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Papers by Rashmi Sreedhar
Journal of Pharmaceutical Research International, 2021
Introduction: Abdominal malignancy is a serious problem in the western world which is presently r... more Introduction: Abdominal malignancy is a serious problem in the western world which is presently rising in India due to change in lifestyle. The etiopathogenesis are hereditary, environmental and lifestyle factors. The signs and symptoms vary depending upon the type and stage of cancer. Routine investigations, tumor markers, radiology, endoscopy and biopsy examine patients. There have been advances in chemotherapy, radiotherapy, and palliation but still surgery is curative. Methods: This is a prospective observational study including all cases of abdominal malignancy presenting to Surgery OPD. The sample size is 46 patients. Results: Mean age of presentation is 54.63 years. Preoperative abnormal parameters such as CEA, CA 19-9, preoperative biopsy, lymph nodal metastasis on CT and liver metastasis on CT were correlated with outcome which were found to be significant. Operative findings such as site, area, spread outside serosa, lymph nodal metastasis, and liver metastasis were correl...
Journal of Evolution of medical and Dental Sciences, 2020
Tumour markers Carcino-Embryonic Antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) are used in... more Tumour markers Carcino-Embryonic Antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) are used in the diagnosis of colorectal cancer. CEA levels are mainly used for the measurement of tumour response to therapy and for detecting recurrence of tumour. To study the use of CEA and CA 19-9 as tumour markers. A total 32 studies has been included in this review till June 2020. A collective review of these studies regarding the use of CEA and CA 19-9, their statistical significance along with their limitations have been discussed and its conclusion is noted in this review article. CEA and CA19-9 are useful in preoperative, postoperative, prognosis and follow up of the patients of colorectal cancer. The two tumour markers mentioned above can be used preoperatively, postoperatively, after chemotherapy / radiotherapy and for prognostic significance in colorectal cancer. It can also be useful in many other adenocarcinomas like gastric adenocarcinoma, pancreatic adenocarcinoma, lung adenocarcinoma and ovarian adenocarcinoma.
Journal of Pharmaceutical Research International, 2021
Introduction: Abdominal malignancy is a serious problem in the western world which is presently r... more Introduction: Abdominal malignancy is a serious problem in the western world which is presently rising in India due to change in lifestyle. The etiopathogenesis are hereditary, environmental and lifestyle factors. The signs and symptoms vary depending upon the type and stage of cancer. Routine investigations, tumor markers, radiology, endoscopy and biopsy examine patients. There have been advances in chemotherapy, radiotherapy, and palliation but still surgery is curative. Methods: This is a prospective observational study including all cases of abdominal malignancy presenting to Surgery OPD. The sample size is 46 patients. Results: Mean age of presentation is 54.63 years. Preoperative abnormal parameters such as CEA, CA 19-9, preoperative biopsy, lymph nodal metastasis on CT and liver metastasis on CT were correlated with outcome which were found to be significant. Operative findings such as site, area, spread outside serosa, lymph nodal metastasis, and liver metastasis were correl...
Journal of Evolution of medical and Dental Sciences, 2020
Tumour markers Carcino-Embryonic Antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) are used in... more Tumour markers Carcino-Embryonic Antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) are used in the diagnosis of colorectal cancer. CEA levels are mainly used for the measurement of tumour response to therapy and for detecting recurrence of tumour. To study the use of CEA and CA 19-9 as tumour markers. A total 32 studies has been included in this review till June 2020. A collective review of these studies regarding the use of CEA and CA 19-9, their statistical significance along with their limitations have been discussed and its conclusion is noted in this review article. CEA and CA19-9 are useful in preoperative, postoperative, prognosis and follow up of the patients of colorectal cancer. The two tumour markers mentioned above can be used preoperatively, postoperatively, after chemotherapy / radiotherapy and for prognostic significance in colorectal cancer. It can also be useful in many other adenocarcinomas like gastric adenocarcinoma, pancreatic adenocarcinoma, lung adenocarcinoma and ovarian adenocarcinoma.