Renata Navarro Cassu - Academia.edu (original) (raw)

Papers by Renata Navarro Cassu

Journal of Acupuncture and Meridian Studies, Aug 31, 2022

Journal of Acupuncture and Meridian Studies

Background: Pharmacopuncture is an acupuncture-related technique that has been used to amplify th... more Background: Pharmacopuncture is an acupuncture-related technique that has been used to amplify the therapeutic effects of different medications. Objectives: To investigate the analgesic efficacy of a lidocaine injection at acupoints in cats undergoing ovariohysterectomy. Methods: Thirty cats were randomly distributed into two groups (n = 15, per group). The experimental group received a bilateral administration of lidocaine at the following acupoints: Stomach 36 (ST-36) and Spleen 6 (SP-6) (Lido group). The control group did not receive lidocaine (Control group). All cats were sedated with dexmedetomidine and anesthesia was induced with propofol and maintained with isoflurane. Intraoperatively, fentanyl was given to control cardiovascular responses to surgical stimulation. Postoperative pain was assessed at various time points, up to 24 hours after extubation, using the UNESP-Botucatu multidimensional composite pain scale (MCPS) and Glasgow feline composite measure pain scale (CMPS-Feline). Sedation scores were measured at the same time points. Morphine/meloxicam was administered as rescue analgesia. Data were analyzed using t-tests, Fisher´s exact test, the Mann-Whitney test, and the Friedman test (p < 0.05). Results: Intraoperatively, more cats in the Control group required analgesic supplementation than those in the Lido group, but the difference was not significant (p = 0.65). Postoperative pain, sedation scores, and analgesic requirements did not differ between groups. Rescue analgesia was given to 67% (10/15) of the cats in each group. Conclusion: The administration of lidocaine at ST-36 and SP-6 acupuncture points did not provide significant perioperative analgesic benefits in healthy cats undergoing ovariohysterectomy.

Journal of Acupuncture and Meridian Studies, Apr 30, 2022

Gabapentin as an adjuvant for postoperative pain management in dogs undergoing mastectomy

The aim of this study was to evaluate the analgesic effects of adjunctive gabapentin for postoper... more The aim of this study was to evaluate the analgesic effects of adjunctive gabapentin for postoperative pain control in dogs. Twenty dogs (10.5 ± 3.0 years; 3.3 to 34 kg ASA II and III) were randomly distributed into two groups of 10 animals each and received: 10 mg/ kg orally gabapentin solution (Gabapentin) every 12 hours starting 120 min prior to surgery or an equivalent volume of vehicle (Placebo). All animals were premedicated IM with acepromazine (0.03 mg/kg) in combination with morphine (0.5 mg/kg). Twenty minutes later, continuous IV infusion of morphine (0.1 mg/kg/h) was initiated and maintained until the end of the surgical procedure. Anesthesia was induced and maintained with propofol (dose effect, IV) and isoflurane, respectively. Meloxicam (0.2 mg/kg IV) was administered prior to surgery and was maintained at a daily dose of 0.1 mg/kg PO, for 10 days. Postoperative analgesia was assessed by a blinded observer for 72 hours after extubation, using the Dynamic and Interacti...

This study evaluates the application of laser acupuncture points adjuvant to control postoperativ... more This study evaluates the application of laser acupuncture points adjuvant to control postoperative pain in cats. In a blind study, a total of 20 healthy cats, undergoing ovariosalpingohysterectomy (OSH), were randomly distributed in two groups with 10 animals each: Laser: application of infra-red laser (wavelength: 904 nm, frequency: 124 Hz and power: 3 J/cm2) on 36 acupoints in the stomach and 6 in the spleen-pancreas, bilaterally, for 9 seconds at each point; Control: did not receive stimulus on the acupuncture points. All animals were sedated with a combination of ketamine (5 mg/kg), midazolam (0.5 mg/kg) and tramadol (2 mg/kg), intramuscular. Fifteen minutes later, laser acupuncture started in the cats of the Laser group. Propofol (3 mg/kg, IV) and isoflurane were used to induce and maintain anesthesia, respectively. The surgeries were performed by the same surgeon using the average celiotomy technique. Postoperatively, the degree of analgesia was measured by an observer unware ...

