Razieh Azimi - Academia.edu (original) (raw)
Papers by Razieh Azimi
Scientific reports, Mar 30, 2024
There are 16 species in the genus Satureja L. (Lamiaceae), of which 10 are native. This research ... more There are 16 species in the genus Satureja L. (Lamiaceae), of which 10 are native. This research aimed to investigate the effect of gamma rays and storage conditions and duration on the percentage and components of the essential oil and some biochemical characteristics of Satureja mutica Fisch & C.A. Mey at the Research Institute of Forests and Rangelands. Plants were collected at the full flowering stage and exposed to different doses of gamma rays (0, 2.5, 5, 7.5, and 10 kGy) at the Atomic Energy Organization, Iran. The samples were kept in a refrigerator (4 °C) and in the shade (25 ± 2 °C) for 0, 120, and 240 h. This experiment was performed in a completely randomized design. Essential oil extraction was done by water distillation for 2 h. The composition of their essential oil components was identified using GC and GC/MS. Some biochemical traits, including phenol content, antioxidant capacity, and carbohydrate content, were measured. The results indicated that irradiation on the percentage of essential oil showed a statistically significant difference. In addition, the interaction effect of irradiation × storage conditions, irradiation × duration of storage, on the percentage of essential oil was significant. According to a comparison of the means, 2.5 kGy irradiation produced the highest percentage of essential oil (0.4%); in contrast, a significant decrease was detected in components with 7.5 and 10 kGy irradiation. It was observed that the percentage of some essential oil compounds decreased with the gamma-ray intensity increase. 2.5 kGy of gamma rays and shade storage conditions for 240 h led to the highest content of p-cymene and carvacrol. Nevertheless, the highest thymol content was obtained under refrigeration conditions without irradiation. The maximum phenol content and antioxidant capacity were obtained when the plants were irradiated with 2.5 and 7.5 kGy gamma rays. However, the maximum carbohydrate rate was observed in non-irradiated plants. It was concluded that low-intensity gamma rays could improve the percentage of essential oil and main components like p-cymene and carvacrol in S. mutica Fisch & C.A. Mey.
Scientific reports, Mar 30, 2024
There are 16 species in the genus Satureja L. (Lamiaceae), of which 10 are native. This research ... more There are 16 species in the genus Satureja L. (Lamiaceae), of which 10 are native. This research aimed to investigate the effect of gamma rays and storage conditions and duration on the percentage and components of the essential oil and some biochemical characteristics of Satureja mutica Fisch & C.A. Mey at the Research Institute of Forests and Rangelands. Plants were collected at the full flowering stage and exposed to different doses of gamma rays (0, 2.5, 5, 7.5, and 10 kGy) at the Atomic Energy Organization, Iran. The samples were kept in a refrigerator (4 °C) and in the shade (25 ± 2 °C) for 0, 120, and 240 h. This experiment was performed in a completely randomized design. Essential oil extraction was done by water distillation for 2 h. The composition of their essential oil components was identified using GC and GC/MS. Some biochemical traits, including phenol content, antioxidant capacity, and carbohydrate content, were measured. The results indicated that irradiation on the percentage of essential oil showed a statistically significant difference. In addition, the interaction effect of irradiation × storage conditions, irradiation × duration of storage, on the percentage of essential oil was significant. According to a comparison of the means, 2.5 kGy irradiation produced the highest percentage of essential oil (0.4%); in contrast, a significant decrease was detected in components with 7.5 and 10 kGy irradiation. It was observed that the percentage of some essential oil compounds decreased with the gamma-ray intensity increase. 2.5 kGy of gamma rays and shade storage conditions for 240 h led to the highest content of p-cymene and carvacrol. Nevertheless, the highest thymol content was obtained under refrigeration conditions without irradiation. The maximum phenol content and antioxidant capacity were obtained when the plants were irradiated with 2.5 and 7.5 kGy gamma rays. However, the maximum carbohydrate rate was observed in non-irradiated plants. It was concluded that low-intensity gamma rays could improve the percentage of essential oil and main components like p-cymene and carvacrol in S. mutica Fisch & C.A. Mey.
