Rahul Kunkulol - Academia.edu (original) (raw)

Papers by Rahul Kunkulol

Wellcome open research, Jun 21, 2024

International journal of basic and clinical pharmacology, Apr 25, 2024

Journal of medical research, Feb 28, 2024

Journal of Conservative Dentistry and Endodontics, Dec 31, 2022

PubMed, 2023

Background’: India is ranked second in the world in terms of tobacco use and tops the list of eig... more Background’: India is ranked second in the world in terms of tobacco use and tops the list of eight high-burden countries that account for two-thirds of the new tuberculosis (TB) cases globally. As tobacco smoking among TB patients is associated with unsuccessful TB treatment outcomes, effective smoking cessation interventions for TB patients is essential to combat this double pandemic. Aim: The study determined the effectiveness of nicotine replacement therapy (NRT) on smoking reduction and cessation among pulmonary TB patients. Settings and design: The study included 300 pulmonary TB patients undergoing antitubercular treatment in government health care centers of Dakshina Kannada district in southern India. Materials and methods: The participants in this two-armed, single-blinded, placebo-controlled, block-randomized trial were divided equally (n = 150) for experimental arm (brief advice + NRT) and control arm (brief advice + placebo). The total duration of treatment and follow-up was 6 months. Unadjusted relative risk (URR) and adjusted relative risk (ARR) were calculated for treatment outcomes at 95% confidence interval (CI). Generalized linear regression analysis was performed upon variables with P value less than 0.2. Results: After 6 months of intervention including follow up, there was a significant reduction in self-reported smoking (ARR = 1.08, 95% CI 1.01-1.17, P = 0.03) in the experimental arm compared with the control arm. Biochemically verified smoking abstinence was not significantly different between the two arms (ARR = 1.01, 95% CI 0.72-1.38, P = 0.97). Conclusion: The study showed statistically significant effectiveness of NRT for self-reported smoking reduction.

Frontiers in Human Neuroscience, May 2, 2023

Feasibility, acceptability, and preliminary e cacy of yoga to improve maternal mental health and ... more Feasibility, acceptability, and preliminary e cacy of yoga to improve maternal mental health and immune function during the COVID-crisis (Yoga-M trial): a pilot randomized controlled trial.

Journal of Drug Delivery and Therapeutics, Sep 15, 2018

In last few decades, though significant progress has been made in the treatment and control strat... more In last few decades, though significant progress has been made in the treatment and control strategies of tubercular infections by introducing new diagnostic and monitoring tools and combination therapy, it still continues to be severe problem. The need of study was only because of there are many drugs in market to treat infection but most of the drugs are showing resistance because of the same it is difficult to treat the infection. In this study we chosen coumarin nucleus for study. Thus with the aim of developing novel molecule with improved potency for treating Mycobacterium tuberculosis H37Rv strain infections and with decreased probability of developing drug resistance. The synthesis of coumarin derivatives, starting from salicyaldehyde and ethyl acetoacetate, by conventional organic reaction and results of investigations of their anti-mycobacterial activity. MICs of the synthesized compounds are compared with existing drugs Cytotoxicity. Many compounds have shown promising activity while some were inactive. It was found that Compound A 1 , A 2 , B 1 , B 2 , C 1 , C 2 have shown promising anti tubercular activity against std. Streptomycin

International Journal of Medical Research & Health Sciences, 2015

Objectives: The study was undertaken to investigate the effect of decreased oxygenation status in... more Objectives: The study was undertaken to investigate the effect of decreased oxygenation status in a patient of head injury and its outcome in terms of prognosis of patients with regards to neurological damage. The objective was to find out a co-relation between the SpO2 levels in a patient on admission and the severity of head injury. Methods: Prospective observational study was carried out after the approval of Institutional ethical committee. Patient with head injury coming to the emergency department of Pravara Rural hospital were assessed for the severity using Glasgow Coma scale (GCS) and hypoxic status by using pulse oximeter with bedside monitors. The SpO2 levels were monitored at 2hrs, 4hrs, 8hrs, 24hrs and 48hrs by pulse oximeter. At the time of discharge outcome was assessed again by Glasgow Outcome Scale (GOS) and the treatment that followed it. Results & Conclusions: Oxygenation status of patient on admission affects the prognosis of the patient in terms of residual neurological deficit as assessed by the Glasgow Outcome scale. There is significant co-relation between the Oxygen saturation at the time of admission and the outcome at the time of discharge. Therefore the SpO2 values are significant in patients with head injury as a prognostic factor.

