Ranjit Singh - Academia.edu (original) (raw)

Papers by Ranjit Singh

The Safety Journal

Journal of Patient Safety, 2007

ABSTRACT Context: National and international agencies have recognized the need to train all healt... more ABSTRACT Context: National and international agencies have recognized the need to train all health care workers in the principles of patient safety. Objective: To design a safety "journal" to encourage and aid in reporting of and learning from errors and to engage learners in system-based safety improvement. Setting and Participants: Large multisite family medicine residency program. Thirty third-year residents participated over a 2-year period. Curriculum Design: As part of a patient safety curriculum, third-year residents take a didactic course on systems approach to patient safety. To reinforce the material, they are encouraged to keep a safety journal in which they record incidents (observed errors, anticipated errors, and close calls) and propose solutions, based on the principles taught in the didactic. Outcome Measure: Number and quality of safety journal entries with particular emphasis on the ability to devise feasible system-based solutions. Results: In the first year, 42 entries were submitted, of which 55% included appropriate system-based solutions. In year 2, to encourage more structured thinking, a visual format for the journal was devised. Twenty-seven entries were submitted, and 81% included system-based solutions. Conclusions: The safety journal in the revised visual format, coupled with a didactic course, appeared to be effective as a teaching tool for stimulating residents to think from a systems perspective and to devise practical, system-based solutions to safety problems in their practices. However, the challenge remains to incorporate such tools, in a training environment, into institutional quality improvement efforts so as to bring to life for learners the importance of error reporting for improving patient safety.

State space synthesis of the biquadratic voltage transfer function using grounded capacitors

IEE-IERE Proceedings - India, 1975

Stale variable synthesis of a biquadratic voltage transfer function using equal-valued grounded c... more Stale variable synthesis of a biquadratic voltage transfer function using equal-valued grounded capacitors is presented. Numerator coefficients of transfer function, pole-pair resonant frequency and Q factor can each be independently controlled. A wider range of Q values is possible than in other schemes. Supporting experimental results are included.

Innovation for Sustainable Manufacturing Proceedings of the 4th international and 25th All India Manufacturing Technology, Design and Research Conference (AIMTDR 2012)

The identification of the undercut features and design of side-cores for a die-casting part is a ... more The identification of the undercut features and design of side-cores for a die-casting part is a non-trivial task, which depends on part geometry and process requirements. This requires lot of time and effort of a die-casting die-design expert and also increases lead time, particularly in case of complex undercut features. By complex undercut features, we mean those features which can’t be released in a single withdrawal direction and need to be divided. Present work is about automated recognition of undercut features, including complex ones, from CAD model of the die-casting part. Algorithm proposed in this paper addresses identification and classification of undercut features. Separation of complex undercut features into simple undercut features and determination of their release directions is also discussed. Important features of the proposed algorithm and its implementation on an example die-casting part have been discussed in this paper.

Journal of the American Medical Informatics Association : JAMIA, Jan 14, 2015

The objective of this research is to empirically explore the drivers of patients' consent to ... more The objective of this research is to empirically explore the drivers of patients' consent to sharing of their medical records on health information exchange (HIE) platforms. The authors analyze a dataset consisting of consent choices of 20 076 patients in Western New York. A logistic regression is applied to empirically investigate the effects of patients' age, gender, complexity of medical conditions, and the role of primary care physicians on patients' willingness to disclose medical information on HIE platforms. The likelihood of providing consent increases by age (odds ratio (OR) = 1.055; P < .0001). Female patients are more likely to provide consent (OR = 1.460; P = .0003). As the number of different physicians involved in the care of the patient increases, the odds of providing consent slightly increases (OR = 1.024; P = .0031). The odds of providing consent is significantly higher for the patients whom a primary care physician has been involved in their medical...

Journal of Innovation in Health Informatics, 2008

Motion Estimation in Medical Imaging

IFMBE Proceedings

... Page 4. 606 S. Ranjit, KS Sim, R. Besar and CP Tso ... IEEE Trans-actions on Biomedical Engin... more ... Page 4. 606 S. Ranjit, KS Sim, R. Besar and CP Tso ... IEEE Trans-actions on Biomedical Engineering, 51 (9):1599-1608 4. Rajapakse JC, DeCarli C, McLaughlin A, Giedd JN et al. (1996) Cerebral Magnetic Resonance Image Segmentation using Data Fu-sion. ...

