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Papers by Karthikeyan Ramadoss

Research paper thumbnail of  Pharmaceutical Cocrystals a Patentable Composition - A Review

International Journal of Pharmaceutical Research and Allied Sciences

Research paper thumbnail of Quantitative analysis of favipiravir in bulk and pharmaceutical dosage forms using UV visible spectrophotometer

Journal of medical pharmaceutical and allied sciences

The main aim of this study is to develop a rapid and cheap Ultraviolet (UV) spectrophotometric me... more The main aim of this study is to develop a rapid and cheap Ultraviolet (UV) spectrophotometric method for the estimation of Favipiravir (400mg) in tablets and validate as per International Conference on Harmonization (ICH) guidelines. The developed method uses the solvent Ethanol: Water (30:70) for the assay of Favipiravir whose λmax was found to be 231nm. In this method, Favipiravirshows linearity in the range 2-10 μg/ml. The accuracy was carried out by using standard addition method and the precision is ascertained by calculating the relative standard deviation. A cheap and rapid UV spectrophotometric method was developed and validated for the estimation of Favipiravir and hence it can be used for the routine pharmaceutical analysis.

Research paper thumbnail of Study on the Influence of Nanoadditives on Surface roughness of newly synthesized Magnesium Alloy during Turning operation

A new magnesium (Mg) alloy with combination of Mg-9Al-0.7Zn-X Ca-X Y (Rare Earth) weight % was st... more A new magnesium (Mg) alloy with combination of Mg-9Al-0.7Zn-X Ca-X Y (Rare Earth) weight % was stir casted. Turning operation leads to production of high temperature followed by the risk of metal fire. In this paper an attempt is made to reduce the temperature between tools and job by introducing Minimum Quantity Lubrication (MQL) technique which reduced the cost of the coolant/lubricating liquid as well as to produce minimum pollutant resulting in green atmosphere. Three types of nano additives such nano TiO 2 , nano SiC and nano CuO with particle size of 40-50 nm were mixed with coolant. Three different concentrations such as 0.5%, 1% and 2% (wt %) were used in the coolant and their influence on surface roughness, Tool interface temperature and tool wear were analyzed.

Research paper thumbnail of A Systems Biological Approach to the Identification of Exosomal NTRK1 as a Potent Biomarker for Prolonged type II Diabetes-Induced Alzheimer’s Disease

Annals of the Romanian Society for Cell Biology, Mar 1, 2021

Research paper thumbnail of Novel Cefixime Loaded Citric Acid Dendrimer for Antibacterial Activity against Pseudomonas Aeruginosa and Staphylococcus Aureus

Nanomedicine & Nanotechnology Open Access, 2016

Research paper thumbnail of Isolation, Characterization and Determination of Nordihydroguaiaretic Acid in Nutrition Supplement by Using Reversed Phase-High Performance Liquid Chromatography

Eurasian Journal of Analytical Chemistry, 2016

Nordihydroguaiaretic acid (NDGA) is a lignan found in large amounts in the ethnobotanically impor... more Nordihydroguaiaretic acid (NDGA) is a lignan found in large amounts in the ethnobotanically important plant, Larrea tridentata (Moc. & Sess.) Cov. (Zygophyllaceae). So far NDGA was not isolated and estimated in larrea tridentata (moc. & sess.) cov. In this study isolation of Nordihydroguaiaretic acid was achieved by preparative TLC and the compound thus isolated was characterised by Ultraviolet and Mass spectral analysis. Mass spectral data shows molecular ion peak of m/z=302.2. An isocratic RP-HPLC method was developed for the estimation of Nordihydroguaiaretic acid in marketed formulation. Retention time of Nordihydroguaiaretic acid was found as 4.173 min. This method has obeyed linearity over the concentration range of 1050μg/ml and the regression coefficient obtained from linearity plot for Nordihydroguaiaretic acid was found as 0.999. RP-HPLC method was validated in pursuance of International conference on Harmonization (ICH) guidelines. This method is simple and economic one a...

Research paper thumbnail of Magnetic Nanoparticle-Based Approaches in Cancer Therapy–A Critical Review

International Journal of Applied Pharmaceutics

Cancer is definitely one of the leading causes of mortality worldwide. Failure in the efficacy of... more Cancer is definitely one of the leading causes of mortality worldwide. Failure in the efficacy of the standard treatments (chemo-, radiotherapy and surgery), and the severe side effects, resistance of tumor cells to chemotherapeutics have necessitated alternative therapeutic strategies. Magnetic nanoparticles (MNPs) have been assessed as potential cancer therapy materials. Their intrinsic magnetic properties provide a cancer detection, monitoring, and therapy platform based on multimodal theranostics. MNPs can be functionalized by binding them to a wide variety of substances, including chemotherapeutic drugs, radionuclides, nucleic acids, and antibodies. They can be used for drug delivery, magnetic or photothermal induced local hyperthermia and photodynamic therapy aimed at killing cancer cells at the tumor site. MNPs may also be useful to challenge drug resistance. The combination of different options of these treatment modalities offers a synergistic effect and significantly reduc...

