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Papers by Rajnikant Suthar

Research paper thumbnail of Development of Fast Dissolving Tablets Containing Ondansetron via Camphor Sublimation and its Characterization

Research & Reviews: Journal of Pharmacy and Pharmaceutical Sciences, 2012

Ondansetron Hydrochloride (OSH) is a sparingly water-soluble drug. In this investigation fast dis... more Ondansetron Hydrochloride (OSH) is a sparingly water-soluble drug. In this investigation fast dissolving tablets (FDTs) of ondansetron were prepared using different superdisintegrants by sublimation method. FDTs were evaluated for physicochemical properties and in vitro dissolution. The wetting time (10.5s) of formulation batch containing crospovidone (F2) was least and tablets showed fastest disintegration (3.2s). The drug release from FDTs containing superdisintegrants was more as compared to FDTs without superdisintegrant and it was found to be highest (98% drug release after 30 min) with formulation batch containing crospovidone (F2) so it can be concluded as promising formulation.

Research paper thumbnail of Handbook of Drug Store and Business Management

The pharmaceutical industry is considered to be "Lifeline" industry. It plays important... more The pharmaceutical industry is considered to be "Lifeline" industry. It plays important role in raising general health standards. The availability is an ever increasing measures, of wide range of quality drugs to people through effective distribution media is note worthy. Retail pharmacist is a vital link in the health care services of a nation. To run the drug store effectively and efficiently management principles and techniques are very much useful. Since competition is increasing day by day, managing drug store becoming challenging job. This book emphasize the theoretical management principles in practical aspects to run the drug store. This book emphasize the principles of management, pharmaceutical marketing, role of drug store along with identifying location, optimum design characteristics, regarding various types of business organizations, purchasing and inventory control, personal administration. This book provides guidelines to start strategies to rule out compet...

Research paper thumbnail of Formulation and Evaluation of Fast Dissolving Tablets of Ondansetron by Solid Dispersion in Superdisintegrants

Ondansetron Hydrochloride (OSH) is a sparingly water-soluble drug. The aim of the present investi... more Ondansetron Hydrochloride (OSH) is a sparingly water-soluble drug. The aim of the present investigation was to prepare solid dispersion (SD) of OSH using superdisintegrants as carrier and formulate it as fast dissolving tablets (FDTs) with an objective to improve solubility and enhance dissolution of drug. SD of drug using superdisintegrants like croscarmellose sodium (CCS), crospovidone (CP), sodium starch glycolate (SSG), and low substituted hydroxy propyl cellulose (L-HPC) respectively as carriers was prepared by solvent evaporation method. The prepared SD formulations were characterized by equilibrium solubility, fourier transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC) and dissolution study. FTIR spectra revealed no chemical interaction between the drug and superdisintegrants. XRPD and DSC data indicated that OSH was in the amorphous form, which explains the better dissolution rate of the drug from its solid dispers...

Research paper thumbnail of Handbook of Cosmetic Science and Technology

... Topical Delivery by Iontophoresis 211 Veronique Preat and Rita Vanbever 19. Mousses 221 Alber... more ... Topical Delivery by Iontophoresis 211 Veronique Preat and Rita Vanbever 19. Mousses 221 Albert Zorko Abram and Roderick Peter John Tomlinson 20. ... Antioxidants 299 Stefan Udo Weber, John K. Lodge, Claude Saliou, and Lester Packer Page 8. Contents vii 27. ...

Research paper thumbnail of Exploration of Novel Co-Processed Multifunctional Excipient for Tablet Dosage Form

The aim of the present investigation is to formulate novel co-processed multifunctional excipient... more The aim of the present investigation is to formulate novel co-processed multifunctional excipient for tablet dosage form. Co- processed particles of chitosan, microcrystalline cellulose (MCC) and aerosil-200 were fabricated by wet granulation technique to be used as a directly compressible excipient in tablet formulation. The developed co-processed excipients (CPE) were evaluated for their excipient related and dosage form related parameters. As expected, all the prepared batches exhibited acceptable angle of repose (<35 0 ) and quick disintegration time (<1min). The “intimate” physical association between chitosan, MCC and aerosil-200 has created an insoluble, hydrophilic, highly absorbent material, resulting in superiority in water uptake, water saturation for gelling formation, and compactability among other superdisintegrants. The developed CPE could be act as a superdisintegrant and pharmaceutical filler at the same time.

