Renato Sotto-Mayor - Academia.edu (original) (raw)
Papers by Renato Sotto-Mayor
Cancer Treatment Reviews, 1990
![Research paper thumbnail of [Chronic obstructive pulmonary disease]](https://attachments.academia-assets.com/92468902/thumbnails/1.jpg)
](Acta medica portuguesa, 2001
Chronic obstructive pulmonary disease (COPD) includes two entities, Chronic Bronchitis (C.B.) and... more Chronic obstructive pulmonary disease (COPD) includes two entities, Chronic Bronchitis (C.B.) and Emphysema (E.), assembled by their common physiopathological feature, a progressive expiratory airflow obstruction. The presence of hyperreactivity is common and partial reversibility may be observed. The coexistence of CB and E. is largely the most prevalent. Cigarette smoking is the main risk factor per se or associated with other urban or occupational air pollutants. Therefore epidemiological COPD rats follow the prevalence of smoking habits in the population. The main goal of the strategy against the disease are preventive decisions and measures, as far as smoking is concerned. FEV1 values lower than 75% of FVC and a decline of FEV1 higher than 30 ml/year indicate a high risk of COPD among smokers. The assessment of FEV1 is important for monitoring and guiding treatment and is valid for grading the severity of COPD. Once the disease is confirmed the therapeutic skills are the follow...
![Research paper thumbnail of [Epipericardial fat necrosis - Case report]](https://attachments.academia-assets.com/84630372/thumbnails/1.jpg)
](Revista portuguesa de pneumologia, 2010
Epipericardial fat necrosis is an uncommon benign entity of unknown cause, with only 20 cases rep... more Epipericardial fat necrosis is an uncommon benign entity of unknown cause, with only 20 cases reported in the English-language literature. It should be remembered as a possible diagnosis in a person who presents with acute pleuritic chest pain and paracardiac density or pleural effusion on chest radiography (X-ray). The computed tomography (CT) or surgical approach allows the final diagnosis and characterization. The authors describe a case of a 48-year-old woman, admitted to our department because of complaints of fatigue, cough and sudden pleuritic pain on thoracic left side. The chest X-ray showed mild/moderate left pleural effusion and CT scan revealed local slight thickening of pericardium and epipericardial fat, surrounded by thick rim of higher density in the left cardiophrenic space. This made the diagnosis of epipericardial fat necrosis. During hospitalization the patient remained stable and was discharged home with symptomatic relieve therapy. Because of benign, self-limit...
![Research paper thumbnail of [Pleural effusion of non-neoplastic etiology in a patient with a rare form of myeloma]](https://attachments.academia-assets.com/84630371/thumbnails/1.jpg)
](Acta medica portuguesa, 1995
Pleural effusions can be a manifestation of several nosological entities. Etiologic diagnosis inv... more Pleural effusions can be a manifestation of several nosological entities. Etiologic diagnosis involves a good clinical history, followed by thoracocentesis with pleural biopsy and eventually bronchoscopy or thoracoscopy. The differentiation between transudates and exudates, by the biochemical characteristics of the pleural effusions, can orientate the underlying disorder. It is known that there are more than 35 different etiological entities of exudative pleural effusions. However, pneumonia, malignancies, pulmonary embolism, abdominal disease and tuberculosis are the major causes (around 90%). Transudative effusions are more frequently due to congestive heart failure, renal or hepatic failure. The AA present a clinical situation of pleural effusion, the etiology of which was initially attributed to congestive heart failure, with a good response, clinical and radiological response to the treatment established. However the laboratory alteration persisted (anaemia, renal failure, acut...
![Research paper thumbnail of [Pulmonary sequestration. Report of a clinical case]](https://attachments.academia-assets.com/84630370/thumbnails/1.jpg)
](Concerning a clinical situation of intralobar pulmonary sequestration, in a seventeen year old yo... more Concerning a clinical situation of intralobar pulmonary sequestration, in a seventeen year old young man, the authors review this nosological entity. They emphasize the importance of the complementary examens of diagnosis, namely of thoracic scan and aortography, for the establishment of the said diagnosis.