ChemInform, Apr 23, 2015
DABCO-Functionalized Mesoporous SBA-15: An Efficient and Recyclable Catalyst for the Synthesis of... more DABCO-Functionalized Mesoporous SBA-15: An Efficient and Recyclable Catalyst for the Synthesis of Spiro-Pyranoxindoles as Antioxidant Agents.-The catalyst is recyclable and reusable at least 2 times though the amount of recovered catalyst is reduced. All spiro-pyranoxindoles are examined on their antioxidant activity in the 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) scavenging assay. All products show moderate to good DPPH radical scavenging ability with (IVf), (VIb) and (VIf) being the most effective scavengers of this series.
Postharvest Biology and Technology
Biocatalysis and Agricultural Biotechnology
Organic Preparations and Procedures International, 2019
Multicomponent reactions (MCRs) have become important tools for the synthesis of highly functiona... more Multicomponent reactions (MCRs) have become important tools for the synthesis of highly functionalized organic molecules. This is due to their convergence, simplicity, atom economy, and green characteristics. 1-4 MCRs are quicker and cheaper than conventional reactions, since they are performed by mixing compounds together in one pot, without separating any intermediate. 5 Isocyanide-based MCRs (IMCRs) are especially significant, because of their diversity and flexibility. 6-9 Rhodanine (2-thioxothiazolidin-4-one) is a privileged scaffold and is found in a variety of biologically active compounds, including some with antiviral, 10 antibacterial, 11,12 antifungal, 12,13 antitubercular, 14 anticancer, 15,16 anticonvulsant, 17 and hypnotic activities. 18 Following our interests in isocyanide-based reactions and our studies towards the development of new directions for the synthesis of novel organic compounds with biological activities, 19-21 we now provide a preliminary report on our exploration of the multicomponent reaction of aromatic aldehydes 1 in the presence of aniline 2, rhodanine-N-acetic acid 3 and isocyanides 4 in THF. The reaction affords rhodanine-based amides 5 in good yields (Scheme 1). Initially we examined the reaction of benzaldehyde 1a (1 (R 1 ¼ H), 1.0 mmol), aniline 2 (1.0 mmol), rhodanine-N-acetic acid 3 (1.0 mmol), and tert-butyl isocyanide 4a (4 (R 2 ¼ t-Bu), 1.0 mmol) in tetrahydrofuran (THF) at room temperature as a model reaction. This condensation reaction did not afford the expected Ugi product 6a (6, R 1 ¼ H, R 2 ¼ t-Bu). Instead, 2-(5-benzylidene-4-oxo-2-thioxo-thiazolidin-3-yl)-N-tertbutyl-acetamide 5a, was obtained in 90% yield (Scheme 1, see Experimental Section for full structural characterization). In fact, it seems clear that the Knoevenagel condensation between benzaldehyde and rhodanine-N-acetic acid in the presence of aniline proceeds much faster than the Ugi reaction. Even with 2.0 mmol benzaldehyde in the model reaction under reflux conditions, we found compound 5a as the main product (91%) with only a trace amount of the Ugi product 6a. In the absence of aniline, even after 24 h at reflux, only starting materials were recovered. Additionally, the reaction of
Research on Chemical Intermediates, 2022
Today, plant extracts based on synthetic procedures have drawn consideration over conventional me... more Today, plant extracts based on synthetic procedures have drawn consideration over conventional methods like physical and chemical procedures to synthesize nanomaterials. Green synthesis of nanomaterials has become an area of interest because of numerous advantages such as non-hazardous, economical, and feasible methods with a variety of applications in biomedicine, nanotechnology and nano-optoelectronics and as catalysts for various organic transformations. In this research, silver nanoparticles were deposited on the surface of nano-silica spheres by an in-situ reduction of Ag+ ions using an aqueous extract of Thymus kotschyanus aerial parts as a natural reducing and a capping agent. The result recorded from ultraviolet–visible (UV–Vis) spectrometer, Fourier transform infrared spectroscopy (FT-IR), thermal gravimetric analysis, scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM–EDS) and X-ray powder diffraction supports the biosynthesis and characterization of Ag/SiO2 nanoparticles. The results indicated that the average size of Ag/SiO2 nanoparticles is 25–60 nm. The Ag/SiO2 nanoparticles act as an environmentally friendly heterogeneous catalyst in the synthesis of spirooxindoles via the three-component condensation reaction of isatins, activated methylene reagents, and 1,3-dicarbonyl compounds in aqueous media, and the desired products were obtained with yields ranging from 90 to 98%. The catalyst can be recovered easily and used repetitively without significant loss of catalytic activity.
