotriosidazın önemi hakkında bilgi edinilmesi amaçlandı. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Prospektif vaka-kontrol çalışması olarak planlandı. Çalışma 10. gebelik haftasının altında olan 81 spontan abortus olgusu ve 61 normal gebe olmak üzere, toplam 142 gebelik olgusu üzerinde yapıldı. Spontan abortus grubundan beş gebe ve sağlıklı gebe grubundan bir gebe çalışma dışı bırakıldı. Bu gebelerden maternal periferik kan örneği alındı. Bu örneklerden fluorometri yöntemi ile kitotriosidaz aktivitesi belirlendi. B Bu ul lg gu ul la ar r: : Spontan abortus grubunda maternal serum kitotriosidaz aktivitesi, kontrol grubuna göre anlamlı şekilde yüksek bulundu (p<0,001). Maternal serum kitotriosidaz aktivitesi için 46 nmol/mL/saat eşik değerinin sensivitesi %53,9 ve spesifitesi %85 olarak saptandı. Abortus tipi ile kitotriosidaz aktivitesi arasında anlamlı bir fark bulunmadı (p>0,05). S So on nu uç ç: : Abortus patogenezinde aktive makrofajların rolü olabilir. Bu konuda ileri çalışmalara ihtiyaç vardır. Bu çalışma, spontan abortuslarda makrofaj aktivasyonunu değerlendiren ilk çalışmadır.

Research paper thumbnail of Perinatal risk factors affecting the maternal and fetal asymmetric dimethylarginine levels

The aim of this study was to investigate the relationship between maternal risk factors, neonatal... more The aim of this study was to investigate the relationship between maternal risk factors, neonatal demographic features and asymmetric dimethylarginine (ADMA) levels in a randomly selected group of pregnancies during delivery. The subjects were categorized into five groups as having: no maternal risk factor, maternal hypertension, gestational diabetes, maternal smoking history, and meconium staining. Blood samples were taken from the mothers before delivery and from the umbilical vein after delivery. Mean ADMA levels were significantly lower in the cord blood when compared with maternal levels in all groups. Mean ADMA level of neonates in the meconium staining group was found to be significantly higher than in the other groups (p<0.001). Maternal age, delivery type, parity and sex did not show any effect on cord blood ADMA levels. Overall, umbilical vein ADMA levels are modulated independent of several maternal features and risk factors. Although these factors are interrelated and...

Research paper thumbnail of Normal ve Aborte Eden Gebeliklerde Kitotriosidaz Aktivitesi

Turkiye Klinikleri Journal of Medical Sciences, 2013

C hitin is the most abundant polysaccharide in the world following cellulose. Chitotriosidase (CH... more C hitin is the most abundant polysaccharide in the world following cellulose. Chitotriosidase (CHIT) is an enzyme of the chitinase class, which can hydrolyze chitin and various artificial substrates. The human CHIT gene is located on 1q31-q32, and contains a sequence of 20 kb, consisting of 12 exons. 1 CHIT enzymes are synthesized selectively in re-Chitotriosidase Activity in Normal Pregnancies and in Abortions A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : The aim of this study was to gather data on the importance of chitotriosidase in the prediction of abortion by comparing maternal serum chitotriosidase activity in normal pregnancies and in abortions. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : This study was designed as a prospective case-control study and included 142 pregnancies; 81 ended with abortion before 10 weeks of gestation, and 61 normal pregnancies. Five women in the spontaneous abortion group and one woman in the normal pregnancy group were excluded from the study. Peripheral blood samples were obtained from all pregnant women. Chitotriosidase activity was studied in these samples using the fluorometric method. R Re es su ul lt ts s: : Chitotriosidase activity was significantly higher in the spontaneous abortion group compared to the control group (p<0.01). A threshold of 46 nmol/mL/hour for maternal chitotriosidase activity yielded 53.9% sensitivity and 85% specificity. There was no significant difference between the type of abortion and chitotriosidase activity (p>0.05). C Co on nc cl lu us si io on n: : Activated macrophages may play a role in the pathogenesis of abortion. Further studies are warranted on this subject. This is the first study evaluating macrophage activation in spontaneous abortion. K Ke ey y W Wo or rd ds s: : Chitotriosidase; abortion, spontaneous Ö ÖZ ZE ET T A Am ma aç ç: : Çalışmamızda normal ve abortus tanısı almış gebelerde maternal serum kitotriosidaz aktivitesini karşılaştırarak abortus öngörüsünde kitotriosidazın önemi hakkında bilgi edinilmesi amaçlandı. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Prospektif vaka-kontrol çalışması olarak planlandı. Çalışma 10. gebelik haftasının altında olan 81 spontan abortus olgusu ve 61 normal gebe olmak üzere, toplam 142 gebelik olgusu üzerinde yapıldı. Spontan abortus grubundan beş gebe ve sağlıklı gebe grubundan bir gebe çalışma dışı bırakıldı. Bu gebelerden maternal periferik kan örneği alındı. Bu örneklerden fluorometri yöntemi ile kitotriosidaz aktivitesi belirlendi. B Bu ul lg gu ul la ar r: : Spontan abortus grubunda maternal serum kitotriosidaz aktivitesi, kontrol grubuna göre anlamlı şekilde yüksek bulundu (p<0,001). Maternal serum kitotriosidaz aktivitesi için 46 nmol/mL/saat eşik değerinin sensivitesi %53,9 ve spesifitesi %85 olarak saptandı. Abortus tipi ile kitotriosidaz aktivitesi arasında anlamlı bir fark bulunmadı (p>0,05). S So on nu uç ç: : Abortus patogenezinde aktive makrofajların rolü olabilir. Bu konuda ileri çalışmalara ihtiyaç vardır. Bu çalışma, spontan abortuslarda makrofaj aktivasyonunu değerlendiren ilk çalışmadır.