International Journal of Pharmaceutical Sciences Review and Research

Adverse drug reactions pose a major health problem worldwide. Drug reactions range from minor mac... more Adverse drug reactions pose a major health problem worldwide. Drug reactions range from minor maculopapular rash to erythema multiforme to severe Stevens Johnson Syndrome (SJS) or Toxic epidermal necrolysis (TEN). SJS is a life threatening vesicobullous disease characterised by an acute eruption that involves skin and mucous membranes. Here we present 4 cases of Stevens Johnson Syndrome which came to Pravara Rural Hospital, Loni, Ahmednagar, Maharashtra. First case is a 65 year old female presenting with severe mucocutaneous bleeding with exudative haemorrhagic ulcers on the back and chest next day after ingestion of ceftriaxone. Second case is a 74 year old elderly female presenting with peeling of the skin, blisters on neck, face, mouth, groin, chest region with ulcers in the oropharynx. The patient had history of consumption of ceftriaxone after which the skin lesions started. Third case is a 69 year old female presenting with dry scales with itching all over the body after taking ceftriaxone leading to Stevens Johnson Syndrome. The fourth case is a 22 year old female with history of ingestion of unknown medication from a local doctor and presented to our hospital with severe exudative ulcers on the mouth, lips and chest diagnosed to be Stevens Johnson syndrome. This case series highlights the importance of prescription of commonly used antibiotic like ceftriaxone with extreme caution. Early identification of severe adverse drug reactions can reduce the morbidity and mortality in these patients.

International Journal of Clinical and Biomedical Research, 2019

Introduction: Sleep has become one of the most ignored factors today. More sleep or less sleep do... more Introduction: Sleep has become one of the most ignored factors today. More sleep or less sleep does not matter it is just compensated the next day. Importance of regular and timely sleep amongst the students and their correlation with blood pressure is necessary to be found out so that the students can be made aware of and can be provided treatment to prevent further complications. Method: Demographic profile was noted it includes name, age, gender, professional year of MBBS and residence. History of sleeping was noted and other factors which influences sleeping pattern (i.e, alcohol, smoking, an association of dreams with sleep, midnight awakenings with sleep, caffeine intake before bed and average stress levels) through a well-structured questionnaire. Blood pressures of all eligible students were recorded 3 times in a week at the same time by the principal investigator with the same instrument according to the JNC 7 classification for hypertension. Results: Amongst all the medic...

International Journal of Clinical and Biomedical Research, 2019

Introduction: School children majorly face stress due to the pressure and expectations from their... more Introduction: School children majorly face stress due to the pressure and expectations from their parents besides academics, athletics, etc. It is known that depression, stress increases blood pressure. Such wide variations in blood pressure at such a young age can increase the incidence of cerebrovascular accidents, ischemic heart diseases, renal failure and preterm death in the adulthood of such children. This survey will guide the parents and teachers to the various problems student face and how can they help the student cope with it. Method: The blood pressure of each student was taken three times to reduce them to minimise the possibility of errors and the blood pressures of all the students were compared according to their age (13-16 years) and the schooling type (boarders and day scholars). Results: On comparing the prehypertensive stage, the numbers of pre-hypertensives are found to be greater in the age group of 15 years in both day scholars and boarders i.e. 14% and 8% re...

IP International Journal of Comprehensive and Advanced Pharmacology

The study was aimed to determineperceptions and reviews of the currently available tobacco cessat... more The study was aimed to determineperceptions and reviews of the currently available tobacco cessation mobile applications (apps) by online and on-field surveys. In Phase I, the most commonly used tobacco cessation applications with the highest rating from Google Play Store were selected. The most relevant, positive and critical reviews of these apps were recorded. In Phase II, tobacco users with smart phone & internet connectivity and ready to give verbal consent were included in the study. The same apps were allocated to the study participants. At the end of the 2nd week of app use, the participants were subjected to a questionnaire for feedback on liked, disliked & most used features, frequency of app use, utility, expectations, and suggestions for app. The selected apps were QuitNow, Smoke Free, Quit Tracker, Stop Smoking – EasyQuit and Quit Smoking – SSC. The positive responses in Phase I were customer support, tracking statistics, reward system, craving management, user friendli...