![Research paper thumbnail of Efficient synthesis of 9,10-dihydropyrano[2,3-<i>h</i>]chromene-2,8-dione derivatives in ionic liquid and the study of their antioxidant activity](https://attachments.academia-assets.com/87098106/thumbnails/1.jpg)
](Ionic liquid <i>N</i>,<i>N</i>,<i>N′</i>,<i>N′</i>... more Ionic liquid <i>N</i>,<i>N</i>,<i>N′</i>,<i>N′</i>-tetramethylguanidinium trifluoroacetate (TMGT) has been applied as a green and reusable catalyst for the one-pot synthesis of 10-aryl substituted-9,10-dihydropyrano[2,3-<i>h</i>]chromene-2,8-diones via reaction of various aromatic aldehydes, 5,7-dihydroxycoumarin derivatives and Meldrum's acid. The reactions were rapid, clean and the products were prepared in good yield. The ionic liquid was stable during the reaction process and reused without significant loss of its activity. The synthesised compounds were evaluated for their antioxidant activity by a 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay. Lasemi et al. 'Efficient synthesis of 9,10-dihydropyrano[2,3-h]chromene-2,8-dione derivatives in ionic liquid and the study of their antioxidant activity'
Journal of the Iranian Chemical Society, 2022
An electrochemical DNA hybridization biosensor developed based on graphite screen-printed electro... more An electrochemical DNA hybridization biosensor developed based on graphite screen-printed electrodes (GSPEs) modified with Fe3O4@SiO2/DABCO was used for detection of short-sequence DNA of prostate cancer gene by using two different methods including direct and indirect. The proposed sensor was prepared by immobilization of a 19-mer ssDNA probe on the modified GSPEs surface for detecting the hybridization between the probe and its complementary and non-complementary sequence of the prostate cancer gene as a target. The hybridization process was detected based on the differential pulse voltammetric signals of the guanine oxidation and the hemin reduction as an electrochemical indicator through direct and indirect methods, respectively. The selectivity of the biosensor was studied by the using of non-complementary oligonucleotide strands capable of distinguishing complementary and non-complementary DNA sequence of the prostate cancer gene. The peak current intensity of guanine oxidation and hemin reduction showed an enhancement by increasing the concentrations of complementary strands from 1.0 × 10–11 to 2.0 × 10–6 M and 7.5 × 10–12 to 2.0 × 10–6 M, respectively. The limits of detection, LOD (based on 3σ), were found as 8.0 × 10–12 M and 6.4 × 10–12 M for direct and indirect detection methods, respectively.
Hacia un derecho administrativo, fiscal y medioambiental romano IV. Volumen II. Derecho fiscal y miscelánea., 2021
Materiali in tehnologije, 2016
To improve the solubility, thermal properties and processability of polyxanthones, a new class of... more To improve the solubility, thermal properties and processability of polyxanthones, a new class of polyxanthones, poly(xanthone-imide)s (PXIs), with a high yield was prepared using a two-step chemical imidation of 2,7-diaminoxanthone with pyromellitic dianhydride (PMDA), 3,3',4,4'-benzophenone tetracarboxylic dianhydride (BTDA) and 2,2'-bis-(3,4-dicarboxyphenyl) hexafluoropropane dianhydride (6-FDA)). These PXIs were characterized with FT-IR and 1 H NMR spectroscopies. They presented a good solubility in aprotic polar solvents such as N,N-dimethyl acetamide (DMAc), N,N-dimethyl formamide (DMF), N-methyl pyrrolidone (NMP) and dimethyl sulfoxide (DMSO), and showed inherent viscosities in a range of 0.34-0.58 dL/g. These PXIs exhibited lower glass-transition temperatures than the original polyxanthones and a high thermal stability. The obtained results of the UV-vis absorption and photoluminescence indicated that the maximum absorption and fluorescence emission of PXIs were in the range of 300-304 nm and 432-510 nm, respectively. The antioxidant activity of PXIs was evaluated with a DPPH assay. The antioxidant values for PXIs were greater than for the parent xanthone (X). The polyimides were investigated for the extraction of environmentally noxious metal ions such as Cr (VI), Co (II), Ni (II), Cu (II), Pb (II) and Cd (II) from aqueous solutions.
