Ralph Roan Rodriguez - Academia.edu (original) (raw)
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Papers by Ralph Roan Rodriguez
Drawing New Color Lines, 2014
Small Group Research, 1998
The present study examined the impact of within-group value diversity on personal satisfaction, g... more The present study examined the impact of within-group value diversity on personal satisfaction, group creativity, and group effectiveness. After accountingfordiversity in race/nation-ality, gender, and age, value diversity predicted greater personal satisfaction, and higher perceived group creativity and effectiveness.
Nature Cell Biology, 2003
The mechanisms involved in transduction of the Hedgehog (Hh) signal are of considerable interest ... more The mechanisms involved in transduction of the Hedgehog (Hh) signal are of considerable interest to developmental and cancer biologists. Stabilization of the integral membrane protein Smoothened (Smo) at the plasma membrane is a crucial step in Hh signalling but the molecular events immediately downstream of Smo remain to be elucidated. We have shown previously that the transcriptional mediator Cubitus interruptus (Ci) is associated in a protein complex with at least two other proteins, the kinesin-like Costal2 (Cos2) and the serine-threonine kinase Fused (Fu). This protein complex governs the access of Ci to the nucleus. Here we show that, consequent on the stabilization of Smo, Cos2 and Fu are destabilized. Moreover, we find that the Cos2-Fu-Ci protein complex is associated with Smo in membrane fractions both in vitro and in vivo. We also show that Cos2 binding on Smo is necessary for the Hh-dependent dissociation of Ci from this complex. We propose that the association of the Cos2 protein complex with Smo at the plasma membrane controls the stability of the complex and allows Ci activation, eliciting its nuclear translocation.
Men and Masculinities, 2007
MELUS: Multi-Ethnic Literature of the United States, 2000
... The writers from the various sites (eg, Palestine, Lebanon, and South Africa) that she discus... more ... The writers from the various sites (eg, Palestine, Lebanon, and South Africa) that she discusses, though not necessarily bearing arms, are so inti-mately tied into the armed struggle, that she is able to demonstrate powerfully the mutually reinforcing relationship between the ...
Developmental Cell, 2003
which is secreted, does not (Beachy et al., 1997, and the references therein). Numerous questions... more which is secreted, does not (Beachy et al., 1997, and the references therein). Numerous questions have been raised about the role of the cholesterol adduct on Hh function. How could the cholesterol modification fit in with both the short-and
Developmental Biology, 2009
Hedgehog (Hh) signalling plays a crucial role in the development and patterning of many tissues i... more Hedgehog (Hh) signalling plays a crucial role in the development and patterning of many tissues in both vertebrates and invertebrates. Aberrations in this pathway lead to severe developmental defects and cancer. Hh signal transduction in receiving cells is a well studied phenomenon; however questions still remain concerning the mechanism of repression of the pathway activator Smoothened (Smo) in the absence of Hh. Here we describe a novel repressor of the Hh pathway, Target of Wingless (Tow). Tow represents the Drosophila homolog of a conserved uncharacterised protein family. We show that Tow acts in Hh receiving cells, where its overexpression represses all levels of Hh signalling, and that this repression occurs upstream or at the level of Smo and downstream of the Hh receptor Patched (Ptc). In addition, we find that like Ptc, overexpression of Tow causes an accumulation of lipophorin in the wing disc. We demonstrate that loss of tow enhances different ptc alleles in a similar manner to another pathway repressor, Suppressor of Fused (SuFu), possibly through mediating Ptc dependant lipophorin internalisation. Combined, these results demonstrate that Tow is an important novel regulator of the Hh pathway in the wing imaginal disc, and may shed light on the mechanism of Ptc repression of Smo.
Contemporary Literature, 2002
... volume Sonny Baca series (Zia Summer, Rio Grande Fall, and Shaman Winter), but again he did n... more ... volume Sonny Baca series (Zia Summer, Rio Grande Fall, and Shaman Winter), but again he did not need the detective novel genre to garner an audience ... All three novels in his George Sueno and Ernie Bascom series have come out with a commercial press (Soho and Bantam ...
Comparative Literature Studies, 2005
Aztlán: A Journal of Chicano Studies, 2007
... Elizondo, Juan Gómez-Quiñones, Judy Lucero, José Montoya, Rodolfo Corky Gonzales, Angela de... more ... Elizondo, Juan Gómez-Quiñones, Judy Lucero, José Montoya, Rodolfo Corky Gonzales, Angela de Hoyos ... perhaps worthy of further study includes Ricardo Aguilar, Ivan Arguelles, Miriam Bornstein-Somoza ... portion of the story.10 I have in mind here Castañeda Shular, Ybarra ...
American Literary History, 2009
... to in the nineteenth century as the Mexican Question); the literary writings of María Ampar... more ... to in the nineteenth century as the Mexican Question); the literary writings of María Amparo Ruiz de ... In his essays we meet Kiko, Erica, Fernando, Arturo, Nieves, and a host of other individuals who ... 5 I would second Luis Urrea, the author of two key studies of the border, Across ...