Research journal of pharmacy and technology, May 31, 2023

Asthma in chronic condition is very tedious to cure and which is very common disease. The aim of ... more Asthma in chronic condition is very tedious to cure and which is very common disease. The aim of study was to evaluate anti-asthmatic activity root part of. A. aspera. Collection of root part of is done from Rahata District Ahmednagar (Maharashtra). For authentication of of Achyranthes aspera A. aspera Herbarium of plant was made and sent to Biological Survey of India, Pune. The collected material was proceeded for air dry at 35-40º C and then it was pulverized in electric grinder. Extraction of obtained powder was completed in ethanol,Water-ethanol and Petroleum ether by using Soxhlet Apparatus.. The presence of Steroids, flavonides, phenolic compound, glycosides, tannins, saponins, alkaloids and carbohydrates were revealed by phytochemical screening. The extract obtained were of aerial part of screened for anti-asthmatic activity. The Petroleum ether extract of root part was result the right side shift of dose Achyranthes aspera response curve in isolated goat chain and isolated guinea pig so it is indicating antiasthmatic action of drug extract.

National Journal of Physiology, Pharmacy and Pharmacology, 2022

Journal of family medicine and primary care, 2023

International Journal of Medical Research and Health Sciences, 2015

National Journal of Physiology, Pharmacy and Pharmacology, 2022

Background: The prevalence of hypertension is rapidly increasing among both rural and urban popul... more Background: The prevalence of hypertension is rapidly increasing among both rural and urban populations and is a matter of concern in India. L-Arginine serves as a principle substrate for nitric oxide production which is a potent vasodilator. Aims and Objectives: This study was designed to determine the effects of oral L-arginine on blood pressure in hypertensive patients on antihypertensive drugs. Materials and Methods: This was a randomized clinical trial, registration in Clinical Trial Registry of India (CTRI) Registration number: CTRI/2019/03/018026. All patients with hypertension visiting the medicine outpatient department of Dr. Vitthalrao Vikhe Patil Pravara Rural Hospital, Loni, were included in the study. Study participants were randomized into intervention group (I group) and control group (C group). The I group includes 74 participants and the C group includes 75 participants. The I group received antihypertensive therapy along with add-on L-arginine oral supplementation for 14 days. The C group received only standard antihypertensive therapy and had followed up similar to that of the participants of the I group. Results: The baseline systolic blood pressure (SBP) and diastolic blood pressure (DBP) of the I group and C group was statistically non-significant as analyzed by unpaired t-test, whereas in the I group, there was a significant decrease in SBP and DBP on the 1 st , 2 nd , and 3 rd follow-up visits compared to the C group (Friedman test). Conclusion: The findings of the present study showed that add-on L-arginine supplementation at a dose of 3 g/d (L-arginine 5 g sachet) for 2 weeks in patients of hypertension resulted in significant decrease in the SBP and DBP.

Journal of family medicine and primary care, 2023

International journal of basic and clinical pharmacology, May 23, 2019

Background: The present study was done with an objective to evaluate the effect of melatonin as a... more Background: The present study was done with an objective to evaluate the effect of melatonin as an antioxidant in patients suffering from periodontitis. Methods: This study was conducted in the Department of Periodontics, Rural Dental College, Loni. Patients of chronic periodontitis, of age between 18 to 65 years of either gender ready to give informed consent to participate in the study were included. Postoperative patients, patients having night duties, drivers and those using heavy machinery, pregnant women, lactating mothers, patients with any clinically significant systemic disease and patients on any other drugs were excluded from the study. Patients were divided into three Groups. Group A included patients who underwent SRP (Scaling and Root Planning) alone, Group B included patients who underwent SRP & supplemented with Vitamin E 200 IU daily at night for 4 weeks. Group C included patients who underwent SRP & supplemented with tablet melatonin 3 mg daily at night for 4 weeks. Estimation of Malondialdehyde (MDA) for serum lipid peroxidation8, Superoxide dismutase (SOD) and Glutathione peroxidase (GPx) was done on day 0, day 30, day 60 and day 90. Results: A total 240 patients were enrolled in the study. It was demonstrated that there was considerable oxidative stress in periodontitis patients, as established by high serum MDA levels, which was reduced significantly by melatonin reflecting its antioxidant potential. Pretreatment levels of SOD and GPx also were low, which were improved with the treatment of melatonin far better than with vitamin E. Conclusions: Melatonin acts as an antioxidant in the patients of periodontitis which has positive effect on biochemical parameters of periodontitis, conferring a new facet to the management of periodontitis and an attempt to impede the disease progression.