Research paper thumbnail of Dendritic Architechture for the Delivery of Levofloxacin against Resistant Producing Strains

The present study was aimed at developing and exploring the use of PEGylated poly (propylene imin... more The present study was aimed at developing and exploring the use of PEGylated poly (propylene imine) dendritic architecture for the delivery of an anti-bacterial drug, Levofloxacin. For this study, PEGylated poly(propylene imine) dendritic architecture was synthesized and loaded with Levofloxacin and targeted to the resistant producing strains of Klebsiella pneumoniae and E.coli. The antibacterial activity was carried out by cup and bore method to compare the zone of inhibition with standard drug and control (DMSO). The study showed that the Levofloxacin loaded dendrimer has significant antibacterial activity than the plain drug and control treated, but standard drug was not shown zone of inhibition upon both microorganisms. In this study antibacterial activity of synthesized system are also relatively safer and hold potential to deliver some other drugs also.

Research paper thumbnail of In-vitro anti tubercular activity of flowers of Couroupita guanensis L

Modern civilization is facing hundreds of disorders associated with microorganisms. The natural p... more Modern civilization is facing hundreds of disorders associated with microorganisms. The natural phytochemicals fromnon-edible plants are gaining importance to fight against these disease The intention of this study is to evaluatethe ethanol and dichloromethane extracts of flower of Couroupita guianensis (Lecithydaceae) for anti-tubercular activity. The anti-tubercular activity of all the extracts of Couroupita guianensishave been evaluated againstMycobacterium tuberculosis H73Rv strain using Microplate Alamar Blue Assay (MABA). The activity wasdocumented within MIC range of 0.8 to 100I¼g/ml. The results of MABA showed that both ethanol and dichloromethane extractexhibited significant anti-tubercular activity. The present investigation suggests that Couroupita guianensispossess remarkableanti-tubercular activity.

Research paper thumbnail of  Pharmaceutical Cocrystals a Patentable Composition - A Review

International Journal of Pharmaceutical Research and Allied Sciences

Research paper thumbnail of Quantitative analysis of favipiravir in bulk and pharmaceutical dosage forms using UV visible spectrophotometer

Journal of medical pharmaceutical and allied sciences

The main aim of this study is to develop a rapid and cheap Ultraviolet (UV) spectrophotometric me... more The main aim of this study is to develop a rapid and cheap Ultraviolet (UV) spectrophotometric method for the estimation of Favipiravir (400mg) in tablets and validate as per International Conference on Harmonization (ICH) guidelines. The developed method uses the solvent Ethanol: Water (30:70) for the assay of Favipiravir whose λmax was found to be 231nm. In this method, Favipiravirshows linearity in the range 2-10 μg/ml. The accuracy was carried out by using standard addition method and the precision is ascertained by calculating the relative standard deviation. A cheap and rapid UV spectrophotometric method was developed and validated for the estimation of Favipiravir and hence it can be used for the routine pharmaceutical analysis.

Research paper thumbnail of Study on the Influence of Nanoadditives on Surface roughness of newly synthesized Magnesium Alloy during Turning operation

A new magnesium (Mg) alloy with combination of Mg-9Al-0.7Zn-X Ca-X Y (Rare Earth) weight % was st... more A new magnesium (Mg) alloy with combination of Mg-9Al-0.7Zn-X Ca-X Y (Rare Earth) weight % was stir casted. Turning operation leads to production of high temperature followed by the risk of metal fire. In this paper an attempt is made to reduce the temperature between tools and job by introducing Minimum Quantity Lubrication (MQL) technique which reduced the cost of the coolant/lubricating liquid as well as to produce minimum pollutant resulting in green atmosphere. Three types of nano additives such nano TiO 2 , nano SiC and nano CuO with particle size of 40-50 nm were mixed with coolant. Three different concentrations such as 0.5%, 1% and 2% (wt %) were used in the coolant and their influence on surface roughness, Tool interface temperature and tool wear were analyzed.

