Rajan Patel - Academia.edu (original) (raw)

Papers by Rajan Patel

Toxics, 2021

The green chemistry method is the preferred approach for synthesizing metal and metal oxide nanop... more The green chemistry method is the preferred approach for synthesizing metal and metal oxide nanoparticles because of its low toxicity, environmental friendliness, feasibility, and safety to human health compared with other chemical or physical methods. The present work reports the phytogenic synthesis of palladium nanoparticles (PdNPs) using an aqueous extract of Matricaria recutita (Chamomile). The phytochemical-mediated synthesis of PdNPs is an economical and eco-friendly approach without using toxic elements as reducing and capping or stabilizing agents. The UV-visible spectroscopic characterization was initially used to confirm the preparation of PdNPs using an aqueous extract of M. recutita flowers as a bioreductant for the reduction of Pd2+ to Pd0 without using any extra capping and reducing agents. The appearance of surface plasmon resonance (SPR) peak at 286 nm confirmed the formation of M. recutita extract-based PdNPs. Furthermore, the PdNPs were characterized by TEM, SEM, ...

Journal of Molecular Structure, 2019

This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

$Research paper thumbnail of {"__content__"=>"A novel biocompatible Ni tethered moiety as a glucose uptake agent and a hit against methicillin-resistant Staphylococcus aureus.", "sup"=>{"__content__"=>"II"}}$

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, Jan 5, 2018

In the efforts to develop a biocompatible transition metal complex as a drug alike for some of th... more In the efforts to develop a biocompatible transition metal complex as a drug alike for some of the prevailing non-communicable diseases (NCDs) and communicable diseases (CDs), a novel binuclear Ni compound [{Ni(hpdbal-sbdt)}] (2) has been synthesized by the reaction of Ni(OAc).4HO and Hhpdbal-sbdt (1) [1 is a dibasic tridentate ONS donor Schiff base ligand obtained by the condensation of 2-hydroxy-5-(phenyldiazenyl)benzaldehyde (Hhpdbal) and S-benzyldithiocarbazate (Hsbdt)]. Both ligand 1 and compound 2 were structurally characterized in the solid and solution state using various spectroscopic techniques like ATIR, H NMR, C NMR, TGA, FESEM, EDS and CHNS analysis. The antidiabetic activity of Hhpdbal-sbdt (1) and [{Ni(hpdbal-sbdt)}] (2) were assessed using 2-NBDG uptake assay. The assay results showed 85% and 95% of fluorescent glucose uptake by insulin resistant HePG2 cells treated with compounds 1 and 2 respectively. The 2-NBDG uptake by the cells treated with the compound 2 was ob...

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, Jan 11, 2018

The binding nature of amphiphilic drugs viz. promethazine hydrochloride (PMT) and adiphenine hydr... more The binding nature of amphiphilic drugs viz. promethazine hydrochloride (PMT) and adiphenine hydrochloride (ADP), with human hemoglobin (Hb) was unraveled by fluorescence, absorbance, time resolved fluorescence, fluorescence resonance energy transfer (FRET) and circular dichroism (CD) spectral techniques in combination with molecular docking and molecular dynamic simulation methods. The steady state fluorescence spectra indicated that both PMT and ADP quenches the fluorescence of Hb through static quenching mechanism which was further confirmed by time resolved fluorescence spectra. The UV-Vis spectroscopy suggested ground state complex formation. The activation energy (E) was observed more in the case of Hb-ADP than Hb-PMT interaction system. The FRET result indicates the high probability of energy transfer from β Trp37 residue of Hb to the PMT (r=2.02nm) and ADP (r=2.33nm). The thermodynamic data reveal that binding of PMT with Hb are exothermic in nature involving hydrogen bondin...

