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Research paper thumbnail of Development and Elemental Analysis of a Novel Strontium-Doped Nano-Hydroxyapatite Paste and Evaluation of Its Remineralization Potential: An In Vitro Study

Research paper thumbnail of Comparative evaluation of remineralizing potential of three agents on artificially demineralized human enamel: An in vitro study

Journal of Conservative Dentistry, 2013

Remineralization as a treatment procedure has received much attention from clinicians. The object... more Remineralization as a treatment procedure has received much attention from clinicians. The objective of this in vitro study was to find out the efficacy of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP), casein phosphopeptide-amorphous calcium phosphate fluoride (CPP-ACPF), and tricalcium phosphate fluoride (TCP-F) in remineralizing enamel surface on which artificial caries lesion had been created. The changes were analyzed using DIAGNOdent(®) (KaVo) and scanning electron microscope (SEM). A total of 52 premolars and 24 molars were selected and classified into four groups of 13 premolars and 6 molars in each: I (CPP-ACP), II (CPP-ACPF), III (TCP-F), and IV (artificial saliva). All the samples were assessed using DIAGNOdent at the baseline and after demineralization and remineralization. Ten samples were randomly selected from each group baseline after demineralization and after remineralization for surface evaluation using SEM. Statistical analysis showed that all the experimental groups had a significantly higher amount of remineralization except for group IV. All the three experimental groups showed a statistically significant amount of remineralization. However, because of the added benefit of fluoride (NaF 0.2%), CPP-ACPF (Tooth Mousse-Plus(®)) and TCP-F showed marginally more amount of remineralization than did CPP-ACP (Tooth Mousse(®)). Remineralization efficacy was TCP-F > CPP-ACPF > CPP-ACP.

Research paper thumbnail of Effect of remineralization agents on white spot lesions: A systematic review

Journal of Pharmacy and Bioallied Sciences, 2022

Research paper thumbnail of Evaluation of remineralization potential and cytotoxicity of a novel strontium-doped nanohydroxyapatite paste: An in vitro study

Journal of Conservative Dentistry, 2020

Background:The focus of caries management has shifted to the early detection of caries and noninv... more Background:The focus of caries management has shifted to the early detection of caries and noninvasive methods of management of incipient lesions with novel remineralizing agents.Aim:The aim of this study is to evaluate and compare the remineralization potential of a novel laboratory synthesized strontium-doped nanohydroxyapatite (SrnHAp) paste to a commercially available regular dentifrice.Materials and Methods:Sixty enamel specimens (4 mm × 4 mm × 1 mm) were divided into two groups based on the type of dentifrice applied: Group I – regular toothpaste and Group II – SrnHAp paste. Calcium/phosphorous ratio of all sound specimens was evaluated using Scanning Electron Microscopy-Energy Dispersive X-ray analysis. Samples in both groups were subjected to demineralization, and the calcium/phosphorous ratio was analyzed. The samples were then subjected to remineralization using the specific agents in each group, and the mean calcium–phosphorus ratio was assessed. Cytotoxic evaluation of both pastes was done by direct microscopic observation and MTT assay.Statistical Analysis:Comparison of mean calcium and phosphorous values of sound enamel, demineralized, and remineralized specimen in Groups I and II was done using the one-way ANOVA and Tukeys post hoc test. Intergroup comparison after remineralization was done using the Student's t-test.Results and Conclusion:Group II showed higher remineralization potential than Group I and was statistically significant. Cytotoxicity of novel paste was less compared to the regular toothpaste. SrnHAp showed better remineralization than regular toothpaste and can be considered for enamel repair in incipient carious lesions.

