Ratul Dey - Academia.edu (original) (raw)

Uploads

Papers by Ratul Dey

Cureus

The study aims to determine the role of intratympanic dexamethasone (ITD) on the hearing profile ... more The study aims to determine the role of intratympanic dexamethasone (ITD) on the hearing profile of patients with head and neck cancer post-chemoradiotherapy. Study design This study employs a prospective case-control design. Subjects and methods In total 834 patients were evaluated for eligibility. Seven hundred and eleven were excluded because they didn't meet the inclusion criteria. A hundred cases out of 123 were diagnosed with head and neck cancer for which the treatment protocol included cisplatin concurrent to radiotherapy recruited. Before each cisplatin treatment session, ITD was injected into one ear (experimental ear) while the other ear of the same patient served as the control. Pure-tone audiometry (PTA) and distortion product otoacoustic emissions (DPOAE) test results of the baseline and follow-up examinations in the sixth and 12th weeks were compared within and between the study and control ears. Results For pure tone thresholds, significant hearing threshold change was noticed at 8 kHz in the experimental group at six weeks and at ≥ 6 kHz in the control group. At 12 weeks, high frequencies were significantly affected at ≥ 4 kHz in the control group. When the baseline was compared across the groups in the 12th week, for otoacoustic emissions, high frequencies showed a loss in the control group more compared to the experimental side (Wilcoxon signed-rank test). Conclusion ITD functions less effectively at higher frequencies because the basal turn of the cochlea is more susceptible to cisplatin ototoxicity. ITD might have potential in the reduction of cisplatin-induced hearing loss.

National Journal of Physiology, Pharmacy and Pharmacology, 2020

Background: Epilepsy being a neurological disorder is characterized by excessive abnormal dischar... more Background: Epilepsy being a neurological disorder is characterized by excessive abnormal discharge in neurons of brain. Such abnormal activity rapidly engages many cortical and subcortical structures. As a result, this could influence auditory information processing of neuronal pathways in brainstem. Aims and Objectives: The objectives of the study were (1) To assess the cochlear responses transient evoked otoacoustic emissions (TEOAEs) in newly diagnosed drug-naive patients of epilepsy and (2) To assess the brainstem auditory evoked responses (ABR) in newly diagnosed drug-naive patients of epilepsy. Materials and Methods: The study was done in the department of audiology in a tertiary care institute. Three audiological tests, i.e., pure tone audiometry (PTA), auditory brainstem evoked responses (ABR), and TEOAEs were recorded on 30 patients in the age group of 1545 years diagnosed with epilepsy and 30 age- and gender-matched controls. Results: All the participants chosen for the study were having normal hearing thresholds bilaterally as confirmed by PTA (air conduction thresholds below 25 dB HL across the audiometric frequencies of 250 Hz8000 Hz). The absolute latency values of ABR were prolonged in patients of epilepsy (P < 0.05). The difference in interpeak latencies was found to be statistically non-significant. The amplitude values for waves III and V of ABR were reduced in epileptics (P < 0.05). The TEOAEs recorded in these patients of epilepsy showed no significant change in amplitude, noise floor, and signal-to-noise ratio. Conclusion: The findings of this study suggest that the epileptic patients have delayed absolute peak latencies and decreased amplitudes of waves III and V, indicating the possible involvement of lower brainstem due to seizure activity. However, this study also suggests that epileptic seizure is less likely to result in any alteration at the level of outer hair cells.

Clinical Epidemiology and Global Health, 2017

International Journal Of Community Health And Medical Research

Journal of the Association for Research in Otolaryngology, 2015

The auditory brainstem response (ABR) is a useful electrophysiological technique for assessing he... more The auditory brainstem response (ABR) is a useful electrophysiological technique for assessing hearing sensitivity in patients whose age or handicaps rule out the use of conventional behavioral audiometric techniques. Tone burst ABR has great role to play as it offers frequency specific responses over that of click evoked ABR. To use tone-burst ABRs for site of lesion testing, it is necessary to have separate normative of absolute latency, inter-wave intervals, and amplitude ratio. The above study was taken up to find out the normative values of various parameters of tone burst ABR. Hundred adults with normal hearing were tested using tone burst stimuli to find out values of various parameters. It was found that all the parameters absolute latency, inter-wave latency differences, amplitude ratio differed in terms of their mean values from those with click evoked ABR. Findings of the present study will be useful as a normative and any deviation from these can be considered as being d...