![Research paper thumbnail of [Whole lung lavage - Report of four cases of alveolar proteinosis]](https://attachments.academia-assets.com/84630369/thumbnails/1.jpg)
](Whole lung lavage is a technique that was developed in the 1960s with the purpose of removing lip... more Whole lung lavage is a technique that was developed in the 1960s with the purpose of removing lipoproteinaceous material that accumulates in the bronchi of patients with alveolar proteinosis, leading to clinical and functional improvement. There has been an evolution in the technique; initially it was performed under local anesthesia to each segment of the lung and currently it is performed under general anesthesia sequentially to both lungs. This review describes the whole lung lavage, its major indication, alveolar proteinosis and some data on the experience of our hospital.
Journal of Thoracic Oncology, 2018
Background: Lung cancer is the most common cancer and remains the main death cause worldwide. The... more Background: Lung cancer is the most common cancer and remains the main death cause worldwide. The aim of study was to determinate the incidence and survival rate of lung cancer in a population of affiliates in a private institution (ONCOSALUD-AUNA). Method: In a dynamic cohort, the incidence of lung cancer was evaluated in a population of affiliates to ONCOSALUD-AUNA between 2008-2013 (n¼1'096,140). Overall survival (OS) was evaluated in patients treated in ONCOSALUD e AUNA between 2000-2005 (n ¼ 114). The incidence rate was calculated based on new cases/persons-year of observation. The incidence rate standardized by age was calculated having the structure of the world standard population. OS was estimated using the Kaplan-Meier method and comparisons of survival curves were performed using the Log-rank or Breslow test. Results: The median age at affiliation was 33 years (range: <1, 98), 18.9% were under 15 years old, 5.6% were older than 64, and 55.7% were women. A total of 2,611,438.3 persons-year of observation was calculated and 394 affiliates (193 and 201 in women and men, respectively) were diagnosed with lung cancer. The median age at diagnosis was 70 years (range: 35, 98). The standardized incidence rate by age was 7.9 per 100,000 persons-year (6.5 and 10.0 in women and men per 100,000 persons-year, respectively), and 74 years cumulative risk was 1.0% (0.9 and 1.3% in women and men, respectively). For survival assessment, the median age at diagnosis was 69 years, 37.9% were women and 76.3% had advanced disease (CS III: 18.2% and CS IV: 58.1%). With a 10.6-year follow-up, the median survival was 0.62 years (CI95%: 0.46, 0.78). The OS rate at 5 and 10 years were 16.4% and 12.9%, no significant differences in relation to sex (p ¼ 0.118), age (<60 vs. >60 years: p ¼ 0.300) were observed, and it shows significant difference according clinical stage (CS I-II vs. IIIeIV: p < 0.001). Conclusion: The incidence rate of lung cancer in our population is slightly lower than reported by the IARC for the Peruvian population. The survival rate at 5 and 10 years is similar to reported by other series.
Revista Portuguesa de Pneumologia, 2008
Caso Clínico Case Report Resumo O linfoma intravascular é uma forma muito rara de linfoma não Hod... more Caso Clínico Case Report Resumo O linfoma intravascular é uma forma muito rara de linfoma não Hodgkin de células grandes B. Caracteriza-se pela proliferação celular tumoral de linfócitos limitada aos pequenos vasos, particularmente nos capilares. Apresentamos o caso de uma doente de 54 anos, não fumadora, que foi admitida no nosso hospital para investigação de um quadro com quatro meses de evolução de febre, sudorese nocturna, ema-Abstract Intravascular lymphoma is a very rare form of large B cell non-Hodgkin's lymphoma, characterised by the presence of lymphoma cells in the lumina of small vessels only, particulary in the capillaries. We report a 54 year-old female non-smoker, admitted to hospital for further examination of a four month long clinical condition involving high fever, night sweats, unqualified weight loss and progressive dyspnea. Patient's Linfoma intravascular do pulmão: A propósito de um caso clínico com boa resposta à terapêutica Intravascular pulmonary lymphoma with good response to treatment. A case report Recebido para publicação/received for publication: 08.08.24 Aceite para publicação/accepted for publication: 08.09.13
Revista Portuguesa de Pneumologia, 1998
Revista Portuguesa de Pneumologia, 2003
Revista Portuguesa de Pneumologia (English Edition), 2009
Revista Portuguesa de Pneumologia (English Edition), 2008
Revista Portuguesa de Pneumologia (English Edition), 2010
Revista Portuguesa de Pneumologia (English Edition), 2008
Revista portuguesa de pneumologia
Lung cancer is the most common form of cancer death in the world. Five-year survival is about 15%... more Lung cancer is the most common form of cancer death in the world. Five-year survival is about 15%, without any change to this picture envisaged. It is the 3rd most prevalent type of cancer in Portugal and the primary cause of cancer death. 85% of lung cancer cases are attributable to smoking. One study performed in Portugal for 3 years (2000/2002) by the Lung Oncology Work Committee of the Portuguese Society of Pulmonology in 22 Hospitals showed that of a total of 4396 patients with lung cancer, 81.8% were male and 18.2% were female, with a mean age of 64.49 +/- 11.28 years. About 70% of patients were smokers or former smokers, with 50.3% of patients presenting with performance status (Zubrod) 1. Histologically, 37.5% were adenocarcinoma, followed by squamous carcinoma in 30.5% of cases, and small cell lung cancer in 12.5%; neuroendocrine carcinoma presented in 1.4% of cases; non small cell lung cancer in 10.5%; mixed carcinoma in 0.7%; large cell carcinoma in 2.3%; and others/not s...