Research paper thumbnail of Comparative evaluation of remineralisation potential of bioactive glass, casein phosphopeptide-amorphous calcium phosphate and novel strontium-doped nanohydroxyapatite paste: An In-Vitro study

Indian Journal of Dental Research, 2022

Research paper thumbnail of Comparative Evaluation of Remineralizing Potential of a Paste Containing Bioactive Glass and a Topical Cream Containing Casein Phosphopeptide-Amorphous Calcium Phosphate: An in Vitro Study

Brazilian Research in Pediatric Dentistry and Integrated Clinic, 2019

Objective: To evaluate and compare the remineralization potential of a dentifrice containing bioa... more Objective: To evaluate and compare the remineralization potential of a dentifrice containing bioactive glass and a topical cream containing casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) in remineralizing artificial carious lesion on enamel. Material and Methods: Forty-five freshly extracted human permanent premolar teeth were selected. Samples were divided into three groups: GI-regular tooth paste without specific remineralizing agent; GII-tooth paste containing calcium sodium-phosphosilicate (novamin) and GIII-topical cream containing casein phosphopeptide-amorphous calcium phosphate. All the sound enamel samples were viewed under scanning electron microscope (SEM) to assess the topographical pictures of enamel surface and energy dispersing x-ray analysis (EDAX) was done to estimate quantitatively the amounts of mineral (calcium and phosphorous). The mineral content of calcium and phosphorus after demineralization in each group was noted. The samples were then subjected to SEM and EDAX. Results: GI does not show any increase in the calcium and phosphorus after applying toothpaste without any remineralizing agent but GII and GIII showed a net increase in calcium and phosphorous values after applying concern-remineralizing agents. Inter group comparison showed GIII yield higher net calcium and phosphorous values than GII. Conclusion: Two remineralizing agents showed remineralization potential on enamel surfaces. Casein phosphopeptide-amorphous calcium phosphate showed better remineralizing potential than calcium sodium phosphosilicate. Hence CPP-ACP can be considered as the material of choice in remineralizing early enamel carious lesions.

Research paper thumbnail of Single-visit Apexification using Biodentin

Conservative dentistry & endodontic journal, 2017

Trauma to the tooth mainly results in pulpal injury, and these injuries during formative stage ca... more Trauma to the tooth mainly results in pulpal injury, and these injuries during formative stage can result in incomplete root formation. This can result in failure in closure of root apex, resulting in wide open apex. This causes problem for the conventional root canal therapy as there is no apical stop against which the obturation material can be condensed. The management of a nonvital tooth with open apex is aimed at creation of an apical barrier. The newly introduced bioactive dentin substitute commercially available as biodentin is a promising material. It is a cement for stimulating hard tissue formation, i.e., the formation of reactive or reparative (tertiary) dentin. This case report describes the management of a traumatized permanent maxillary central incisor with an open apex.

Research paper thumbnail of Development of strontium-doped nano hydroxyapatite dentifrice and compare its remineralising potential with a topical cream containing casein phosphopeptide- amorphous calcium phosphate – An In Vitro study

Indian Journal of Dental Research, 2021

Aim: To develop and evaluate the efficacy of synthesised strontium-doped nano hydroxyapatite dent... more Aim: To develop and evaluate the efficacy of synthesised strontium-doped nano hydroxyapatite dentifrice and compare its remineralizing potential with a topical cream containing Casein Phospho Peptide – Amorphous Calcium Phosphate, in remineralizing artificial carious lesion on enamel. Materials and Methods: Enamel specimens of 4 x 4 x 1 mm were prepared from 90 freshly extracted teeth. Specimens were divided into 3 groups of 30 samples each, based on the type of dentifrice applied that is a control group (Group I) and two experimental groups (Groups II, III). Surface topography and the calcium/phosphorous ratio of all sound specimen were evaluated using Scanning electron microscope and Energy Dispersive X-ray Analysis (SEM-EDAX). The samples in group I and each of the experimental groups were subjected to demineralisation and the calcium/phosphorous ratio of the demineralized specimen were analysed. The samples were then subjected to remineralisation using different agents in each group. Samples in the control group (Group I) were brushed with a conventional dentifrice. In the experimental groups, Group II topical cream with Casein Phosphopeptide and Amorphous Calcium phosphate (CPP-ACP) was used and in Group III laboratory synthesized Strontium-doped nanohydroxyapatite paste (Sr-nHAP), respectively for 28 consecutive days. The samples in the both the control and the two experimental groups were again subjected to SEM-EDAX analysis to analyse the calcium phosphorus ratio following remineralisation cycle. Groupwise comparison of the data was done with one way ANOVA followed by Tukeys Post hoc Test. Results: Both experimental groups (II, III) showed statistically significant remineralisation potential after demineralisation, compared to the control group I. Intergroup comparison showed that the samples in Group III showed the higher remineralisation potential than Group II and was statistically significant. Conclusion: Both CPP- ACP containing tooth cream as well as Sr doped nHAp showed remineralisation potential. Sr doped nanohydroxyapatite showed better remineralisation than CPP ACP and can be considered for enamel repair in incipient carious lesions.