Research paper thumbnail of Yapışık İkizin Çok Nadir Bir Şekli: İlk Trimesterde Transvajinal Ultrasonografi ile Tanı Konulan Diprosopus İkiz: Case Report

Turkiye Klinikleri Journal of Medical Sciences, 2012

Research paper thumbnail of Good perinatal outcome of the pump twin in the twin reversed-arterial-perfusion sequence diagnosed at the ninth week of pregnancy and managed conservatively

Journal of Maternal-Fetal and Neonatal Medicine, 2009

Research paper thumbnail of Assessing leptin and soluble leptin receptor levels in full-term asymmetric small for gestational age and healthy neonates

The Turkish journal of pediatrics

The aim in this study was to determine the factors affecting leptin and soluble leptin receptor (... more The aim in this study was to determine the factors affecting leptin and soluble leptin receptor (sOB-R) levels in term small for gestational age (SGA) and appropriate for gestational age (AGA) newborns. The study group consisted of SGA (n=20) and AGA (n=20) newborns and their mothers. The leptin and sOB-R levels were tested using the ELISA method. The cord blood leptin concentrations were found significantly higher in the AGA group than in the SGA group (p=0.048). It was observed that cord blood leptin levels increased as body weight increased in the AGA group (r=0.681, p=0.001). The cord blood leptin levels were found higher in female infants than male infants (p=0.021). The plasma leptin levels were higher in the mothers of SGA neonates than those of AGA neonates (p=0.014). A positive correlation was detected between cord blood and amniotic fluid sOB-R concentrations in the AGA group (AGA: r=0.492, p=0.028). We conclude that the main determinants of leptin in SGA and AGA newborns ...

Research paper thumbnail of Risk Factors in Prediction of Shoulder Distocia

Research Square (Research Square), Jun 29, 2022

The aim of this study was to evaluate the maternal, obstetric, and fetal risk factors, shoulder d... more The aim of this study was to evaluate the maternal, obstetric, and fetal risk factors, shoulder dystocia maneuvers, and perinatal outcomes of shoulder dystocia cases. Methods In this descriptive retrospective cross-sectional study, 66 documented shoulder dystocia (incidence 0.18%) groups from 36390 singleton vaginal deliveries between 2017 and 2022 in a gynecology&obstetrics hospital and 201 control groups selected from the computer-assisted randomization program on pregnancy, delivery, fetal and newborn outcomes data were evaluated and compared. Regression analysis were used to explain the relationship between the shoulder dystocia and risk factors. Results Mean age was signi cantly higher in the shoulder dystocia group (p < 0.05). In the stepwise binary logistic regression model analysis, hemoglobin level, abdominal circumference, femur length, estimated fetal weight, birth weight and second stage of labor were found to be signi cant risk factors for shoulder dystocia (p < 0.05). Measurement of abdominal circumference (sensitivity 81.8%, speci city 91.0%) and birth weight (sensitivity 62.4%, speci city 91.5%) were found to be the most signi cant risk factors for shoulder dystocia, while the other risk factors had low sensitivity (< 60.0%). Conclusion The low sensitivity of shoulder dystocia risk factors other than birth weight and abdominal circumference measurement indicates that the unpredictable feature of shoulder dystocia is preserved.

