Raquel Eugenia Flores - Academia.edu (original) (raw)

Papers by Raquel Eugenia Flores

Frontiers in Psychiatry

BackgroundResilience allows a more positive coping and improves parents' wellbeing when they ... more BackgroundResilience allows a more positive coping and improves parents' wellbeing when they face a difficult situation like having a child with a neurodevelopmental disorder (NDD). We aim to analyze the development of resilience in parents of children with different NDD (ASD, DLD and ADHD) with different levels of structural language and social cognition, as well as the social support available for their families, and compare it to children with typical development (TD).MethodWe analyzed the level of resilience of 156 parents, 73 with children with TD and 73 with three different NDD, taking into account variables such as age, structural language (receptive grammar) and social cognition (emotional understanding) of the children, and also the type of social support available to them.ResultsChildren with DLD and ASD showed lower receptive grammar and emotional comprehension skills, although only parents of children with ASD obtained better resilience scores. Moreover, age of child...

International Journal of Environmental Research and Public Health

Schools are a fundamental context for processes of promotion and generation of resilience, since ... more Schools are a fundamental context for processes of promotion and generation of resilience, since they focus not only on aspects of academic development, but also of personal and social development. Resilience in the teacher has a dual function. On the one hand, as resilient professionals, teachers can foster the development of resilience in their students; on the other hand, teaching resilience facilitates their own personal and professional well-being. Despite research highlighting the benefits of resilience in education, there is scarce research focused on assessing resilience in teachers. Thus, the aim of this paper is to analyze the psychometric properties of the Spanish version of Connor and Davidson’s 10-item resilience scale (CD-RISC 10©) in a sample of 290 teachers. A confirmatory factorial analysis (CFA) is performed, which shows that the 10 items on the CD-RISC 10© Resilience Scale form a one-dimensional structure, with high reliability, McDonald’s Omega coefficient (ω = 0...

Children

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Scientific Reports, 2020

An amendment to this paper has been published and can be accessed via a link at the top of the pa... more An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Scientific Reports, 2019

This work explores the development of highly sensitive salinity sensors. The demonstrated sensors... more This work explores the development of highly sensitive salinity sensors. The demonstrated sensors are based on optical fibres and consist on Fabry-Pérot optical cavities formed by optimized processes that include chemical etching and fusion splicing, on which microfluidic channels are milled by focused ion beam. Two configurations are presented and their performance compared, including a design that makes use of Vernier-effect for the simultaneous measurement of salinity and temperature with high sensitivity. The interrogation of the devices is carried out by spectral measurements using a broadband light source yielding sensitivities to salinity up to 82.61 nm/M, or 6830.0 nm/RIU.

Problemas del Desarrollo. Revista Latinoamericana de Economía, 2009

A lo largo del artículo identificaremos las principales estrategias de comercialización que se ha... more A lo largo del artículo identificaremos las principales estrategias de comercialización que se han desarrollado durante las últimas décadas en el sector agroalimentario en Europa. Y extrapolaremos dichas estrategias a la industria del sector del aceite de oliva en España, para centrarnos en nuestro caso de análisis: Castilla-La Mancha. Curiosamente, ésta es la segunda región productora de aceite de oliva en España, sin embargo, a pesar de las cifras, la industria de primera transformación está perdiendo buena parte del valor añadido al permitir que una gran parte de su producción se venda a granel en lugar de venderse envasado. Buscaremos, por tanto, las causas de esa pérdida de ganancia y damos algunas posibles estrategias que deberían desarrollarse en esta industria en caso de que desee introducirse en nuevos segmentos de mercado.

International Journal of Colorectal Disease, 2017

The aim of this study was to evaluate the accuracy of serum procalcitonin (PCT) and C-reactive pr... more The aim of this study was to evaluate the accuracy of serum procalcitonin (PCT) and C-reactive protein (CRP) for early diagnosis of postoperative intra-abdominal infections (PIAI) after elective surgery for colorectal cancer. Methods Prospective observational study including patients operated on for colorectal cancer between January and December of 2015 was performed. Serum PCT and CRP levels were measured before surgery and daily until postoperative day 3. Results One hundred twenty patients were included. Seven patients (5.8%) had PIAI. PCT levels were significantly higher in patients with PIAI on postoperative days 1 and 3, whereas CRP levels only were significantly more elevated on postoperative day 3. The ratio between CRP levels on postoperative day 3 and CRP levels on postoperative days 2 (CRP D3/CRP D2) and 1 (CRP D3/CRP D1) was significantly higher in patients with PIAI. PCT on postoperative day 3, for a cutoff of 0.45 ng/mL, had the best sensitivity (100%) with a specificity of 73.8%. The ratio CRP D3/CRP D1 yielded the higher specificity and positive predictive value (90.9 and 27.3%, respectively, for a cutoff of 1.8). The higher negative predictive value was obtained for PCT on postoperative days 1 and 3 (100%, with cutoff of 0.76 and 0.45 ng/mL, respectively) and for CRP on postoperative day 3 (100% with cutoff of 10 mg/dL). Conclusion PCT and CRP serum levels are associated with the appearance of PIAI after colorectal cancer surgery, although the positive predictive values were low for both PCT and CRP. However, the negative predictive values were high.