Research paper thumbnail of Development of strontium-doped nano hydroxyapatite dentifrice and compare its remineralising potential with a topical cream containing casein phosphopeptide- amorphous calcium phosphate – An In Vitro study

Indian Journal of Dental Research

Aim: To develop and evaluate the efficacy of synthesised strontium-doped nano hydroxyapatite dent... more Aim: To develop and evaluate the efficacy of synthesised strontium-doped nano hydroxyapatite dentifrice and compare its remineralizing potential with a topical cream containing Casein Phospho Peptide – Amorphous Calcium Phosphate, in remineralizing artificial carious lesion on enamel. Materials and Methods: Enamel specimens of 4 x 4 x 1 mm were prepared from 90 freshly extracted teeth. Specimens were divided into 3 groups of 30 samples each, based on the type of dentifrice applied that is a control group (Group I) and two experimental groups (Groups II, III). Surface topography and the calcium/phosphorous ratio of all sound specimen were evaluated using Scanning electron microscope and Energy Dispersive X-ray Analysis (SEM-EDAX). The samples in group I and each of the experimental groups were subjected to demineralisation and the calcium/phosphorous ratio of the demineralized specimen were analysed. The samples were then subjected to remineralisation using different agents in each group. Samples in the control group (Group I) were brushed with a conventional dentifrice. In the experimental groups, Group II topical cream with Casein Phosphopeptide and Amorphous Calcium phosphate (CPP-ACP) was used and in Group III laboratory synthesized Strontium-doped nanohydroxyapatite paste (Sr-nHAP), respectively for 28 consecutive days. The samples in the both the control and the two experimental groups were again subjected to SEM-EDAX analysis to analyse the calcium phosphorus ratio following remineralisation cycle. Groupwise comparison of the data was done with one way ANOVA followed by Tukeys Post hoc Test. Results: Both experimental groups (II, III) showed statistically significant remineralisation potential after demineralisation, compared to the control group I. Intergroup comparison showed that the samples in Group III showed the higher remineralisation potential than Group II and was statistically significant. Conclusion: Both CPP- ACP containing tooth cream as well as Sr doped nHAp showed remineralisation potential. Sr doped nanohydroxyapatite showed better remineralisation than CPP ACP and can be considered for enamel repair in incipient carious lesions.

Research paper thumbnail of Comparative evaluation of remineralisation potential of bioactive glass, casein phosphopeptide-amorphous calcium phosphate and novel strontium-doped nanohydroxyapatite paste: An In-Vitro study

Indian Journal of Dental Research

Research paper thumbnail of Effect of remineralization agents on white spot lesions: A systematic review

Journal of Pharmacy And Bioallied Sciences

Research paper thumbnail of Evaluation of remineralization potential and cytotoxicity of a novel strontium-doped nanohydroxyapatite paste: An in vitro study