Revista portuguesa de pneumologia
Combined chemotherapy and radiotherapy has shown to be the correct treatment of unresectable non-... more Combined chemotherapy and radiotherapy has shown to be the correct treatment of unresectable non-small cell lung cancer, after many years of poor survival figures with standard radiotherapy alone. It has also been demonstrated that the benefit of chemotherapy is mainly achieved if cisplatin-based schedules are used. The authors present a retrospective study of 100 cases of stage III non-small cell lung cancer treated with a sequential approach of chemotherapy and radiotherapy and evaluate median and overall survival, local progression-free survival and distant progression-free survival. The results of our series are quite similar to those published in literature.
Revista Portuguesa de Pneumologia (English Edition), 2009
![Research paper thumbnail of [Chronic obstructive pulmonary disease]](https://attachments.academia-assets.com/84879596/thumbnails/1.jpg)
](Acta médica portuguesa
Chronic obstructive pulmonary disease (COPD) includes two entities, Chronic Bronchitis (C.B.) and... more Chronic obstructive pulmonary disease (COPD) includes two entities, Chronic Bronchitis (C.B.) and Emphysema (E.), assembled by their common physiopathological feature, a progressive expiratory airflow obstruction. The presence of hyperreactivity is common and partial reversibility may be observed. The coexistence of CB and E. is largely the most prevalent. Cigarette smoking is the main risk factor per se or associated with other urban or occupational air pollutants. Therefore epidemiological COPD rats follow the prevalence of smoking habits in the population. The main goal of the strategy against the disease are preventive decisions and measures, as far as smoking is concerned. FEV1 values lower than 75% of FVC and a decline of FEV1 higher than 30 ml/year indicate a high risk of COPD among smokers. The assessment of FEV1 is important for monitoring and guiding treatment and is valid for grading the severity of COPD. Once the disease is confirmed the therapeutic skills are the follow...
Cancer Treatment Reviews, 1990
Acta medica portuguesa, 2001
Chronic obstructive pulmonary disease (COPD) includes two entities, Chronic Bronchitis (C.B.) and... more Chronic obstructive pulmonary disease (COPD) includes two entities, Chronic Bronchitis (C.B.) and Emphysema (E.), assembled by their common physiopathological feature, a progressive expiratory airflow obstruction. The presence of hyperreactivity is common and partial reversibility may be observed. The coexistence of CB and E. is largely the most prevalent. Cigarette smoking is the main risk factor per se or associated with other urban or occupational air pollutants. Therefore epidemiological COPD rats follow the prevalence of smoking habits in the population. The main goal of the strategy against the disease are preventive decisions and measures, as far as smoking is concerned. FEV1 values lower than 75% of FVC and a decline of FEV1 higher than 30 ml/year indicate a high risk of COPD among smokers. The assessment of FEV1 is important for monitoring and guiding treatment and is valid for grading the severity of COPD. Once the disease is confirmed the therapeutic skills are the follow...
Revista portuguesa de pneumologia, 2010
Epipericardial fat necrosis is an uncommon benign entity of unknown cause, with only 20 cases rep... more Epipericardial fat necrosis is an uncommon benign entity of unknown cause, with only 20 cases reported in the English-language literature. It should be remembered as a possible diagnosis in a person who presents with acute pleuritic chest pain and paracardiac density or pleural effusion on chest radiography (X-ray). The computed tomography (CT) or surgical approach allows the final diagnosis and characterization. The authors describe a case of a 48-year-old woman, admitted to our department because of complaints of fatigue, cough and sudden pleuritic pain on thoracic left side. The chest X-ray showed mild/moderate left pleural effusion and CT scan revealed local slight thickening of pericardium and epipericardial fat, surrounded by thick rim of higher density in the left cardiophrenic space. This made the diagnosis of epipericardial fat necrosis. During hospitalization the patient remained stable and was discharged home with symptomatic relieve therapy. Because of benign, self-limit...
