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Case Reports in Cardiology, 2016
Complete atrioventricular (AV) block is known to be reversible in some cases of acute inferior wa... more Complete atrioventricular (AV) block is known to be reversible in some cases of acute inferior wall myocardial infarction (MI). The reversibility of high-grade AV block in non-MI coronary artery disease (CAD), however, is rarely described in the literature. Herein we perform a literature review to assess what is known about the reversibility of high-grade AV block after right coronary artery revascularization in CAD patients who present without an acute MI. To illustrate this phenomenon we describe a case of 2 : 1 AV block associated with unstable angina, in which revascularization resulted in immediate and durable restoration of 1 : 1 AV conduction, thereby obviating the need for permanent pacemaker implantation. The literature review suggests two possible explanations: a vagally mediated response or a mechanism dependent on conduction system ischemia. Due to the limited understanding of AV block reversibility following revascularization in non-acute MI presentations, it remains difficult to reliably predict which patients presenting with high-grade AV block in the absence of MI may have the potential to avoid permanent pacemaker implantation via coronary revascularization. We thus offer this review as a potential starting point for the approach to such patients.
Japanese journal of infectious diseases, 2011
Dengue is currently the most important arboviral disease in the world, particularly in tropical c... more Dengue is currently the most important arboviral disease in the world, particularly in tropical countries in which the environmental conditions favor the development and proliferation of the mosquito vector. Dengue hemorrhagic fever presents in two phases: an initial phase, which is characterized by sudden onset of fever and a variety of nonspecific signs and symptoms, and a critical phase, which is characterized by the recovery from fever and development of hemorrhagic symptoms and circulatory insufficiency. This report documents a case of splenic rupture in a patient with dengue hemorrhagic fever who developed hypovolemic shock and subsequently died. Although splenic rupture is a known complication of other acute infections, it is a rare complication of dengue; therefore, it may be misdiagnosed. In the case described here, the poor outcome mainly resulted from the sudden onset of complications; the patient died of splenic rupture less than 24 h after admission, and the cause of de...
Mycoses, 2014
Regulatory T (Treg) cells may play an important role in the pathogenesis of paracoccidioidomycosi... more Regulatory T (Treg) cells may play an important role in the pathogenesis of paracoccidioidomycosis (PCM), but data on the role of Treg cells in the context of oral PCM are still scarce. The objectives of this study were to investigate the density of FoxP3 + T regulatory cells in oral PCM and to correlate the results with the density of Paracoccidioides brasiliensis in the lesions. Cases of chronic oral PCM seen between 2000 and 2008 were included in this study. The diagnosis of all lesions was confirmed with histopathological examination and Grocott-Gomori staining. The quantitative analysis of the viable fungi was conducted in all cases with Grocott-stained slides. Treg cells were identified using antibodies against FoxP3. Pearson correlation coefficient was used to test the correlation between the density of fungi and Treg cells. Results were considered significant when P < 0.05. A total of 11 cases of oral PCM were obtained. There was a positive correlation between fungal density and FoxP3 + Treg cells density in oral lesions, however, without statistical significance. A positive relation between Treg cells and fungal density was seen in oral PCM. Further studies are required to further elucidate the role of these cells in the pathogenesis of oral PCM, as well the clinical significance of these findings.