International Journal of Dermatology, 1993

Case 1: A 14-year-old young woman was referred to us for painful palmoplantar keratoderma. At the... more Case 1: A 14-year-old young woman was referred to us for painful palmoplantar keratoderma. At the age of 1 year, the parents noted erythema and scaling of the heels and palms with painful fissuring. At the age of 4 years, she developed erythematous hyperkeratotic plaques over the knees, knuckles, and ankles. Her teeth erupted at age 1 year. During her third year the parents noted swelling and bleeding of the gums and subsequently exfoliation of all tbe deciduous teeth. After exfoliation of her deciduous teeth the gums healed completely. During the ensuing years, the child suffered similar loss of all the permanent teeth except the third molars. Clinical examination of the skin showed a diffuse, well demarcated, yellowish palmoplantar keratoderma (Fig. 1) with extension of the rash to the back of the fingers and dorsum of the feet (Fig. 2). Symmetrical erythematous psoriasiform plaques were noted on the elbows and knees. Nails of the fingers were convex, and the terminal phalanges were clawlike (Fig. 3). Hair and sweating were normal. Oral examination revealed presence of only the third molars. This patient is the fourth of six children of consanguineous parents. Two of the siblings are affected.

A review on different activity of quinolone derivatives

Scientia Horticulturae, 1981

The efficacy of foliar spray of various macro-and micro-nutrients in different concentrations on ... more The efficacy of foliar spray of various macro-and micro-nutrients in different concentrations on granulation and fruit quality in 'Dancy tangerine' (Citrus reticulata Blanco), a cultivar which suffers badly from granulation, was studied in the research orchard at the Punjab Agricultural University during 1974-75 and 1975-76. The combined spray of zinc sulphate 0.5% + copper sulphate 0.5% reduced the incidence of granulation to 45% from 78% in control during 1974-75 (42% reduction over control). Potassium nitrate 1% (included in the second year of experimentation) gave the lowest granulation of 50% against 74% in control. The former treatment followed it closely. Low concentrations of boric acid (25 and 50 mg 1-1) and calcium hydroxide 2% also markedly reduced the disorder. All these treatments improved the fruit quality and gave much more pulp, juice, T.S.S., sugars and ascorbic acid content than control, and they also markedly reduced peel, rag, total acidity and starch during both years. The application of nutrients is, therefore, considered to be a successful tool in reducing granulation in this cultivar of mandarin.

Medicinal Chemistry Research, 2014

3D QSAR models using 3D pharmacophore, CoMFA, and CoMSIA approaches were developed for a series o... more 3D QSAR models using 3D pharmacophore, CoMFA, and CoMSIA approaches were developed for a series of quinoline derivatives as PDE4 receptor antagonists. Hypogen method was used to engender the 3D pharmacophore model. The top scoring four feature pharmacophore models, Hypo1 contains one hydrogen-bond acceptor, two hydrogen-bond donors, and a hydrophobic feature. Hypo1 was validated using test set, Fischer's randomization test, and screening of decoy set. CoMFA and CoMSIA models were developed using the alignment obtained by pharmacophore (Hypo1), substructure alignment, and by application of region focusing. Substructure alignment followed by region focusing provided the best CoMFA and CoMSIA models. Based on the results of 3D QSAR studies, some new molecules were designed and evaluated by Docking and Lipinski filters. The designed molecules were synthesized and two top scoring molecules were subjected to preliminary evaluation of their efficacy in treatment of asthma and COPD. The molecules demonstrated efficacy comparable to standard drugs in treatment of asthma and COPD.