International Journal of Medical Research & Health Sciences, 2015

Wellcome open research, Jun 21, 2024

International journal of basic and clinical pharmacology, Apr 25, 2024

Journal of medical research, Feb 28, 2024

Journal of Conservative Dentistry and Endodontics, Dec 31, 2022

PubMed, 2023

Background’: India is ranked second in the world in terms of tobacco use and tops the list of eig... more Background’: India is ranked second in the world in terms of tobacco use and tops the list of eight high-burden countries that account for two-thirds of the new tuberculosis (TB) cases globally. As tobacco smoking among TB patients is associated with unsuccessful TB treatment outcomes, effective smoking cessation interventions for TB patients is essential to combat this double pandemic. Aim: The study determined the effectiveness of nicotine replacement therapy (NRT) on smoking reduction and cessation among pulmonary TB patients. Settings and design: The study included 300 pulmonary TB patients undergoing antitubercular treatment in government health care centers of Dakshina Kannada district in southern India. Materials and methods: The participants in this two-armed, single-blinded, placebo-controlled, block-randomized trial were divided equally (n = 150) for experimental arm (brief advice + NRT) and control arm (brief advice + placebo). The total duration of treatment and follow-up was 6 months. Unadjusted relative risk (URR) and adjusted relative risk (ARR) were calculated for treatment outcomes at 95% confidence interval (CI). Generalized linear regression analysis was performed upon variables with P value less than 0.2. Results: After 6 months of intervention including follow up, there was a significant reduction in self-reported smoking (ARR = 1.08, 95% CI 1.01-1.17, P = 0.03) in the experimental arm compared with the control arm. Biochemically verified smoking abstinence was not significantly different between the two arms (ARR = 1.01, 95% CI 0.72-1.38, P = 0.97). Conclusion: The study showed statistically significant effectiveness of NRT for self-reported smoking reduction.

Frontiers in Human Neuroscience, May 2, 2023

Feasibility, acceptability, and preliminary e cacy of yoga to improve maternal mental health and ... more Feasibility, acceptability, and preliminary e cacy of yoga to improve maternal mental health and immune function during the COVID-crisis (Yoga-M trial): a pilot randomized controlled trial.

Journal of Drug Delivery and Therapeutics, Sep 15, 2018

In last few decades, though significant progress has been made in the treatment and control strat... more In last few decades, though significant progress has been made in the treatment and control strategies of tubercular infections by introducing new diagnostic and monitoring tools and combination therapy, it still continues to be severe problem. The need of study was only because of there are many drugs in market to treat infection but most of the drugs are showing resistance because of the same it is difficult to treat the infection. In this study we chosen coumarin nucleus for study. Thus with the aim of developing novel molecule with improved potency for treating Mycobacterium tuberculosis H37Rv strain infections and with decreased probability of developing drug resistance. The synthesis of coumarin derivatives, starting from salicyaldehyde and ethyl acetoacetate, by conventional organic reaction and results of investigations of their anti-mycobacterial activity. MICs of the synthesized compounds are compared with existing drugs Cytotoxicity. Many compounds have shown promising activity while some were inactive. It was found that Compound A 1 , A 2 , B 1 , B 2 , C 1 , C 2 have shown promising anti tubercular activity against std. Streptomycin

International Journal of Medical Research & Health Sciences, 2015

Objectives: The study was undertaken to investigate the effect of decreased oxygenation status in... more Objectives: The study was undertaken to investigate the effect of decreased oxygenation status in a patient of head injury and its outcome in terms of prognosis of patients with regards to neurological damage. The objective was to find out a co-relation between the SpO2 levels in a patient on admission and the severity of head injury. Methods: Prospective observational study was carried out after the approval of Institutional ethical committee. Patient with head injury coming to the emergency department of Pravara Rural hospital were assessed for the severity using Glasgow Coma scale (GCS) and hypoxic status by using pulse oximeter with bedside monitors. The SpO2 levels were monitored at 2hrs, 4hrs, 8hrs, 24hrs and 48hrs by pulse oximeter. At the time of discharge outcome was assessed again by Glasgow Outcome Scale (GOS) and the treatment that followed it. Results & Conclusions: Oxygenation status of patient on admission affects the prognosis of the patient in terms of residual neurological deficit as assessed by the Glasgow Outcome scale. There is significant co-relation between the Oxygen saturation at the time of admission and the outcome at the time of discharge. Therefore the SpO2 values are significant in patients with head injury as a prognostic factor.