Journal of Conservative Dentistry, 2020

Background: The focus of caries management has shifted to the early detection of caries and nonin... more Background: The focus of caries management has shifted to the early detection of caries and noninvasive methods of management of incipient lesions with novel remineralizing agents. Aim: The aim of this study is to evaluate and compare the remineralization potential of a novel laboratory synthesized strontium-doped nanohydroxyapatite (SrnHAp) paste to a commercially available regular dentifrice. Materials and Methods: Sixty enamel specimens (4 mm × 4 mm × 1 mm) were divided into two groups based on the type of dentifrice applied: Group I – regular toothpaste and Group II – SrnHAp paste. Calcium/phosphorous ratio of all sound specimens was evaluated using Scanning Electron Microscopy-Energy Dispersive X-ray analysis. Samples in both groups were subjected to demineralization, and the calcium/phosphorous ratio was analyzed. The samples were then subjected to remineralization using the specific agents in each group, and the mean calcium–phosphorus ratio was assessed. Cytotoxic evaluation of both pastes was done by direct microscopic observation and MTT assay. Statistical Analysis: Comparison of mean calcium and phosphorous values of sound enamel, demineralized, and remineralized specimen in Groups I and II was done using the one-way ANOVA and Tukeys post hoc test. Intergroup comparison after remineralization was done using the Student's t-test. Results and Conclusion: Group II showed higher remineralization potential than Group I and was statistically significant. Cytotoxicity of novel paste was less compared to the regular toothpaste. SrnHAp showed better remineralization than regular toothpaste and can be considered for enamel repair in incipient carious lesions.

Research paper thumbnail of Single-visit Apexification using Biodentin

Conservative Dentistry and Endodontic Journal, 2017

Trauma to the tooth mainly results in pulpal injury, and these injuries during formative stage ca... more Trauma to the tooth mainly results in pulpal injury, and these injuries during formative stage can result in incomplete root formation. This can result in failure in closure of root apex, resulting in wide open apex. This causes problem for the conventional root canal therapy as there is no apical stop against which the obturation material can be condensed. The management of a nonvital tooth with open apex is aimed at creation of an apical barrier. The newly introduced bioactive dentin substitute commercially available as biodentin is a promising material. It is a cement for stimulating hard tissue formation, i.e., the formation of reactive or reparative (tertiary) dentin. This case report describes the management of a traumatized permanent maxillary central incisor with an open apex. How to cite this article Nazar F, Nair KR, Praveena G, Anilkumar A, Rajendran R. Single-visit Apexification using Biodentin. Cons Dent Endod J 2017;2(1):40-42.

Research paper thumbnail of Management of Discolored Tooth with separated Instrument

Conservative Dentistry and Endodontic Journal, 2017

Tooth discoloration commonly occurs after trauma to tooth, which leads to pulpal injury. Trauma t... more Tooth discoloration commonly occurs after trauma to tooth, which leads to pulpal injury. Trauma to the pulpal blood vessel leads to hemorrhage and releases iron from hemoglobin. The iron which is released from hemoglobin combines with hydrogen sulfide to form iron sulfide, which gives the tooth its characteristic dark appearance. Tooth discoloration can be treated by nonvital tooth bleaching, if the tooth structure is intact. A combination of hydrogen peroxide and sodium perborate reduces the discoloration of the tooth by a process of oxidation. During root canal preparation procedures, the common mishap that occurs is instrument separation inside the root canal. The fractured fragment in the root canal can hinder proper preparation of root canal space. Continuous pain or discomfort may result if it is not removed or bypassed. It is more conservative to bypass the fractured instrument, particularly in cases where access to the fragment is restricted (apical one-third of canal or bey...

Research paper thumbnail of Management of an Anterior Tooth with External and Internal Resorption

Conservative Dentistry and Endodontic Journal, 2017

Tooth resorption is a condition associated with either a physiologic or a pathologic process resu... more Tooth resorption is a condition associated with either a physiologic or a pathologic process resulting in a loss of dentin, cementum, and/or bone. Inflammatory process is initiated when the predentin or precemental layer of the tooth is damaged. Resorption can either be external or internal in form. In order to control the tooth resorption, it is necessary to treat the root canal by removing all the pulp tissue. Due to varied root canal morphology, root canal treatment poses a challenge for the clinician. In such cases a combination of conventional lateral compaction and thermoplasticized gutta percha can enable the three-dimensional obturation of the canal space. This case report describes a nonsurgical mode of management of a tooth having internal and external (surface) resorption. How to cite this article Anilkumar A, Nair KR, Nazar F, Rajendran R. Management of an Anterior Tooth with External and Internal Resorption. Cons Dent Endod J 2017;2(1):32-35.