Research paper thumbnail of Evaluation of The Effects of Different Progesterone Treatment Methods on Fetal Aneuploidy Screening Tests

Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi

In this study, the effect of progesterone use on biomarkers due to abortion complaints in aneuplo... more In this study, the effect of progesterone use on biomarkers due to abortion complaints in aneuploidy screenings was investigated. Two hundred seventy-six singleton pregnant patients with threatened abortion were enrolled in this retrospective study. The treatment group consisted of patients who received oral, vaginal, or intramuscular progesterone (n=137) while the control group received no progesterone (n=139). The results of the double and triple screening tests of the study groups were compared. Nuchal translucency measurements and pregnancy-associated plasma protein-A (PAPP-A), (MoM) values were significantly lower in the group that received treatment with progesterone compared to the control group (p=0.009 and p<0.001, respectively). Beta-human chorionic gonadotropin (βhCG), (MoM) and alpha-fetoprotein (MoM) were found to be statistically significantly higher in the group receiving oral progesterone treatment compared to the group receiving other types of progesterone treatm...

Research paper thumbnail of Maternal and Perinatal Outcomes of Pregnancies with Uterine Leiomyomas

Gynecology obstetrics & reproductive medicine, Mar 29, 2023

Research paper thumbnail of Risk Factors in Prediction of Shoulder Distocia

Purpose The aim of this study was to evaluate the maternal, obstetric, and fetal risk factors, sh... more Purpose The aim of this study was to evaluate the maternal, obstetric, and fetal risk factors, shoulder dystocia maneuvers, and perinatal outcomes of shoulder dystocia cases. Methods In this descriptive retrospective cross-sectional study, 66 documented shoulder dystocia (incidence 0.18%) groups from 36390 singleton vaginal deliveries between 2017 and 2022 in a gynecology&obstetrics hospital and 201 control groups selected from the computer-assisted randomization program on pregnancy, delivery, fetal and newborn outcomes data were evaluated and compared. Regression analysis were used to explain the relationship between the shoulder dystocia and risk factors. Results Mean age was significantly higher in the shoulder dystocia group (p < 0.05). In the stepwise binary logistic regression model analysis, hemoglobin level, abdominal circumference, femur length, estimated fetal weight, birth weight and second stage of labor were found to be significant risk factors for shoulder dystocia...

Research paper thumbnail of 3c-2 ハイブリッドカーの静粛性が視覚障害者の歩行の安全性に及ぼす影響 : 路地横断時の事故の可能性に関する事例検討とガソリン車との音響比較(セッション3-C「歩行者・歩行環境2」,研究発表座長報告,日本福祉のまちづくり学会 第8回全国大会)

Research paper thumbnail of 視覚障害児 者の知覚 行動特性と環境の相互依存性を考慮した歩行支援手法の開発

Research paper thumbnail of Asymmetric Small for Gestational Age

leptin and soluble leptin receptor levels in full-term

Research paper thumbnail of Comparison of Triple and Qadrupple Test in Second Trimester Down Syndrome Screening

OBJECTIVE: To compare the Down syndrome detection ratio of triple test and qaudruple test in the ... more OBJECTIVE: To compare the Down syndrome detection ratio of triple test and qaudruple test in the second trimester of pregnancy. STUDY DESIGN: 148 patients whose were admitted to our clinic in the second trimester of their pregnancy were included in this study. All the patients were screened for trisomy 21, trisomy 18 and neural tube defects (NTD) with both triple and quadruple tests. Each patient gave one blood sample and both triple and quadruple tests were studied within the same sample. Any sign of down syndrome, trisomy 18 and NTD was not detected by ultrasound examination. Treshold value for down syndrome is 1/300, for trisomy 18 is 1/300 and for NTD is 1/1000. Amniocentesis was performed to the patients with high test results for trisomy 21 and 18. RESULTS: There were 6 patients (4.05%) in triple test and 5 patients (3.37%) in quadruple test with high risk results for Down syndrome. In three patient both triple and quadruple tests were reported as high risk. There were 12 pati...

