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Papers by Rhonda Friedman
Brain and Language, Oct 1, 1992
The role of spelling-to-sound correspondence rules in oral word reading was investigated by askin... more The role of spelling-to-sound correspondence rules in oral word reading was investigated by asking patients with Alzheimer's Disease (AD) and normal controls to read aloud pronounceable letter strings that do not happen to be real words. These pseudowords were of two types: those that have orthographically similar "neighbors," and those that have no neighbors. The patients with AD were mildly impaired relative to the normal controls in reading pseudowords with neighbors, but were markedly impaired in reading pseudowords with no neighbors. The results are interpreted as favoring a model of reading in which words and pseudowords are normally read via the same lexical mechanism. An ancillary route involving the conscious application of spelling-to-sound rules is available only to cognitively intact readers.
Thesis (Ph.D)--Massachusetts Institute of Technology, Dept. of Psychology, 1978.MICROFICHE COPY A... more Thesis (Ph.D)--Massachusetts Institute of Technology, Dept. of Psychology, 1978.MICROFICHE COPY AVAILABLE IN ARCHIVES AND HUMANITIES.Vita.Bibliography: leaves 112-115.by Rhonda B. Friedman.Ph.
Neurocase, Jun 1, 1995
Abstract A patient with pure alexia was presented with a series of tachistoscopic tests involving... more Abstract A patient with pure alexia was presented with a series of tachistoscopic tests involving words, letters, pictures, and lines. Low level perceptual processing remained intact. A major deficit was revealed in the speed of identifying orthographic material. This ...
Neurology
Background and Objectives Primary progressive aphasia (PPA) is a neurodegenerative condition that... more Background and Objectives Primary progressive aphasia (PPA) is a neurodegenerative condition that predominantly impairs language. Most investigations of how focal atrophy affects language consider 1 time point compared with healthy controls. However, true atrophy quantification requires comparing individual brains over time. In this observational cohort study, we identified areas where focal atrophy was associated with contemporaneous decline in naming in the same individuals. Methods Cross-sectional analyses–related Boston Naming Test (BNT) performance and volume in 22 regions of interests (ROIs) at each time point using Least Absolute Shrinkage and Selection Operator (LASSO) regression. Longitudinal analysis evaluated changes in BNT performance and change in volume in the same ROIs. Results Participants (N = 62; 50% female; mean age = 66.8 ± 7.4 years) with PPA completed the BNT and MRI twice (mean = 343.9 ± 209.0 days apart). In cross-sectional left inferior frontal gyrus pars op...
Journal of Cognitive Neuroscience, Mar 1, 2000
The Journal of Neuroscience, May 6, 2019
Aphasiology, Mar 1, 1994
Page 1. APHASIOLOGY, 1994, VOL. 8, NO. 2, 181-195 Rationale and efficacy of a tactile kinaestheti... more Page 1. APHASIOLOGY, 1994, VOL. 8, NO. 2, 181-195 Rationale and efficacy of a tactile kinaesthetic treatment for alexia SUSAN NITZBERG LOTT, RHONDA B. FRIEDMANt and CRAIG W. LINEBAUGHS Department of Speech ...
Brain and Language, Dec 1, 2013
Neurology, Jul 1, 1985
In pure alexia, reading is impaired despite almost normal speech, spelling, and writing. We studi... more In pure alexia, reading is impaired despite almost normal speech, spelling, and writing. We studied a right-handed man with pure alexia, but no hemianopia. He had more difficulty reading longer words (word-length effect), but had no selective reading impairment in phonologic or semantic analysis. Clinical-CT correlation suggests that (1) left hemisphere visual pathways crucial for reading arise from or pass close to the left occipitotemporal or inferior temporal gyrus, and (2) relevant transcallosal fibers from the right hemisphere course inferior to the posterior horn of the left lateral ventricle before ascending to left hemisphere language areas.
Cortex, Sep 1, 1990
Two patients exhibited all the characteristics of deep alexia shortly following brain injury. Bot... more Two patients exhibited all the characteristics of deep alexia shortly following brain injury. Both subsequently recovered some reading abilities and evolved to show a pattern of oral reading consistent with phonological alexia. These findings suggest that deep alexia and phonological alexia share common underlying deficits that are mediated by common neurological systems. A two-deficit psycholinguistic model is presented to account for the apparent continuity between deep alexia and phonological alexia.
