Ramazan Cetinkaya - Academia.edu (original) (raw)

Papers by Ramazan Cetinkaya

Akdeniz Medical Journal

Dünyayı tehlike altına alan COVID-19 pandemi süreci tüm ülkeleri tehdit etmeye devam etmektedir. ... more Dünyayı tehlike altına alan COVID-19 pandemi süreci tüm ülkeleri tehdit etmeye devam etmektedir. Bu süreç içinde sosyal mesafe ve izolasyon sebebiyle birçok faaliyete ara verilmiştir. Bu araştırmada, söz konusu pandemi sürecinde yüz yüze eğitime ara verilmesi sonucunda Akdeniz Üniversitesi'nde uygulanan uzaktan eğitimin değerlendirilmesi amaçlamaktadır.

Turkiye Klinikleri Nephrology - Special Topics, 2019

Background: Dialysis adequacy is an important parameter with regards to morbidity and mortality i... more Background: Dialysis adequacy is an important parameter with regards to morbidity and mortality in chronic hemodialysis patients. Besides many other factors affecting this parameter, the effect of different permanent vascular access types (PVA), essential for the hemodialysis treatment, on this parameter should be further investigated. As PVA 's, native arteriovenous fistulas (NAVF), graft (polytetrafluoroethylene) arteriovenous fistulas (GA VF) and permanent hemodialysis catheters (PHC) are used. One of the factors during the performing a PVA is to find an answer to whether or not the type of PVA has an effect on Kt/V ratio and recirculation (R%). Our purpose was to find whether there was any difference depending on the type of PVA in terms of Kt/V and R%. Method: Sixty-one patients who have been on hemodialysis with the same vascular access for the past 6 months were grouped according to their types of PVA. Of them, 37 were NAVF, 12 were GAVF and the remaining 12 were with PHC and they all received bicarbonate dialysis with low-flux dialysers 4 hours 3 times a week. Mean average Kt/V and R% ratios for six months were calculated. Kruskal-Wallis H test was used for statistically analysis.

Pain Clinic, Jun 1, 2002

ABSTRACT A 50 year old, previously healthy woman came to our attention with high fever, arthralgi... more ABSTRACT A 50 year old, previously healthy woman came to our attention with high fever, arthralgia and oliguria. Serological tests were positive for antinuclear antibodies, anti-double-stranded-DNA antibodies and cardiolipin antibodies. Renal histology indicated diffuse proliferative lupus nephritis. Three days after the hospitalisation, the patient developed massive pulmonary embolism and dialysis-dependent acute renal failure, for which she was dialysed. Heparin 1000 U/hour (7 days), methylprednisolone (1000 mg/day for 3 days) and cyclophosphamide (500 mg for one day) were administered. This therapy led to a dramatic improvement of renal and pulmonary functions and, consequently, treatment with hemodialysis could be stopped after 3 weeks. This case illustrates an uncommon manifestation of systemic lupus erythematosus associated with antiphospholipid syndrome.

Page 1. ERKEK AKTİF BEHÇET HASTALARINDA SERUM SEKS HORMON DÜZEYLERİ SERUM SEX HORMON LEVELS IN TH... more Page 1. ERKEK AKTİF BEHÇET HASTALARINDA SERUM SEKS HORMON DÜZEYLERİ SERUM SEX HORMON LEVELS IN THE MALE PATIENTS WITH ACTlVE BEHCET&#x27;S DISEASE Ali Rıza ODABAŞ, Ramazan ÇETİNKAYA ...

Turkiye Klinikleri Nephrology - Special Topics, 2010

Turkiye Klinikleri Nephrology - Special Topics, 2014

The Eurasian Journal of Medicine, Nov 12, 2015

New-onset diabetes after transplantation and impaired glucose tolerance are very common in renal ... more New-onset diabetes after transplantation and impaired glucose tolerance are very common in renal transplant patients. New-onset diabetes after transplantation (NODAT) is associated with increased cardiovascular morbidity and mortality, reduced graft and patient survival. Several risk factors for NODAT have been identified: age, obesity, family history of diabetes mellitus and HCV infection. In addition, steroid and calcineurin inhibitors also contribute to the development of NODAT. Sirolimus causes immunosuppressive effects by inhibiting mammalian target of rapamycin (mTOR), and has well known side effects. The effects of sirolimus on glucose metabolism and contribution to NODAT development are not clearly known. In this report, we presented five RTX patients who developed NODAT under the treatment of sirolimus.