Research paper thumbnail of A Systematic Review on the Effect of Strontium-Doped Nanohydroxyapatite in Remineralizing Early Caries Lesion

Research paper thumbnail of Development and Elemental Analysis of a Novel Strontium-Doped Nano-Hydroxyapatite Paste and Evaluation of Its Remineralization Potential: An In Vitro Study

Research paper thumbnail of Comparative evaluation of remineralizing potential of three agents on artificially demineralized human enamel: An in vitro study

Journal of Conservative Dentistry, 2013

Remineralization as a treatment procedure has received much attention from clinicians. The object... more Remineralization as a treatment procedure has received much attention from clinicians. The objective of this in vitro study was to find out the efficacy of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP), casein phosphopeptide-amorphous calcium phosphate fluoride (CPP-ACPF), and tricalcium phosphate fluoride (TCP-F) in remineralizing enamel surface on which artificial caries lesion had been created. The changes were analyzed using DIAGNOdent(®) (KaVo) and scanning electron microscope (SEM). A total of 52 premolars and 24 molars were selected and classified into four groups of 13 premolars and 6 molars in each: I (CPP-ACP), II (CPP-ACPF), III (TCP-F), and IV (artificial saliva). All the samples were assessed using DIAGNOdent at the baseline and after demineralization and remineralization. Ten samples were randomly selected from each group baseline after demineralization and after remineralization for surface evaluation using SEM. Statistical analysis showed that all the experimental groups had a significantly higher amount of remineralization except for group IV. All the three experimental groups showed a statistically significant amount of remineralization. However, because of the added benefit of fluoride (NaF 0.2%), CPP-ACPF (Tooth Mousse-Plus(®)) and TCP-F showed marginally more amount of remineralization than did CPP-ACP (Tooth Mousse(®)). Remineralization efficacy was TCP-F > CPP-ACPF > CPP-ACP.

Research paper thumbnail of Effect of remineralization agents on white spot lesions: A systematic review

Journal of Pharmacy and Bioallied Sciences, 2022

Research paper thumbnail of Evaluation of remineralization potential and cytotoxicity of a novel strontium-doped nanohydroxyapatite paste: An in vitro study

Journal of Conservative Dentistry, 2020

Background:The focus of caries management has shifted to the early detection of caries and noninv... more Background:The focus of caries management has shifted to the early detection of caries and noninvasive methods of management of incipient lesions with novel remineralizing agents.Aim:The aim of this study is to evaluate and compare the remineralization potential of a novel laboratory synthesized strontium-doped nanohydroxyapatite (SrnHAp) paste to a commercially available regular dentifrice.Materials and Methods:Sixty enamel specimens (4 mm × 4 mm × 1 mm) were divided into two groups based on the type of dentifrice applied: Group I – regular toothpaste and Group II – SrnHAp paste. Calcium/phosphorous ratio of all sound specimens was evaluated using Scanning Electron Microscopy-Energy Dispersive X-ray analysis. Samples in both groups were subjected to demineralization, and the calcium/phosphorous ratio was analyzed. The samples were then subjected to remineralization using the specific agents in each group, and the mean calcium–phosphorus ratio was assessed. Cytotoxic evaluation of both pastes was done by direct microscopic observation and MTT assay.Statistical Analysis:Comparison of mean calcium and phosphorous values of sound enamel, demineralized, and remineralized specimen in Groups I and II was done using the one-way ANOVA and Tukeys post hoc test. Intergroup comparison after remineralization was done using the Student's t-test.Results and Conclusion:Group II showed higher remineralization potential than Group I and was statistically significant. Cytotoxicity of novel paste was less compared to the regular toothpaste. SrnHAp showed better remineralization than regular toothpaste and can be considered for enamel repair in incipient carious lesions.