RESUMO A Arnica montana homeopatica vem sendo utilizada ha muitos anos para favorecer a recuperac... more RESUMO A Arnica montana homeopatica vem sendo utilizada ha muitos anos para favorecer a recuperacao pos-operatoria. Objetivou-se comparar a recuperacao pos-operatoria, incluindo avaliacao de dor, alteracao neuroendocrina e edema, em caes medicados com meloxicam isolado ou associado a Arnica montana CH12. Foram avaliadas 14 cadelas, em estudo duplo-cego, encaminhadas para realizacao de ovariossalpingohisterectomia eletiva. Todos os animais foram pre-medicados com acepromazina 0,2% (0,05 mg/kg iv), com inducao anestesica com tiopental sodico (12,5 mg/kg), seguindo-se manutencao com anestesia geral inalatoria, com halotano. Os animais foram distribuidos em dois grupos: GM (n=7): tratamento com meloxicam (0,2 mg/kg, iv), 5 minutos antes da incisao cirurgica e durante 3 dias apos a cirurgia. GA: tratamento com Arnica montana CH12, 15 dias antes do inicio do experimento, mantendo-se ate 3 dias apos a cirurgia (5 globulos, 3 vezes ao dia), alem do tratamento com meloxicam, semelhante ao ef...

Brazilian Journal of Veterinary Research and Animal Science, 2004

Anestesiologia o término da administração do anestésico até a ausência da resposta dolorosa provo... more Anestesiologia o término da administração do anestésico até a ausência da resposta dolorosa provocada pelo pinçamento da região interdigital e da pele, tanto da porção cranial do rádio, quanto das porções cranial e lateral do úmero. A resposta dolorosa foi comprovada através da atitude do animal (resposta'cornportamental), frente aos estímulos dolorosos. Esta resposta comportamental foi identificada através da presença de meneios de cabeça, vocalização, tentativa de mordedura e movimentos de outras partes do corpo; c) Tempo de instalação do bloqueio motor ou tempo de latência motora: período transcorrido entre o término da administração do anestésico até a ausência da resposta motora provocada pelo pinçamento da região interdigital e da pele, tanto da porção cranial do rádio, quanto das porções cranial e lateral do úmero. A resposta motora foi comprovada através da flexão do membro após os pinçamentos. O resultado obtido no grupo GI foi de 85,71 % de eficácia, concordando com Baranowski e demonstrando a eficácia do estimulador de nervos periféricos. Já no grupo GIl foi obtido 71,42% de eficácia, sendo este último resultado semelhante ao de Moens e Caulkett. Em relação ao tempo de latência motora e sensitiva, respectivamente, o GI obteve 7,5 e 15,3 minutos, enquanto que o GIl obteve uma leve diferença, atingindo o tempo de latência motora de 9,4 e sensitiva de 15,8 minutos. Mediante os resultados obtidos pode-se concluir que as duas técnicas são factíveis de serem empregadas na prática veterinária. Contudo, a opção pela técnica da estimulação de nervos periféricos depende da disponibilidade do aparelho estimulador de nervos. Anestesia epidural com ropivacaína ou lidocaína isolada ou associada à xilazina em cães

A acupuntura é uma antiga arte da terapêutica chinesa, empregada para o tratamento de diversas en... more A acupuntura é uma antiga arte da terapêutica chinesa, empregada para o tratamento de diversas enfermidades, sendo capaz de promover analgesia – sobretudo a eletroacupuntura (EA) –, com as vantagens de ser um método prático, de baixo custo, além de permitir o tratamento da dor com mínimos efeitos colaterais. O uso da acupuntura para fins analgésicos em procedimentos cirúrgicos ou pós-cirúrgicos é recente. No final da década de 70, foram registrados os primeiros procedimentos cirúrgicos realizados com eletroacupuntura, tanto na Medicina como na Medicina Veterinária. A EA é indicada para o tratamento de processos crônicos, doenças envolvendo o sistema nervoso central e neuropatias periféricas, indução de analgesia em casos de dor aguda e crônica e também para obtenção de hipoalgesia cirúrgica.

