Ricardo Cerda - Academia.edu (original) (raw)

Papers by Ricardo Cerda

Research paper thumbnail of Heritability and Genetic Correlations of Metabolic Disease– Related Phenotypes in Mexico: Preliminary Report from the GEMM Family Study

Cardiovascular disease (CVD) is a major cause of mortality in the Republic of Mexico, and metabol... more Cardiovascular disease (CVD) is a major cause of mortality in the Republic of Mexico, and metabolic syndrome, a complex of CVD risk factors, is increasingly prevalent. To date, however, there have been few studies of the genetic epidemiology of the metabolic syndrome in Mexico. As a first step in implementing the GEMM Family Study, a large, multicenter collaborative study, we recruited 375 individuals in 21 extended families, without ascertainment on disease, at 9 medical institutions across Mexico. Participants were measured for anthropometric (stature, weight, waist circumference) and hemodynamic (blood pressure, heart rate) phenotypes; glucose, cholesterol, and triglycerides levels were measured in fasting blood. Variance components-based quantitative genetic analyses were performed using SOLAR. All phenotypes except diastolic blood pressure were significantly heritable. Consistent with the definition of metabolic syndrome, many phenotypes exhibited significant environmental correlation, and significant genetic correlations were found between measures of adiposity and fasting

Research paper thumbnail of Two-year controlled effectiveness trial of a school-based intervention to prevent obesity in Chilean children

Public Health Nutrition, 2009

Objective: Obesity prevalence among Chilean children is 19?4 %. The present study aimed to assess... more Objective: Obesity prevalence among Chilean children is 19?4 %. The present study aimed to assess the effectiveness of a school-based obesity prevention programme. Design: Non-randomized controlled study. The intervention included activities in nutrition and physical activity, fully applied the first year and partially in the second one. Primary outcomes were BMI Z-score (BMIZ) and obesity prevalence; secondary outcomes were waist circumference and triceps skinfold thickness. Time effects were assessed by changes in BMI-related variables by gender and period (ANOVA and Tukey test), while intervention effects were determined by comparing changes in (i) obesity prevalence by gender and period (PROC GENMOD) and (ii) BMIZ according gender, age and period (PROC MIXED). Setting: Primary schools in the Chilean cities of Casablanca (intervention group) and Quillota (control group). Subjects: One thousand seven hundred and fifty-nine children from three schools (intervention group) and 671 from one school (control group). Results: Over the two years, obesity prevalence and BMIZ declined significantly in the intervention group; from 17?0 % to 12?3 % and 14?1 % to 10?3 % in boys and girls, respectively, and from 0?62 to 0?53 and 0?64 to 0?58, respectively. In the control group, obesity remained stable at about 21 % and 15 %, while BMIZ increased significantly in the second year. BMIZ declined in both genders and all age categories in the intervention group during the first year (significant only in younger boys). No changes occurred during the summer, while during the second year, BMIZ increased in boys and girls from both groups (significant only in the younger control boys). Obesity declined significantly only in boys during the first year. Conclusion: Effectiveness was greater in the first school year and more evident in younger boys.

Research paper thumbnail of Two-year controlled effectiveness trial of a school-based intervention to prevent obesity in Chilean children

Public Health Nutrition, 2009

Objective: Obesity prevalence among Chilean children is 19?4 %. The present study aimed to assess... more Objective: Obesity prevalence among Chilean children is 19?4 %. The present study aimed to assess the effectiveness of a school-based obesity prevention programme. Design: Non-randomized controlled study. The intervention included activities in nutrition and physical activity, fully applied the first year and partially in the second one. Primary outcomes were BMI Z-score (BMIZ) and obesity prevalence; secondary outcomes were waist circumference and triceps skinfold thickness. Time effects were assessed by changes in BMI-related variables by gender and period (ANOVA and Tukey test), while intervention effects were determined by comparing changes in (i) obesity prevalence by gender and period (PROC GENMOD) and (ii) BMIZ according gender, age and period (PROC MIXED). Setting: Primary schools in the Chilean cities of Casablanca (intervention group) and Quillota (control group). Subjects: One thousand seven hundred and fifty-nine children from three schools (intervention group) and 671 from one school (control group). Results: Over the two years, obesity prevalence and BMIZ declined significantly in the intervention group; from 17?0 % to 12?3 % and 14?1 % to 10?3 % in boys and girls, respectively, and from 0?62 to 0?53 and 0?64 to 0?58, respectively. In the control group, obesity remained stable at about 21 % and 15 %, while BMIZ increased significantly in the second year. BMIZ declined in both genders and all age categories in the intervention group during the first year (significant only in younger boys). No changes occurred during the summer, while during the second year, BMIZ increased in boys and girls from both groups (significant only in the younger control boys). Obesity declined significantly only in boys during the first year. Conclusion: Effectiveness was greater in the first school year and more evident in younger boys.