Drug Delivery and Translational Research, 2011

Over the past few years, new insights into immunobiology and delivery systems have allowed the de... more Over the past few years, new insights into immunobiology and delivery systems have allowed the development of better vaccines and for a wider range of diseases. Currently available vaccines represent outstanding success story in modern medicine and have had a dramatic effect on morbidity and mortality worldwide. Conventional vaccines have been based on live attenuated, or killed, viruses or bacteria, or recombinant proteins from these organisms. The design of live attenuated vaccines depended to some extent on serendipity and resulted in low success rates. Both live attenuated and killed vaccines require handling of live pathogens and are associated with safety problems. Despite the success of vaccines, there is a clear need for novel antigen delivery technologies to improve vaccine efficacy and safety. Antigen stability, safety, and immunogenicity are the key hurdles in development of novel antigen delivery technologies. Nowadays, various novel drug delivery systems are becoming one of the fastest growing sectors in the pharmaceutical and biotechnological industries. Delivery of vaccines via oral, intranasal, transcutaneous, and intradermal routes will decrease the risk of needle-borne diseases and may eliminate the need for trained personnel and sterile equipment. Currently, various techniques involving DNA vaccines, adjuvants, nanoparticles, liposome, microneedle, and NanoMAP technology are being developed and evaluated. This review focuses on the current development of some novel vaccine delivery systems and will explore the non-parenteral routes of vaccine administrations.

Tropical Journal of Pharmaceutical Research, 2014

Purpose: To design and develop halogenated chalcone derivatives and evaluate them as anticancer a... more Purpose: To design and develop halogenated chalcone derivatives and evaluate them as anticancer agents using different cancer cell lines. Methods: Based on in silico design and docking on known target, crystal structure of the complex of interleukin-1beta converting enzyme (ICE) with a peptide based inhibitor, (3S)-N-Methanesulfonyl-3-({1-[N-(2-naphtoyl)-l-valyl]-l-prolyl}amino)-4-oxobutanamide (1BMQ), novel halogenated chalcone derivatives were designed (7a-h) employing LigandFit module of Accelrys (Discovery Studio, 2.1 version). Standard protocols for ligand and protein preparation were employed and their binding orientation validated using (3S)-N-Methanesulfonyl-3-({1-[N-(2-naphtoyl)-l-valyl]-l-prolyl}amino)-4oxobutanamide (MNO 601), a caspase inhibitor as reference standard. Energy minimized conformers with best dock scores were considered for the identification of interacting amino acid residues with ligands. Selected derivatives were synthesized and analyzed by melting point, 1 H NMR, IR and mass spectroscopy. Their evaluation for anticancer activity was carried out using adriamycin, paclitaxel and 5fluorouracil as reference standards on prostrate (PC-3), colon (COLO-205), ovary (OVCAR-5), liver (HEP-2) and neuroblastoma (IMR-32) cancer cell lines, and % growth inhibition and half maximal inhibitory concentration (IC50) values were calculated. Results: Among synthesized compounds, 7b showed the most promising cytotoxic activity with an IC50 of 49.9 µM on colon cancer cell lines (Colo-205), followed by 7d with an IC50 of 66.6 µM against ovarian cancer cell lines (OVCAR-5). Conclusion: We report the successful synthesis, spectral characterization and in vitro anticancer evaluation of a series of novel halogenated chalcone derivatives against a number of human cancer cell lines. The findings indicate the emergence of new anticancer compounds.

Studies of thermally stimulated currents and surface charge in polystyrene thin films

Thin Solid Films, 1980

A careful study was undertaken of the initial charge developed on the non-metallized surface and ... more A careful study was undertaken of the initial charge developed on the non-metallized surface and of short-circuit thermally stimulated currents (TSCs) in unilaterally metallized polystyrene (PS) films 25 microm thick. The films had been negatively charged by Townsend breakdown at a voltage of −5 kV at various temperatures ranging from 90 to 130°C. The surface charge densities observed were of the order of 10-8 C cm-2, corresponding to full trap densities of the order of 1014 cm−3. The short-circuit TSC spectra of newly charged samples show a single peak at a temperature between 98 and 102°C. The thermal activation energy associated with this peak was found to be 1.2 eV. An analysis of TSCs indicates that electrons are subject to fast retrapping in PS. The ratio of the mean charge depth to the sample thickness is found to increase from 0.069 to 0.12 with the increase in the temperature of polarization, indicating a higher charge accommodation at higher temperatures of polarization. The trap-modulated mobility values for electrons at the TSC peak temperatures are the order of 10−12 cm2 V−1s−1. Such low mobility values at peak temperatures are considered to indicate the excellent charge storage properties of PS.