Journal of Veterinary Pharmacology and Therapeutics, 2020

Magnesium may be used as an adjunctive analgesic for perioperative pain management because of its... more Magnesium may be used as an adjunctive analgesic for perioperative pain management because of its antinociceptive properties. This study investigated the analgesic efficacy of intraperitoneal ropivacaine combined with magnesium sulfate in canine ovariohysterectomy. Forty-five dogs sedated with acepromazine/meperidine and anesthetized with propofol/isoflurane were randomly distributed into three treatments, administered intraperitoneally (n = 15 per group): saline solution (group S), 0.25% ropivacaine (3 mg/kg) alone (group R), or in combination with magnesium sulfate (20 mg/kg, group R-Mg). Intravenous fentanyl was given to control cardiovascular responses to surgical stimulation. Postoperative pain was assessed using an Interactive Visual Analog Scale (IVAS), the short form of the Glasgow Composite Pain Scale, and mechanical nociceptive thresholds. Morphine/meloxicam was administered as rescue analgesia. Intraoperatively, the R-Mg group required less fentanyl (p = .02) and exhibited higher incidence of hypotension (systolic arterial pressure <90 mm Hg, p = .006) compared with the S group. Lower IVAS pain scores were recorded during the first hour in the R-Mg group than the other groups (p = .007-.045). Postoperative rescue analgesia did not differ between groups. Intraperitoneal magnesium sulfate administration, in spite of decreasing intraoperative opioid requirements, increased the incidence of hypotension with minimal evidence of postoperative analgesic benefits.

Veterinária e Zootecnia, 2006

Este trabalho objetivou revisar o emprego da máscara laríngea em animais, abordando asprincipais ... more Este trabalho objetivou revisar o emprego da máscara laríngea em animais, abordando asprincipais vantagens e desvantagens, comparativamente à sonda endotraqueal e à máscarafacial, bem como as perspectivas do uso clínico da mesma na anestesiologia veterinária.

Journal of Veterinary Medical Science, 2019

The aim of this study was to compare the effects of laser acupuncture and electroacupuncture on p... more The aim of this study was to compare the effects of laser acupuncture and electroacupuncture on postoperative pain and analgesic requirements in cats. In a prospective, randomized and blinded clinical study, thirty cats undergoing ovariohysterectomy were sedated with intramuscular (IM) ketamine (5 mg/kg), midazolam (0.5 mg/kg), and tramadol (2 mg/ kg). Before the induction of anesthesia, the animals were randomly distributed into three groups of ten cats each: LA: bilateral Stomach 36 (ST-36) and Spleen 6 (SP-6) acupoints were stimulated with an infrared laser; EA: bilateral ST-36 and SP-6 acupoints were stimulated with an electrical stimulus; Control: no acupuncture was applied. Postoperative analgesia was evaluated in the first 24 hr post-extubation using the Interactive Visual Analogue Scale and UNESP-Botucatu Multidimensional Composite Pain Scale. Rescue analgesia was provided with IM tramadol (2 mg/ kg), and the pain scores were reassessed 30 min after the rescue intervention. If the analgesia remained insufficient, meloxicam (0.2 mg/kg IM, single dose) was administered. Data were analyzed using t-tests, the Mann-Whitney U test, and Friedman test. P<0.05 was considered significant. The pain scores did not significantly differ between the treatment groups at any time point (P>0.05). The prevalence of rescue analgesia was significantly higher in the Control group than in the LA and EA groups (P=0.033). Preoperative laser and electroacupuncture reduced the need for rescue analgesia during the first 24 hr after ovariohysterectomy.

Journal of Veterinary Medical Science, 2019

The aim of this study was to evaluate the efficacy and safety of the intra-articular (IA) injecti... more The aim of this study was to evaluate the efficacy and safety of the intra-articular (IA) injection of botulinum toxin type A (BoNT/A) to the management of chronic pain in dogs. In a randomized, controlled, double-blinded study sixteen dogs with osteoarthritis secondary to hip dysplasia were distributed into two groups: 25 IU BoNT/A (BoNT) or saline solution (Control) was administered IA in each affected joint. All dogs received oral supplements (90 days) and carprofen (15 days). The dogs were assessed by a veterinarian on five occasions and the owner completed an assessment form at the same time (baseline to 90 days). The data were analyzed using unpaired-t test, Fisher's exact test, analysis of variance and the Tukey's test (P<0.05). There were no differences between groups in the veterinarian and owner assessments. Lower scores were observed in both groups during 90 days after IA therapy in the owner assessments (P<0.001). Compared with baseline, the Vet score was lower from 15-90 days after IA injection in the BoNT group, and at 15 and 30 days in the Control group (P<0.001). Both treatments were safe and reduced the clinical signs associated with hip osteoarthritis. However, IA BoNT/A (25 IU) did not provide better pain relief than the control treatment.