Research paper thumbnail of Two-year controlled effectiveness trial of a school-based intervention to prevent obesity in Chilean children

Public Health Nutrition, 2009

Objective: Obesity prevalence among Chilean children is 19?4 %. The present study aimed to assess... more Objective: Obesity prevalence among Chilean children is 19?4 %. The present study aimed to assess the effectiveness of a school-based obesity prevention programme. Design: Non-randomized controlled study. The intervention included activities in nutrition and physical activity, fully applied the first year and partially in the second one. Primary outcomes were BMI Z-score (BMIZ) and obesity prevalence; secondary outcomes were waist circumference and triceps skinfold thickness. Time effects were assessed by changes in BMI-related variables by gender and period (ANOVA and Tukey test), while intervention effects were determined by comparing changes in (i) obesity prevalence by gender and period (PROC GENMOD) and (ii) BMIZ according gender, age and period (PROC MIXED). Setting: Primary schools in the Chilean cities of Casablanca (intervention group) and Quillota (control group). Subjects: One thousand seven hundred and fifty-nine children from three schools (intervention group) and 671 from one school (control group). Results: Over the two years, obesity prevalence and BMIZ declined significantly in the intervention group; from 17?0 % to 12?3 % and 14?1 % to 10?3 % in boys and girls, respectively, and from 0?62 to 0?53 and 0?64 to 0?58, respectively. In the control group, obesity remained stable at about 21 % and 15 %, while BMIZ increased significantly in the second year. BMIZ declined in both genders and all age categories in the intervention group during the first year (significant only in younger boys). No changes occurred during the summer, while during the second year, BMIZ increased in boys and girls from both groups (significant only in the younger control boys). Obesity declined significantly only in boys during the first year. Conclusion: Effectiveness was greater in the first school year and more evident in younger boys.

Research paper thumbnail of Two-year controlled effectiveness trial of a school-based intervention to prevent obesity in Chilean children

Public Health Nutrition, 2009

Objective: Obesity prevalence among Chilean children is 19?4 %. The present study aimed to assess... more Objective: Obesity prevalence among Chilean children is 19?4 %. The present study aimed to assess the effectiveness of a school-based obesity prevention programme. Design: Non-randomized controlled study. The intervention included activities in nutrition and physical activity, fully applied the first year and partially in the second one. Primary outcomes were BMI Z-score (BMIZ) and obesity prevalence; secondary outcomes were waist circumference and triceps skinfold thickness. Time effects were assessed by changes in BMI-related variables by gender and period (ANOVA and Tukey test), while intervention effects were determined by comparing changes in (i) obesity prevalence by gender and period (PROC GENMOD) and (ii) BMIZ according gender, age and period (PROC MIXED). Setting: Primary schools in the Chilean cities of Casablanca (intervention group) and Quillota (control group). Subjects: One thousand seven hundred and fifty-nine children from three schools (intervention group) and 671 from one school (control group). Results: Over the two years, obesity prevalence and BMIZ declined significantly in the intervention group; from 17?0 % to 12?3 % and 14?1 % to 10?3 % in boys and girls, respectively, and from 0?62 to 0?53 and 0?64 to 0?58, respectively. In the control group, obesity remained stable at about 21 % and 15 %, while BMIZ increased significantly in the second year. BMIZ declined in both genders and all age categories in the intervention group during the first year (significant only in younger boys). No changes occurred during the summer, while during the second year, BMIZ increased in boys and girls from both groups (significant only in the younger control boys). Obesity declined significantly only in boys during the first year. Conclusion: Effectiveness was greater in the first school year and more evident in younger boys.

Research paper thumbnail of Empresas Familiares y Responsabilidad Social en México

Los valores fundamentales de empresa tradicionalmente se han centrado en la generación de valor e... more Los valores fundamentales de empresa tradicionalmente se han centrado en la generación de valor económico. Podríamos citar entre ellos a la rentabilidad, la productividad, la eficiencia y la eficacia. En el caso de las empresas familiares estos valores corresponden tan sólo a una mitad de la ecuación, y corresponden a la dimensión empresarial. En cuanto a la otra mitad, la dimensión familiar, se puede asegurar que el valor fundamental es el amor, del cual se derivan muchos otros como la lealtad, el apoyo incondicional, el compromiso, la fidelidad y la generosidad. Estos valores de familia son propios de la Responsabilidad Social.