Acta medica portuguesa, 1995
Pleural effusions can be a manifestation of several nosological entities. Etiologic diagnosis inv... more Pleural effusions can be a manifestation of several nosological entities. Etiologic diagnosis involves a good clinical history, followed by thoracocentesis with pleural biopsy and eventually bronchoscopy or thoracoscopy. The differentiation between transudates and exudates, by the biochemical characteristics of the pleural effusions, can orientate the underlying disorder. It is known that there are more than 35 different etiological entities of exudative pleural effusions. However, pneumonia, malignancies, pulmonary embolism, abdominal disease and tuberculosis are the major causes (around 90%). Transudative effusions are more frequently due to congestive heart failure, renal or hepatic failure. The AA present a clinical situation of pleural effusion, the etiology of which was initially attributed to congestive heart failure, with a good response, clinical and radiological response to the treatment established. However the laboratory alteration persisted (anaemia, renal failure, acut...
Concerning a clinical situation of intralobar pulmonary sequestration, in a seventeen year old yo... more Concerning a clinical situation of intralobar pulmonary sequestration, in a seventeen year old young man, the authors review this nosological entity. They emphasize the importance of the complementary examens of diagnosis, namely of thoracic scan and aortography, for the establishment of the said diagnosis.
Whole lung lavage is a technique that was developed in the 1960s with the purpose of removing lip... more Whole lung lavage is a technique that was developed in the 1960s with the purpose of removing lipoproteinaceous material that accumulates in the bronchi of patients with alveolar proteinosis, leading to clinical and functional improvement. There has been an evolution in the technique; initially it was performed under local anesthesia to each segment of the lung and currently it is performed under general anesthesia sequentially to both lungs. This review describes the whole lung lavage, its major indication, alveolar proteinosis and some data on the experience of our hospital.
Journal of Thoracic Oncology, 2018
Background: Lung cancer is the most common cancer and remains the main death cause worldwide. The... more Background: Lung cancer is the most common cancer and remains the main death cause worldwide. The aim of study was to determinate the incidence and survival rate of lung cancer in a population of affiliates in a private institution (ONCOSALUD-AUNA). Method: In a dynamic cohort, the incidence of lung cancer was evaluated in a population of affiliates to ONCOSALUD-AUNA between 2008-2013 (n¼1'096,140). Overall survival (OS) was evaluated in patients treated in ONCOSALUD e AUNA between 2000-2005 (n ¼ 114). The incidence rate was calculated based on new cases/persons-year of observation. The incidence rate standardized by age was calculated having the structure of the world standard population. OS was estimated using the Kaplan-Meier method and comparisons of survival curves were performed using the Log-rank or Breslow test. Results: The median age at affiliation was 33 years (range: <1, 98), 18.9% were under 15 years old, 5.6% were older than 64, and 55.7% were women. A total of 2,611,438.3 persons-year of observation was calculated and 394 affiliates (193 and 201 in women and men, respectively) were diagnosed with lung cancer. The median age at diagnosis was 70 years (range: 35, 98). The standardized incidence rate by age was 7.9 per 100,000 persons-year (6.5 and 10.0 in women and men per 100,000 persons-year, respectively), and 74 years cumulative risk was 1.0% (0.9 and 1.3% in women and men, respectively). For survival assessment, the median age at diagnosis was 69 years, 37.9% were women and 76.3% had advanced disease (CS III: 18.2% and CS IV: 58.1%). With a 10.6-year follow-up, the median survival was 0.62 years (CI95%: 0.46, 0.78). The OS rate at 5 and 10 years were 16.4% and 12.9%, no significant differences in relation to sex (p ¼ 0.118), age (<60 vs. >60 years: p ¼ 0.300) were observed, and it shows significant difference according clinical stage (CS I-II vs. IIIeIV: p < 0.001). Conclusion: The incidence rate of lung cancer in our population is slightly lower than reported by the IARC for the Peruvian population. The survival rate at 5 and 10 years is similar to reported by other series.