Research paper thumbnail of Unilateral twin tubal pregnancy successfully treated with methotrexate

International Journal of Gynecology & Obstetrics, 2008

Research paper thumbnail of Hyperemesis Gravidarum and Helicobacter pylori Infection

Obstetrics & Gynecology, 2007

To systematically review studies examining the relationship between hyperemesis gravidarum and He... more To systematically review studies examining the relationship between hyperemesis gravidarum and Helicobacter pylori (H pylori) infection. A 1966 to January 2007 search using MEDLINE/PubMed, EMBASE, and Web of Science included MeSH terms: &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;Helicobacter pylori,&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;Helicobacter infections,&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;hyperemesis gravidarum,&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; and the text words &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;nausea,&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;vomit,&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;pregnancy,&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; and &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;Helicobacter.&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; References of selected papers were examined for additional relevant studies. We evaluated studies investigating a relationship between hyperemesis gravidarum and H pylori infection. Studies were included in which the diagnosis of hyperemesis gravidarum was made at or before entry into the study, and H pylori diagnosis was made by serum antibody sample, gastric biopsy, saliva test, or stool sample. The search produced 169 titles; 22 were reviewed in further detail. Fourteen case-control studies met established criteria, involving 1,732 participants and controls tested for H pylori infection. Studies were evaluated according to patient demographics and study methodology (case definition, exclusion criteria, H pylori testing). An estimate of the odds ratios with 95% confidence intervals was calculated by using a random effects model for dichotomous variables with review article software. Ten studies showed a significant association between hyperemesis gravidarum and H pylori infection. Odds ratios varied from 0.55 to 109.33; three results were less than 1.0. Tests for heterogeneity applied to several subgroups were considerable with values above 75% for all groups. An association between hyperemesis gravidarum and H pylori infection is suggested by this systematic review. However, the considerable heterogeneity among studies highlights study limitations.

Research paper thumbnail of Successfull treatment of cervical pregnancy with methotrexate administration: A case report

A case of cervical pregnancy which was successfully treated by intramuscular methotrexate therapy... more A case of cervical pregnancy which was successfully treated by intramuscular methotrexate therapy is presented. It is suggested that, in cervical pregnancies in which fertility preservation is desired, medical treatment would be applied if the patient condition is proper.

Research paper thumbnail of Asymmetric Small for Gestational Age

leptin and soluble leptin receptor levels in full-term

Research paper thumbnail of Assessing leptin and soluble leptin receptor levels in full-term asymmetric small for gestational age and healthy neonates

The aim in this study was to determine the factors affecting leptin and soluble leptin receptor (... more The aim in this study was to determine the factors affecting leptin and soluble leptin receptor (sOB-R) levels in term small for gestational age (SGA) and appropriate for gestational age (AGA) newborns. The study group consisted of SGA (n=20) and AGA (n=20) newborns and their mothers. The leptin and sOB-R levels were tested using the ELISA method. The cord blood leptin concentrations were found significantly higher in the AGA group than in the SGA group (p=0.048). It was observed that cord blood leptin levels increased as body weight increased in the AGA group (r=0.681, p=0.001). The cord blood leptin levels were found higher in female infants than male infants (p=0.021). The plasma leptin levels were higher in the mothers of SGA neonates than those of AGA neonates (p=0.014). A positive correlation was detected between cord blood and amniotic fluid sOB-R concentrations in the AGA group (AGA: r=0.492, p=0.028). We conclude that the main determinants of leptin in SGA and AGA newborns ...

Research paper thumbnail of Chitotriosidase Activity in Normal Pregnancies and in Abortions