Research paper thumbnail of Heritability and Genetic Correlations of Metabolic Disease– Related Phenotypes in Mexico: Preliminary Report from the GEMM Family Study

Cardiovascular disease (CVD) is a major cause of mortality in the Republic of Mexico, and metabol... more Cardiovascular disease (CVD) is a major cause of mortality in the Republic of Mexico, and metabolic syndrome, a complex of CVD risk factors, is increasingly prevalent. To date, however, there have been few studies of the genetic epidemiology of the metabolic syndrome in Mexico. As a first step in implementing the GEMM Family Study, a large, multicenter collaborative study, we recruited 375 individuals in 21 extended families, without ascertainment on disease, at 9 medical institutions across Mexico. Participants were measured for anthropometric (stature, weight, waist circumference) and hemodynamic (blood pressure, heart rate) phenotypes; glucose, cholesterol, and triglycerides levels were measured in fasting blood. Variance components-based quantitative genetic analyses were performed using SOLAR. All phenotypes except diastolic blood pressure were significantly heritable. Consistent with the definition of metabolic syndrome, many phenotypes exhibited significant environmental correlation, and significant genetic correlations were found between measures of adiposity and fasting

Research paper thumbnail of Two-year controlled effectiveness trial of a school-based intervention to prevent obesity in Chilean children

Public Health Nutrition, 2009

Objective: Obesity prevalence among Chilean children is 19?4 %. The present study aimed to assess... more Objective: Obesity prevalence among Chilean children is 19?4 %. The present study aimed to assess the effectiveness of a school-based obesity prevention programme. Design: Non-randomized controlled study. The intervention included activities in nutrition and physical activity, fully applied the first year and partially in the second one. Primary outcomes were BMI Z-score (BMIZ) and obesity prevalence; secondary outcomes were waist circumference and triceps skinfold thickness. Time effects were assessed by changes in BMI-related variables by gender and period (ANOVA and Tukey test), while intervention effects were determined by comparing changes in (i) obesity prevalence by gender and period (PROC GENMOD) and (ii) BMIZ according gender, age and period (PROC MIXED). Setting: Primary schools in the Chilean cities of Casablanca (intervention group) and Quillota (control group). Subjects: One thousand seven hundred and fifty-nine children from three schools (intervention group) and 671 from one school (control group). Results: Over the two years, obesity prevalence and BMIZ declined significantly in the intervention group; from 17?0 % to 12?3 % and 14?1 % to 10?3 % in boys and girls, respectively, and from 0?62 to 0?53 and 0?64 to 0?58, respectively. In the control group, obesity remained stable at about 21 % and 15 %, while BMIZ increased significantly in the second year. BMIZ declined in both genders and all age categories in the intervention group during the first year (significant only in younger boys). No changes occurred during the summer, while during the second year, BMIZ increased in boys and girls from both groups (significant only in the younger control boys). Obesity declined significantly only in boys during the first year. Conclusion: Effectiveness was greater in the first school year and more evident in younger boys.

Research paper thumbnail of Two-year controlled effectiveness trial of a school-based intervention to prevent obesity in Chilean children

Public Health Nutrition, 2009

Objective: Obesity prevalence among Chilean children is 19?4 %. The present study aimed to assess... more Objective: Obesity prevalence among Chilean children is 19?4 %. The present study aimed to assess the effectiveness of a school-based obesity prevention programme. Design: Non-randomized controlled study. The intervention included activities in nutrition and physical activity, fully applied the first year and partially in the second one. Primary outcomes were BMI Z-score (BMIZ) and obesity prevalence; secondary outcomes were waist circumference and triceps skinfold thickness. Time effects were assessed by changes in BMI-related variables by gender and period (ANOVA and Tukey test), while intervention effects were determined by comparing changes in (i) obesity prevalence by gender and period (PROC GENMOD) and (ii) BMIZ according gender, age and period (PROC MIXED). Setting: Primary schools in the Chilean cities of Casablanca (intervention group) and Quillota (control group). Subjects: One thousand seven hundred and fifty-nine children from three schools (intervention group) and 671 from one school (control group). Results: Over the two years, obesity prevalence and BMIZ declined significantly in the intervention group; from 17?0 % to 12?3 % and 14?1 % to 10?3 % in boys and girls, respectively, and from 0?62 to 0?53 and 0?64 to 0?58, respectively. In the control group, obesity remained stable at about 21 % and 15 %, while BMIZ increased significantly in the second year. BMIZ declined in both genders and all age categories in the intervention group during the first year (significant only in younger boys). No changes occurred during the summer, while during the second year, BMIZ increased in boys and girls from both groups (significant only in the younger control boys). Obesity declined significantly only in boys during the first year. Conclusion: Effectiveness was greater in the first school year and more evident in younger boys.