Acta Poloniae Pharmaceutica - Drug Research, 2012
Antioxidant and antihemolytic activities of acetone extracts of Hyssopus angustifolius flowers, l... more Antioxidant and antihemolytic activities of acetone extracts of Hyssopus angustifolius flowers, leaf and stems were investigated employing different in vitro and ex vivo assay systems. IC50, for 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical-scavenging activity were 239.4 +/- 8.4 microg/mL for flowers, 357.8 +/- 11.1 microg/mL for stems and 182.5 +/- 7.5 microg/mL for leaf. All extracts showed moderate nitric oxide scavenging activity. The leaf extract exhibited better hydrogen peroxide scavenging and Fe2+ chelating activity than the others (IC50 were 261.0 +/- 6.2 microg/mL for hydrogen peroxide and 534.0 +/- 9.9 microg/mL for Fe3+ chelating activity). The extracts exhibited good antioxidant activity in linoleic acid peroxidation system and weak reducing power ability. The leaf extract showed better antihemolytic activity than the flower and stem (IC50 = 65.7 +/- 1.8 microg/mL).
This study was designed to evaluate antioxidant and antihemolytic activities of Hyssopus angustif... more This study was designed to evaluate antioxidant and antihemolytic activities of Hyssopus angustifolius flower, stem and leaf methanol extracts by employing various in vitro assays. The leaf extract showed the best activity in DPPH (63.2 ± 2.3 μg mL -1 ) and H 2 O 2 (55.6 ± 2.6 μg mL -1 ) models compared to the other extracts. However, flower extract exhibited the highest Fe 2+ chelating activity (131.4 ± 4.4 μg mL -1 ). The extracts exhibited good antioxidant activity in linoleic acid peroxidation and reducing power assays, but were not comparable to vitamin C. The stem (23.58 ± 0.7 μg mL -1 ) and leaf (26.21 ± 1 μg mL -1 ) extracts showed highest level of antihemolytic activity than the flower extract.
Polycyclic Aromatic Compounds
Polymer Engineering & Science
Industrial Crops and Products
Abstract Drought stress often reduces plant growth. Therefore, in order to decrease the negative ... more Abstract Drought stress often reduces plant growth. Therefore, in order to decrease the negative effect of drought stress on rosemary growth and prevent its severe reduction, an experiment was carried out through drought stress treatments along with increasing tolerance and quality of plant using salicylic acid in 2014 at the Research Institute of Forests and Rangelands (Iran) under field conditions. The experiment was conducted as split-plot in a randomized complete block design with three replications. The main factor included drought stress at three levels of 30 % (severe stress), 60 % (mild stress) and 90 % (control) of field capacity, and the subfactor was the salicylic acid foliar application at four levels of 0, 1, 2, and 3 mM. According to the results, the most suitable levels of stress and salicylic acid treatments for the production of essential oil was 60 % FC and 1 as well as 2 mM salicylic acid, respectively. Rosemary is one of the most drought tolerant plants with an annual consumption of 4500 to 5500 m3 of water per hectare in a growth period. Also, a mild stress – 60 % of the field capacity- would be produced the optimum production of this plant.
Environmental Chemistry Letters
The combination of two or more different heterocyclic moieties in a single molecule would enhance... more The combination of two or more different heterocyclic moieties in a single molecule would enhance biological activity significantly. The indole and furan scaffolds are promising candidates in drug design, and they have been widely found in natural products and therapeutic agents. Owing to their pharmaceutical importance, there is an urgent need to design rapid, efficient and environmentally benign protocols for the synthesis of indole–dihydrofuran biheterocycles. Herein, we have developed a novel ecofriendly approach for the diastereoselective synthesis of indole-based 4,5-dihydrofurans through a three-component reaction of 3-cyanoacetyl indoles with various aldehydes and N-phenacylpyridinium bromides in the presence of potassium carbonate as an inexpensive and non-toxic base in water under low power microwave irradiation. The findings show that aromatic and heteroaromatic aldehydes tolerated well in this reaction. The products were obtained in 85–98% yields in 4–20 min. The advantages of this method consist of the environmental friendly reaction conditions, use of green solvent and safe base, availability of raw materials, wide range of usable substrates, short reaction times, excellent yields and absence of any tedious workup or purification.