Nephrology Dialysis Transplantation, Jun 1, 2019

International Surgery, Nov 29, 2016

Aim: Our aim was to compare the short and long term clinical outcomes of HbsAg(+) renal transplan... more Aim: Our aim was to compare the short and long term clinical outcomes of HbsAg(+) renal transplant recipients with HbsAg(-) recipients. Patients and Methods: Two hundered and four patients who underwent renal transplantation in our center between 2001 and 2014 were included in the study. The patients were divided into two groups. Group 1: HbsAg(-) group (n=136) and Group 2: HbsAg(+) group (n=68). There was no significant difference between the groups in terms of lymphocyte cross matches, numbers of mismatches, immunosuppressive treatment protocols and induction treatments. In HbsAg(+) group, 51 patients were HBV DNA(+), 64 patients were HbeAg(-) and 4 patients were HbeAg(+). Fifty-seven (83.8%) patients were treated with Lamivudine, 4 (5.9%) patients with Entecavir and 7 (10.3%) patients with Tenofovir for Hepatitis B infection. Graft and patient survival rates, graft functions, acute hepatitis rates, acute rejection rates and other clinical outcomes of the groups were compared. Results: Demographic data and immuologic risk profiles of the groups were similar. Acute rejection rates, graft survival rates and patient survival rates were similar. Acute hepatitis rates, glomerular filtration rates on the last controls and delayed graft function rates were higher in Group 2, while chronic allograft disfunction and new onset Powered by Editorial Manager® and ProduXion Manager® from Aries Systems Corporation diabetes mellitus after transplantation (NODAT) rates were similar between the groups. Conclusion: Our study revealed that, graft and patient survival and acute rejection rates were similar between HbsAg(+) and HbsAg(-) recipients, while acute hepatitis rate was higher in HbsAg(+) recipients.

Transplant Infectious Disease, Jan 30, 2016

The aim of this study was to determine the effects of hepatitis B surface antigen (HBsAg) positiv... more The aim of this study was to determine the effects of hepatitis B surface antigen (HBsAg) positivity of the donors on graft survival and liver complications in HBsAg(+) renal transplant recipients.

Journal of Investigative Medicine, Apr 1, 2017

CD200 is a novel immune-effective molecule, existing in a cell membrane-bound form, as well as in... more CD200 is a novel immune-effective molecule, existing in a cell membrane-bound form, as well as in a soluble form in serum, which performs to modulate inflammatory and acquired immune responses. Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the development of large renal cysts and progressive loss of renal function. As defects in cell cycle arrest and apoptosis of renal tubular epithelial cells occur in ADPKD, we asked whether serum soluble CD200 might underlie and effect on ADPKD. Serum soluble CD200 levels were measured in 44 patients with ADPKD and 24 healthy volunteers. Concentrations of soluble CD200 in the serum samples were quantified using an ELISA kit. The mean serum soluble CD200 levels were higher in patients with ADPKD than in the control group (71.4±29.2 and 21.4±5.6 pg/mL, p<0.001). Positive correlation was detected between serum soluble CD200 levels and glomerular filtration rate (r=0.772, p<0.001), and serum albumin level (r=0.466, p=0.001). Negative correlation was detected between serum soluble CD200 levels and serum creatinine levels (r=−0.761, p<0.001), and C reactive protein levels (r=−0.364, p=0.015). In the ADPKD patients group, serum soluble CD200 levels were lower in patients with stage 5 chronic kidney disease (CKD) than in patients with stages 1–2 (p<0.001), 3 (p=0.005) and 4 CKD (p=0.006). Serum soluble CD200 levels were similar in patients with stages 1–2, 3, and 4 CKD (p>0.05). Our results show that patients with ADPKD have activated soluble CD200 levels which were related to renal function and inflammation.

Seminars in Dialysis

Encapsulated peritoneal sclerosis (EPS) is a rare, but frequently fatal, long‐term complication o... more Encapsulated peritoneal sclerosis (EPS) is a rare, but frequently fatal, long‐term complication of peritoneal dialysis. Endometriosis is a common gynecological problem but hemoperitoneum due to endometriosis has been reported to be extremely rare in hemodialysis (HD) patients. A 25‐year‐old female HD patient was admitted to our clinic with nausea, vomiting, abdominal pain, and weight loss for last 3 months. Candida tropicalis and Candida glabrata were isolated in the fungal cultures from peritoneal fluid. Her abdominal computerized tomography scan has shown irregular peritoneal calcifications, diffuse peritoneal thickening, dilatation of the small bowel loops, and cocoon formation which all were typical for EPS. Hemoperitoneum was reported to recur for four times with intervals suggesting menstrual cycles. Her peritoneal biopsy, along with the signs of EPS, has also revealed the presence of endometriosis. The patient died with symptoms of septic shock in the first year of EPS diagno...

Türk nefroloji diyaliz ve transplantasyon dergisi, 2010

Laboratory Medicine, 2021

Objective To create an efficient and robust mass spectrometric method for the simultaneous quanti... more Objective To create an efficient and robust mass spectrometric method for the simultaneous quantitation of podocin and podocalyxin in urine samples and to evaluate urinary podocin and podocalyxin levels in patients with nephrotic syndrome (NS). Methods A mass spectrometric method was generated for the measurement of tryptic peptides in urine sediment. Separation of peptides was achieved via liquid chromatography, and mass spectrometric analyses were conducted by electrospray ionization triple-quadrupole mass spectrometry in the multiple reaction monitoring mode. Results Intra- and interassay precision values were below 12% and accuracies ranged from 87% to 111% for both of peptides. The validated method was successfully applied to detect these peptides in patients with NS. Urine podocin and podocalyxin levels were significantly higher in patients with NS compared to healthy controls. Conclusions This proposed mass spectrometric method provides technological evidence that will benefi...

