Sayoni Ray - Academia.edu (original) (raw)
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Papers by Sayoni Ray
Cancer Imaging, Oct 2, 2015
One of the holy grails in cancer detection and therapy is to simultaneously image and deliver dru... more One of the holy grails in cancer detection and therapy is to simultaneously image and deliver drugs to the tumor site using a safe nanoparticle. Liposomes are a well-known safe and stable nanoparticles that can be loaded with a drug and suitable contrast agent for magnetic resonance imaging (MRI). However, the loading of a contrast agent such as gadolinium in liposomes generally results in poor contrast and various artifacts in in vivo experiments, compared to free gadolinium chelate experiments. Current work demonstrates the effective filtering of artifacts and contrast enhancement to obtain high quality images of the tumor sites in mouse models using paramagnetic liposome nanoparticles as contrast agent, a novel pulse sequence in active-feedback MRI, and nonlinear fitting. Our results show a significant improvement in eliminating artifacts and increasing contrast compared to the standard MRI techniques, and a close correlation with histopathology and inductively coupled mass spect...
Author(s): Ray, Sayoni | Advisor(s): Gelbart, William M; Knobler, Charles M | Abstract: One of th... more Author(s): Ray, Sayoni | Advisor(s): Gelbart, William M; Knobler, Charles M | Abstract: One of the holy grails in cancer therapy is to simultaneously image and deliver drugs to the tumor site. The first part of the thesis has developed new ideas in cancer theranostics and the second part is about the development of a novel contrast agent for risk-free imaging of the tumor. In the first project of the thesis, I have discussed the development of a liposome-based cargo delivery strategy that can simultaneously monitor alternating magnetic field–induced drug release by observing the change in MRI relaxation parameter R1, and the location and condition of liposomal site (such as tumor) from MRI parameter R2. However, the loading of a contrast agent in liposomes generally results in poor contrast and suffers from various artifacts in in vivo experiments, compared to the use of free contrast agent. Thus, the second project of my work in this part demonstrates the effective filtering of art...
Cancer Imaging, Oct 2, 2015
One of the holy grails in cancer detection and therapy is to simultaneously image and deliver dru... more One of the holy grails in cancer detection and therapy is to simultaneously image and deliver drugs to the tumor site using a safe nanoparticle. Liposomes are a well-known safe and stable nanoparticles that can be loaded with a drug and suitable contrast agent for magnetic resonance imaging (MRI). However, the loading of a contrast agent such as gadolinium in liposomes generally results in poor contrast and various artifacts in in vivo experiments, compared to free gadolinium chelate experiments. Current work demonstrates the effective filtering of artifacts and contrast enhancement to obtain high quality images of the tumor sites in mouse models using paramagnetic liposome nanoparticles as contrast agent, a novel pulse sequence in active-feedback MRI, and nonlinear fitting. Our results show a significant improvement in eliminating artifacts and increasing contrast compared to the standard MRI techniques, and a close correlation with histopathology and inductively coupled mass spect...
Author(s): Ray, Sayoni | Advisor(s): Gelbart, William M; Knobler, Charles M | Abstract: One of th... more Author(s): Ray, Sayoni | Advisor(s): Gelbart, William M; Knobler, Charles M | Abstract: One of the holy grails in cancer therapy is to simultaneously image and deliver drugs to the tumor site. The first part of the thesis has developed new ideas in cancer theranostics and the second part is about the development of a novel contrast agent for risk-free imaging of the tumor. In the first project of the thesis, I have discussed the development of a liposome-based cargo delivery strategy that can simultaneously monitor alternating magnetic field–induced drug release by observing the change in MRI relaxation parameter R1, and the location and condition of liposomal site (such as tumor) from MRI parameter R2. However, the loading of a contrast agent in liposomes generally results in poor contrast and suffers from various artifacts in in vivo experiments, compared to the use of free contrast agent. Thus, the second project of my work in this part demonstrates the effective filtering of art...