Brain and Language, Oct 1, 1992
The role of spelling-to-sound correspondence rules in oral word reading was investigated by askin... more The role of spelling-to-sound correspondence rules in oral word reading was investigated by asking patients with Alzheimer's Disease (AD) and normal controls to read aloud pronounceable letter strings that do not happen to be real words. These pseudowords were of two types: those that have orthographically similar "neighbors," and those that have no neighbors. The patients with AD were mildly impaired relative to the normal controls in reading pseudowords with neighbors, but were markedly impaired in reading pseudowords with no neighbors. The results are interpreted as favoring a model of reading in which words and pseudowords are normally read via the same lexical mechanism. An ancillary route involving the conscious application of spelling-to-sound rules is available only to cognitively intact readers.
Thesis (Ph.D)--Massachusetts Institute of Technology, Dept. of Psychology, 1978.MICROFICHE COPY A... more Thesis (Ph.D)--Massachusetts Institute of Technology, Dept. of Psychology, 1978.MICROFICHE COPY AVAILABLE IN ARCHIVES AND HUMANITIES.Vita.Bibliography: leaves 112-115.by Rhonda B. Friedman.Ph.
Neurocase, Jun 1, 1995
Abstract A patient with pure alexia was presented with a series of tachistoscopic tests involving... more Abstract A patient with pure alexia was presented with a series of tachistoscopic tests involving words, letters, pictures, and lines. Low level perceptual processing remained intact. A major deficit was revealed in the speed of identifying orthographic material. This ...
Neurology
Background and Objectives Primary progressive aphasia (PPA) is a neurodegenerative condition that... more Background and Objectives Primary progressive aphasia (PPA) is a neurodegenerative condition that predominantly impairs language. Most investigations of how focal atrophy affects language consider 1 time point compared with healthy controls. However, true atrophy quantification requires comparing individual brains over time. In this observational cohort study, we identified areas where focal atrophy was associated with contemporaneous decline in naming in the same individuals. Methods Cross-sectional analyses–related Boston Naming Test (BNT) performance and volume in 22 regions of interests (ROIs) at each time point using Least Absolute Shrinkage and Selection Operator (LASSO) regression. Longitudinal analysis evaluated changes in BNT performance and change in volume in the same ROIs. Results Participants (N = 62; 50% female; mean age = 66.8 ± 7.4 years) with PPA completed the BNT and MRI twice (mean = 343.9 ± 209.0 days apart). In cross-sectional left inferior frontal gyrus pars op...
Journal of Cognitive Neuroscience, Mar 1, 2000
The Journal of Neuroscience, May 6, 2019
Aphasiology, Mar 1, 1994
Page 1. APHASIOLOGY, 1994, VOL. 8, NO. 2, 181-195 Rationale and efficacy of a tactile kinaestheti... more Page 1. APHASIOLOGY, 1994, VOL. 8, NO. 2, 181-195 Rationale and efficacy of a tactile kinaesthetic treatment for alexia SUSAN NITZBERG LOTT, RHONDA B. FRIEDMANt and CRAIG W. LINEBAUGHS Department of Speech ...
Brain and Language, Dec 1, 2013
Neurology, Jul 1, 1985
In pure alexia, reading is impaired despite almost normal speech, spelling, and writing. We studi... more In pure alexia, reading is impaired despite almost normal speech, spelling, and writing. We studied a right-handed man with pure alexia, but no hemianopia. He had more difficulty reading longer words (word-length effect), but had no selective reading impairment in phonologic or semantic analysis. Clinical-CT correlation suggests that (1) left hemisphere visual pathways crucial for reading arise from or pass close to the left occipitotemporal or inferior temporal gyrus, and (2) relevant transcallosal fibers from the right hemisphere course inferior to the posterior horn of the left lateral ventricle before ascending to left hemisphere language areas.
Cortex, Sep 1, 1990
Two patients exhibited all the characteristics of deep alexia shortly following brain injury. Bot... more Two patients exhibited all the characteristics of deep alexia shortly following brain injury. Both subsequently recovered some reading abilities and evolved to show a pattern of oral reading consistent with phonological alexia. These findings suggest that deep alexia and phonological alexia share common underlying deficits that are mediated by common neurological systems. A two-deficit psycholinguistic model is presented to account for the apparent continuity between deep alexia and phonological alexia.