Research paper thumbnail of Development of Fast Dissolving Tablets Containing Ondansetron via Camphor Sublimation and its Characterization

Research & Reviews: Journal of Pharmacy and Pharmaceutical Sciences, 2012

Ondansetron Hydrochloride (OSH) is a sparingly water-soluble drug. In this investigation fast dis... more Ondansetron Hydrochloride (OSH) is a sparingly water-soluble drug. In this investigation fast dissolving tablets (FDTs) of ondansetron were prepared using different superdisintegrants by sublimation method. FDTs were evaluated for physicochemical properties and in vitro dissolution. The wetting time (10.5s) of formulation batch containing crospovidone (F2) was least and tablets showed fastest disintegration (3.2s). The drug release from FDTs containing superdisintegrants was more as compared to FDTs without superdisintegrant and it was found to be highest (98% drug release after 30 min) with formulation batch containing crospovidone (F2) so it can be concluded as promising formulation.

Research paper thumbnail of Handbook of Drug Store and Business Management

The pharmaceutical industry is considered to be "Lifeline" industry. It plays important... more The pharmaceutical industry is considered to be "Lifeline" industry. It plays important role in raising general health standards. The availability is an ever increasing measures, of wide range of quality drugs to people through effective distribution media is note worthy. Retail pharmacist is a vital link in the health care services of a nation. To run the drug store effectively and efficiently management principles and techniques are very much useful. Since competition is increasing day by day, managing drug store becoming challenging job. This book emphasize the theoretical management principles in practical aspects to run the drug store. This book emphasize the principles of management, pharmaceutical marketing, role of drug store along with identifying location, optimum design characteristics, regarding various types of business organizations, purchasing and inventory control, personal administration. This book provides guidelines to start strategies to rule out compet...

Research paper thumbnail of Formulation and Evaluation of Fast Dissolving Tablets of Ondansetron by Solid Dispersion in Superdisintegrants

Ondansetron Hydrochloride (OSH) is a sparingly water-soluble drug. The aim of the present investi... more Ondansetron Hydrochloride (OSH) is a sparingly water-soluble drug. The aim of the present investigation was to prepare solid dispersion (SD) of OSH using superdisintegrants as carrier and formulate it as fast dissolving tablets (FDTs) with an objective to improve solubility and enhance dissolution of drug. SD of drug using superdisintegrants like croscarmellose sodium (CCS), crospovidone (CP), sodium starch glycolate (SSG), and low substituted hydroxy propyl cellulose (L-HPC) respectively as carriers was prepared by solvent evaporation method. The prepared SD formulations were characterized by equilibrium solubility, fourier transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC) and dissolution study. FTIR spectra revealed no chemical interaction between the drug and superdisintegrants. XRPD and DSC data indicated that OSH was in the amorphous form, which explains the better dissolution rate of the drug from its solid dispers...

Research paper thumbnail of Handbook of Cosmetic Science and Technology

... Topical Delivery by Iontophoresis 211 Veronique Preat and Rita Vanbever 19. Mousses 221 Alber... more ... Topical Delivery by Iontophoresis 211 Veronique Preat and Rita Vanbever 19. Mousses 221 Albert Zorko Abram and Roderick Peter John Tomlinson 20. ... Antioxidants 299 Stefan Udo Weber, John K. Lodge, Claude Saliou, and Lester Packer Page 8. Contents vii 27. ...

Research paper thumbnail of Exploration of Novel Co-Processed Multifunctional Excipient for Tablet Dosage Form

The aim of the present investigation is to formulate novel co-processed multifunctional excipient... more The aim of the present investigation is to formulate novel co-processed multifunctional excipient for tablet dosage form. Co- processed particles of chitosan, microcrystalline cellulose (MCC) and aerosil-200 were fabricated by wet granulation technique to be used as a directly compressible excipient in tablet formulation. The developed co-processed excipients (CPE) were evaluated for their excipient related and dosage form related parameters. As expected, all the prepared batches exhibited acceptable angle of repose (<35 0 ) and quick disintegration time (<1min). The “intimate” physical association between chitosan, MCC and aerosil-200 has created an insoluble, hydrophilic, highly absorbent material, resulting in superiority in water uptake, water saturation for gelling formation, and compactability among other superdisintegrants. The developed CPE could be act as a superdisintegrant and pharmaceutical filler at the same time.