Journal of Molecular Liquids, 2017

, Self-aggregation of ionic liquid-cationic surfactant mixed micelles in water and in diethylene ... more , Self-aggregation of ionic liquid-cationic surfactant mixed micelles in water and in diethylene glycol-water mixtures: Conductometric, tensiometric, and spectroscopic studies. The address for the corresponding author was captured as affiliation for all authors. Please check if appropriate. Molliq(2017),

RSC Advances, 2017

Protein interactions with surfactants are dependent on their physiochemical properties.

ChemistrySelect, 2017

The present work reports the interaction of morpholinium based ionic liquid with the transporter ... more The present work reports the interaction of morpholinium based ionic liquid with the transporter protein, human serum album (HSA). The ionic liquids with morpholinium cationic groups are reported to be comparatively less toxic than other cationic groups of the ionic liquids such as imidazolium, pyridinium, piperidinium, pyrrolidinium etc. This work highlight the effect of N-butyl-N-methyl-morpholinium bromide, [Mor1,4] [Br] ionic liquid on the structural stability of HSA. The effect was analyzed by using fluorescence, time resolved fluorescence, UV-visible, CD spectroscopic techniques and molecular docking method. The results show that [Mor1,4][Br] binds with HSA through weak interactions in which hydrogen bonding and van der Waals forces play major role. [Mor1,4][Br] has a binding site on HSA and binds in the hydrophobic pocket of subdomain IIA of HSA. It was observed that [Mor1,4][Br] retain native conformation of HSA upto certain concentration range. This study endows new insight for designing of such type of nontoxic ILs that augments their protein stabilizing nature.

Journal of Biomolecular Structure and Dynamics, 2016

Herein, the binding of 1-methyl-3-octylimidazolium chloride [OMIM][Cl] ionic liquid with hen egg ... more Herein, the binding of 1-methyl-3-octylimidazolium chloride [OMIM][Cl] ionic liquid with hen egg white lysozyme (HEWL) has been studied using fluorescence, time resolved fluorescence, UV-visible and circular dichroism (CD) spectroscopy, in combination with computational study. The fluorescence results revealed that [OMIM][Cl] quenches the fluorophore of HEWL through static quenching mechanism. The calculated thermodynamic parameters show that [OMIM][Cl] bind with HEWL through hydrophobic interactions. In addition, the negative value of Gibbs energy change (∆G) indicates that the binding process was spontaneous. Furthermore, UV-vis and CD results indicate that [OMIM][Cl] induce the conformational change in HEWL and increase its enzymatic activity. Additionally, molecular docking results showed that [OMIM][Cl] binds at the active site of HEWL where both the fluorophore residues (Trp108 and Trp62) and the catalytic residues (Glu35 and Asp52) reside. Molecular dynamic simulation results show the reduction of intra-molecular hydrogen bond of HEWL when it binds with [OMIM][Cl].

Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2016

h i g h l i g h t s • [C 12-4-C 12 im]Br 2 quenches the fluorescence intensity of gramicidin thro... more h i g h l i g h t s • [C 12-4-C 12 im]Br 2 quenches the fluorescence intensity of gramicidin through static quenching mechanism. • REES suggests possible interactions of [C 12-4-C 12 im]Br 2 with channel form gramicidin. • CD results show the substantial change in the conformation of the channel form of gramicidin on interaction. • [C 12-4-C 12 im]Br 2 form aggregates at the surface of gramicidin vesicles.

Journal of biomolecular structure & dynamics, Jan 4, 2016

Herein, we have explored the interaction between amitriptyline hydrochloride (AMT) and hemoglobin... more Herein, we have explored the interaction between amitriptyline hydrochloride (AMT) and hemoglobin (Hb), using steady state and time resolved fluorescence spectroscopy, UV-visible spectroscopy, and circular dichroism spectroscopy, in combination with molecular docking and molecular dynamic simulation methods. The steady state fluorescence reveals the static quenching mechanism in the interaction system, which was further confirmed by UV-visible and time resolved fluorescence spectroscopy. The binding constant, number of binding sites and thermodynamic parameters viz. ΔG, ΔH, ΔS are also considered; result confirms that the binding of the AMT with Hb is a spontaneous process, involving hydrogen bonding and van der Waals interactions with a single binding site, as also confirmed by molecular docking study. Synchronous fluorescence, CD data and molecular dynamic (MD) simulation results contribute towards understanding the effect of AMT on Hb to interpret the conformational change in Hb ...