Scientific reports, Mar 30, 2024
There are 16 species in the genus Satureja L. (Lamiaceae), of which 10 are native. This research ... more There are 16 species in the genus Satureja L. (Lamiaceae), of which 10 are native. This research aimed to investigate the effect of gamma rays and storage conditions and duration on the percentage and components of the essential oil and some biochemical characteristics of Satureja mutica Fisch & C.A. Mey at the Research Institute of Forests and Rangelands. Plants were collected at the full flowering stage and exposed to different doses of gamma rays (0, 2.5, 5, 7.5, and 10 kGy) at the Atomic Energy Organization, Iran. The samples were kept in a refrigerator (4 °C) and in the shade (25 ± 2 °C) for 0, 120, and 240 h. This experiment was performed in a completely randomized design. Essential oil extraction was done by water distillation for 2 h. The composition of their essential oil components was identified using GC and GC/MS. Some biochemical traits, including phenol content, antioxidant capacity, and carbohydrate content, were measured. The results indicated that irradiation on the percentage of essential oil showed a statistically significant difference. In addition, the interaction effect of irradiation × storage conditions, irradiation × duration of storage, on the percentage of essential oil was significant. According to a comparison of the means, 2.5 kGy irradiation produced the highest percentage of essential oil (0.4%); in contrast, a significant decrease was detected in components with 7.5 and 10 kGy irradiation. It was observed that the percentage of some essential oil compounds decreased with the gamma-ray intensity increase. 2.5 kGy of gamma rays and shade storage conditions for 240 h led to the highest content of p-cymene and carvacrol. Nevertheless, the highest thymol content was obtained under refrigeration conditions without irradiation. The maximum phenol content and antioxidant capacity were obtained when the plants were irradiated with 2.5 and 7.5 kGy gamma rays. However, the maximum carbohydrate rate was observed in non-irradiated plants. It was concluded that low-intensity gamma rays could improve the percentage of essential oil and main components like p-cymene and carvacrol in S. mutica Fisch & C.A. Mey.
Scientific reports, Mar 30, 2024
There are 16 species in the genus Satureja L. (Lamiaceae), of which 10 are native. This research ... more There are 16 species in the genus Satureja L. (Lamiaceae), of which 10 are native. This research aimed to investigate the effect of gamma rays and storage conditions and duration on the percentage and components of the essential oil and some biochemical characteristics of Satureja mutica Fisch & C.A. Mey at the Research Institute of Forests and Rangelands. Plants were collected at the full flowering stage and exposed to different doses of gamma rays (0, 2.5, 5, 7.5, and 10 kGy) at the Atomic Energy Organization, Iran. The samples were kept in a refrigerator (4 °C) and in the shade (25 ± 2 °C) for 0, 120, and 240 h. This experiment was performed in a completely randomized design. Essential oil extraction was done by water distillation for 2 h. The composition of their essential oil components was identified using GC and GC/MS. Some biochemical traits, including phenol content, antioxidant capacity, and carbohydrate content, were measured. The results indicated that irradiation on the percentage of essential oil showed a statistically significant difference. In addition, the interaction effect of irradiation × storage conditions, irradiation × duration of storage, on the percentage of essential oil was significant. According to a comparison of the means, 2.5 kGy irradiation produced the highest percentage of essential oil (0.4%); in contrast, a significant decrease was detected in components with 7.5 and 10 kGy irradiation. It was observed that the percentage of some essential oil compounds decreased with the gamma-ray intensity increase. 2.5 kGy of gamma rays and shade storage conditions for 240 h led to the highest content of p-cymene and carvacrol. Nevertheless, the highest thymol content was obtained under refrigeration conditions without irradiation. The maximum phenol content and antioxidant capacity were obtained when the plants were irradiated with 2.5 and 7.5 kGy gamma rays. However, the maximum carbohydrate rate was observed in non-irradiated plants. It was concluded that low-intensity gamma rays could improve the percentage of essential oil and main components like p-cymene and carvacrol in S. mutica Fisch & C.A. Mey.