PLoS genetics, Jan 10, 2017

Obesity is a multifactorial disorder with high heritability (50-75%), which is probably higher in... more Obesity is a multifactorial disorder with high heritability (50-75%), which is probably higher in early-onset and severe cases. Although rare monogenic forms and several genes and regions of susceptibility, including copy number variants (CNVs), have been described, the genetic causes underlying the disease still remain largely unknown. We searched for rare CNVs (>100kb in size, altering genes and present in <1/2000 population controls) in 157 Spanish children with non-syndromic early-onset obesity (EOO: body mass index >3 standard deviations above the mean at <3 years of age) using SNP array molecular karyotypes. We then performed case control studies (480 EOO cases/480 non-obese controls) with the validated CNVs and rare sequence variants (RSVs) detected by targeted resequencing of selected CNV genes (n = 14), and also studied the inheritance patterns in available first-degree relatives. A higher burden of gain-type CNVs was detected in EOO cases versus controls (OR = ...

La Recherche En Education, 2014

Notre recherche aborde une problematique liee au processus de stage des etudiants de la filiere p... more Notre recherche aborde une problematique liee au processus de stage des etudiants de la filiere pedagogique en Education Generale Primaire en cours du soir, c’est-a-dire les etudiants qui travaillent pendant la journee et etudient le soir. Notre etude s’attache a devoiler leurs perceptions quant au processus et leurs experiences a l’interieur des salles de classes afin d’identifier leurs besoins et leurs interets tout au long de leur developpement professionnel. La methodologie de cette recherche est basee sur une etude qualitative, avec un design de recherche-action. Ainsi notre objectif est aussi de transformer et d’ameliorer le modele du stage professionnel des etudiants en cours du soir. Le but de cette etude est donc de contribuer au processus de formation professionnelle des etudiants du programme d’Education Primaire selon les modalites du cours du soir. Dans un premier temps, trois focus groups ont ete realises avec des etudiants et des superviseurs de la filiere d’education primaire. Dans un second temps nous avons realise des interviews avec des professionnels d’universites chiliennes qui dirigent et coordonnent des stages professionnels dans le domaine des programmes d’education primaire. Les resultats, les reflexions et les recommandations se presentent afin d’initier un processus de reformulation du modele de stages pour les etudiants en cours du soir du programme d’education primaire generale. L’un de nos principaux resultats porte sur les objectifs, les valeurs et les theories sous-jacents au domaine des stages professionnels ; ceci met en lumiere la necessite du caractere integral, realiste du processus et de ses caracteristiques de progressivite, d’ouverture et d’innovation.

Desarrollo Rural Y Economia Social Resumenes De Conferencias Y Comunicaciones 2005 Isbn 84 96311 06 6 Pags 172 176, 2005

10O Congreso De Economia De Castilla Y Leon Competitividad Y Marco Institucional Comunicaciones Valladolid 23 Y 24 Noviembre 2006 Vol 2 2006 Isbn 84 690 0401 8 Pags 373 384, 2006

Revista Espanola De Desarrollo Y Cooperacion, 2011

Os trabalhos de estágio em administração são feitos nas diversas áreas de conhecimento, tais como... more Os trabalhos de estágio em administração são feitos nas diversas áreas de conhecimento, tais como, recursos humanos, produção, materiais, mercadológica, organização, sistemas e métodos e administração geral. Estas áreas possibilitam o desenvolvimento de diversos temas mais específicos, como a aplicação de ferramentas de gestão, pesquisas com clientes internos e externos, desenvolvimento de sistemas, análise de planos e programas entre outros. O estágio deve ser desenvolvido numa empresa, que autoriza a investigação científica e a prática administrativa, em contrapartida tem seus interesses em resolver alguma necessidade. E, o acadêmico nas suas atividades também tem seus interesses de conhecimento e profissionais. A integração escola-setor privado é extremamente importante tanto para o acadêmico quanto para a empresa e universidade. Assim, como o objetivo de analisar a cooperação Empresa-Universidade na área da administração, adotou-se como procedimentos metodológicos á pesquisa exploratória, com tipologia de estudo de caso e delineamento de método predominantemente qualitativo. Os participantes da pesquisa foram as empresas cedentes de estágio em administração, representados pelos supervisores de campo. Os resultados permitiram ao setor de estágios corrigir procedimentos e estabelecer políticas mais consistentes visando maximizar a cooperação Empresa-Universidade através das atividades de estágio.

