Raju Nandhakumar - Profile on Academia.edu (original) (raw)
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Cobalt(III) complexes containing pyridoxal N(4)-substituted thiosemicarbazone ligands with the co... more Cobalt(III) complexes containing pyridoxal N(4)-substituted thiosemicarbazone ligands with the composition [Co(HL 1À2 ÁCl)(HL 1À2 ÁH 2 O)] (1–2) have been synthesized from the reaction of [CoCl 2 (PPh 3) 2 ] and pyridoxal N-methyl-thiosemicarbazone hydrochloride (H 3 L 1 ÁCl)/pyridoxal N-phenyl-thiosemicarbazone hydrochloride (H 3 L 2 ÁCl). The richness of the coordination chemistry of this ligand is highlighted by the modulation of its charge from neutral (H 3 LÁCl) (L) to dianionic (HLÁCl) (L 2À) and monoanionic forms (HLÁH 2 O) (L À) and coordinated as tridentate binegative mode around cobalt(III) ion by forming neutral complex. The new complexes were characterized by various analytical and spectroscopic techniques (IR, electronic, 1 H NMR and ESI-Mass). The X-ray crystal structure of the complex 2, demonstrated distorted octahedral coordination geometry around the metal centre. Further, the investigation of effect of substitution (CH 3 or C 6 H 5) on terminal N(4)-nitrogen of thiosemicarbazone exhibited its influence on the potential binding and cleavage ability with DNA, BSA binding, free radical scavenging and cytotoxicity.
Cobalt(III) complexes containing pyridoxal N(4)-substituted thiosemicarbazone ligands with the co... more Cobalt(III) complexes containing pyridoxal N(4)-substituted thiosemicarbazone ligands with the composition [Co(HL 1À2 ÁCl)(HL 1À2 ÁH 2 O)] (1–2) have been synthesized from the reaction of [CoCl 2 (PPh 3) 2 ] and pyridoxal N-methyl-thiosemicarbazone hydrochloride (H 3 L 1 ÁCl)/pyridoxal N-phenyl-thiosemicarbazone hydrochloride (H 3 L 2 ÁCl). The richness of the coordination chemistry of this ligand is highlighted by the modulation of its charge from neutral (H 3 LÁCl) (L) to dianionic (HLÁCl) (L 2À) and monoanionic forms (HLÁH 2 O) (L À) and coordinated as tridentate binegative mode around cobalt(III) ion by forming neutral complex. The new complexes were characterized by various analytical and spectroscopic techniques (IR, electronic, 1 H NMR and ESI-Mass). The X-ray crystal structure of the complex 2, demonstrated distorted octahedral coordination geometry around the metal centre. Further, the investigation of effect of substitution (CH 3 or C 6 H 5) on terminal N(4)-nitrogen of thiosemicarbazone exhibited its influence on the potential binding and cleavage ability with DNA, BSA binding, free radical scavenging and cytotoxicity.