ChemInform, Apr 23, 2015
DABCO-Functionalized Mesoporous SBA-15: An Efficient and Recyclable Catalyst for the Synthesis of... more DABCO-Functionalized Mesoporous SBA-15: An Efficient and Recyclable Catalyst for the Synthesis of Spiro-Pyranoxindoles as Antioxidant Agents.-The catalyst is recyclable and reusable at least 2 times though the amount of recovered catalyst is reduced. All spiro-pyranoxindoles are examined on their antioxidant activity in the 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) scavenging assay. All products show moderate to good DPPH radical scavenging ability with (IVf), (VIb) and (VIf) being the most effective scavengers of this series.
Postharvest Biology and Technology
Biocatalysis and Agricultural Biotechnology
Organic Preparations and Procedures International, 2019
Multicomponent reactions (MCRs) have become important tools for the synthesis of highly functiona... more Multicomponent reactions (MCRs) have become important tools for the synthesis of highly functionalized organic molecules. This is due to their convergence, simplicity, atom economy, and green characteristics. 1-4 MCRs are quicker and cheaper than conventional reactions, since they are performed by mixing compounds together in one pot, without separating any intermediate. 5 Isocyanide-based MCRs (IMCRs) are especially significant, because of their diversity and flexibility. 6-9 Rhodanine (2-thioxothiazolidin-4-one) is a privileged scaffold and is found in a variety of biologically active compounds, including some with antiviral, 10 antibacterial, 11,12 antifungal, 12,13 antitubercular, 14 anticancer, 15,16 anticonvulsant, 17 and hypnotic activities. 18 Following our interests in isocyanide-based reactions and our studies towards the development of new directions for the synthesis of novel organic compounds with biological activities, 19-21 we now provide a preliminary report on our exploration of the multicomponent reaction of aromatic aldehydes 1 in the presence of aniline 2, rhodanine-N-acetic acid 3 and isocyanides 4 in THF. The reaction affords rhodanine-based amides 5 in good yields (Scheme 1). Initially we examined the reaction of benzaldehyde 1a (1 (R 1 ¼ H), 1.0 mmol), aniline 2 (1.0 mmol), rhodanine-N-acetic acid 3 (1.0 mmol), and tert-butyl isocyanide 4a (4 (R 2 ¼ t-Bu), 1.0 mmol) in tetrahydrofuran (THF) at room temperature as a model reaction. This condensation reaction did not afford the expected Ugi product 6a (6, R 1 ¼ H, R 2 ¼ t-Bu). Instead, 2-(5-benzylidene-4-oxo-2-thioxo-thiazolidin-3-yl)-N-tertbutyl-acetamide 5a, was obtained in 90% yield (Scheme 1, see Experimental Section for full structural characterization). In fact, it seems clear that the Knoevenagel condensation between benzaldehyde and rhodanine-N-acetic acid in the presence of aniline proceeds much faster than the Ugi reaction. Even with 2.0 mmol benzaldehyde in the model reaction under reflux conditions, we found compound 5a as the main product (91%) with only a trace amount of the Ugi product 6a. In the absence of aniline, even after 24 h at reflux, only starting materials were recovered. Additionally, the reaction of
Research on Chemical Intermediates, 2022
Today, plant extracts based on synthetic procedures have drawn consideration over conventional me... more Today, plant extracts based on synthetic procedures have drawn consideration over conventional methods like physical and chemical procedures to synthesize nanomaterials. Green synthesis of nanomaterials has become an area of interest because of numerous advantages such as non-hazardous, economical, and feasible methods with a variety of applications in biomedicine, nanotechnology and nano-optoelectronics and as catalysts for various organic transformations. In this research, silver nanoparticles were deposited on the surface of nano-silica spheres by an in-situ reduction of Ag+ ions using an aqueous extract of Thymus kotschyanus aerial parts as a natural reducing and a capping agent. The result recorded from ultraviolet–visible (UV–Vis) spectrometer, Fourier transform infrared spectroscopy (FT-IR), thermal gravimetric analysis, scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM–EDS) and X-ray powder diffraction supports the biosynthesis and characterization of Ag/SiO2 nanoparticles. The results indicated that the average size of Ag/SiO2 nanoparticles is 25–60 nm. The Ag/SiO2 nanoparticles act as an environmentally friendly heterogeneous catalyst in the synthesis of spirooxindoles via the three-component condensation reaction of isatins, activated methylene reagents, and 1,3-dicarbonyl compounds in aqueous media, and the desired products were obtained with yields ranging from 90 to 98%. The catalyst can be recovered easily and used repetitively without significant loss of catalytic activity.