International Urology and Nephrology, 2021

Purpose Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney... more Purpose Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease that may progress to end-stage renal disease, characterized by increased kidney volume due to cystic formations. In this study, we aimed to investigate the relationship between serum uromodulin levels, total kidney volume and estimated glomerular filtration rate (eGFR) in patients with ADPKD. Methods This study included a total of 54 ADPKD patients and 18 healthy volunteers (control group). Total kidney volumes were calculated through magnetic resonance images using ellipsoid method. Serum uromodulin measurements were measured using an ELISA method. Results Serum uromodulin levels were lower in patients compared with the control group (2.47 ± 0.16 vs 2.6 ± 0.28, p = 0.021). There was no significant difference in uromodulin values among the patients in chronic kidney disease (CKD) stages 1–2, 3 and 4–5. TKV measurements of CKD stage 4–5 patients were significantly higher than the stage 1–2 patients ( p = 0.015). A negative correlation was observed between TKV and eGFR ( r = − 0.433, p = 0.001). A positive correlation was observed between uromodulin and eGFR ( r = 0.274, p = 0.02). When the serum levels of uromodulin and the level of eGFR were evaluated using simple linear regression analysis, R 2 value was found to be 0.075, suggesting that 7.5% change in serum uromodulin values corresponds with the change in eGFR value. Conclusion These findings are consistent with previous studies that reported that serum uromodulin may be a good biomarker for demonstrating renal function in the early stages of CKD, before eGFR levels deteriorate. Serum uromodulin level may be useful in demonstrating renal functions in the follow-up of individuals with ADPKD.

Nephrology Dialysis Transplantation, 2019

association of MetS and variability of metabolic components with prostate cancer development in t... more association of MetS and variability of metabolic components with prostate cancer development in the Korean population METHODS: We evaluated the data of 17,539,992 Korean individuals of the National semi-compulsive cohort who underwent regular health checkups between 2009 and 2010. MetS represents a cluster of metabolic derangements that confer an increased risk of cardiovascular disease and type 2 diabetes mellitus. Its individual components include obesity, dyslipidemia, high blood pressure, and high fasting glucose level. Presence of MetS and its components were checked two times through examination. We classified four groups of MetS and its components; none, pre, post, both. RESULTS: Compared to subjects without MetS components, the hazard ratio for prostate cancer development in patients with MetS was 1.157 (95% Confidence Interval [CI]1.128-1.186), and this association is strongly related to the more components of MetS. And even if MetS and its component improved after 2years of period, the hazard ratio for prostate cancer development is still remained (HR 1.108 [95% CI 1.066-1.151] in the pre group, HR 1.095 [95% CI 1.05-1.141] in the post group, HR 1.21 [95% CI 1.175-1.245] in the both group). Among the components of MetS, the association was the highest in the patients with low high-density lipoprotein cholesterol (HR 1.146 [95% CI 1.105-1.19] in the pre group, HR 1.113 [95% CI 1.067-1.161] in the post group, HR 1.22 [95% CI 1.182-1.258] in the both group) CONCLUSIONS: Individuals with MetS are at increased risk of development of prostate cancer. And especially individuals with multiple MetS or low HDL-C levels show higher risk of development of prostate cancer. And the patients who have ever been diagnosed with metabolic syndrome and positive of metabolic components, may need to undergo thorough screening for prostate cancer.

Nephrology Dialysis Transplantation, 2015

Akdeniz Medical Journal, 2019

Objective: In this retrospective study, we aimed to clarify the reasons for high creatinine level... more Objective: In this retrospective study, we aimed to clarify the reasons for high creatinine levels and proteinuria in kidney transplants. Material and Methods: The research data were obtained from patient files and the hospital database. Results: Ninety-two patients, consisting of 24 females and 68 males, were biopsied. Histopathological examination of the biopsy samples showed borderline changes in 20 patients, acute antibody-mediated rejection (AMR) in two, chronic active AMR in 10, acute T-cell-mediated rejection (TCMR) in seven, recurrence of the primary disease or de novo glomerulonephritis in eight, coagulation necrosis in one, tubular atrophy and interstitial fibrosis in nine, calcineurin inhibitor drug toxicity in six, and polyomavirus nephropathy in seven. Average creatinine was 2.58±1.1 mg/dl. The proteinuria levels ranged from 83 to 12600 mg/day with the average value being 2142±2619 mg/day. Among the patients with a proteinuria value of less than 1000 mg/day, two had acute AMR, three chronic active AMR, 21 acute TCMR-borderline, and seven chronic active TCMR, and 12 biopsies revealed other causes. For the 1000-3500 mg/day proteinuria group, five chronic active AMR, two acute TCMRborderline, and five chronic active TCMR were identified, and 11 biopsies indicated other causes. Lastly, of the patients with a proteinuria level of greater than 3500 mg/day, two had chronic active AMR, four acute TCMR-borderline, and eight chronic active TCMR, and seven biopsies revealed other conditions. Conclusion: Diagnosis of renal allograft biopsies may vary from one center to another due to different diagnostic approaches to dysfunction and proteinuria in renal allografts.