Ram Prajapati - Academia.edu (original) (raw)

Papers by Ram Prajapati

The Creative Launcher

The modern world has witnessed radical changes in all sorts of discourses. Different kinds of cha... more The modern world has witnessed radical changes in all sorts of discourses. Different kinds of changes in environment, culture and humanistic approach have brought relevant dimensions in literature. The points are quite interesting, contemporary, burning and have masculine, vital and thought-provoking concerns. Everyone is running after ease and comfort forgetting the importance of nature and environment. This can be reiterated in the words of William Wordsworth that getting and spending we are busy in wasting our powers, health, knowledge, wisdom, human feelings. Further, he says that we have lost all our sensibilities to realize the relevance and grateful towards nature. Actually, we do not even realize the importance of nature in our life. The paper explores the concept of environmental, cultural and humanistic concerns in the poetry of Robert Frost, Kazuyosi Ikeda and Syed Ameeruddin.

Hemosuccus Pancreaticus (HP) is a rare & potentially life threatening clinical entity. It is desc... more Hemosuccus Pancreaticus (HP) is a rare & potentially life threatening clinical entity. It is described as bleeding from Ampulla of Vater via the Pancreatic Duct (PD).This condition is classically attributed to erosion of Splenic artery Aneurysm into the PD or bleeding into a pseudocyst as a result of Acute or Chronic Pancreatitis causing intermittent severe upper gastrointestinal (GI) bleeding. It poses a significant diagnostic & therapeutic dilemma because of its rarity, anatomic location & intermittency of bleeding. When Obscure GI bleeding is encountered, HP should be considered in cases of pancreatitis. Mesenteric Angiographic intervention remains the modality of choice for diagnosis & treatment. However if embolization of bleeding vessel fails, emergency surgery should be undertaken. We describe our experience with a case of HP who presented to us with hematochezia with hemodynamic instability and the diagnostic as well as therapeutic difficulties faced.

AIP Advances, 2021

The Kelvin-Helmholtz (K-H) instability in a magnetized nonuniform velocity sheared dusty plasma i... more The Kelvin-Helmholtz (K-H) instability in a magnetized nonuniform velocity sheared dusty plasma is investigated accounting for the effects of dust polarization force due to inhomogeneity in background plasma number densities. A three-component fluid model for dusty plasma is formulated considering Boltzmann electron/ion fluids and flowing magnetized dust fluids whose dynamics are affected due to the presence of dust polarization force. A dispersion relation for the K-H instability is derived by applying normal mode analysis on the linearized perturbation equations of the system. It is found that the polarization parameter dependent dust acoustic mode significantly modifies the dispersion relation of the K-H instability. The critical shear required to excite the K-H instability (S > S crit) decreases with an increase in the dust polarization parameter and dust cyclotron frequency. The growth rate of the K-H instability is observed to be suppressed due to the presence of the dust polarization parameter. The results have been discussed for experimental magnetized dusty plasmas, which shows that under considered parametric limits, one cannot ignore the presence of dust polarization force on the excitation of the K-H instability in dusty plasmas. The astrophysical consequences are also discussed in Saturn's E-ring in the limiting case of varying dust grain size.

SSRN Electronic Journal, 2020

The outbreak of COVID-19 has adversely affected all sectors of the economy as well as the life of... more The outbreak of COVID-19 has adversely affected all sectors of the economy as well as the life of the people across the countries. But its impact is varying sector-specific across the counties due to the extent and scale of the virus spread. This paper examined the potential impact of COVID-19 on food security and the development of agriculture using demand and supply of food items in the Asian region. For the smooth supply of food at the national and global level depend on the normalcy of supply-chain. While for the demand for food, consumption will occur through income, which directly related to employment. Both supply-chain and employment are negatively affected due to the lockdown policy adopted by many Asian counties to control the spread of the virus. The paper analyzes the impact of lockdown policies on food security and future agriculture development in Asian counties.