International Journal of Pharmaceutical Sciences Review and Research

Adverse drug reactions pose a major health problem worldwide. Drug reactions range from minor mac... more Adverse drug reactions pose a major health problem worldwide. Drug reactions range from minor maculopapular rash to erythema multiforme to severe Stevens Johnson Syndrome (SJS) or Toxic epidermal necrolysis (TEN). SJS is a life threatening vesicobullous disease characterised by an acute eruption that involves skin and mucous membranes. Here we present 4 cases of Stevens Johnson Syndrome which came to Pravara Rural Hospital, Loni, Ahmednagar, Maharashtra. First case is a 65 year old female presenting with severe mucocutaneous bleeding with exudative haemorrhagic ulcers on the back and chest next day after ingestion of ceftriaxone. Second case is a 74 year old elderly female presenting with peeling of the skin, blisters on neck, face, mouth, groin, chest region with ulcers in the oropharynx. The patient had history of consumption of ceftriaxone after which the skin lesions started. Third case is a 69 year old female presenting with dry scales with itching all over the body after taking ceftriaxone leading to Stevens Johnson Syndrome. The fourth case is a 22 year old female with history of ingestion of unknown medication from a local doctor and presented to our hospital with severe exudative ulcers on the mouth, lips and chest diagnosed to be Stevens Johnson syndrome. This case series highlights the importance of prescription of commonly used antibiotic like ceftriaxone with extreme caution. Early identification of severe adverse drug reactions can reduce the morbidity and mortality in these patients.

International Journal of Clinical and Biomedical Research, 2019

Introduction: Sleep has become one of the most ignored factors today. More sleep or less sleep do... more Introduction: Sleep has become one of the most ignored factors today. More sleep or less sleep does not matter it is just compensated the next day. Importance of regular and timely sleep amongst the students and their correlation with blood pressure is necessary to be found out so that the students can be made aware of and can be provided treatment to prevent further complications. Method: Demographic profile was noted it includes name, age, gender, professional year of MBBS and residence. History of sleeping was noted and other factors which influences sleeping pattern (i.e, alcohol, smoking, an association of dreams with sleep, midnight awakenings with sleep, caffeine intake before bed and average stress levels) through a well-structured questionnaire. Blood pressures of all eligible students were recorded 3 times in a week at the same time by the principal investigator with the same instrument according to the JNC 7 classification for hypertension. Results: Amongst all the medic...

International Journal of Clinical and Biomedical Research, 2019

Introduction: School children majorly face stress due to the pressure and expectations from their... more Introduction: School children majorly face stress due to the pressure and expectations from their parents besides academics, athletics, etc. It is known that depression, stress increases blood pressure. Such wide variations in blood pressure at such a young age can increase the incidence of cerebrovascular accidents, ischemic heart diseases, renal failure and preterm death in the adulthood of such children. This survey will guide the parents and teachers to the various problems student face and how can they help the student cope with it. Method: The blood pressure of each student was taken three times to reduce them to minimise the possibility of errors and the blood pressures of all the students were compared according to their age (13-16 years) and the schooling type (boarders and day scholars). Results: On comparing the prehypertensive stage, the numbers of pre-hypertensives are found to be greater in the age group of 15 years in both day scholars and boarders i.e. 14% and 8% re...

IP International Journal of Comprehensive and Advanced Pharmacology

The study was aimed to determineperceptions and reviews of the currently available tobacco cessat... more The study was aimed to determineperceptions and reviews of the currently available tobacco cessation mobile applications (apps) by online and on-field surveys. In Phase I, the most commonly used tobacco cessation applications with the highest rating from Google Play Store were selected. The most relevant, positive and critical reviews of these apps were recorded. In Phase II, tobacco users with smart phone & internet connectivity and ready to give verbal consent were included in the study. The same apps were allocated to the study participants. At the end of the 2nd week of app use, the participants were subjected to a questionnaire for feedback on liked, disliked & most used features, frequency of app use, utility, expectations, and suggestions for app. The selected apps were QuitNow, Smoke Free, Quit Tracker, Stop Smoking – EasyQuit and Quit Smoking – SSC. The positive responses in Phase I were customer support, tracking statistics, reward system, craving management, user friendli...

