Rashmi Mishra - Academia.edu (original) (raw)
Uploads
Papers by Rashmi Mishra
Indian Journal of Sleep Medicine, 2011
Present study was an attempt to evaluate sleep parameters and characteristics of circadian rhythm... more Present study was an attempt to evaluate sleep parameters and characteristics of circadian rhythm in rest-activity in sickle cell diseased patients. Rest-activity rhythm was studied on ten patients (6 males and 4 females) non-invasively with the help of wrist actigraphy, and compared with 10 age-matched normal subjects (6 males and 4 females). Several sleep parameters, such as time in bed, assumed sleep, actual sleep time, actual wake time, sleep efficiency, sleep latency, and fragmentation index were recorded by selecting fifteen second epoch length for collection of data. The results of the present study validated a statistically significant circadian rhythm in rest-activity for all subjects with drastic alteration in circadian rhythm parameters in sickling patients. Dichotomy index declined significantly in the group of sickling patients. Results of sleep parameters revealed that sickling patients had lower assumed sleep duration, and exhibited less sleep efficiency as compared to that of the control subjects. More sleep latency and higher fragmentation index indicates deterioration of sleep among sickling patients. In conclusion, the results of the present study document disruption of circadian rhythm and sleep impairment in sickling patients. Alterations of circadian rhythm and deterioration of sleep could be attributed to diseased status.
International Journal of Research in Ayurveda & Pharmacy, 2016
Plant and plant based products are the basis of many of the modern pharmaceuticals we use today f... more Plant and plant based products are the basis of many of the modern pharmaceuticals we use today for various ailments. Astavarga group have a long history of use in traditional system of indigenous medicine. In present study, the powdered plant material was extracted using different solvents. Phytochemical screening and HPTLC fingerprinting analysis were carried out by using CAMAG LINOMAT 5 instrument. The result revealed that ethanol and chloroform extract of Roscea procera (Kakoli) and, ethyl acetate and chloroform extract of Lilium polyphyllum (Kshirkakoli) showed appreciable amount of secondary metabolites as compared to another solvent system. The HPTLC fingerprinting analysis was carried out for alkaloid, flavonoids and glycoside group of Kakoli extracts and for saponin and steroid groups of Kshirkakoli. The result scientifically validates the use of both plants in traditional medicine and it can be used to treat various disorders. Further studies are going on these plants in order to isolate, identify, characterize and elucidate the structure of the bioactive compounds.
Biological Rhythm Research, 2013
Sickle cell disease (HbSS) is the most common variant of β-globin gene, resulting from the replac... more Sickle cell disease (HbSS) is the most common variant of β-globin gene, resulting from the replacement of glutamic acid by valine at position 6 in the β chain. Under the action of certain factors, such as cold, fever, dehydration, and infections, sickle cell crisis is usually precipitated. The crisis predisposes to aggregation of sickle cells, which may produce vaso-occlusion of
Indian Journal of Sleep Medicine, 2011
Present study was an attempt to evaluate sleep parameters and characteristics of circadian rhythm... more Present study was an attempt to evaluate sleep parameters and characteristics of circadian rhythm in rest-activity in sickle cell diseased patients. Rest-activity rhythm was studied on ten patients (6 males and 4 females) non-invasively with the help of wrist actigraphy, and compared with 10 age-matched normal subjects (6 males and 4 females). Several sleep parameters, such as time in bed, assumed sleep, actual sleep time, actual wake time, sleep efficiency, sleep latency, and fragmentation index were recorded by selecting fifteen second epoch length for collection of data. The results of the present study validated a statistically significant circadian rhythm in rest-activity for all subjects with drastic alteration in circadian rhythm parameters in sickling patients. Dichotomy index declined significantly in the group of sickling patients. Results of sleep parameters revealed that sickling patients had lower assumed sleep duration, and exhibited less sleep efficiency as compared to that of the control subjects. More sleep latency and higher fragmentation index indicates deterioration of sleep among sickling patients. In conclusion, the results of the present study document disruption of circadian rhythm and sleep impairment in sickling patients. Alterations of circadian rhythm and deterioration of sleep could be attributed to diseased status.
International Journal of Research in Ayurveda & Pharmacy, 2016
Plant and plant based products are the basis of many of the modern pharmaceuticals we use today f... more Plant and plant based products are the basis of many of the modern pharmaceuticals we use today for various ailments. Astavarga group have a long history of use in traditional system of indigenous medicine. In present study, the powdered plant material was extracted using different solvents. Phytochemical screening and HPTLC fingerprinting analysis were carried out by using CAMAG LINOMAT 5 instrument. The result revealed that ethanol and chloroform extract of Roscea procera (Kakoli) and, ethyl acetate and chloroform extract of Lilium polyphyllum (Kshirkakoli) showed appreciable amount of secondary metabolites as compared to another solvent system. The HPTLC fingerprinting analysis was carried out for alkaloid, flavonoids and glycoside group of Kakoli extracts and for saponin and steroid groups of Kshirkakoli. The result scientifically validates the use of both plants in traditional medicine and it can be used to treat various disorders. Further studies are going on these plants in order to isolate, identify, characterize and elucidate the structure of the bioactive compounds.
Biological Rhythm Research, 2013
Sickle cell disease (HbSS) is the most common variant of β-globin gene, resulting from the replac... more Sickle cell disease (HbSS) is the most common variant of β-globin gene, resulting from the replacement of glutamic acid by valine at position 6 in the β chain. Under the action of certain factors, such as cold, fever, dehydration, and infections, sickle cell crisis is usually precipitated. The crisis predisposes to aggregation of sickle cells, which may produce vaso-occlusion of