Semina: Ciências Agrárias, 2015

This study aimed to compare the sedative and cardiopulmonary effects of detomidine in combination... more This study aimed to compare the sedative and cardiopulmonary effects of detomidine in combination with saline, morphine or methadone and to determine whether the addition of these opioids increases the degree of sedation in horses submitted to experimental oral stimuli. In a blinded, randomized, experimental study, six adult mares were evaluated using a crossover design with at least 15 days between trials: 10?g/kg detomidine in combination with saline (D/SAL), 0.1mg/kg morphine (D/ MORPH) or 0.1mg/kg methadone (D/METH). The degree of sedation, response to oral stimuli and cardiopulmonary parameters were monitored for 120 minutes. Parametric data were analyzed using the ANOVA and Tukey’s tests, and non- parametric data were analyzed with the Kruskal-Wallis and Friedman’s tests with the post-Dunn test (P<0.05). The degree of sedation was significantly greater for the D/SAL than for the D/MORPH and D/METH treatments at 30 min. The horses´ responses to the oral stimuli decreased sig...

Evidence-Based Complementary and Alternative Medicine, 2015

The aim of this study was to evaluate laser acupuncture as an adjuvant for postoperative pain man... more The aim of this study was to evaluate laser acupuncture as an adjuvant for postoperative pain management in cats. Twenty cats, undergoing ovariohysterectomy, were sedated with intramuscular (IM) ketamine (5 mg kg−1), midazolam (0.5 mg kg−1), and tramadol (2 mg kg−1). Prior to induction of anaesthesia, the subjects were randomly distributed into two groups of 10 cats: Laser: bilateral stomach 36 and spleen 6 acupoints were stimulated with infrared laser; Control: no acupuncture was applied. Anaesthesia was induced using intravenous propofol (4 mg kg−1) and maintained with isoflurane. Postoperative analgesia was evaluated by a blinded assessor for 24 h following extubation using the Dynamic Interactive Visual Analogue Scale and Multidimensional Composite Pain Scale. Rescue analgesia was provided with IM tramadol (2 mg kg−1), and the pain scores were reassessed 30 min after the rescue intervention. If the analgesia remained insufficient, meloxicam (0.2 mg kg−1IM, single dose) was admin...

The Journal of veterinary medical science / the Japanese Society of Veterinary Science, Jan 29, 2015

This study aimed to evaluate the analgesic efficacy of gabapentin as an adjuvant for postoperativ... more This study aimed to evaluate the analgesic efficacy of gabapentin as an adjuvant for postoperative pain management in dogs. Twenty dogs undergoing mastectomy were randomized to receive perioperative oral placebo or gabapentin (10 mg/kg). All dogs were premedicated with intramuscular acepromazine (0.03 mg/kg) and morphine (0.3 mg/ kg). Anesthesia was induced with propofol (4 mg/kg) intravenously and maintained with isoflurane. Intravenous meloxicam (0.2 mg/kg) was administered preoperatively. Postoperative analgesia was evaluated for 72 hr. Rescue analgesia was provided with intramuscular morphine (0.5 mg/kg). Dogs in the Placebo group received significantly more morphine doses than the Gabapentin group (P=0.021) despite no significant differences in pain scores. Perioperative gabapentin reduced the postoperative morphine requirements in dogs after mastectomy.

RESUMO. Objetivou-se avaliar o efeito cardiorrespiratório e analgésico da anestesia por infusão c... more RESUMO. Objetivou-se avaliar o efeito cardiorrespiratório e analgésico da anestesia por infusão contínua em cães pré-medicados com levomepromazina, distribuídos em 04 grupos. A indução e manutenção anestésicas foram realizadas por via intravenosa com propofol nos grupos G1 (n=6) e G1-OSH (n=8), e propofol/cetamina nos grupos G2 (n=6) e G2-OSH (n=8). Os animais do G1 e G2 foram mantidos anestesiados durante 60 minutos, enquanto os animais do G1-OSH e G2-OSH foram submetidos à ovariosalpingohisterectomia (OSH). Os animais fo-ram mantidos em ventilação controlada, após a indução anestésica. Avaliaram-se eletrocardiografia, frequência cardíaca e respiratória, pressão arterial, temperatura retal, oximetria, capnografia, volume corrente e minuto, pH, bicarbonato e gases sanguíneos no sangue arterial, concentração plasmática de propofol, grau de analgesia, tempo e qualidade de recuperação anestésica. Em todos os grupos houve hipotensão dose-dependente. A qualidade de recuperação foi semelhante entre os grupos, com tempo mais prolongado de recuperação nos grupos G1