Zeitschrift für Naturforschung A, 2015

The Jeans instability of rotating viscoelastic fluid in the presence of uniform magnetic field is... more The Jeans instability of rotating viscoelastic fluid in the presence of uniform magnetic field is investigated using the generalised hydrodynamic (GH) model. A general dispersion relation is derived with the help of linearised perturbation equations using the normal mode analysis, which is further discussed for axis of rotation parallel and perpendicular to the direction of the magnetic field in both the weakly coupled (hydrodynamic) and strongly coupled (kinetic) limits. The onset criterion of Jeans instability for magnetised rotating viscoelastic fluid is obtained, which remains unaffected by the presence of rotation and magnetic field but depends upon viscoelastic effects. The graphical illustrations are depicted to see the influence of rotation, Mach number, shear and viscous effects, and sound speed on the growth rate of Jeans instability. It is found that all these parameters have stabilising influence on the growth rate of Jeans instability; hence, they are capable of collaps...

Journal of emergencies, trauma, and shock

A departmental audit in March 2015 revealed significant mortality rate of 40% in blunt chest trau... more A departmental audit in March 2015 revealed significant mortality rate of 40% in blunt chest trauma patients (much greater than the global 25%). A study was thus planned to study morbidity and predictors of mortality in blunt chest trauma patients admitted to our hospital. This study was a prospective observational study of 139 patients with a history of blunt chest trauma between June 2015 and November 2015 after the Institutional Ethics Committee approval in April 2015. The sample size was calculated from the prevalence rate in our institute from the past medical records. The morbidity factors following blunt chest injuries apart from pain were need for Intensive Care Unit stay, mechanical ventilation, and pneumonia/acute respiratory distress syndrome. Significant predictors of mortality in our study were SpO2 <80 at the time of presentation, Glasgow coma scale ≤ 8, patients with four or more rib fractures, presence of associated head injury, Injury Severity Score >16, and n...

International Journal of Health Sciences and Research, 2013

The Turkish journal of pediatrics

The treatment and early diagnosis of choledochal cyst are very important to prevent complications... more The treatment and early diagnosis of choledochal cyst are very important to prevent complications of the disease. Delay in treatment can cause lethal complications like biliary cirrhosis and increased morbidity in patients. We studied 26 children with choledochal cyst retrospectively for their clinical presentation, and for the diagnostic tools and treatment modalities, used. The most common findings of choledochal cyst in our series were abdominal pain, vomiting, and ictures in contrast to the classical triad of the disease of jaundice, mass and pain. The most useful diagnostic tool was abdominal ultrasonography. For the treatment, we preferred Roux-en-Y hepaticojejunostomy to the internal drainage procedures, and the results were excellent with minimal mortality and morbidity. We underline prompt diagnosis and treatment to prevent late complications of the disease.

Thermal Science, 2016

In this paper we investigate the effect of surface tension on hydromagnetic Rayleigh-Taylor (R-T)... more In this paper we investigate the effect of surface tension on hydromagnetic Rayleigh-Taylor (R-T) instability of two incompressible superimposed fluids in a porous medium with suspended dust particles immersed in a uniform horizontal magnetic field. The relevant linearized perturbation equations have been solved using normal mode technique and the dispersion relation is derived analytically for the considered system. The dispersion relation is influenced by the simultaneous presence of medium porosity, suspended dust particles, permeability, magnetic field and surface tension. The onset criteria of R-T stability and instability are obtained and discussed. The growth rate of R-T instability is calculated numerically and is affected by the simultaneous presence of surface tension and magnetic field. The effects of various parameters on the growth rate of the R-T instability are discussed.

Indian Journal of Surgery, 2014

Chronic pancreatitis is a fairly common condition with pain being the major symptom, and longitud... more Chronic pancreatitis is a fairly common condition with pain being the major symptom, and longitudinal pancreaticojejunostomy (LPJ) is performed for symptomatic relief. The aim of the study is to assess relief of pain post-LPJ for chronic pancreatitis and to evaluate the factors influencing relief of symptoms. A prospective observational noninterventional study enrolling 28 patients. This study involved a questionnaire studying various risk factors and pain related to chronic pancreatitis, pancreaticojejunostomy, and postoperative assessment of pain relief at 1 and 6 months from surgery. Pain was assessed using Visual analogue scale (VAS). In chronic pancreatitis, there is a significant relief in symptoms of pain post-LPJ; the degree of relief was less in the alcoholics vs non-alcoholics (p=0.09) and smokers. There was also reduction in analgesic requirement and frequency of acute attacks of pain. Fifty-seven percent of patients had a complete remission of their pain after LPJ for CP. In chronic pancreatitis, there is a significant relief in symptoms of pain post-LPJ, although the degree of relief is less in the alcoholics and smokers.