Research paper thumbnail of Comparative evaluation of remineralisation potential of bioactive glass, casein phosphopeptide-amorphous calcium phosphate and novel strontium-doped nanohydroxyapatite paste: An In-Vitro study

Indian Journal of Dental Research, 2022

Research paper thumbnail of Comparative Evaluation of Remineralizing Potential of a Paste Containing Bioactive Glass and a Topical Cream Containing Casein Phosphopeptide-Amorphous Calcium Phosphate: An in Vitro Study

Brazilian Research in Pediatric Dentistry and Integrated Clinic, 2019

Objective: To evaluate and compare the remineralization potential of a dentifrice containing bioa... more Objective: To evaluate and compare the remineralization potential of a dentifrice containing bioactive glass and a topical cream containing casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) in remineralizing artificial carious lesion on enamel. Material and Methods: Forty-five freshly extracted human permanent premolar teeth were selected. Samples were divided into three groups: GI-regular tooth paste without specific remineralizing agent; GII-tooth paste containing calcium sodium-phosphosilicate (novamin) and GIII-topical cream containing casein phosphopeptide-amorphous calcium phosphate. All the sound enamel samples were viewed under scanning electron microscope (SEM) to assess the topographical pictures of enamel surface and energy dispersing x-ray analysis (EDAX) was done to estimate quantitatively the amounts of mineral (calcium and phosphorous). The mineral content of calcium and phosphorus after demineralization in each group was noted. The samples were then subjected to SEM and EDAX. Results: GI does not show any increase in the calcium and phosphorus after applying toothpaste without any remineralizing agent but GII and GIII showed a net increase in calcium and phosphorous values after applying concern-remineralizing agents. Inter group comparison showed GIII yield higher net calcium and phosphorous values than GII. Conclusion: Two remineralizing agents showed remineralization potential on enamel surfaces. Casein phosphopeptide-amorphous calcium phosphate showed better remineralizing potential than calcium sodium phosphosilicate. Hence CPP-ACP can be considered as the material of choice in remineralizing early enamel carious lesions.

Research paper thumbnail of Single-visit Apexification using Biodentin

Conservative dentistry & endodontic journal, 2017

Trauma to the tooth mainly results in pulpal injury, and these injuries during formative stage ca... more Trauma to the tooth mainly results in pulpal injury, and these injuries during formative stage can result in incomplete root formation. This can result in failure in closure of root apex, resulting in wide open apex. This causes problem for the conventional root canal therapy as there is no apical stop against which the obturation material can be condensed. The management of a nonvital tooth with open apex is aimed at creation of an apical barrier. The newly introduced bioactive dentin substitute commercially available as biodentin is a promising material. It is a cement for stimulating hard tissue formation, i.e., the formation of reactive or reparative (tertiary) dentin. This case report describes the management of a traumatized permanent maxillary central incisor with an open apex.

Research paper thumbnail of Development of strontium-doped nano hydroxyapatite dentifrice and compare its remineralising potential with a topical cream containing casein phosphopeptide- amorphous calcium phosphate – An In Vitro study

Indian Journal of Dental Research, 2021

Aim: To develop and evaluate the efficacy of synthesised strontium-doped nano hydroxyapatite dent... more Aim: To develop and evaluate the efficacy of synthesised strontium-doped nano hydroxyapatite dentifrice and compare its remineralizing potential with a topical cream containing Casein Phospho Peptide – Amorphous Calcium Phosphate, in remineralizing artificial carious lesion on enamel. Materials and Methods: Enamel specimens of 4 x 4 x 1 mm were prepared from 90 freshly extracted teeth. Specimens were divided into 3 groups of 30 samples each, based on the type of dentifrice applied that is a control group (Group I) and two experimental groups (Groups II, III). Surface topography and the calcium/phosphorous ratio of all sound specimen were evaluated using Scanning electron microscope and Energy Dispersive X-ray Analysis (SEM-EDAX). The samples in group I and each of the experimental groups were subjected to demineralisation and the calcium/phosphorous ratio of the demineralized specimen were analysed. The samples were then subjected to remineralisation using different agents in each group. Samples in the control group (Group I) were brushed with a conventional dentifrice. In the experimental groups, Group II topical cream with Casein Phosphopeptide and Amorphous Calcium phosphate (CPP-ACP) was used and in Group III laboratory synthesized Strontium-doped nanohydroxyapatite paste (Sr-nHAP), respectively for 28 consecutive days. The samples in the both the control and the two experimental groups were again subjected to SEM-EDAX analysis to analyse the calcium phosphorus ratio following remineralisation cycle. Groupwise comparison of the data was done with one way ANOVA followed by Tukeys Post hoc Test. Results: Both experimental groups (II, III) showed statistically significant remineralisation potential after demineralisation, compared to the control group I. Intergroup comparison showed that the samples in Group III showed the higher remineralisation potential than Group II and was statistically significant. Conclusion: Both CPP- ACP containing tooth cream as well as Sr doped nHAp showed remineralisation potential. Sr doped nanohydroxyapatite showed better remineralisation than CPP ACP and can be considered for enamel repair in incipient carious lesions.