Turkiye Klinikleri Journal of Medical Sciences, 2013

C hitin is the most abundant polysaccharide in the world following cellulose. Chitotriosidase (CH... more C hitin is the most abundant polysaccharide in the world following cellulose. Chitotriosidase (CHIT) is an enzyme of the chitinase class, which can hydrolyze chitin and various artificial substrates. The human CHIT gene is located on 1q31-q32, and contains a sequence of 20 kb, consisting of 12 exons. 1 CHIT enzymes are synthesized selectively in re-Chitotriosidase Activity in Normal Pregnancies and in Abortions A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : The aim of this study was to gather data on the importance of chitotriosidase in the prediction of abortion by comparing maternal serum chitotriosidase activity in normal pregnancies and in abortions. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : This study was designed as a prospective case-control study and included 142 pregnancies; 81 ended with abortion before 10 weeks of gestation, and 61 normal pregnancies. Five women in the spontaneous abortion group and one woman in the normal pregnancy group were excluded from the study. Peripheral blood samples were obtained from all pregnant women. Chitotriosidase activity was studied in these samples using the fluorometric method. R Re es su ul lt ts s: : Chitotriosidase activity was significantly higher in the spontaneous abortion group compared to the control group (p<0.01). A threshold of 46 nmol/mL/hour for maternal chitotriosidase activity yielded 53.9% sensitivity and 85% specificity. There was no significant difference between the type of abortion and chitotriosidase activity (p>0.05). C Co on nc cl lu us si io on n: : Activated macrophages may play a role in the pathogenesis of abortion. Further studies are warranted on this subject. This is the first study evaluating macrophage activation in spontaneous abortion. K Ke ey y W Wo or rd ds s: : Chitotriosidase; abortion, spontaneous Ö ÖZ ZE ET T A Am ma aç ç: : Çalışmamızda normal ve abortus tanısı almış gebelerde maternal serum kitotriosidaz aktivitesini karşılaştırarak abortus öngörüsünde kitotriosidazın önemi hakkında bilgi edinilmesi amaçlandı. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Prospektif vaka-kontrol çalışması olarak planlandı. Çalışma 10. gebelik haftasının altında olan 81 spontan abortus olgusu ve 61 normal gebe olmak üzere, toplam 142 gebelik olgusu üzerinde yapıldı. Spontan abortus grubundan beş gebe ve sağlıklı gebe grubundan bir gebe çalışma dışı bırakıldı. Bu gebelerden maternal periferik kan örneği alındı. Bu örneklerden fluorometri yöntemi ile kitotriosidaz aktivitesi belirlendi. B Bu ul lg gu ul la ar r: : Spontan abortus grubunda maternal serum kitotriosidaz aktivitesi, kontrol grubuna göre anlamlı şekilde yüksek bulundu (p<0,001). Maternal serum kitotriosidaz aktivitesi için 46 nmol/mL/saat eşik değerinin sensivitesi %53,9 ve spesifitesi %85 olarak saptandı. Abortus tipi ile kitotriosidaz aktivitesi arasında anlamlı bir fark bulunmadı (p>0,05). S So on nu uç ç: : Abortus patogenezinde aktive makrofajların rolü olabilir. Bu konuda ileri çalışmalara ihtiyaç vardır. Bu çalışma, spontan abortuslarda makrofaj aktivasyonunu değerlendiren ilk çalışmadır.

Research paper thumbnail of Perinatal risk factors affecting the maternal and fetal asymmetric dimethylarginine levels

The aim of this study was to investigate the relationship between maternal risk factors, neonatal... more The aim of this study was to investigate the relationship between maternal risk factors, neonatal demographic features and asymmetric dimethylarginine (ADMA) levels in a randomly selected group of pregnancies during delivery. The subjects were categorized into five groups as having: no maternal risk factor, maternal hypertension, gestational diabetes, maternal smoking history, and meconium staining. Blood samples were taken from the mothers before delivery and from the umbilical vein after delivery. Mean ADMA levels were significantly lower in the cord blood when compared with maternal levels in all groups. Mean ADMA level of neonates in the meconium staining group was found to be significantly higher than in the other groups (p<0.001). Maternal age, delivery type, parity and sex did not show any effect on cord blood ADMA levels. Overall, umbilical vein ADMA levels are modulated independent of several maternal features and risk factors. Although these factors are interrelated and...

Research paper thumbnail of Normal ve Aborte Eden Gebeliklerde Kitotriosidaz Aktivitesi