Journal of Acupuncture and Meridian Studies, Aug 31, 2022

Journal of Acupuncture and Meridian Studies

Background: Pharmacopuncture is an acupuncture-related technique that has been used to amplify th... more Background: Pharmacopuncture is an acupuncture-related technique that has been used to amplify the therapeutic effects of different medications. Objectives: To investigate the analgesic efficacy of a lidocaine injection at acupoints in cats undergoing ovariohysterectomy. Methods: Thirty cats were randomly distributed into two groups (n = 15, per group). The experimental group received a bilateral administration of lidocaine at the following acupoints: Stomach 36 (ST-36) and Spleen 6 (SP-6) (Lido group). The control group did not receive lidocaine (Control group). All cats were sedated with dexmedetomidine and anesthesia was induced with propofol and maintained with isoflurane. Intraoperatively, fentanyl was given to control cardiovascular responses to surgical stimulation. Postoperative pain was assessed at various time points, up to 24 hours after extubation, using the UNESP-Botucatu multidimensional composite pain scale (MCPS) and Glasgow feline composite measure pain scale (CMPS-Feline). Sedation scores were measured at the same time points. Morphine/meloxicam was administered as rescue analgesia. Data were analyzed using t-tests, Fisher´s exact test, the Mann-Whitney test, and the Friedman test (p < 0.05). Results: Intraoperatively, more cats in the Control group required analgesic supplementation than those in the Lido group, but the difference was not significant (p = 0.65). Postoperative pain, sedation scores, and analgesic requirements did not differ between groups. Rescue analgesia was given to 67% (10/15) of the cats in each group. Conclusion: The administration of lidocaine at ST-36 and SP-6 acupuncture points did not provide significant perioperative analgesic benefits in healthy cats undergoing ovariohysterectomy.

Journal of Acupuncture and Meridian Studies, Apr 30, 2022

Gabapentin as an adjuvant for postoperative pain management in dogs undergoing mastectomy

The aim of this study was to evaluate the analgesic effects of adjunctive gabapentin for postoper... more The aim of this study was to evaluate the analgesic effects of adjunctive gabapentin for postoperative pain control in dogs. Twenty dogs (10.5 ± 3.0 years; 3.3 to 34 kg ASA II and III) were randomly distributed into two groups of 10 animals each and received: 10 mg/ kg orally gabapentin solution (Gabapentin) every 12 hours starting 120 min prior to surgery or an equivalent volume of vehicle (Placebo). All animals were premedicated IM with acepromazine (0.03 mg/kg) in combination with morphine (0.5 mg/kg). Twenty minutes later, continuous IV infusion of morphine (0.1 mg/kg/h) was initiated and maintained until the end of the surgical procedure. Anesthesia was induced and maintained with propofol (dose effect, IV) and isoflurane, respectively. Meloxicam (0.2 mg/kg IV) was administered prior to surgery and was maintained at a daily dose of 0.1 mg/kg PO, for 10 days. Postoperative analgesia was assessed by a blinded observer for 72 hours after extubation, using the Dynamic and Interacti...

This study evaluates the application of laser acupuncture points adjuvant to control postoperativ... more This study evaluates the application of laser acupuncture points adjuvant to control postoperative pain in cats. In a blind study, a total of 20 healthy cats, undergoing ovariosalpingohysterectomy (OSH), were randomly distributed in two groups with 10 animals each: Laser: application of infra-red laser (wavelength: 904 nm, frequency: 124 Hz and power: 3 J/cm2) on 36 acupoints in the stomach and 6 in the spleen-pancreas, bilaterally, for 9 seconds at each point; Control: did not receive stimulus on the acupuncture points. All animals were sedated with a combination of ketamine (5 mg/kg), midazolam (0.5 mg/kg) and tramadol (2 mg/kg), intramuscular. Fifteen minutes later, laser acupuncture started in the cats of the Laser group. Propofol (3 mg/kg, IV) and isoflurane were used to induce and maintain anesthesia, respectively. The surgeries were performed by the same surgeon using the average celiotomy technique. Postoperatively, the degree of analgesia was measured by an observer unware ...