Revista Portuguesa de Pneumologia, 2008
Caso Clínico Case Report Resumo O linfoma intravascular é uma forma muito rara de linfoma não Hod... more Caso Clínico Case Report Resumo O linfoma intravascular é uma forma muito rara de linfoma não Hodgkin de células grandes B. Caracteriza-se pela proliferação celular tumoral de linfócitos limitada aos pequenos vasos, particularmente nos capilares. Apresentamos o caso de uma doente de 54 anos, não fumadora, que foi admitida no nosso hospital para investigação de um quadro com quatro meses de evolução de febre, sudorese nocturna, ema-Abstract Intravascular lymphoma is a very rare form of large B cell non-Hodgkin's lymphoma, characterised by the presence of lymphoma cells in the lumina of small vessels only, particulary in the capillaries. We report a 54 year-old female non-smoker, admitted to hospital for further examination of a four month long clinical condition involving high fever, night sweats, unqualified weight loss and progressive dyspnea. Patient's Linfoma intravascular do pulmão: A propósito de um caso clínico com boa resposta à terapêutica Intravascular pulmonary lymphoma with good response to treatment. A case report Recebido para publicação/received for publication: 08.08.24 Aceite para publicação/accepted for publication: 08.09.13
Revista Portuguesa de Pneumologia, 1998
Revista Portuguesa de Pneumologia, 2003
Revista Portuguesa de Pneumologia (English Edition), 2009
Revista Portuguesa de Pneumologia (English Edition), 2008
Revista Portuguesa de Pneumologia (English Edition), 2010
Revista Portuguesa de Pneumologia (English Edition), 2008
Revista portuguesa de pneumologia
Lung cancer is the most common form of cancer death in the world. Five-year survival is about 15%... more Lung cancer is the most common form of cancer death in the world. Five-year survival is about 15%, without any change to this picture envisaged. It is the 3rd most prevalent type of cancer in Portugal and the primary cause of cancer death. 85% of lung cancer cases are attributable to smoking. One study performed in Portugal for 3 years (2000/2002) by the Lung Oncology Work Committee of the Portuguese Society of Pulmonology in 22 Hospitals showed that of a total of 4396 patients with lung cancer, 81.8% were male and 18.2% were female, with a mean age of 64.49 +/- 11.28 years. About 70% of patients were smokers or former smokers, with 50.3% of patients presenting with performance status (Zubrod) 1. Histologically, 37.5% were adenocarcinoma, followed by squamous carcinoma in 30.5% of cases, and small cell lung cancer in 12.5%; neuroendocrine carcinoma presented in 1.4% of cases; non small cell lung cancer in 10.5%; mixed carcinoma in 0.7%; large cell carcinoma in 2.3%; and others/not s...
Revista portuguesa de pneumologia
Combined chemotherapy and radiotherapy has shown to be the correct treatment of unresectable non-... more Combined chemotherapy and radiotherapy has shown to be the correct treatment of unresectable non-small cell lung cancer, after many years of poor survival figures with standard radiotherapy alone. It has also been demonstrated that the benefit of chemotherapy is mainly achieved if cisplatin-based schedules are used. The authors present a retrospective study of 100 cases of stage III non-small cell lung cancer treated with a sequential approach of chemotherapy and radiotherapy and evaluate median and overall survival, local progression-free survival and distant progression-free survival. The results of our series are quite similar to those published in literature.
Revista Portuguesa de Pneumologia (English Edition), 2009
Acta médica portuguesa
Chronic obstructive pulmonary disease (COPD) includes two entities, Chronic Bronchitis (C.B.) and... more Chronic obstructive pulmonary disease (COPD) includes two entities, Chronic Bronchitis (C.B.) and Emphysema (E.), assembled by their common physiopathological feature, a progressive expiratory airflow obstruction. The presence of hyperreactivity is common and partial reversibility may be observed. The coexistence of CB and E. is largely the most prevalent. Cigarette smoking is the main risk factor per se or associated with other urban or occupational air pollutants. Therefore epidemiological COPD rats follow the prevalence of smoking habits in the population. The main goal of the strategy against the disease are preventive decisions and measures, as far as smoking is concerned. FEV1 values lower than 75% of FVC and a decline of FEV1 higher than 30 ml/year indicate a high risk of COPD among smokers. The assessment of FEV1 is important for monitoring and guiding treatment and is valid for grading the severity of COPD. Once the disease is confirmed the therapeutic skills are the follow...