Revista Brasileira de Ortopedia, 2014
r e v b r a s o r t o p . 2 0 1 4;4 9(3):305-308 w w w . r b o . o r g . b r Relato de caso infor... more r e v b r a s o r t o p . 2 0 1 4;4 9(3):305-308 w w w . r b o . o r g . b r Relato de caso informações sobre o artigo Histórico do artigo: Recebido em 1 de maio de 2013 Aceito em 7 de maio de 2013 On-line em 28 de fevereiro de 2014 Palavras-chave: Ameloblastoma/etiologia Ameloblastoma/diagnóstico Ameloblastoma/cirurgia Neoplasias mandibulares r e s u m o Os ameloblastomas são tumores odontogênicos, localmente invasivos e de crescimento lento. Sua etiologia ainda não foi bem definida e as formas de tratamento são amplamente discutidas, por causa de possíveis recidivas do tumor e complicaç ões pós-operatórias. Neste trabalho, foram avaliados seis pacientes diagnosticados com ameloblastoma na região mandibular e tratados no Departamento de Ortopedia e Traumatologia do HC-UFG, de 1958 a 1963. Foram avaliadas as características radiológicas, clínicas e terapêuticas. Não houve predomínio em relação ao gênero na amostra estudada. Os sintomas mais apresentados pelos pacientes foram dor e tumoração. As características radiológicas de maior incidência são de uma lesão multilocular e o tratamento usado em todos os pacientes foi o cirúrgico radical. A recidiva foi nula em um tempo mínimo de um ano e sete meses de seguimento. a b s t r a c t Ameloblastomas are odontogenic tumors that are locally invasive and slow-growing. Their etiology is still not well defined, but the forms of treatment have been widely discussed because of the possibility of tumor recurrence and postoperative complications. In this study, six patients who were diagnosed with ameloblastoma in the mandibular region and were treated in the Department of Orthopedics and Traumatology of Hospital das Clínicas,
Revista Brasileira de Ortopedia (English Edition), 2014
Pages 4 r e v b r a s o r t o p . 2 0 1 4;x x x(x x):xxx-xxx w w w . r b o . o r g . b r Case Rep... more Pages 4 r e v b r a s o r t o p . 2 0 1 4;x x x(x x):xxx-xxx w w w . r b o . o r g . b r Case Report Available online xxx Keywords: Ameloblastoma/etiology Ameloblastoma/diagnosis Ameloblastoma/surgery Mandibular neoplasms a b s t r a c t Ameloblastomas are odontogenic tumors that are locally invasive and slow-growing. Their etiology is still not well defined, but the forms of treatment have been widely discussed because of the possibility of tumor recurrence and postoperative complications. In this study, six patients who were diagnosed with ameloblastoma in the mandibular region and were treated in the Department of Orthopedics and Traumatology of Hospital das Clínicas, Federal University of Goiás, between 1958 and 1963, were evaluated. The radiological, clinical and therapeutic characteristics were evaluated. There was no predominance regarding gender in the sample studied. The symptoms most often presented by the patients were pain and tumor formation. The radiological characteristics with greatest incidence were multilocular lesions and the treatment used for all the patients was radical surgery. There was no recurrence over the minimum follow-up period of one year and six months. Ameloblastoma: uma análise clínica e terapêutica de seis casos Palavras-chave: Ameloblastoma/etiologia Ameloblastoma/diagnóstico Ameloblastoma/cirurgia Neoplasias mandibulares r e s u m o Os ameloblastomas são tumores odontogênicos, localmente invasivos e de crescimento lento. Sua etiologia ainda não foi bem definida e as formas de tratamento são amplamente discutidas, por causa de possíveis recidivas do tumor e complicaç ões pós-operatórias. Neste trabalho, foram avaliados seis pacientes diagnosticados com ameloblastoma na região mandibular e tratados no Departamento de Ortopedia e Traumatologia do HC-UFG, de 1958 a 1963. Foram avaliadas as características radiológicas, clínicas e terapêuticas. Não houve predomínio em relação ao gênero na amostra estudada. Os sintomas mais apresentados pelos pacientes foram dor e tumoração. As características radiológicas de maior ଝ Work performed in the RBOE-143; No. of Pages 4 2 r e v b r a s o r t o p . 2 0 1 4;x x x(x x):xxx-xxx incidência são de uma lesão multilocular e o tratamento usado em todos os pacientes foi o cirúrgico radical. A recidiva foi nula em um tempo mínimo de um ano e sete meses de seguimento.
Journal of the American College of Cardiology, 2015
Journal of the American College of Cardiology, 2015
Journal of the American College of Cardiology, 2015
Journal of the American College of Cardiology, 2015
Circulation, Nov 25, 2014
Circulation, Nov 25, 2014
Circulation, Nov 25, 2014
Journal of the American College of Cardiology, 2015
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, Jan 20, 2015
The role of right ventricular outflow tract (RVOT) prestenting in the prevention of Melody valve ... more The role of right ventricular outflow tract (RVOT) prestenting in the prevention of Melody valve stent fractures (SFs) is not well defined. We aimed to perform a systematic review and meta-analysis comparing the incidence of SF in Melody valve transcatheter pulmonary implants with and without prestenting. PubMed, EMBASE, and Cochrane Central were searched for studies that reported the incidence of SF in Melody valve transcatheter pulmonary implants stratified by the presence or absence of RVOT prestenting. Subgroup analyses were performed for (1) SF associated with a loss of stent integrity and (2) SF requiring reintervention. Five studies and 360 patients were included, of whom 207 (57.5%) received prestenting. Follow-up ranged from 15 to 30 months. SF were significantly reduced in the prestenting group (16.7%) when compared to no prestenting (33.5%) (odds-ratio [OR] 0.39; 95%CI 0.22-0.69). Patients who received prestenting also had a lower incidence of (1) SF associated with loss ...