RESUMO A Arnica montana homeopatica vem sendo utilizada ha muitos anos para favorecer a recuperac... more RESUMO A Arnica montana homeopatica vem sendo utilizada ha muitos anos para favorecer a recuperacao pos-operatoria. Objetivou-se comparar a recuperacao pos-operatoria, incluindo avaliacao de dor, alteracao neuroendocrina e edema, em caes medicados com meloxicam isolado ou associado a Arnica montana CH12. Foram avaliadas 14 cadelas, em estudo duplo-cego, encaminhadas para realizacao de ovariossalpingohisterectomia eletiva. Todos os animais foram pre-medicados com acepromazina 0,2% (0,05 mg/kg iv), com inducao anestesica com tiopental sodico (12,5 mg/kg), seguindo-se manutencao com anestesia geral inalatoria, com halotano. Os animais foram distribuidos em dois grupos: GM (n=7): tratamento com meloxicam (0,2 mg/kg, iv), 5 minutos antes da incisao cirurgica e durante 3 dias apos a cirurgia. GA: tratamento com Arnica montana CH12, 15 dias antes do inicio do experimento, mantendo-se ate 3 dias apos a cirurgia (5 globulos, 3 vezes ao dia), alem do tratamento com meloxicam, semelhante ao ef...

Brazilian Journal of Veterinary Research and Animal Science, 2004

Anestesiologia o término da administração do anestésico até a ausência da resposta dolorosa provo... more Anestesiologia o término da administração do anestésico até a ausência da resposta dolorosa provocada pelo pinçamento da região interdigital e da pele, tanto da porção cranial do rádio, quanto das porções cranial e lateral do úmero. A resposta dolorosa foi comprovada através da atitude do animal (resposta'cornportamental), frente aos estímulos dolorosos. Esta resposta comportamental foi identificada através da presença de meneios de cabeça, vocalização, tentativa de mordedura e movimentos de outras partes do corpo; c) Tempo de instalação do bloqueio motor ou tempo de latência motora: período transcorrido entre o término da administração do anestésico até a ausência da resposta motora provocada pelo pinçamento da região interdigital e da pele, tanto da porção cranial do rádio, quanto das porções cranial e lateral do úmero. A resposta motora foi comprovada através da flexão do membro após os pinçamentos. O resultado obtido no grupo GI foi de 85,71 % de eficácia, concordando com Baranowski e demonstrando a eficácia do estimulador de nervos periféricos. Já no grupo GIl foi obtido 71,42% de eficácia, sendo este último resultado semelhante ao de Moens e Caulkett. Em relação ao tempo de latência motora e sensitiva, respectivamente, o GI obteve 7,5 e 15,3 minutos, enquanto que o GIl obteve uma leve diferença, atingindo o tempo de latência motora de 9,4 e sensitiva de 15,8 minutos. Mediante os resultados obtidos pode-se concluir que as duas técnicas são factíveis de serem empregadas na prática veterinária. Contudo, a opção pela técnica da estimulação de nervos periféricos depende da disponibilidade do aparelho estimulador de nervos. Anestesia epidural com ropivacaína ou lidocaína isolada ou associada à xilazina em cães

A acupuntura é uma antiga arte da terapêutica chinesa, empregada para o tratamento de diversas en... more A acupuntura é uma antiga arte da terapêutica chinesa, empregada para o tratamento de diversas enfermidades, sendo capaz de promover analgesia – sobretudo a eletroacupuntura (EA) –, com as vantagens de ser um método prático, de baixo custo, além de permitir o tratamento da dor com mínimos efeitos colaterais. O uso da acupuntura para fins analgésicos em procedimentos cirúrgicos ou pós-cirúrgicos é recente. No final da década de 70, foram registrados os primeiros procedimentos cirúrgicos realizados com eletroacupuntura, tanto na Medicina como na Medicina Veterinária. A EA é indicada para o tratamento de processos crônicos, doenças envolvendo o sistema nervoso central e neuropatias periféricas, indução de analgesia em casos de dor aguda e crônica e também para obtenção de hipoalgesia cirúrgica.