Ionic liquid <i>N</i>,<i>N</i>,<i>N′</i>,<i>N′</i>... more Ionic liquid <i>N</i>,<i>N</i>,<i>N′</i>,<i>N′</i>-tetramethylguanidinium trifluoroacetate (TMGT) has been applied as a green and reusable catalyst for the one-pot synthesis of 10-aryl substituted-9,10-dihydropyrano[2,3-<i>h</i>]chromene-2,8-diones via reaction of various aromatic aldehydes, 5,7-dihydroxycoumarin derivatives and Meldrum's acid. The reactions were rapid, clean and the products were prepared in good yield. The ionic liquid was stable during the reaction process and reused without significant loss of its activity. The synthesised compounds were evaluated for their antioxidant activity by a 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay. Lasemi et al. 'Efficient synthesis of 9,10-dihydropyrano[2,3-h]chromene-2,8-dione derivatives in ionic liquid and the study of their antioxidant activity'
Journal of the Iranian Chemical Society, 2022
An electrochemical DNA hybridization biosensor developed based on graphite screen-printed electro... more An electrochemical DNA hybridization biosensor developed based on graphite screen-printed electrodes (GSPEs) modified with Fe3O4@SiO2/DABCO was used for detection of short-sequence DNA of prostate cancer gene by using two different methods including direct and indirect. The proposed sensor was prepared by immobilization of a 19-mer ssDNA probe on the modified GSPEs surface for detecting the hybridization between the probe and its complementary and non-complementary sequence of the prostate cancer gene as a target. The hybridization process was detected based on the differential pulse voltammetric signals of the guanine oxidation and the hemin reduction as an electrochemical indicator through direct and indirect methods, respectively. The selectivity of the biosensor was studied by the using of non-complementary oligonucleotide strands capable of distinguishing complementary and non-complementary DNA sequence of the prostate cancer gene. The peak current intensity of guanine oxidation and hemin reduction showed an enhancement by increasing the concentrations of complementary strands from 1.0 × 10–11 to 2.0 × 10–6 M and 7.5 × 10–12 to 2.0 × 10–6 M, respectively. The limits of detection, LOD (based on 3σ), were found as 8.0 × 10–12 M and 6.4 × 10–12 M for direct and indirect detection methods, respectively.
Hacia un derecho administrativo, fiscal y medioambiental romano IV. Volumen II. Derecho fiscal y miscelánea., 2021
Materiali in tehnologije, 2016
To improve the solubility, thermal properties and processability of polyxanthones, a new class of... more To improve the solubility, thermal properties and processability of polyxanthones, a new class of polyxanthones, poly(xanthone-imide)s (PXIs), with a high yield was prepared using a two-step chemical imidation of 2,7-diaminoxanthone with pyromellitic dianhydride (PMDA), 3,3',4,4'-benzophenone tetracarboxylic dianhydride (BTDA) and 2,2'-bis-(3,4-dicarboxyphenyl) hexafluoropropane dianhydride (6-FDA)). These PXIs were characterized with FT-IR and 1 H NMR spectroscopies. They presented a good solubility in aprotic polar solvents such as N,N-dimethyl acetamide (DMAc), N,N-dimethyl formamide (DMF), N-methyl pyrrolidone (NMP) and dimethyl sulfoxide (DMSO), and showed inherent viscosities in a range of 0.34-0.58 dL/g. These PXIs exhibited lower glass-transition temperatures than the original polyxanthones and a high thermal stability. The obtained results of the UV-vis absorption and photoluminescence indicated that the maximum absorption and fluorescence emission of PXIs were in the range of 300-304 nm and 432-510 nm, respectively. The antioxidant activity of PXIs was evaluated with a DPPH assay. The antioxidant values for PXIs were greater than for the parent xanthone (X). The polyimides were investigated for the extraction of environmentally noxious metal ions such as Cr (VI), Co (II), Ni (II), Cu (II), Pb (II) and Cd (II) from aqueous solutions.