$Research paper thumbnail of Volumetric, viscometric and refractive index study of amino acids in mixed solvents at 308.15 K$

Physics and Chemistry of Liquids, 2006

Densities, ρ, viscosities, η and refractive indices nD for solutions of (0.10, 0.20, 0.30, 0.40 a... more Densities, ρ, viscosities, η and refractive indices nD for solutions of (0.10, 0.20, 0.30, 0.40 and 0.50 M) glycine (Gly), DL-alanine (Ala) and L-serine (Ser) in aqueous 1-propanol (10 and 30% v/v) at 308.15 K have been determined. These data have been used to calculate apparent molar volumes, φv, partial molar volumes, and Falkenhagen and Jones–Dole coefficients, A and B, respectively. Free energies of activation of viscous flow, and per mole of solvent and solute, respectively, were obtained by using transition state theory to the B-coefficient data. The molar refractive indices, RD were calculated from the experimental values of refractive indices for all the three amino acids + aqueous 1-propanol ternary mixtures. These parameters were used to discuss the solute–solute and solute–solvent interactions and also the effect of cosolvent (1-propanol) on these interactions.

Bulletin of the Chemical Society of Japan, 2006

The densities () and ultrasonic speeds (u) of pure dimethyl sulfoxide (DMSO), benzene, toluene, o... more The densities () and ultrasonic speeds (u) of pure dimethyl sulfoxide (DMSO), benzene, toluene, o-xylene, mxylene, p-xylene, and mesitylene, and those of their binary mixtures, with DMSO as the common component, over the whole composition range have been measured at 298.15, 303.15, 308.15, 313.15, and 318.15 K. The excess molar volume (V E), deviation in isentropic compressibility (Ák s), apparent molar volume (V ;2), apparent molar compressibility (K ;2), partial molar volume (" V V ;2), and partial molar compressibility (" K K ;2) of aromatic hydrocarbons in DMSO at infinite dilution have been calculated from the experimental data. The variation of these parameters with the composition and temperature of the mixtures indicates that the interaction (DMSO-aromatic hydrocarbons) follows the order: benzene > toluene > p-xylene > m-xylene > o-xylene > mesitylene. The effect of the number and position of the methyl groups in these aromatic hydrocarbons on molecular interactions in these mixtures is also discussed. The V E values have also been calculated theoretically by using Flory's statistical theory and the Prigogine-Flory-Patterson theory. The calculated V E values were found to be in good agreement with the experimental V E values for most of the mixtures.

Journal of photochemistry and photobiology. B, Biology, Jan 5, 2014

Herein, we report the interaction of synthesized pyrrolidinium based ionic liquid, N-butyl-N-meth... more Herein, we report the interaction of synthesized pyrrolidinium based ionic liquid, N-butyl-N-methyl-2-oxopyrrolidinium bromide (BMOP) with human serum albumin (HSA). The BMOP was characterized by using (1)H NMR, (13)C NMR and FT-IR techniques. The critical micelle concentration (cmc) of BMOP was confirmed by surface tension, conductivity and contact angle measurements. The interactions between HSA and BMOP were studied by steady-state and time-resolved fluorescence, UV-visible, FT-IR spectroscopic and molecular docking methods. The steady-state fluorescence spectra showed that BMOP quenched the fluorescence of HSA through combined quenching mechanism. Corresponding thermodynamic parameters viz. Gibbs free energy change (ΔG), entropy change (ΔS) and enthalpy change (ΔH) illustrated that the binding process was spontaneous and entropy driven. It is also suggested that hydrophobic forces play a key role in the binding of BMOP to HSA. In addition, the pyrene probe analysis again suggest...