René Holst - Academia.edu (original) (raw)

Papers by René Holst

Research and Practice in Thrombosis and Haemostasis

Trials

Background Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used to treat sciatica, despi... more Background Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used to treat sciatica, despite insufficient evidence from placebo-controlled trials. NSAIDs may cause serious side effects; hence, there is a strong need to clarify their potential beneficial effects in patients with sciatica. Methods This is a multicentre, randomized, placebo-controlled, parallel-group superiority trial. Participants will be recruited among sciatica patients referred to outpatient clinics at hospitals in Norway who have radiating pain below the knee with a severity score of ≥ 4 on a 0–10 numeric rating scale and clinical signs of nerve root or spinal nerve involvement. The intervention consists of oral naproxen 500 mg or placebo twice daily for 10 days. Participants will report the outcomes and adverse events daily using an electronic case report form. The primary endpoint is change in leg pain intensity from baseline to day 10 based on daily observations. The secondary outcomes are back pain inte...

Chilean Journal of Statistics, 2015

We propose a versatile class of multiplicative generalized linear longitudinal mixed models (GLLM... more We propose a versatile class of multiplicative generalized linear longitudinal mixed models (GLLMM) with additive dispersion components, based on explicit modelling of the covariance structure. The class incorporates a longitudinal structure into the random effects models and retains a marginal as well as a conditional interpretation. The estimation procedure is based on a computationally efficient quasi-score method for the regression parameters combined with a REML-like bias-corrected Pearson estimating function for the dispersion and correlation parameters. This avoids the multidimensional integral of the conventional GLMM likelihood and allows an extension of the robust empirical sandwich estimator for use with both association and regression parameters. The method is applied to a set of otholit data, used for age determination of fish.

Frontiers in Microbiology, 2017

BMC health services research, Jan 29, 2017

Decentralised acute care services have, through the establishment of municipality acute wards (MA... more Decentralised acute care services have, through the establishment of municipality acute wards (MAWs), been launched in Norway. The aim is to provide treatment for patients who otherwise would need hospitalisation. Currently there is a lack of studies investigating patient experiences in such services. The aims of this study were therefore to a) translate and validate the Picker Patient Experience Questionnaire (PPE-15) in Norwegian, and b) assess patient experiences in decentralised acute care, and potential factors associated with these experiences. Patients were recruited from five municipal acute wards in southeastern Norway during the period from June 2014 to June 2015. Data on socio-demographics, length of stay and comorbidity (Charlson comorbidity index (CCI)) were collected. Patients completed the Picker Patient Experience Questionnaire (PPE-15) and the EuroQOL 5-dimension, 3-level version. Convergent validity of the PPE-15 was assessed by correlation of items in PPE-15 and t...

Rhinology, 2013

The European Position Paper on Rhinosinusitis and Nasal Polyps (EP3OS) incorporates symptomatic a... more The European Position Paper on Rhinosinusitis and Nasal Polyps (EP3OS) incorporates symptomatic and endo- scopic criteria in the clinical diagnosis of chronic rhinosinusitis (CRS), while in epidemiological studies the definition is based on symptoms only. The aim of this study was to evaluate the correlation between questionnaire-based and clinical-based CRS. Based on the GA2LEN postal survey data a total of 366 persons participated at the follow-up at the Danish centre and provided information on questionnaire-based CRS. At the same occasion the 366 participants underwent clinical inter- view and examination by an otorhinolaryngologist to provide information for a clinical-based CRS diagnosis. The association between questionnaire-based and clinical-based CRS diagnosis was determined using logistic regression models and kappa statistics. Mean age of respondents to the postal questionnaire was 45.3 years and 52.9% were female. Persons with asthma were 8.4 % and 26.2 % were actual sm...

... fish”. The modal length of the selection curve for the thin twine was significantly higher fo... more ... fish”. The modal length of the selection curve for the thin twine was significantly higher for the first trials (in agreement with the supposition that thinner twines catch larger fish). ... 974. Madsen, N., Hoist, R., and Foldager, L. 1999a. ...