Journal of the American College of Cardiology, 2015
Journal of the American College of Cardiology, 2015
Catheterization and Cardiovascular Interventions, 2015
The role of right ventricular outflow tract (RVOT) prestenting in the prevention of Melody valve ... more The role of right ventricular outflow tract (RVOT) prestenting in the prevention of Melody valve stent fractures (SFs) is not well defined. We aimed to perform a systematic review and meta-analysis comparing the incidence of SF in Melody valve transcatheter pulmonary implants with and without prestenting. PubMed, EMBASE, and Cochrane Central were searched for studies that reported the incidence of SF in Melody valve transcatheter pulmonary implants stratified by the presence or absence of RVOT prestenting. Subgroup analyses were performed for (1) SF associated with a loss of stent integrity and (2) SF requiring reintervention. Five studies and 360 patients were included, of whom 207 (57.5%) received prestenting. Follow-up ranged from 15 to 30 months. SF were significantly reduced in the prestenting group (16.7%) when compared to no prestenting (33.5%) (odds-ratio [OR] 0.39; 95%CI 0.22-0.69). Patients who received prestenting also had a lower incidence of (1) SF associated with loss of stent integrity (OR 0.16; 95%CI 0.05-0.48) and (2) SF requiring reintervention (OR 0.15; 95%CI 0.02-0.91). Our findings suggest that stenting of the RVOT prior to Melody valve implantation is associated with a reduction in the incidence of SF and fracture-related reinterventions. © 2015 Wiley Periodicals, Inc.
Journal of the American College of Cardiology, 2015
Journal of the American College of Cardiology, 2015
Journal of the American College of Cardiology, 2015
Case Reports in Cardiology, 2016
Complete atrioventricular (AV) block is known to be reversible in some cases of acute inferior wa... more Complete atrioventricular (AV) block is known to be reversible in some cases of acute inferior wall myocardial infarction (MI). The reversibility of high-grade AV block in non-MI coronary artery disease (CAD), however, is rarely described in the literature. Herein we perform a literature review to assess what is known about the reversibility of high-grade AV block after right coronary artery revascularization in CAD patients who present without an acute MI. To illustrate this phenomenon we describe a case of 2 : 1 AV block associated with unstable angina, in which revascularization resulted in immediate and durable restoration of 1 : 1 AV conduction, thereby obviating the need for permanent pacemaker implantation. The literature review suggests two possible explanations: a vagally mediated response or a mechanism dependent on conduction system ischemia. Due to the limited understanding of AV block reversibility following revascularization in non-acute MI presentations, it remains difficult to reliably predict which patients presenting with high-grade AV block in the absence of MI may have the potential to avoid permanent pacemaker implantation via coronary revascularization. We thus offer this review as a potential starting point for the approach to such patients.
Japanese journal of infectious diseases, 2011
Dengue is currently the most important arboviral disease in the world, particularly in tropical c... more Dengue is currently the most important arboviral disease in the world, particularly in tropical countries in which the environmental conditions favor the development and proliferation of the mosquito vector. Dengue hemorrhagic fever presents in two phases: an initial phase, which is characterized by sudden onset of fever and a variety of nonspecific signs and symptoms, and a critical phase, which is characterized by the recovery from fever and development of hemorrhagic symptoms and circulatory insufficiency. This report documents a case of splenic rupture in a patient with dengue hemorrhagic fever who developed hypovolemic shock and subsequently died. Although splenic rupture is a known complication of other acute infections, it is a rare complication of dengue; therefore, it may be misdiagnosed. In the case described here, the poor outcome mainly resulted from the sudden onset of complications; the patient died of splenic rupture less than 24 h after admission, and the cause of de...