Journal of Veterinary Pharmacology and Therapeutics, 2020

Magnesium may be used as an adjunctive analgesic for perioperative pain management because of its... more Magnesium may be used as an adjunctive analgesic for perioperative pain management because of its antinociceptive properties. This study investigated the analgesic efficacy of intraperitoneal ropivacaine combined with magnesium sulfate in canine ovariohysterectomy. Forty-five dogs sedated with acepromazine/meperidine and anesthetized with propofol/isoflurane were randomly distributed into three treatments, administered intraperitoneally (n = 15 per group): saline solution (group S), 0.25% ropivacaine (3 mg/kg) alone (group R), or in combination with magnesium sulfate (20 mg/kg, group R-Mg). Intravenous fentanyl was given to control cardiovascular responses to surgical stimulation. Postoperative pain was assessed using an Interactive Visual Analog Scale (IVAS), the short form of the Glasgow Composite Pain Scale, and mechanical nociceptive thresholds. Morphine/meloxicam was administered as rescue analgesia. Intraoperatively, the R-Mg group required less fentanyl (p = .02) and exhibited higher incidence of hypotension (systolic arterial pressure <90 mm Hg, p = .006) compared with the S group. Lower IVAS pain scores were recorded during the first hour in the R-Mg group than the other groups (p = .007-.045). Postoperative rescue analgesia did not differ between groups. Intraperitoneal magnesium sulfate administration, in spite of decreasing intraoperative opioid requirements, increased the incidence of hypotension with minimal evidence of postoperative analgesic benefits.

Veterinária e Zootecnia, 2006

Este trabalho objetivou revisar o emprego da máscara laríngea em animais, abordando asprincipais ... more Este trabalho objetivou revisar o emprego da máscara laríngea em animais, abordando asprincipais vantagens e desvantagens, comparativamente à sonda endotraqueal e à máscarafacial, bem como as perspectivas do uso clínico da mesma na anestesiologia veterinária.

Journal of Veterinary Medical Science, 2019

The aim of this study was to compare the effects of laser acupuncture and electroacupuncture on p... more The aim of this study was to compare the effects of laser acupuncture and electroacupuncture on postoperative pain and analgesic requirements in cats. In a prospective, randomized and blinded clinical study, thirty cats undergoing ovariohysterectomy were sedated with intramuscular (IM) ketamine (5 mg/kg), midazolam (0.5 mg/kg), and tramadol (2 mg/ kg). Before the induction of anesthesia, the animals were randomly distributed into three groups of ten cats each: LA: bilateral Stomach 36 (ST-36) and Spleen 6 (SP-6) acupoints were stimulated with an infrared laser; EA: bilateral ST-36 and SP-6 acupoints were stimulated with an electrical stimulus; Control: no acupuncture was applied. Postoperative analgesia was evaluated in the first 24 hr post-extubation using the Interactive Visual Analogue Scale and UNESP-Botucatu Multidimensional Composite Pain Scale. Rescue analgesia was provided with IM tramadol (2 mg/ kg), and the pain scores were reassessed 30 min after the rescue intervention. If the analgesia remained insufficient, meloxicam (0.2 mg/kg IM, single dose) was administered. Data were analyzed using t-tests, the Mann-Whitney U test, and Friedman test. P<0.05 was considered significant. The pain scores did not significantly differ between the treatment groups at any time point (P>0.05). The prevalence of rescue analgesia was significantly higher in the Control group than in the LA and EA groups (P=0.033). Preoperative laser and electroacupuncture reduced the need for rescue analgesia during the first 24 hr after ovariohysterectomy.

Journal of Veterinary Medical Science, 2019

The aim of this study was to evaluate the efficacy and safety of the intra-articular (IA) injecti... more The aim of this study was to evaluate the efficacy and safety of the intra-articular (IA) injection of botulinum toxin type A (BoNT/A) to the management of chronic pain in dogs. In a randomized, controlled, double-blinded study sixteen dogs with osteoarthritis secondary to hip dysplasia were distributed into two groups: 25 IU BoNT/A (BoNT) or saline solution (Control) was administered IA in each affected joint. All dogs received oral supplements (90 days) and carprofen (15 days). The dogs were assessed by a veterinarian on five occasions and the owner completed an assessment form at the same time (baseline to 90 days). The data were analyzed using unpaired-t test, Fisher's exact test, analysis of variance and the Tukey's test (P<0.05). There were no differences between groups in the veterinarian and owner assessments. Lower scores were observed in both groups during 90 days after IA therapy in the owner assessments (P<0.001). Compared with baseline, the Vet score was lower from 15-90 days after IA injection in the BoNT group, and at 15 and 30 days in the Control group (P<0.001). Both treatments were safe and reduced the clinical signs associated with hip osteoarthritis. However, IA BoNT/A (25 IU) did not provide better pain relief than the control treatment.