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Selektivitets analyser, 1999

Page 1. STATISTISK MODELLERING I REDSKABS FORSØG SIDE 1 Statistisk modellering i redskabs forsøg ... more Page 1. STATISTISK MODELLERING I REDSKABS FORSØG SIDE 1 Statistisk modellering i redskabs forsøg Selektivitets analyser René Holst ConStat Nordsøcentret 9850 Hirtshals rene@constat.dk www.constat.dk Indledning ...

ICES CM, 1999

Within the EU-financed BACOMA-project a fishing experiment was designed to assess the effect of v... more Within the EU-financed BACOMA-project a fishing experiment was designed to assess the effect of vessel-size, hauling technology and vessel-gear interaction upon codend selectivity in Baltic cod fishery. Seven commercial trawlers were randomly chosen ...

Scandinavian Journal of Medicine & Science in Sports, 2013

The objectives of this prospective cohort study were to report the incidence, prevalence, and dur... more The objectives of this prospective cohort study were to report the incidence, prevalence, and duration of traumatic and overuse injuries during a period of 2.5 years and to estimate the odds of injury types. In all, 1259 schoolchildren, aged 6-12, were surveyed each week with an automated mobile phone text message asking questions on the presence of any musculo-skeletal problems and participation in leisure-time sport. Children were examined and injuries classified as overuse or traumatic. The overall injury incidence and prevalence were 1.2% and 4.6% per week, with 2.5 times more overuse than traumatic injuries in lower extremities, and mean injury duration of 5.3 and 4.8 weeks, respectively. A reverse pattern was found for upper extremities, with 3.1 times more traumatic than overuse injuries and mean durations of 3.3 and 5.2 weeks, respectively. Grade level, school type, leisure-time sport, and seasonal variation were associated with the risk of sustaining lower extremity injuries. Only grade level was associated with upper extremity injuries. The magnitude of overuse and traumatic limb injuries emphasizes the need for health professionals, coaches, and parents to pay special attention in relation to the growing and physically active child.

Preventive Medicine, 2013

Objective. To evaluate the effect of a school based physical education (PE) program and the amoun... more Objective. To evaluate the effect of a school based physical education (PE) program and the amount of leisure time sport (LTS) on children's bone health and to examine if LTS influences the impact of school type on children's bone health. Methods. Children attending "sports" schools (6 × 45 min PE lessons per week) were compared to children at "traditional" schools (2 × 45 min of PE lessons per week) in Svendborg, Denmark. Whole-body DXA scans were performed at baseline (2008) and at a two-year follow-up (2010). Bone mineral content (BMC), bone mineral density (BMD), and bone area (BA) were measured. Multilevel regression analyses examined the impact of school type and LTS participation on bone. Results. 742/800 (93%) invited children accepted to participate. 682/742 (92%) participated at two-year follow-up. Mean (SD) age was 9.5 years (0.9) at baseline. A positive association between LTS and BMC, BMD (p b 0.001) and for BA (p b 0.05) (total body less head (TBLH) and lower limb (LL)) was found. All effects regarding school type were insignificant. Conclusion. A positive impact of attending LTS on bone traits was found. There was no effect on BMC, BMD and BA (TBLH, and LL) for children attending sports schools compared to traditional schools.

Fisheries Science, 2012

A substantial improvement in the bycatch selectivity of Norway lobster Nephrops norvegicus trawls... more A substantial improvement in the bycatch selectivity of Norway lobster Nephrops norvegicus trawls is required, particularly with respect to cod Gadus morhua, whose stocks are at low levels in several areas. Conventional escape windows are not adequate to properly release cod and other bycatch species caught in the trawls. To address this issue, we developed a novel sorting box concept consisting of a four-panel section with a window on the top in order to improve the escape of cod and other bycatch species through an escape window while retaining the target catch of Norway lobster. The concept was tested on a commercial trawler in Kattegat and Skagerrak. Two different window mesh sizes and two different sorting box heights were tested using a traditional codend cover and a dual codend cover. We observed greatly reduced bycatches of both cod and other fish species compared to a standard codend. The reduction in bycatch decreased with decreasing mesh size and increasing height of the sorting box. Escape of Norway lobster through the escape window was limited. A modified version of the sorting box concept was implemented in the Kattegat fishery from 2009 onwards.