Mycoses, 2014
Regulatory T (Treg) cells may play an important role in the pathogenesis of paracoccidioidomycosi... more Regulatory T (Treg) cells may play an important role in the pathogenesis of paracoccidioidomycosis (PCM), but data on the role of Treg cells in the context of oral PCM are still scarce. The objectives of this study were to investigate the density of FoxP3 + T regulatory cells in oral PCM and to correlate the results with the density of Paracoccidioides brasiliensis in the lesions. Cases of chronic oral PCM seen between 2000 and 2008 were included in this study. The diagnosis of all lesions was confirmed with histopathological examination and Grocott-Gomori staining. The quantitative analysis of the viable fungi was conducted in all cases with Grocott-stained slides. Treg cells were identified using antibodies against FoxP3. Pearson correlation coefficient was used to test the correlation between the density of fungi and Treg cells. Results were considered significant when P < 0.05. A total of 11 cases of oral PCM were obtained. There was a positive correlation between fungal density and FoxP3 + Treg cells density in oral lesions, however, without statistical significance. A positive relation between Treg cells and fungal density was seen in oral PCM. Further studies are required to further elucidate the role of these cells in the pathogenesis of oral PCM, as well the clinical significance of these findings.
Revista Brasileira de Ortopedia, 2014
r e v b r a s o r t o p . 2 0 1 4;4 9(3):305-308 w w w . r b o . o r g . b r Relato de caso infor... more r e v b r a s o r t o p . 2 0 1 4;4 9(3):305-308 w w w . r b o . o r g . b r Relato de caso informações sobre o artigo Histórico do artigo: Recebido em 1 de maio de 2013 Aceito em 7 de maio de 2013 On-line em 28 de fevereiro de 2014 Palavras-chave: Ameloblastoma/etiologia Ameloblastoma/diagnóstico Ameloblastoma/cirurgia Neoplasias mandibulares r e s u m o Os ameloblastomas são tumores odontogênicos, localmente invasivos e de crescimento lento. Sua etiologia ainda não foi bem definida e as formas de tratamento são amplamente discutidas, por causa de possíveis recidivas do tumor e complicaç ões pós-operatórias. Neste trabalho, foram avaliados seis pacientes diagnosticados com ameloblastoma na região mandibular e tratados no Departamento de Ortopedia e Traumatologia do HC-UFG, de 1958 a 1963. Foram avaliadas as características radiológicas, clínicas e terapêuticas. Não houve predomínio em relação ao gênero na amostra estudada. Os sintomas mais apresentados pelos pacientes foram dor e tumoração. As características radiológicas de maior incidência são de uma lesão multilocular e o tratamento usado em todos os pacientes foi o cirúrgico radical. A recidiva foi nula em um tempo mínimo de um ano e sete meses de seguimento. a b s t r a c t Ameloblastomas are odontogenic tumors that are locally invasive and slow-growing. Their etiology is still not well defined, but the forms of treatment have been widely discussed because of the possibility of tumor recurrence and postoperative complications. In this study, six patients who were diagnosed with ameloblastoma in the mandibular region and were treated in the Department of Orthopedics and Traumatology of Hospital das Clínicas,
Revista Brasileira de Ortopedia (English Edition), 2014
Pages 4 r e v b r a s o r t o p . 2 0 1 4;x x x(x x):xxx-xxx w w w . r b o . o r g . b r Case Rep... more Pages 4 r e v b r a s o r t o p . 2 0 1 4;x x x(x x):xxx-xxx w w w . r b o . o r g . b r Case Report Available online xxx Keywords: Ameloblastoma/etiology Ameloblastoma/diagnosis Ameloblastoma/surgery Mandibular neoplasms a b s t r a c t Ameloblastomas are odontogenic tumors that are locally invasive and slow-growing. Their etiology is still not well defined, but the forms of treatment have been widely discussed because of the possibility of tumor recurrence and postoperative complications. In this study, six patients who were diagnosed with ameloblastoma in the mandibular region and were treated in the Department of Orthopedics and Traumatology of Hospital das Clínicas, Federal University of Goiás, between 1958 and 1963, were evaluated. The radiological, clinical and therapeutic characteristics were evaluated. There was no predominance regarding gender in the sample studied. The symptoms most often presented by the patients were pain and tumor formation. The radiological characteristics with greatest incidence were multilocular lesions and the treatment used for all the patients was radical surgery. There was no recurrence over the minimum follow-up period of one year and six months. Ameloblastoma: uma análise clínica e terapêutica de seis casos Palavras-chave: Ameloblastoma/etiologia Ameloblastoma/diagnóstico Ameloblastoma/cirurgia Neoplasias mandibulares r e s u m o Os ameloblastomas são tumores odontogênicos, localmente invasivos e de crescimento lento. Sua etiologia ainda não foi bem definida e as formas de tratamento são amplamente discutidas, por causa de possíveis recidivas do tumor e complicaç ões pós-operatórias. Neste trabalho, foram avaliados seis pacientes diagnosticados com ameloblastoma na região mandibular e tratados no Departamento de Ortopedia e Traumatologia do HC-UFG, de 1958 a 1963. Foram avaliadas as características radiológicas, clínicas e terapêuticas. Não houve predomínio em relação ao gênero na amostra estudada. Os sintomas mais apresentados pelos pacientes foram dor e tumoração. As características radiológicas de maior ଝ Work performed in the RBOE-143; No. of Pages 4 2 r e v b r a s o r t o p . 2 0 1 4;x x x(x x):xxx-xxx incidência são de uma lesão multilocular e o tratamento usado em todos os pacientes foi o cirúrgico radical. A recidiva foi nula em um tempo mínimo de um ano e sete meses de seguimento.