Research paper thumbnail of Development of strontium-doped nano hydroxyapatite dentifrice and compare its remineralising potential with a topical cream containing casein phosphopeptide- amorphous calcium phosphate – An In Vitro study

Indian Journal of Dental Research

Aim: To develop and evaluate the efficacy of synthesised strontium-doped nano hydroxyapatite dent... more Aim: To develop and evaluate the efficacy of synthesised strontium-doped nano hydroxyapatite dentifrice and compare its remineralizing potential with a topical cream containing Casein Phospho Peptide – Amorphous Calcium Phosphate, in remineralizing artificial carious lesion on enamel. Materials and Methods: Enamel specimens of 4 x 4 x 1 mm were prepared from 90 freshly extracted teeth. Specimens were divided into 3 groups of 30 samples each, based on the type of dentifrice applied that is a control group (Group I) and two experimental groups (Groups II, III). Surface topography and the calcium/phosphorous ratio of all sound specimen were evaluated using Scanning electron microscope and Energy Dispersive X-ray Analysis (SEM-EDAX). The samples in group I and each of the experimental groups were subjected to demineralisation and the calcium/phosphorous ratio of the demineralized specimen were analysed. The samples were then subjected to remineralisation using different agents in each group. Samples in the control group (Group I) were brushed with a conventional dentifrice. In the experimental groups, Group II topical cream with Casein Phosphopeptide and Amorphous Calcium phosphate (CPP-ACP) was used and in Group III laboratory synthesized Strontium-doped nanohydroxyapatite paste (Sr-nHAP), respectively for 28 consecutive days. The samples in the both the control and the two experimental groups were again subjected to SEM-EDAX analysis to analyse the calcium phosphorus ratio following remineralisation cycle. Groupwise comparison of the data was done with one way ANOVA followed by Tukeys Post hoc Test. Results: Both experimental groups (II, III) showed statistically significant remineralisation potential after demineralisation, compared to the control group I. Intergroup comparison showed that the samples in Group III showed the higher remineralisation potential than Group II and was statistically significant. Conclusion: Both CPP- ACP containing tooth cream as well as Sr doped nHAp showed remineralisation potential. Sr doped nanohydroxyapatite showed better remineralisation than CPP ACP and can be considered for enamel repair in incipient carious lesions.

Research paper thumbnail of Comparative evaluation of remineralisation potential of bioactive glass, casein phosphopeptide-amorphous calcium phosphate and novel strontium-doped nanohydroxyapatite paste: An In-Vitro study

Indian Journal of Dental Research

Research paper thumbnail of Effect of remineralization agents on white spot lesions: A systematic review

Journal of Pharmacy And Bioallied Sciences

Research paper thumbnail of Evaluation of remineralization potential and cytotoxicity of a novel strontium-doped nanohydroxyapatite paste: An in vitro study

