Raziye Akcılar - Academia.edu (original) (raw)

Papers by Raziye Akcılar

Bratislava Medical Journal, 2020

AIMS: Hypoxic ischemic encephalopathy is one of the main causes of neonatal deaths. The objective... more AIMS: Hypoxic ischemic encephalopathy is one of the main causes of neonatal deaths. The objective of this study was to evaluate the neuroprotective effect of antioxidant and anti-infl ammatory properties of sodium hydrosulfi de (NaHS) in neonatal rats with hypoxic ischemic encephalopathy, as well as its effect on neuronal apoptosis through histopathological and biochemical tests. METHODS: Forty-seven-day-old rats with induced hypoxia-ischemia (HI) were randomly separated into four groups. Half an hour after the induction of hypoxic-ischemia, serum physiological (SF), 50 μmol/kg NaHS, or 100 μmol/kg NaHS were intraperitoneally given to the rats. RESULTS: Apoptotic cells in the brain tissue of rats in HI + NaHS 50 μmol/kg, and HI + NaHS 100 μmol/kg groups decreased compared to HI group (p = 0.00). While HI + NaHS 50 μmol/kg and HI + NaHS 100 μmol/ kg groups yielded no difference in TNF-α, IL-6, and iNOS levels as compared to the HI group, an increase in NGF was detected in the 50 μmol/kg and 100 μmol/kg NaHS groups (p = 0.34, p = 0.24, p = 0.26, p = 0.026, p = 0.017). When TOS, TAS and OSI levels were compared, an increase in TAS and OSI and a decrease in TOS were observed in the treatment groups as compared to HI group. CONCLUSIONS: NaHS given to hypoxic-ischemic encephalopathy model signifi cantly decreased apoptosis in neurons and had a neuroprotective effi cacy with an increase in NGF levels (Tab.

The Turkish Journal of Pediatrics

Journal of Maternal-fetal & Neonatal Medicine, Nov 22, 2022

Osmangazi tıp dergisi, Oct 5, 2022

Necrotizing enterocolitis (NEC) is the most common gastrointestinal problem in premature infants.... more Necrotizing enterocolitis (NEC) is the most common gastrointestinal problem in premature infants. The aim of this study is to evaluate the protective and antioxidant effects of silymarin (SLY) in newborn rats with NEC model. Twenty-eight Sprague-Dawley rats were included in the study. The rats were randomized into four groups: control (C), C+SLY, NEC and NEC+SLY. NEC was induced by hyperosmolar enteral formula feeding, and the pups were exposed to hypoxia and cold stress. Macroscopic scoring of the intestinal tissue was evaluated and tissue samples were obtained for biochemical, histopathological examination. Superoxide dismutase (SOD), glutathione peroxidase (GPx), nitric oxide (NO), malondialdehyde (MDA), total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) levels were biochemically evaluated. Results: In the NEC + SLY group, there was a considerable rise in tissue TAS (p = 0.007), SOD (p = 0.004) and GPx levels, as well as a decrease in NO levels. Significantly higher tissue MDA, TOS (p = 0.001) and OSI (p = 0.001) values were detected in the NEC group. The intestinal tissue of rats in the NEC + SLY group had better histopathology than rats in the NEC group when evaluated. Silymarin has beneficial effects against NEC in neonatal rat. It appears that SLY reduces free radical levels and oxidative stress, increases antioxidant capacity, and ameliorates the severity of intestinal damage due to NEC

Bratislavské lekárske listy, 2020

Journal of The European Academy of Dermatology and Venereology, Oct 10, 2011

Background Acne vulgaris is a multifactorial disease of the skin. Several studies have shown tha... more Background Acne vulgaris is a multifactorial disease of the skin. Several studies have shown that elevated levels of serum insulin‐like growth factor‐I (IGF‐I) correlate with overproduction of sebum and acne. Recently functional relationship between IGF‐I (CA) polymorphism and circulating IGF‐I levels in adults has been reported.

The Journal of Maternal-Fetal & Neonatal Medicine

Journal of Neurological Sciences-turkish, 2014

Clinical Hemorheology and Microcirculation, 2014

Apelin is a hypotensive peptide. Red blood cell (RBC) deformability and aggregation were previous... more Apelin is a hypotensive peptide. Red blood cell (RBC) deformability and aggregation were previously demonstrated to be altered in various hypertension (HT) models. In the present study, we investigated possible alterations in RBC deformability and aggregation in response to apelin in DOCA-salt hypertensive rats. Rats were randomly divided into 4 groups: Control (C), Hypertension (HT), Apelin, and Apelin + Hypertension (Apelin + HT). HT was induced by injection of DOCA-salt (25 mg/kg, s.c.) twice weekly for 4 weeks, whereas apelin was administered (200 μg/kg i.p.) for 17 days. RBC deformability and aggregation were determined using an ektacytometer. Blood pressure was monitored using a tail cuff system. Systolic blood pressure was decreased in the Apelin and Apelin + HT groups and increased in the HT group. RBC deformability was not significantly altered in the HT group. Apelin administration induced a statistically significant increase in RBC deformability in control animals, whereas erythrocytic deformability in the Apelin + HT group was decreased compared to the Apelin group. RBC aggregation of hypertensive animals was reduced compared to controls. Apelin administration induced increased RBC aggregation in hypertensive rats. Our results showed favorable effects of apelin on RBC deformability in control animals, but not in hypertensive rats.