Research paper thumbnail of Two-year controlled effectiveness trial of a school-based intervention to prevent obesity in Chilean children

Public Health Nutrition, 2009

Objective: Obesity prevalence among Chilean children is 19?4 %. The present study aimed to assess... more Objective: Obesity prevalence among Chilean children is 19?4 %. The present study aimed to assess the effectiveness of a school-based obesity prevention programme. Design: Non-randomized controlled study. The intervention included activities in nutrition and physical activity, fully applied the first year and partially in the second one. Primary outcomes were BMI Z-score (BMIZ) and obesity prevalence; secondary outcomes were waist circumference and triceps skinfold thickness. Time effects were assessed by changes in BMI-related variables by gender and period (ANOVA and Tukey test), while intervention effects were determined by comparing changes in (i) obesity prevalence by gender and period (PROC GENMOD) and (ii) BMIZ according gender, age and period (PROC MIXED). Setting: Primary schools in the Chilean cities of Casablanca (intervention group) and Quillota (control group). Subjects: One thousand seven hundred and fifty-nine children from three schools (intervention group) and 671 from one school (control group). Results: Over the two years, obesity prevalence and BMIZ declined significantly in the intervention group; from 17?0 % to 12?3 % and 14?1 % to 10?3 % in boys and girls, respectively, and from 0?62 to 0?53 and 0?64 to 0?58, respectively. In the control group, obesity remained stable at about 21 % and 15 %, while BMIZ increased significantly in the second year. BMIZ declined in both genders and all age categories in the intervention group during the first year (significant only in younger boys). No changes occurred during the summer, while during the second year, BMIZ increased in boys and girls from both groups (significant only in the younger control boys). Obesity declined significantly only in boys during the first year. Conclusion: Effectiveness was greater in the first school year and more evident in younger boys.

Research paper thumbnail of Two-year controlled effectiveness trial of a school-based intervention to prevent obesity in Chilean children

Public Health Nutrition, 2009

Objective: Obesity prevalence among Chilean children is 19?4 %. The present study aimed to assess... more Objective: Obesity prevalence among Chilean children is 19?4 %. The present study aimed to assess the effectiveness of a school-based obesity prevention programme. Design: Non-randomized controlled study. The intervention included activities in nutrition and physical activity, fully applied the first year and partially in the second one. Primary outcomes were BMI Z-score (BMIZ) and obesity prevalence; secondary outcomes were waist circumference and triceps skinfold thickness. Time effects were assessed by changes in BMI-related variables by gender and period (ANOVA and Tukey test), while intervention effects were determined by comparing changes in (i) obesity prevalence by gender and period (PROC GENMOD) and (ii) BMIZ according gender, age and period (PROC MIXED). Setting: Primary schools in the Chilean cities of Casablanca (intervention group) and Quillota (control group). Subjects: One thousand seven hundred and fifty-nine children from three schools (intervention group) and 671 from one school (control group). Results: Over the two years, obesity prevalence and BMIZ declined significantly in the intervention group; from 17?0 % to 12?3 % and 14?1 % to 10?3 % in boys and girls, respectively, and from 0?62 to 0?53 and 0?64 to 0?58, respectively. In the control group, obesity remained stable at about 21 % and 15 %, while BMIZ increased significantly in the second year. BMIZ declined in both genders and all age categories in the intervention group during the first year (significant only in younger boys). No changes occurred during the summer, while during the second year, BMIZ increased in boys and girls from both groups (significant only in the younger control boys). Obesity declined significantly only in boys during the first year. Conclusion: Effectiveness was greater in the first school year and more evident in younger boys.

Research paper thumbnail of Empresas Familiares y Responsabilidad Social en México

Los valores fundamentales de empresa tradicionalmente se han centrado en la generación de valor e... more Los valores fundamentales de empresa tradicionalmente se han centrado en la generación de valor económico. Podríamos citar entre ellos a la rentabilidad, la productividad, la eficiencia y la eficacia. En el caso de las empresas familiares estos valores corresponden tan sólo a una mitad de la ecuación, y corresponden a la dimensión empresarial. En cuanto a la otra mitad, la dimensión familiar, se puede asegurar que el valor fundamental es el amor, del cual se derivan muchos otros como la lealtad, el apoyo incondicional, el compromiso, la fidelidad y la generosidad. Estos valores de familia son propios de la Responsabilidad Social.