Turkiye Klinikleri Journal of Medical Sciences, 2013

C hitin is the most abundant polysaccharide in the world following cellulose. Chitotriosidase (CH... more C hitin is the most abundant polysaccharide in the world following cellulose. Chitotriosidase (CHIT) is an enzyme of the chitinase class, which can hydrolyze chitin and various artificial substrates. The human CHIT gene is located on 1q31-q32, and contains a sequence of 20 kb, consisting of 12 exons. 1 CHIT enzymes are synthesized selectively in re-Chitotriosidase Activity in Normal Pregnancies and in Abortions A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : The aim of this study was to gather data on the importance of chitotriosidase in the prediction of abortion by comparing maternal serum chitotriosidase activity in normal pregnancies and in abortions. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : This study was designed as a prospective case-control study and included 142 pregnancies; 81 ended with abortion before 10 weeks of gestation, and 61 normal pregnancies. Five women in the spontaneous abortion group and one woman in the normal pregnancy group were excluded from the study. Peripheral blood samples were obtained from all pregnant women. Chitotriosidase activity was studied in these samples using the fluorometric method. R Re es su ul lt ts s: : Chitotriosidase activity was significantly higher in the spontaneous abortion group compared to the control group (p<0.01). A threshold of 46 nmol/mL/hour for maternal chitotriosidase activity yielded 53.9% sensitivity and 85% specificity. There was no significant difference between the type of abortion and chitotriosidase activity (p>0.05). C Co on nc cl lu us si io on n: : Activated macrophages may play a role in the pathogenesis of abortion. Further studies are warranted on this subject. This is the first study evaluating macrophage activation in spontaneous abortion. K Ke ey y W Wo or rd ds s: : Chitotriosidase; abortion, spontaneous Ö ÖZ ZE ET T A Am ma aç ç: : Çalışmamızda normal ve abortus tanısı almış gebelerde maternal serum kitotriosidaz aktivitesini karşılaştırarak abortus öngörüsünde kitotriosidazın önemi hakkında bilgi edinilmesi amaçlandı. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Prospektif vaka-kontrol çalışması olarak planlandı. Çalışma 10. gebelik haftasının altında olan 81 spontan abortus olgusu ve 61 normal gebe olmak üzere, toplam 142 gebelik olgusu üzerinde yapıldı. Spontan abortus grubundan beş gebe ve sağlıklı gebe grubundan bir gebe çalışma dışı bırakıldı. Bu gebelerden maternal periferik kan örneği alındı. Bu örneklerden fluorometri yöntemi ile kitotriosidaz aktivitesi belirlendi. B Bu ul lg gu ul la ar r: : Spontan abortus grubunda maternal serum kitotriosidaz aktivitesi, kontrol grubuna göre anlamlı şekilde yüksek bulundu (p<0,001). Maternal serum kitotriosidaz aktivitesi için 46 nmol/mL/saat eşik değerinin sensivitesi %53,9 ve spesifitesi %85 olarak saptandı. Abortus tipi ile kitotriosidaz aktivitesi arasında anlamlı bir fark bulunmadı (p>0,05). S So on nu uç ç: : Abortus patogenezinde aktive makrofajların rolü olabilir. Bu konuda ileri çalışmalara ihtiyaç vardır. Bu çalışma, spontan abortuslarda makrofaj aktivasyonunu değerlendiren ilk çalışmadır.

Research paper thumbnail of Yapışık İkizin Çok Nadir Bir Şekli: İlk Trimesterde Transvajinal Ultrasonografi ile Tanı Konulan Diprosopus İkiz: Case Report

Turkiye Klinikleri Journal of Medical Sciences, 2012

Research paper thumbnail of Good perinatal outcome of the pump twin in the twin reversed-arterial-perfusion sequence diagnosed at the ninth week of pregnancy and managed conservatively

Journal of Maternal-Fetal and Neonatal Medicine, 2009

Research paper thumbnail of Assessing leptin and soluble leptin receptor levels in full-term asymmetric small for gestational age and healthy neonates

The Turkish journal of pediatrics

The aim in this study was to determine the factors affecting leptin and soluble leptin receptor (... more The aim in this study was to determine the factors affecting leptin and soluble leptin receptor (sOB-R) levels in term small for gestational age (SGA) and appropriate for gestational age (AGA) newborns. The study group consisted of SGA (n=20) and AGA (n=20) newborns and their mothers. The leptin and sOB-R levels were tested using the ELISA method. The cord blood leptin concentrations were found significantly higher in the AGA group than in the SGA group (p=0.048). It was observed that cord blood leptin levels increased as body weight increased in the AGA group (r=0.681, p=0.001). The cord blood leptin levels were found higher in female infants than male infants (p=0.021). The plasma leptin levels were higher in the mothers of SGA neonates than those of AGA neonates (p=0.014). A positive correlation was detected between cord blood and amniotic fluid sOB-R concentrations in the AGA group (AGA: r=0.492, p=0.028). We conclude that the main determinants of leptin in SGA and AGA newborns ...