Drawing New Color Lines, 2014
Small Group Research, 1998
The present study examined the impact of within-group value diversity on personal satisfaction, g... more The present study examined the impact of within-group value diversity on personal satisfaction, group creativity, and group effectiveness. After accountingfordiversity in race/nation-ality, gender, and age, value diversity predicted greater personal satisfaction, and higher perceived group creativity and effectiveness.
Nature Cell Biology, 2003
The mechanisms involved in transduction of the Hedgehog (Hh) signal are of considerable interest ... more The mechanisms involved in transduction of the Hedgehog (Hh) signal are of considerable interest to developmental and cancer biologists. Stabilization of the integral membrane protein Smoothened (Smo) at the plasma membrane is a crucial step in Hh signalling but the molecular events immediately downstream of Smo remain to be elucidated. We have shown previously that the transcriptional mediator Cubitus interruptus (Ci) is associated in a protein complex with at least two other proteins, the kinesin-like Costal2 (Cos2) and the serine-threonine kinase Fused (Fu). This protein complex governs the access of Ci to the nucleus. Here we show that, consequent on the stabilization of Smo, Cos2 and Fu are destabilized. Moreover, we find that the Cos2-Fu-Ci protein complex is associated with Smo in membrane fractions both in vitro and in vivo. We also show that Cos2 binding on Smo is necessary for the Hh-dependent dissociation of Ci from this complex. We propose that the association of the Cos2 protein complex with Smo at the plasma membrane controls the stability of the complex and allows Ci activation, eliciting its nuclear translocation.
Men and Masculinities, 2007
MELUS: Multi-Ethnic Literature of the United States, 2000
... The writers from the various sites (eg, Palestine, Lebanon, and South Africa) that she discus... more ... The writers from the various sites (eg, Palestine, Lebanon, and South Africa) that she discusses, though not necessarily bearing arms, are so inti-mately tied into the armed struggle, that she is able to demonstrate powerfully the mutually reinforcing relationship between the ...
Developmental Cell, 2003
which is secreted, does not (Beachy et al., 1997, and the references therein). Numerous questions... more which is secreted, does not (Beachy et al., 1997, and the references therein). Numerous questions have been raised about the role of the cholesterol adduct on Hh function. How could the cholesterol modification fit in with both the short-and
Developmental Biology, 2009
Hedgehog (Hh) signalling plays a crucial role in the development and patterning of many tissues i... more Hedgehog (Hh) signalling plays a crucial role in the development and patterning of many tissues in both vertebrates and invertebrates. Aberrations in this pathway lead to severe developmental defects and cancer. Hh signal transduction in receiving cells is a well studied phenomenon; however questions still remain concerning the mechanism of repression of the pathway activator Smoothened (Smo) in the absence of Hh. Here we describe a novel repressor of the Hh pathway, Target of Wingless (Tow). Tow represents the Drosophila homolog of a conserved uncharacterised protein family. We show that Tow acts in Hh receiving cells, where its overexpression represses all levels of Hh signalling, and that this repression occurs upstream or at the level of Smo and downstream of the Hh receptor Patched (Ptc). In addition, we find that like Ptc, overexpression of Tow causes an accumulation of lipophorin in the wing disc. We demonstrate that loss of tow enhances different ptc alleles in a similar manner to another pathway repressor, Suppressor of Fused (SuFu), possibly through mediating Ptc dependant lipophorin internalisation. Combined, these results demonstrate that Tow is an important novel regulator of the Hh pathway in the wing imaginal disc, and may shed light on the mechanism of Ptc repression of Smo.
Contemporary Literature, 2002
... volume Sonny Baca series (Zia Summer, Rio Grande Fall, and Shaman Winter), but again he did n... more ... volume Sonny Baca series (Zia Summer, Rio Grande Fall, and Shaman Winter), but again he did not need the detective novel genre to garner an audience ... All three novels in his George Sueno and Ernie Bascom series have come out with a commercial press (Soho and Bantam ...
Comparative Literature Studies, 2005
Aztlán: A Journal of Chicano Studies, 2007
... Elizondo, Juan Gómez-Quiñones, Judy Lucero, José Montoya, Rodolfo Corky Gonzales, Angela de... more ... Elizondo, Juan Gómez-Quiñones, Judy Lucero, José Montoya, Rodolfo Corky Gonzales, Angela de Hoyos ... perhaps worthy of further study includes Ricardo Aguilar, Ivan Arguelles, Miriam Bornstein-Somoza ... portion of the story.10 I have in mind here Castañeda Shular, Ybarra ...
American Literary History, 2009
... to in the nineteenth century as the Mexican Question); the literary writings of María Ampar... more ... to in the nineteenth century as the Mexican Question); the literary writings of María Amparo Ruiz de ... In his essays we meet Kiko, Erica, Fernando, Arturo, Nieves, and a host of other individuals who ... 5 I would second Luis Urrea, the author of two key studies of the border, Across ...