The Journal of Risk Finance, 2011

PurposeThe purpose of this paper is to measure the risk perception of the employees in respect of... more PurposeThe purpose of this paper is to measure the risk perception of the employees in respect of equity shares, from the perspective of elements of marketing mix and to ascertain the degree of influence of elements of marketing mix on equity‐related risk perception.Design/methodology/approachPrimary data based on the interview schedule were collected from the employees of Oil India Limited and various tables prepared. For analysis of data, Cronbach's alpha and Friedman test analysis were employed.FindingsOut of the four elements of marketing mix considered in the study, the degree of influence of price driven measure of risk perception is highest and others in order are product, promotion and place driven measure of risk perception, respectively.Originality/valueThe paper is the first of its kind and hence original in nature.

Solid-State Electronics, 1999

A new self-consistent charge-control model incorporating deep level eects is presented. It takes ... more A new self-consistent charge-control model incorporating deep level eects is presented. It takes into account DX centers, substrate trapping and strain in pseudomorphic HEMTs. It is shown that conventional charge-control models are insucient to describe HEMT's operation in a depletion-mode and near pinch-o. The present model provides a good physical understanding of the HEMT operation and has been used to investigate the eects of deep levels on the device performance of a variety of HEMT structures.

Precision Engineering, 1984

Electrochemical drilling (ecd) with stationary electrodes produces an inaccurate and irregular ho... more Electrochemical drilling (ecd) with stationary electrodes produces an inaccurate and irregular hole shape profile. The effect of low speed workpiece (anode) rotation on the accuracy of hole reproduction and other related parameters in ecd has been studied. A theoretical analysis of the effect of workpiece rotation and electrolyte flow velocity is presented. It is concluded that a slow relative rotary motion between the electrodes helps to produce a better hole profile

Pramana, 1992

Doppler-limited high resolution laser optogalvanic spectra of six transitions of rhenium lying in... more Doppler-limited high resolution laser optogalvanic spectra of six transitions of rhenium lying in the range 560-620 nm have been recorded. Isotope shifts between the two natural isotopes of rhenium, ~SSRe and ~S~Re, have been calculated in all the six transitions. Hyperfine coupling constants for eight levels belonging to the configurations 5d S 6s z, 5d 66s, 5d~6s26p and 5dS6s6p are reported. Wherever possible our constants are compared with those given by others.

Physics Letters A, 1993

We report self-induced oscillations in a hollow cathode discharge. The effect of internal noise i... more We report self-induced oscillations in a hollow cathode discharge. The effect of internal noise is modeled using a phenomenological complex Ginzburg-Landau type model. Based on the observations and the model, it is shown that the system transforms from a metastable "window" (4.3-4.75 mA) to a stable period doubled state exponentially with time.

Journal of the Optical Society of America B, 1992

The hyperfine structure of 22 states of niobium is studied by Doppler-limited laser optogalvanic ... more The hyperfine structure of 22 states of niobium is studied by Doppler-limited laser optogalvanic spectroscopy. The sample was prepared by a sputtering technique employing a niobium-neon hollow-cathode lamp. A frequency-stabilized single-frequency ring dye laser was used for excitation, and optogalvanic spectroscopy techniques were used for detection. From the recorded well-resolved hyperfine spectra the magnetic dipole and electric quadrupole coupling constants are evaluated. The hyperfine coupling constants for 13 states belonging to the configurations 4d 45s, 4d 4 5p, and 4d35s5p are being reported for the first time to our knowledge. The values obtained are compared with previous data when available.

The effect of annealing time on thermally stimulated discharge current of corona-charged ethyl cellulose

Journal of Thermal Analysis and Calorimetry, 2010

... Acknowledgements Ajay Pal Indolia gratefully acknowledge the Defence Research & Devel... more ... Acknowledgements Ajay Pal Indolia gratefully acknowledge the Defence Research & Development Organization (DRDO), New Delhi, India (vide letter no. ... J Non-Cryst Solids. 2006;352:47537. 6. Sangawar VS, Dhokne RJ, Ubale AU, Chikhalikar PS, Meshram SD. ...