Ravi Kant - Academia.edu (original) (raw)

Papers by Ravi Kant

Research paper thumbnail of Bio-Medicinal Studies of Some New Triorganobismuth (V) Compounds

International Journal of Chemical Research, 2012

Some new triorganobismuth (V) amide were synthesized by earlier reported method and fully charact... more Some new triorganobismuth (V) amide were synthesized by earlier reported method and fully characterized by their elemental and I.R. spectral analysis along with their antimicrobial activity against different pathogenic bacterial and fungal strains and in-vitro antitumor activity against human breast and mammary cancer cell line. It was found that compounds have great potential as antitumor and antimicrobial agents.

Research paper thumbnail of Synthesis and antibacterial studies of some new amides of 5- sulphosalicylic acid

Some new amides of 5-Sulphosalicylic acid were synthesized by the reaction of suitable amines wit... more Some new amides of 5-Sulphosalicylic acid were synthesized by the reaction of suitable amines with 5-sulphosalicylic acid in 2:1 ratio. The compounds are novel and first time screened for their biological evaluation along with general characterization with the help of elemental analysis, IR spectral analysis. These compounds showed higher to moderate biological activity against different pathogenic microbial strains.

Research paper thumbnail of Rapid synthesis of some medicinally important hexahydro-s-triazine derivatives incorporating benzothiazole

Main Group Chemistry, 2011

A series of 2,4,6-trisubstituted 1,3,5-tris (benzothiazol-2-yl) hexahydro-1,3,5-triazine derivati... more A series of 2,4,6-trisubstituted 1,3,5-tris (benzothiazol-2-yl) hexahydro-1,3,5-triazine derivatives (3) have been synthesized by condensation of substituted benzothiazoles with 2,4,6-trisubstituted 1,3,5-trioxane by conventional as well as microwave irradiation (solvent free and solid support) methods. All compounds were tested for antiproliferative activity and entomological activity. The microwave irradiation technique gives better yield and reaction completion in a shorter period of time. Among solid supported microwave irradiation better yields are obtained with acidic alumina as compared to silica, neutral alumina and basic alumina.The results of biological activities prompted us that change in substitution pattern in benzothiazolyltriazine derivatives may cause marked effect on their antiproliferative activity.

Research paper thumbnail of Synthesis of some biologically important 2-thiobarbituric acid derivatives incorporating benzothiazole moiety

Some N-(4/6-substituted-1,3-benzothiazol-2-yl)–N'-phenyl thiourea derivatives (3) have been s... more Some N-(4/6-substituted-1,3-benzothiazol-2-yl)–N'-phenyl thiourea derivatives (3) have been synthesized by the reaction of substituted benzothiazoles with phenyl isothiocyanate in absolute ethanol. These (3) were condensed with malonic acid in acetyl chloride to get 1-(4/6-substituted-1,3-benzothiazol-2-yl)-3-phenyl-2-thiobarbituric acid derivatives (5). All the synthesized compounds were characterized by elemental analysis, IR, 1 H NMR and Mass spectral studies. Compounds 3 and 5 were screened for their entomological and antibacterial activities.

Research paper thumbnail of Synthesis of some biologically active benzothiazole derivatives

N-(4,5-dihydro-1H-imidazol-2-yl)-6-substituted-1,3-benzothiazol-2-amines and N-(1Hbenzimidazol-2-... more N-(4,5-dihydro-1H-imidazol-2-yl)-6-substituted-1,3-benzothiazol-2-amines and N-(1Hbenzimidazol-2-yl)-6-substituted-1,3-benzothiazol-2-amines were synthesized by the reaction of 6-substituted-2-aminobenzothiazoles with carbon disulphide and methyl iodide. It was followed by the reaction with o-phenylene diamine/ ethylene diamine. All the synthesized compounds were characterized by elemental analysis, IR spectra, 1H NMR and MASS spectral studies. They were screened for their anti-inflammatory, antiulcer, antitumor, entomological (antifeedant, acaricidal, contact toxicity and stomach toxicity) and antibacterial activities.

Research paper thumbnail of Synthesis and Biological Activity of a Novel Compound: (C6F5)2SbPh

Phosphorus, Sulfur, and Silicon and the Related Elements, 2008

Methyl 5-hydroxy-4-oxo-4H-pyran-2-carboxylate was synthesized by esterification of methanol with ... more Methyl 5-hydroxy-4-oxo-4H-pyran-2-carboxylate was synthesized by esterification of methanol with comenic acid under acidic catalysis. The obtained ester was alkylated with 3-(chloromethyl)-5-phenylisoxazole and 4,5-dichloro-3-(chloromethyl)isothiazole to afford corresponding conjugates containing isoxazole and isothiazole moieties which then were transformed into water-soluble Li-salts. During the bioassays of synthesized isoxazole and isothiazole derivatives of comenic acid in mixtures with first-line antitumor drug Temobel (Temozolomid) used in brain tumors chemotherapy, a synergetic effect was observed.