Journal of Conservative Dentistry, 2020

Background: The focus of caries management has shifted to the early detection of caries and nonin... more Background: The focus of caries management has shifted to the early detection of caries and noninvasive methods of management of incipient lesions with novel remineralizing agents. Aim: The aim of this study is to evaluate and compare the remineralization potential of a novel laboratory synthesized strontium-doped nanohydroxyapatite (SrnHAp) paste to a commercially available regular dentifrice. Materials and Methods: Sixty enamel specimens (4 mm × 4 mm × 1 mm) were divided into two groups based on the type of dentifrice applied: Group I – regular toothpaste and Group II – SrnHAp paste. Calcium/phosphorous ratio of all sound specimens was evaluated using Scanning Electron Microscopy-Energy Dispersive X-ray analysis. Samples in both groups were subjected to demineralization, and the calcium/phosphorous ratio was analyzed. The samples were then subjected to remineralization using the specific agents in each group, and the mean calcium–phosphorus ratio was assessed. Cytotoxic evaluation of both pastes was done by direct microscopic observation and MTT assay. Statistical Analysis: Comparison of mean calcium and phosphorous values of sound enamel, demineralized, and remineralized specimen in Groups I and II was done using the one-way ANOVA and Tukeys post hoc test. Intergroup comparison after remineralization was done using the Student's t-test. Results and Conclusion: Group II showed higher remineralization potential than Group I and was statistically significant. Cytotoxicity of novel paste was less compared to the regular toothpaste. SrnHAp showed better remineralization than regular toothpaste and can be considered for enamel repair in incipient carious lesions.

Research paper thumbnail of Single-visit Apexification using Biodentin

Conservative Dentistry and Endodontic Journal, 2017

Trauma to the tooth mainly results in pulpal injury, and these injuries during formative stage ca... more Trauma to the tooth mainly results in pulpal injury, and these injuries during formative stage can result in incomplete root formation. This can result in failure in closure of root apex, resulting in wide open apex. This causes problem for the conventional root canal therapy as there is no apical stop against which the obturation material can be condensed. The management of a nonvital tooth with open apex is aimed at creation of an apical barrier. The newly introduced bioactive dentin substitute commercially available as biodentin is a promising material. It is a cement for stimulating hard tissue formation, i.e., the formation of reactive or reparative (tertiary) dentin. This case report describes the management of a traumatized permanent maxillary central incisor with an open apex. How to cite this article Nazar F, Nair KR, Praveena G, Anilkumar A, Rajendran R. Single-visit Apexification using Biodentin. Cons Dent Endod J 2017;2(1):40-42.

Research paper thumbnail of Management of Discolored Tooth with separated Instrument

Conservative Dentistry and Endodontic Journal, 2017

Tooth discoloration commonly occurs after trauma to tooth, which leads to pulpal injury. Trauma t... more Tooth discoloration commonly occurs after trauma to tooth, which leads to pulpal injury. Trauma to the pulpal blood vessel leads to hemorrhage and releases iron from hemoglobin. The iron which is released from hemoglobin combines with hydrogen sulfide to form iron sulfide, which gives the tooth its characteristic dark appearance. Tooth discoloration can be treated by nonvital tooth bleaching, if the tooth structure is intact. A combination of hydrogen peroxide and sodium perborate reduces the discoloration of the tooth by a process of oxidation. During root canal preparation procedures, the common mishap that occurs is instrument separation inside the root canal. The fractured fragment in the root canal can hinder proper preparation of root canal space. Continuous pain or discomfort may result if it is not removed or bypassed. It is more conservative to bypass the fractured instrument, particularly in cases where access to the fragment is restricted (apical one-third of canal or bey...

Research paper thumbnail of Management of an Anterior Tooth with External and Internal Resorption

Conservative Dentistry and Endodontic Journal, 2017

Tooth resorption is a condition associated with either a physiologic or a pathologic process resu... more Tooth resorption is a condition associated with either a physiologic or a pathologic process resulting in a loss of dentin, cementum, and/or bone. Inflammatory process is initiated when the predentin or precemental layer of the tooth is damaged. Resorption can either be external or internal in form. In order to control the tooth resorption, it is necessary to treat the root canal by removing all the pulp tissue. Due to varied root canal morphology, root canal treatment poses a challenge for the clinician. In such cases a combination of conventional lateral compaction and thermoplasticized gutta percha can enable the three-dimensional obturation of the canal space. This case report describes a nonsurgical mode of management of a tooth having internal and external (surface) resorption. How to cite this article Anilkumar A, Nair KR, Nazar F, Rajendran R. Management of an Anterior Tooth with External and Internal Resorption. Cons Dent Endod J 2017;2(1):32-35.

Research paper thumbnail of A Systematic Review on the Effect of Strontium-Doped Nanohydroxyapatite in Remineralizing Early Caries Lesion