Hemodialysis International, Jul 4, 2016

Introduction: Increasing evidence suggests that inflammation and increased macrophage activity ha... more Introduction: Increasing evidence suggests that inflammation and increased macrophage activity have a central role in pathogenesis of atherosclerosis. It is shown that chitotriosidase (CHIT‐1) is a marker of macrophage activity in atherosclerotic plaque, and is found associated with severity of atherosclerotic lesion. There is no data about CHIT‐1 activity of hemodialysis patients in the literature. Thus, we hypothesized that in hemodialysis patients, CHIT‐1 levels might be a novel biomarker in early atherosclerosis. Methods: Forty‐five hemodialysis patients were included in the study (age: 61.93 ± 13.34). Intima media thickness (IMT) was evaluated with high‐resolution B‐mode ultrasonography. Biomarker levels were measured in serum of patients. Findings: We found positive correlation among IMT, age (R: 0.426, P: 0.004) and, CHIT‐1 value (R: 0.462, P: 0.001) in spearman correlation analysis. When age, CRP, creatinine, P, Alb, CHIT‐1 were chosen as measures that can effect IMT in multiple regression model, IMT level was related with CHIT‐1 (Beta: 0,396, P: 0.012) and age (Beta: 0,313 P: 0,048) independently. Discussion: In conclusion, this is the first report showing that serum CHIT‐1 level was related independently with carotid IMT in hemodialysis patients. This biomarker might have an unknown role in the development of atherosclerosis during uremia.

Renal Failure, Oct 19, 2016

Aim: MicroRNAs (miR) are important diagnostic and treatment targets due to their different tissue... more Aim: MicroRNAs (miR) are important diagnostic and treatment targets due to their different tissue expressions and their central position in the regulation of gene expressions. miR studies might pioneer emerging of new diagnostic tools and treatment goals in kidney diseases. Captopril (CAP) and telmisartan (TEL) were shown to be effective in ischemia reperfusion (IR) injury. There is not any study about the effect of TEL and CAP over miR-21-320-146a. Our aim was to study the effects of CAP and TEL over miR on renal IR model. Methods: We used 12-16 weeks-old Wistar-Albino rats that weigh 300-350 g. Rats (n, 6) were randomized into four groups (Control, IR, IR þ CAP, IR þ TEL). Urea, creatinine, total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), super oxide dismutase (SOD), and miRs were analyzed. Results: Urea, creatinine, TOS, OSI levels of IR þ CAP, and IR þ TEL groups were lower comparing to IR group. TAS and SOD levels were higher in IR group than IR þ TEL group. miR-21-320-146a showed increase in renal IR injury. miR-320, 146a showed significant decrease in IR þ CAP and IR þ TEL groups comparing to IR group. We showed histopathological recovery and decreased apoptosis in IR þ CAP and IR þ T groups than IR group. Conclusion: We, for the first time in the literature, showed that miR-320 is increased in IR injury. miR-320 might be a novel diagnosis and treatment target in renal ischemic reperfusion injury. Also, for the first time, we showed that CAP and TEL cause functional and histopathological recovery and lower miR-146a and miR-320.

Journal of Surgical Research, May 1, 2015

Background: The purpose of this study is to investigate the potential protective effect of the uk... more Background: The purpose of this study is to investigate the potential protective effect of the ukrain on ischemia-reperfusion (IR) injury in rat intestine, which has not previously been studied. Methods: Thirty-one male Sprague-Dawley rats were randomly assigned to four groups, each consisting of 8 rats: (1) a sham group (S) (laparotomy, but no IR injury); (2) Ukrain group (U) (no IR, and Ukrain was administered intraperitoneally one hour before laparotomy); (3) intestinal ischemia-reperfusion (II/R) group (30 min occlusion of the superior mesenteric artery (SMA) then two hour reperfusion); (4) Ukrain + II/R group (U + II/R) (30 min occlusion of the SMA then two hour reperfusion; Ukrain was administered intraperitoneally one hour before ischemia-reperfusion). Results: Serum total oxidant status (TOS) and total antioxidant status (TAS) were measured using Erel's method. Oxidative stress index (OSI) was calculated using the TOS/TAS ratio. TAS levels increased and TOS serum levels were also significantly decreased in the Ukrain + IR group compared with the IR group (respectively p = 0.000 and p= 0.015). Conclusions: In this study, we demonstrated for the first time in the literature that ukrain helps to prevent intestinal tissue breakdown against intestinal ischemia-reperfusion injury and that this effect can be achieved by antioxidant activities.