Research paper thumbnail of Synthesis of some bioactive 4-thiazolidinone derivatives incorporating benzothiazole moiety

pelagiaresearchlibrary.com

Some 2-aryl-3-(substituted benzothiazolyl)-1,3-thiazolidine-4-ones have been synthesized by the r... more Some 2-aryl-3-(substituted benzothiazolyl)-1,3-thiazolidine-4-ones have been synthesized by the reaction of substituted-2-aminobenzothiazole with aromatic aldehyde (benzaldehyde, pchlorobenzaldehyde, anisaldehyde, salicylaldehyde) followed by cyclic condensation with mercapto acetic acid. All the synthesized compounds were characterized by elemental analysis, IR spectra, 1 H NMR and Mass spectral studies. These were screened for their entomological (Antifeedant activity, Acaricidal activity, Contact toxicity, Stomach toxicity) and antibacterial activities.

Research paper thumbnail of Rapid synthesis and biological evaluation of 1,4-dihydropyridine derivatives containing a benzothiazolyl moiety

Central European Journal of Chemistry, 2010

A series of N-(6-methylbenzothiazolyl)-2,3,5,6-tetrasubstituted-4-(aryl)-1,4-dihydropyridines wer... more A series of N-(6-methylbenzothiazolyl)-2,3,5,6-tetrasubstituted-4-(aryl)-1,4-dihydropyridines were synthesized by reaction of 2-amino-6-methylbenzothiazole, aromatic aldehyde and active methylene compound in methanol by conventional, as well as, microwave irradiation (solvent free and solid support) methods. The microwave irradiation technique gives better yield and shorter reaction time. Among solid supported microwave irradiation better yields are obtained in acidic alumina as compared to silica, neutral alumina, and basic alumina. All compounds were tested for antibacterial and antifungal activities and results have been compared with standard drugs. Entomological activities were also tested. The results showed that a change in the substitution pattern in 1,4-dihydropyridine derivatives may cause a marked effect on their antimicrobial activity.

Research paper thumbnail of Conventional and microwave assisted synthesis of 1,4-disubstituted 1,2,3-triazoles from Huisgen cycloaddition

Arkivoc, 2011

In this paper the synthesis of a library of new 1,4-disubstituted 1,2,3-triazoles 1, with a varie... more In this paper the synthesis of a library of new 1,4-disubstituted 1,2,3-triazoles 1, with a variety of additional functional groups on its structure, from an in situ generated benzyl azide 2 and different alkynes and dialkynes 3 is reported. Optimal experimental conditions were established for the conventional click chemistry and for the microwave-assisted synthesis of these 1,2,3triazoles. Comparing the results it was concluded that under microwave-assisted conditions the products are obtained in higher yields in shorter times.

Research paper thumbnail of Bio-Medicinal Studies of Some New Triorganobismuth (V) Compounds

International Journal of Chemical Research, 2012

Some new triorganobismuth (V) amide were synthesized by earlier reported method and fully charact... more Some new triorganobismuth (V) amide were synthesized by earlier reported method and fully characterized by their elemental and I.R. spectral analysis along with their antimicrobial activity against different pathogenic bacterial and fungal strains and in-vitro antitumor activity against human breast and mammary cancer cell line. It was found that compounds have great potential as antitumor and antimicrobial agents.

Research paper thumbnail of Synthesis and antibacterial studies of some new amides of 5- sulphosalicylic acid

Some new amides of 5-Sulphosalicylic acid were synthesized by the reaction of suitable amines wit... more Some new amides of 5-Sulphosalicylic acid were synthesized by the reaction of suitable amines with 5-sulphosalicylic acid in 2:1 ratio. The compounds are novel and first time screened for their biological evaluation along with general characterization with the help of elemental analysis, IR spectral analysis. These compounds showed higher to moderate biological activity against different pathogenic microbial strains.

Research paper thumbnail of Rapid synthesis of some medicinally important hexahydro-s-triazine derivatives incorporating benzothiazole

Main Group Chemistry, 2011

A series of 2,4,6-trisubstituted 1,3,5-tris (benzothiazol-2-yl) hexahydro-1,3,5-triazine derivati... more A series of 2,4,6-trisubstituted 1,3,5-tris (benzothiazol-2-yl) hexahydro-1,3,5-triazine derivatives (3) have been synthesized by condensation of substituted benzothiazoles with 2,4,6-trisubstituted 1,3,5-trioxane by conventional as well as microwave irradiation (solvent free and solid support) methods. All compounds were tested for antiproliferative activity and entomological activity. The microwave irradiation technique gives better yield and reaction completion in a shorter period of time. Among solid supported microwave irradiation better yields are obtained with acidic alumina as compared to silica, neutral alumina and basic alumina.The results of biological activities prompted us that change in substitution pattern in benzothiazolyltriazine derivatives may cause marked effect on their antiproliferative activity.