Research journal of pharmacy and technology, May 31, 2023

Asthma in chronic condition is very tedious to cure and which is very common disease. The aim of ... more Asthma in chronic condition is very tedious to cure and which is very common disease. The aim of study was to evaluate anti-asthmatic activity root part of. A. aspera. Collection of root part of is done from Rahata District Ahmednagar (Maharashtra). For authentication of of Achyranthes aspera A. aspera Herbarium of plant was made and sent to Biological Survey of India, Pune. The collected material was proceeded for air dry at 35-40º C and then it was pulverized in electric grinder. Extraction of obtained powder was completed in ethanol,Water-ethanol and Petroleum ether by using Soxhlet Apparatus.. The presence of Steroids, flavonides, phenolic compound, glycosides, tannins, saponins, alkaloids and carbohydrates were revealed by phytochemical screening. The extract obtained were of aerial part of screened for anti-asthmatic activity. The Petroleum ether extract of root part was result the right side shift of dose Achyranthes aspera response curve in isolated goat chain and isolated guinea pig so it is indicating antiasthmatic action of drug extract.

National Journal of Physiology, Pharmacy and Pharmacology, 2022

Journal of family medicine and primary care, 2023

International Journal of Medical Research and Health Sciences, 2015

National Journal of Physiology, Pharmacy and Pharmacology, 2022

Background: The prevalence of hypertension is rapidly increasing among both rural and urban popul... more Background: The prevalence of hypertension is rapidly increasing among both rural and urban populations and is a matter of concern in India. L-Arginine serves as a principle substrate for nitric oxide production which is a potent vasodilator. Aims and Objectives: This study was designed to determine the effects of oral L-arginine on blood pressure in hypertensive patients on antihypertensive drugs. Materials and Methods: This was a randomized clinical trial, registration in Clinical Trial Registry of India (CTRI) Registration number: CTRI/2019/03/018026. All patients with hypertension visiting the medicine outpatient department of Dr. Vitthalrao Vikhe Patil Pravara Rural Hospital, Loni, were included in the study. Study participants were randomized into intervention group (I group) and control group (C group). The I group includes 74 participants and the C group includes 75 participants. The I group received antihypertensive therapy along with add-on L-arginine oral supplementation for 14 days. The C group received only standard antihypertensive therapy and had followed up similar to that of the participants of the I group. Results: The baseline systolic blood pressure (SBP) and diastolic blood pressure (DBP) of the I group and C group was statistically non-significant as analyzed by unpaired t-test, whereas in the I group, there was a significant decrease in SBP and DBP on the 1 st , 2 nd , and 3 rd follow-up visits compared to the C group (Friedman test). Conclusion: The findings of the present study showed that add-on L-arginine supplementation at a dose of 3 g/d (L-arginine 5 g sachet) for 2 weeks in patients of hypertension resulted in significant decrease in the SBP and DBP.

Journal of family medicine and primary care, 2023

International journal of basic and clinical pharmacology, May 23, 2019

Background: The present study was done with an objective to evaluate the effect of melatonin as a... more Background: The present study was done with an objective to evaluate the effect of melatonin as an antioxidant in patients suffering from periodontitis. Methods: This study was conducted in the Department of Periodontics, Rural Dental College, Loni. Patients of chronic periodontitis, of age between 18 to 65 years of either gender ready to give informed consent to participate in the study were included. Postoperative patients, patients having night duties, drivers and those using heavy machinery, pregnant women, lactating mothers, patients with any clinically significant systemic disease and patients on any other drugs were excluded from the study. Patients were divided into three Groups. Group A included patients who underwent SRP (Scaling and Root Planning) alone, Group B included patients who underwent SRP & supplemented with Vitamin E 200 IU daily at night for 4 weeks. Group C included patients who underwent SRP & supplemented with tablet melatonin 3 mg daily at night for 4 weeks. Estimation of Malondialdehyde (MDA) for serum lipid peroxidation8, Superoxide dismutase (SOD) and Glutathione peroxidase (GPx) was done on day 0, day 30, day 60 and day 90. Results: A total 240 patients were enrolled in the study. It was demonstrated that there was considerable oxidative stress in periodontitis patients, as established by high serum MDA levels, which was reduced significantly by melatonin reflecting its antioxidant potential. Pretreatment levels of SOD and GPx also were low, which were improved with the treatment of melatonin far better than with vitamin E. Conclusions: Melatonin acts as an antioxidant in the patients of periodontitis which has positive effect on biochemical parameters of periodontitis, conferring a new facet to the management of periodontitis and an attempt to impede the disease progression.

International Journal of Medical Research & Health Sciences, 2015