Semina: Ciências Agrárias, 2015

This study aimed to compare the sedative and cardiopulmonary effects of detomidine in combination... more This study aimed to compare the sedative and cardiopulmonary effects of detomidine in combination with saline, morphine or methadone and to determine whether the addition of these opioids increases the degree of sedation in horses submitted to experimental oral stimuli. In a blinded, randomized, experimental study, six adult mares were evaluated using a crossover design with at least 15 days between trials: 10?g/kg detomidine in combination with saline (D/SAL), 0.1mg/kg morphine (D/ MORPH) or 0.1mg/kg methadone (D/METH). The degree of sedation, response to oral stimuli and cardiopulmonary parameters were monitored for 120 minutes. Parametric data were analyzed using the ANOVA and Tukey’s tests, and non- parametric data were analyzed with the Kruskal-Wallis and Friedman’s tests with the post-Dunn test (P<0.05). The degree of sedation was significantly greater for the D/SAL than for the D/MORPH and D/METH treatments at 30 min. The horses´ responses to the oral stimuli decreased sig...

Evidence-Based Complementary and Alternative Medicine, 2015

The aim of this study was to evaluate laser acupuncture as an adjuvant for postoperative pain man... more The aim of this study was to evaluate laser acupuncture as an adjuvant for postoperative pain management in cats. Twenty cats, undergoing ovariohysterectomy, were sedated with intramuscular (IM) ketamine (5 mg kg−1), midazolam (0.5 mg kg−1), and tramadol (2 mg kg−1). Prior to induction of anaesthesia, the subjects were randomly distributed into two groups of 10 cats: Laser: bilateral stomach 36 and spleen 6 acupoints were stimulated with infrared laser; Control: no acupuncture was applied. Anaesthesia was induced using intravenous propofol (4 mg kg−1) and maintained with isoflurane. Postoperative analgesia was evaluated by a blinded assessor for 24 h following extubation using the Dynamic Interactive Visual Analogue Scale and Multidimensional Composite Pain Scale. Rescue analgesia was provided with IM tramadol (2 mg kg−1), and the pain scores were reassessed 30 min after the rescue intervention. If the analgesia remained insufficient, meloxicam (0.2 mg kg−1IM, single dose) was admin...

The Journal of veterinary medical science / the Japanese Society of Veterinary Science, Jan 29, 2015

This study aimed to evaluate the analgesic efficacy of gabapentin as an adjuvant for postoperativ... more This study aimed to evaluate the analgesic efficacy of gabapentin as an adjuvant for postoperative pain management in dogs. Twenty dogs undergoing mastectomy were randomized to receive perioperative oral placebo or gabapentin (10 mg/kg). All dogs were premedicated with intramuscular acepromazine (0.03 mg/kg) and morphine (0.3 mg/ kg). Anesthesia was induced with propofol (4 mg/kg) intravenously and maintained with isoflurane. Intravenous meloxicam (0.2 mg/kg) was administered preoperatively. Postoperative analgesia was evaluated for 72 hr. Rescue analgesia was provided with intramuscular morphine (0.5 mg/kg). Dogs in the Placebo group received significantly more morphine doses than the Gabapentin group (P=0.021) despite no significant differences in pain scores. Perioperative gabapentin reduced the postoperative morphine requirements in dogs after mastectomy.

RESUMO. Objetivou-se avaliar o efeito cardiorrespiratório e analgésico da anestesia por infusão c... more RESUMO. Objetivou-se avaliar o efeito cardiorrespiratório e analgésico da anestesia por infusão contínua em cães pré-medicados com levomepromazina, distribuídos em 04 grupos. A indução e manutenção anestésicas foram realizadas por via intravenosa com propofol nos grupos G1 (n=6) e G1-OSH (n=8), e propofol/cetamina nos grupos G2 (n=6) e G2-OSH (n=8). Os animais do G1 e G2 foram mantidos anestesiados durante 60 minutos, enquanto os animais do G1-OSH e G2-OSH foram submetidos à ovariosalpingohisterectomia (OSH). Os animais fo-ram mantidos em ventilação controlada, após a indução anestésica. Avaliaram-se eletrocardiografia, frequência cardíaca e respiratória, pressão arterial, temperatura retal, oximetria, capnografia, volume corrente e minuto, pH, bicarbonato e gases sanguíneos no sangue arterial, concentração plasmática de propofol, grau de analgesia, tempo e qualidade de recuperação anestésica. Em todos os grupos houve hipotensão dose-dependente. A qualidade de recuperação foi semelhante entre os grupos, com tempo mais prolongado de recuperação nos grupos G1