Research paper thumbnail of Synthesis of some biologically important 2-thiobarbituric acid derivatives incorporating benzothiazole moiety

Some N-(4/6-substituted-1,3-benzothiazol-2-yl)–N'-phenyl thiourea derivatives (3) have been s... more Some N-(4/6-substituted-1,3-benzothiazol-2-yl)–N'-phenyl thiourea derivatives (3) have been synthesized by the reaction of substituted benzothiazoles with phenyl isothiocyanate in absolute ethanol. These (3) were condensed with malonic acid in acetyl chloride to get 1-(4/6-substituted-1,3-benzothiazol-2-yl)-3-phenyl-2-thiobarbituric acid derivatives (5). All the synthesized compounds were characterized by elemental analysis, IR, 1 H NMR and Mass spectral studies. Compounds 3 and 5 were screened for their entomological and antibacterial activities.

Research paper thumbnail of Synthesis of some biologically active benzothiazole derivatives

N-(4,5-dihydro-1H-imidazol-2-yl)-6-substituted-1,3-benzothiazol-2-amines and N-(1Hbenzimidazol-2-... more N-(4,5-dihydro-1H-imidazol-2-yl)-6-substituted-1,3-benzothiazol-2-amines and N-(1Hbenzimidazol-2-yl)-6-substituted-1,3-benzothiazol-2-amines were synthesized by the reaction of 6-substituted-2-aminobenzothiazoles with carbon disulphide and methyl iodide. It was followed by the reaction with o-phenylene diamine/ ethylene diamine. All the synthesized compounds were characterized by elemental analysis, IR spectra, 1H NMR and MASS spectral studies. They were screened for their anti-inflammatory, antiulcer, antitumor, entomological (antifeedant, acaricidal, contact toxicity and stomach toxicity) and antibacterial activities.

Research paper thumbnail of Synthesis and Biological Activity of a Novel Compound: (C6F5)2SbPh

Phosphorus, Sulfur, and Silicon and the Related Elements, 2008

Methyl 5-hydroxy-4-oxo-4H-pyran-2-carboxylate was synthesized by esterification of methanol with ... more Methyl 5-hydroxy-4-oxo-4H-pyran-2-carboxylate was synthesized by esterification of methanol with comenic acid under acidic catalysis. The obtained ester was alkylated with 3-(chloromethyl)-5-phenylisoxazole and 4,5-dichloro-3-(chloromethyl)isothiazole to afford corresponding conjugates containing isoxazole and isothiazole moieties which then were transformed into water-soluble Li-salts. During the bioassays of synthesized isoxazole and isothiazole derivatives of comenic acid in mixtures with first-line antitumor drug Temobel (Temozolomid) used in brain tumors chemotherapy, a synergetic effect was observed.

Research paper thumbnail of Synthesis of some bioactive 4-thiazolidinone derivatives incorporating benzothiazole moiety

pelagiaresearchlibrary.com

Some 2-aryl-3-(substituted benzothiazolyl)-1,3-thiazolidine-4-ones have been synthesized by the r... more Some 2-aryl-3-(substituted benzothiazolyl)-1,3-thiazolidine-4-ones have been synthesized by the reaction of substituted-2-aminobenzothiazole with aromatic aldehyde (benzaldehyde, pchlorobenzaldehyde, anisaldehyde, salicylaldehyde) followed by cyclic condensation with mercapto acetic acid. All the synthesized compounds were characterized by elemental analysis, IR spectra, 1 H NMR and Mass spectral studies. These were screened for their entomological (Antifeedant activity, Acaricidal activity, Contact toxicity, Stomach toxicity) and antibacterial activities.

Research paper thumbnail of Rapid synthesis and biological evaluation of 1,4-dihydropyridine derivatives containing a benzothiazolyl moiety

Central European Journal of Chemistry, 2010

A series of N-(6-methylbenzothiazolyl)-2,3,5,6-tetrasubstituted-4-(aryl)-1,4-dihydropyridines wer... more A series of N-(6-methylbenzothiazolyl)-2,3,5,6-tetrasubstituted-4-(aryl)-1,4-dihydropyridines were synthesized by reaction of 2-amino-6-methylbenzothiazole, aromatic aldehyde and active methylene compound in methanol by conventional, as well as, microwave irradiation (solvent free and solid support) methods. The microwave irradiation technique gives better yield and shorter reaction time. Among solid supported microwave irradiation better yields are obtained in acidic alumina as compared to silica, neutral alumina, and basic alumina. All compounds were tested for antibacterial and antifungal activities and results have been compared with standard drugs. Entomological activities were also tested. The results showed that a change in the substitution pattern in 1,4-dihydropyridine derivatives may cause a marked effect on their antimicrobial activity.

Research paper thumbnail of Conventional and microwave assisted synthesis of 1,4-disubstituted 1,2,3-triazoles from Huisgen cycloaddition

Arkivoc, 2011

In this paper the synthesis of a library of new 1,4-disubstituted 1,2,3-triazoles 1, with a varie... more In this paper the synthesis of a library of new 1,4-disubstituted 1,2,3-triazoles 1, with a variety of additional functional groups on its structure, from an in situ generated benzyl azide 2 and different alkynes and dialkynes 3 is reported. Optimal experimental conditions were established for the conventional click chemistry and for the microwave-assisted synthesis of these 1,2,3triazoles. Comparing the results it was concluded that under microwave-assisted conditions the products are obtained in higher yields in shorter times.