Research paper thumbnail of A Systems Biological Approach to the Identification of Exosomal NTRK1 as a Potent Biomarker for Prolonged type II Diabetes-Induced Alzheimer’s Disease

Annals of the Romanian Society for Cell Biology, Mar 1, 2021

Research paper thumbnail of Novel Cefixime Loaded Citric Acid Dendrimer for Antibacterial Activity against Pseudomonas Aeruginosa and Staphylococcus Aureus

Nanomedicine & Nanotechnology Open Access, 2016

Research paper thumbnail of Isolation, Characterization and Determination of Nordihydroguaiaretic Acid in Nutrition Supplement by Using Reversed Phase-High Performance Liquid Chromatography

Eurasian Journal of Analytical Chemistry, 2016

Nordihydroguaiaretic acid (NDGA) is a lignan found in large amounts in the ethnobotanically impor... more Nordihydroguaiaretic acid (NDGA) is a lignan found in large amounts in the ethnobotanically important plant, Larrea tridentata (Moc. & Sess.) Cov. (Zygophyllaceae). So far NDGA was not isolated and estimated in larrea tridentata (moc. & sess.) cov. In this study isolation of Nordihydroguaiaretic acid was achieved by preparative TLC and the compound thus isolated was characterised by Ultraviolet and Mass spectral analysis. Mass spectral data shows molecular ion peak of m/z=302.2. An isocratic RP-HPLC method was developed for the estimation of Nordihydroguaiaretic acid in marketed formulation. Retention time of Nordihydroguaiaretic acid was found as 4.173 min. This method has obeyed linearity over the concentration range of 1050μg/ml and the regression coefficient obtained from linearity plot for Nordihydroguaiaretic acid was found as 0.999. RP-HPLC method was validated in pursuance of International conference on Harmonization (ICH) guidelines. This method is simple and economic one a...

Research paper thumbnail of Magnetic Nanoparticle-Based Approaches in Cancer Therapy–A Critical Review

International Journal of Applied Pharmaceutics

Cancer is definitely one of the leading causes of mortality worldwide. Failure in the efficacy of... more Cancer is definitely one of the leading causes of mortality worldwide. Failure in the efficacy of the standard treatments (chemo-, radiotherapy and surgery), and the severe side effects, resistance of tumor cells to chemotherapeutics have necessitated alternative therapeutic strategies. Magnetic nanoparticles (MNPs) have been assessed as potential cancer therapy materials. Their intrinsic magnetic properties provide a cancer detection, monitoring, and therapy platform based on multimodal theranostics. MNPs can be functionalized by binding them to a wide variety of substances, including chemotherapeutic drugs, radionuclides, nucleic acids, and antibodies. They can be used for drug delivery, magnetic or photothermal induced local hyperthermia and photodynamic therapy aimed at killing cancer cells at the tumor site. MNPs may also be useful to challenge drug resistance. The combination of different options of these treatment modalities offers a synergistic effect and significantly reduc...

Research paper thumbnail of Dendritic Architechture for the Delivery of Levofloxacin against Resistant Producing Strains

The present study was aimed at developing and exploring the use of PEGylated poly (propylene imin... more The present study was aimed at developing and exploring the use of PEGylated poly (propylene imine) dendritic architecture for the delivery of an anti-bacterial drug, Levofloxacin. For this study, PEGylated poly(propylene imine) dendritic architecture was synthesized and loaded with Levofloxacin and targeted to the resistant producing strains of Klebsiella pneumoniae and E.coli. The antibacterial activity was carried out by cup and bore method to compare the zone of inhibition with standard drug and control (DMSO). The study showed that the Levofloxacin loaded dendrimer has significant antibacterial activity than the plain drug and control treated, but standard drug was not shown zone of inhibition upon both microorganisms. In this study antibacterial activity of synthesized system are also relatively safer and hold potential to deliver some other drugs also.

Research paper thumbnail of In-vitro anti tubercular activity of flowers of Couroupita guanensis L

Modern civilization is facing hundreds of disorders associated with microorganisms. The natural p... more Modern civilization is facing hundreds of disorders associated with microorganisms. The natural phytochemicals fromnon-edible plants are gaining importance to fight against these disease The intention of this study is to evaluatethe ethanol and dichloromethane extracts of flower of Couroupita guianensis (Lecithydaceae) for anti-tubercular activity. The anti-tubercular activity of all the extracts of Couroupita guianensishave been evaluated againstMycobacterium tuberculosis H73Rv strain using Microplate Alamar Blue Assay (MABA). The activity wasdocumented within MIC range of 0.8 to 100I¼g/ml. The results of MABA showed that both ethanol and dichloromethane extractexhibited significant anti-tubercular activity. The present investigation suggests that Couroupita guianensispossess remarkableanti-tubercular activity.