Molecular Pharmaceutics, 2009

The present investigation was aimed at exploring dendrimer-mediated solubilization and formulatio... more The present investigation was aimed at exploring dendrimer-mediated solubilization and formulation development followed by in vitro, in vivo assessment of piroxicam (PXM) nanocomposite. For this, two dendrimer generations (3.0G and 4.0G) were synthesized and characterized by IR, (1)H NMR spectroscopic and electron microscopy techniques. The optimized formulations containing 0.2% w/v of PXM loaded PAMAM dendrimer at pH 7.4 referred to as 0.2-D(3)P(7.4) (3.0G) and 0.2-D(4)P(7.4) (4.0G) resulted in significant enhancements of PXM solubility approximately by 107- and 222-fold, respectively. The in vitro release behavior of PXM from the formulation in medium-I (PBS 7.4) and medium-II (PBS with 1% albumin) and stability studies were also favorable. Pharmacokinetic study showed higher area under curve (AUC(0--&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;t); microg/mL/h) of 293.78 +/- 2.04 and 321.54 +/- 2.37 with optimized 0.2-D(3)P(7.4) and 0.2-D(4)P(7.4) formulations, respectively, as opposed to 279.11 +/- 1.48 with plain PXM. The elimination half-life of the drug encapsulated in the formulation was significantly higher (0.2-D(3)P(7.4), 36.6 and 0.2-D(4)P(7.4), 41.1; h) than that of pure drug (33.7 h; p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.005), and the overall elimination rate constant of formulations was also less as compared to free drug (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.005). Pharmacodynamic assessment by rat-paw model of 0.2-D(3)P(7.4) and 0.2-D(4)P(7.4) formulations displayed inhibition levels of 54.21 +/- 1.25% and 59.33 +/- 0.63%, respectively, which are higher than those of plain PXM (41.81 +/- 2.9) formulations, after the sixth hour of administration. The second, fourth and eighth hour organ distribution data showed significantly higher recovery of PXM in rat paw with dendrimer-based formulations in comparison to plain PXM. However, comparison of overall data suggested 4.0G-based formulations to be superior to 3.0G as well as pure PXM.

Journal of Mathematical Analysis and Applications, 1993

International Journal of Surgery Case Reports, 2014

INTRODUCTION: The POSSG is a pedicled graft based on either the right or left gastro-epiploic art... more INTRODUCTION: The POSSG is a pedicled graft based on either the right or left gastro-epiploic arteries. It is used with a dual mesh in reconstruction of full thickness defects of anterior abdominal wall and covered by skin grafts. PRESENTATION OF CASE: A recurrent malignant peripheral nerve sheath tumor (MPNST) of the anterior abdominal wall was excised leaving a large defect. The POSSG was used for reconstruction. A large dual mesh was placed to close the defect in the abdominal wall by suturing it to the remnant rim of abdominal muscles. The omental pedicle was brought through a keyhole in the mesh, spread out over the mesh, sutured and covered by split skin grafts. The final graft take was 90 percent. DISCUSSION: The POSSG can be used to reconstruct any size of anterior abdominal wall defects due to the malleable nature of omentum. Its prerequisite however is a dual mesh like PROCEED. The POSSG helps keep the more complex musculofasciocutaneous flaps as lifeboats. It can be used singly where multiple musculofasciocutaneous flaps would otherwise have been required. It can be used in patients with poor prognosis of underlying malignancy. It may be used by general surgeons due to familiarity with anatomy of the relevant structures and lack of need for microsurgical skill. CONCLUSION: The POSSG can be used in reconstruction of abdominal wall defects of any size by general surgeons.

Asian Journal of Pharmaceutics, 2009

H ydrophobicity of a bioactive is one area of major concern that poses as a great hindrance in th... more H ydrophobicity of a bioactive is one area of major concern that poses as a great hindrance in the development of a therapeutically effective dosage form and prevents sufficient delivery of the drug to the target site. Since the last decade, dendrimers have emerged as highly promising drug delivery modules because of their unique structure and properties. Solubility enhancement is an important aspect of dendrimers and this is a synergy with site-specific drug delivery. The hydrophobic guests when entrapped in the hydrophobic channels of dendrimers are solubilized in the aqueous solution. The present article explores the various complex interaction mechanisms between the dendrimer and a bioactive. Hence the objective of this review is to reflect the host-guest interactions with the potential role of the proposed system, to enhance drug solubility and bioavailability.