Resumen: La contaminación ambiental por hidrocarburos aromáticos policíclicos (HAP) es actualment... more Resumen: La contaminación ambiental por hidrocarburos aromáticos policíclicos (HAP) es actualmente un problema muy extendido. Los HAP son generados por la combustión incompleta de combustibles fósiles entre otros y, además de sus propiedades tóxicas, son poco solubles en agua. Para abordar este problema, se utilizan surfactantes ya que favorecen la solubilidad de dichos compuestos hidrófobos. La temperatura también influye en las propiedades de los HAP y en el metabolismo de los microorganismos involucrados en su degradación. Enterobacter sp., Pseudomonas sp. y Stenothrophomonas sp., tienen una capacidad degradadora de naftaleno, fenantreno y antraceno eficiente a 15 y 25 ºC.

Epigenetics : official journal of the DNA Methylation Society, 2015

Congenital heart defects represent the most common malformation at birth, occurring also in ∼50% ... more Congenital heart defects represent the most common malformation at birth, occurring also in ∼50% of individuals with Down syndrome. Congenital heart defects are thought to have multifactorial etiology, but the main causes are largely unknown. We have explored the global methylation profile of fetal heart DNA in comparison to blood DNA from control subjects: an absolute correlation with the type of tissue was detected. Pathway analysis revealed a significant enrichment of differential methylation at genes related to muscle contraction and cardiomyopathies in the developing heart DNA. We have also searched for abnormal methylation profiles on developing heart-tissue DNA of syndromic and non-syndromic congenital heart defects. On average, 3 regions with aberrant methylation were detected per sample and 18 regions were found differentially methylated between groups. Several epimutations were detected in candidate genes involved in growth regulation, apoptosis and folate pathway. A likel...

Journal of Medical Genetics, 2015

Background: Williams-Beuren syndrome (WBS, OMIM-194050) is a neurodevelopmental disorder with mul... more Background: Williams-Beuren syndrome (WBS, OMIM-194050) is a neurodevelopmental disorder with multisystemic manifestations caused by a 1.55-1.83 Mb deletion at 7q11.23 including 26-28 genes. Reported endocrine and metabolic abnormalities include transient hypercalcemia of infancy, subclinical hypothyroidism in ~30% of children, and impaired glucose tolerance in ~75% of adult individuals. The purpose of this study was to further study metabolic alterations in WBS patients, as well as in several mouse models to establish potential candidate genes. Methods: We analyzed several metabolic parameters in a cohort of 154 WBS individuals (data available from 69-151 cases per parameter) as well as in several mouse models with complete and partial deletions of the orthologous WBS locus, and searched for causative genes and potential modifiers. Results: Triglyceride plasma levels were significantly decreased in WBS individuals while cholesterol levels were slightly decreased compared to controls. Hyperbilirubinemia, mostly unconjugated, was found in 18.3% of WBS cases and correlated with subclinical hypothyroidism and hypotriglyceridemia suggesting common pathogenic mechanisms. Haploinsufficiency at MLXIPL and increased penetrance for hypomorphic alleles at the UGT1A1 gene promoter might underlie the lipid and bilirubin alterations. Other disturbances included increased protein and iron levels, as well as the known subclinical hypothyroidism and glucose intolerance. Conclusions: Our results show that several unreported biochemical alterations, related to haploinsufficiency for specific genes at 7q11.23, are relatively common in WBS. The early diagnosis, follow-up and management of these metabolic disturbances could prevent long-term complications in this disorder.

Journal of Clinical Investigation, 2007

Williams-Beuren syndrome (WBS), a neurodevelopmental genetic disorder whose manifestations includ... more Williams-Beuren syndrome (WBS), a neurodevelopmental genetic disorder whose manifestations include visuospatial impairment, provides a unique model to link genetically determined loss of neural cell populations at different levels of the nervous system with neural circuits and visual behavior. Given that several of the genes deleted in WBS are also involved in eye development and the differentiation of retinal layers, we examined the retinal phenotype in WBS patients and its functional relation to global motion perception. We discovered a low-level visual phenotype characterized by decreased retinal thickness, abnormal optic disk concavity, and impaired visual responses in WBS patients compared with age-matched controls by using electrophysiology, confocal and coherence in vivo imaging with cellular resolution, and psychophysics. These mechanisms of impairment are related to the magnocellular pathway, which is involved in the detection of temporal changes in the visual scene. Low-level magnocellular performance did not predict high-level deficits in the integration of motion and 3D information at higher levels, thereby demonstrating independent mechanisms of dysfunction in WBS that will require remediation strategies different from those used in other visuospatial disorders. These findings challenge neurodevelopmental theories that explain cortical deficits based on low-level magnocellular impairment, such as regarding dyslexia.