Acta Poloniae Pharmaceutica - Drug Research, 2012
Antioxidant and antihemolytic activities of acetone extracts of Hyssopus angustifolius flowers, l... more Antioxidant and antihemolytic activities of acetone extracts of Hyssopus angustifolius flowers, leaf and stems were investigated employing different in vitro and ex vivo assay systems. IC50, for 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical-scavenging activity were 239.4 +/- 8.4 microg/mL for flowers, 357.8 +/- 11.1 microg/mL for stems and 182.5 +/- 7.5 microg/mL for leaf. All extracts showed moderate nitric oxide scavenging activity. The leaf extract exhibited better hydrogen peroxide scavenging and Fe2+ chelating activity than the others (IC50 were 261.0 +/- 6.2 microg/mL for hydrogen peroxide and 534.0 +/- 9.9 microg/mL for Fe3+ chelating activity). The extracts exhibited good antioxidant activity in linoleic acid peroxidation system and weak reducing power ability. The leaf extract showed better antihemolytic activity than the flower and stem (IC50 = 65.7 +/- 1.8 microg/mL).
This study was designed to evaluate antioxidant and antihemolytic activities of Hyssopus angustif... more This study was designed to evaluate antioxidant and antihemolytic activities of Hyssopus angustifolius flower, stem and leaf methanol extracts by employing various in vitro assays. The leaf extract showed the best activity in DPPH (63.2 ± 2.3 μg mL -1 ) and H 2 O 2 (55.6 ± 2.6 μg mL -1 ) models compared to the other extracts. However, flower extract exhibited the highest Fe 2+ chelating activity (131.4 ± 4.4 μg mL -1 ). The extracts exhibited good antioxidant activity in linoleic acid peroxidation and reducing power assays, but were not comparable to vitamin C. The stem (23.58 ± 0.7 μg mL -1 ) and leaf (26.21 ± 1 μg mL -1 ) extracts showed highest level of antihemolytic activity than the flower extract.
Polycyclic Aromatic Compounds
Polymer Engineering & Science
Industrial Crops and Products
Abstract Drought stress often reduces plant growth. Therefore, in order to decrease the negative ... more Abstract Drought stress often reduces plant growth. Therefore, in order to decrease the negative effect of drought stress on rosemary growth and prevent its severe reduction, an experiment was carried out through drought stress treatments along with increasing tolerance and quality of plant using salicylic acid in 2014 at the Research Institute of Forests and Rangelands (Iran) under field conditions. The experiment was conducted as split-plot in a randomized complete block design with three replications. The main factor included drought stress at three levels of 30 % (severe stress), 60 % (mild stress) and 90 % (control) of field capacity, and the subfactor was the salicylic acid foliar application at four levels of 0, 1, 2, and 3 mM. According to the results, the most suitable levels of stress and salicylic acid treatments for the production of essential oil was 60 % FC and 1 as well as 2 mM salicylic acid, respectively. Rosemary is one of the most drought tolerant plants with an annual consumption of 4500 to 5500 m3 of water per hectare in a growth period. Also, a mild stress – 60 % of the field capacity- would be produced the optimum production of this plant.
Environmental Chemistry Letters
The combination of two or more different heterocyclic moieties in a single molecule would enhance... more The combination of two or more different heterocyclic moieties in a single molecule would enhance biological activity significantly. The indole and furan scaffolds are promising candidates in drug design, and they have been widely found in natural products and therapeutic agents. Owing to their pharmaceutical importance, there is an urgent need to design rapid, efficient and environmentally benign protocols for the synthesis of indole–dihydrofuran biheterocycles. Herein, we have developed a novel ecofriendly approach for the diastereoselective synthesis of indole-based 4,5-dihydrofurans through a three-component reaction of 3-cyanoacetyl indoles with various aldehydes and N-phenacylpyridinium bromides in the presence of potassium carbonate as an inexpensive and non-toxic base in water under low power microwave irradiation. The findings show that aromatic and heteroaromatic aldehydes tolerated well in this reaction. The products were obtained in 85–98% yields in 4–20 min. The advantages of this method consist of the environmental friendly reaction conditions, use of green solvent and safe base, availability of raw materials, wide range of usable substrates, short reaction times, excellent yields and absence of any tedious workup or purification.