Journal of the American College of Cardiology, 2015
Journal of the American College of Cardiology, 2015
Journal of the American College of Cardiology, 2015
Journal of the American College of Cardiology, 2015
Circulation, Nov 25, 2014
Circulation, Nov 25, 2014
Circulation, Nov 25, 2014
Journal of the American College of Cardiology, 2015
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, Jan 20, 2015
The role of right ventricular outflow tract (RVOT) prestenting in the prevention of Melody valve ... more The role of right ventricular outflow tract (RVOT) prestenting in the prevention of Melody valve stent fractures (SFs) is not well defined. We aimed to perform a systematic review and meta-analysis comparing the incidence of SF in Melody valve transcatheter pulmonary implants with and without prestenting. PubMed, EMBASE, and Cochrane Central were searched for studies that reported the incidence of SF in Melody valve transcatheter pulmonary implants stratified by the presence or absence of RVOT prestenting. Subgroup analyses were performed for (1) SF associated with a loss of stent integrity and (2) SF requiring reintervention. Five studies and 360 patients were included, of whom 207 (57.5%) received prestenting. Follow-up ranged from 15 to 30 months. SF were significantly reduced in the prestenting group (16.7%) when compared to no prestenting (33.5%) (odds-ratio [OR] 0.39; 95%CI 0.22-0.69). Patients who received prestenting also had a lower incidence of (1) SF associated with loss ...
Journal of the American College of Cardiology, 2015
Journal of the American College of Cardiology, 2015
Catheterization and Cardiovascular Interventions, 2015
The role of right ventricular outflow tract (RVOT) prestenting in the prevention of Melody valve ... more The role of right ventricular outflow tract (RVOT) prestenting in the prevention of Melody valve stent fractures (SFs) is not well defined. We aimed to perform a systematic review and meta-analysis comparing the incidence of SF in Melody valve transcatheter pulmonary implants with and without prestenting. PubMed, EMBASE, and Cochrane Central were searched for studies that reported the incidence of SF in Melody valve transcatheter pulmonary implants stratified by the presence or absence of RVOT prestenting. Subgroup analyses were performed for (1) SF associated with a loss of stent integrity and (2) SF requiring reintervention. Five studies and 360 patients were included, of whom 207 (57.5%) received prestenting. Follow-up ranged from 15 to 30 months. SF were significantly reduced in the prestenting group (16.7%) when compared to no prestenting (33.5%) (odds-ratio [OR] 0.39; 95%CI 0.22-0.69). Patients who received prestenting also had a lower incidence of (1) SF associated with loss of stent integrity (OR 0.16; 95%CI 0.05-0.48) and (2) SF requiring reintervention (OR 0.15; 95%CI 0.02-0.91). Our findings suggest that stenting of the RVOT prior to Melody valve implantation is associated with a reduction in the incidence of SF and fracture-related reinterventions. © 2015 Wiley Periodicals, Inc.
Journal of the American College of Cardiology, 2015
Journal of the American College of Cardiology, 2015
Journal of the American College of Cardiology, 2015