Ricardo Damatto - Academia.edu (original) (raw)

Papers by Ricardo Damatto

Research paper thumbnail of Effects of Growth Hormone Administration on Cardiac Remodeling Process in Rats with Aortic Stenosis‐Induced Heart Failure

The FASEB Journal

ObjectiveTo evaluate the growth hormone (GH) administration influence on cardiac structures and f... more ObjectiveTo evaluate the growth hormone (GH) administration influence on cardiac structures and function in aortic stenosis‐induced chronic heart failure rats.MethodsMale wistar rats were submitted to surgery to induce aortic stenosis. After heart failure findings detection, rats cardiac structures and ventricular function were assessed by transthoracic echocardiogram. Aortic stenosis group (EAo) animals were randomly subdivided in two groups, EAo GH treated group (EAo‐GH, n=10) and EAo without treatment group (EAo, n=15). Sham group was also constituted(n=18). After the treatment period, all animals were yet submitted to echocardiogram.ResultsGH administration preserved body weight (BW) (Sham 484±42; EAo 415±31; EAo‐GH 476±58 g; p<0.05 EAo vs Sham and EAo‐GH). Left ventricular diastolic diameter/BW was higher in EAo group than Sham; EAo‐GH and Sham groups were similar (Sham 15.5±1.5; EAo18.5±3.2; EAo‐GH 16.5±3.6 mm/kg; p<0.05 EAo vs. Sham). Left ventricular posterior wall thi...

Research paper thumbnail of Signaling pathways involved in skeletal muscle response to oxidative stress in rats with heart failure

The FASEB Journal

This study examined whether mitogen‐activated protein kinases (MAPK) and nuclear factor‐kappaB (N... more This study examined whether mitogen‐activated protein kinases (MAPK) and nuclear factor‐kappaB (NF‐κB) pathways participate in skeletal muscle response to oxidative stress in heart failure rats.MethodsMyocardial infarction (MI) was induced by left coronary occlusion. Four months later, rats were assigned to three groups: Sham (n=8), MI without treatment (n=8), and MI/NAC (MI treated with the antioxidant N‐acetylcysteine, 120 mg/kg/day, n=8). Rats with small MI were excluded. Six months after surgery, total and phosphorylated forms of MAPK (JNK and p38) and NF‐κB proteins were analyzed by Westen blot in soleus muscle.ResultsMI size did not differ between MI and MI/NAC groups (P>0.05; Student's t test). Total JNK, p‐p38 and p‐NF‐κB did not differ among the groups. Table shows the other Western blot results.ConclusionSkeletal muscle response to oxidative stress is combined with JNK and NF‐κB protein expression changes in rats with heart failure. Support: FAPESP, CNPq, and Fundun...

Research paper thumbnail of Inclusion of an Intellectual Disability Student in Physical Education Classes

FIEP Bulletin On-line, 2020

Neurodevelopmental Disorders is a set of changes that has its onset in the child's developmen... more Neurodevelopmental Disorders is a set of changes that has its onset in the child's developmental period. One of the manifestations of this disorder is Intellectual Disability, which occurs during the child's development, causing motor, speech and social failures. The stimuli are extremely important to have an evolution in the cognitive, motor, affective and social development, besides promoting inclusion. Objective of this study was to identify the effectiveness of motor stimulation in a student with intellectual disabilities in physical education classes. The present study is a case report that developed in a 15 years old with intellectual disability Intellectual Development Disorder. The Francisco Rosa Neto Motor Development Scale was used as an assessment instrument. The tests were applied in 50-minute sections to apply all the tests in the manual, namely fine motor skills, overall motor skills, balance, body scheme, organization. spatial, temporal organization and laterality. After initial evaluation, two further evaluations were performed during the 10-week stimulation period, one on the 5th and the 10th week. Having some evolutions in certain abilities such as fine motor coordination, balance, body schema, temporal organization, being verified statistically significant improvement already in the 5th week of stimulation, the spatial organization showed statistically significant improvement in the 10th week and the body schema skills, temporal organization presented statistically significant improvement on week 5 and 10, indicating that there was a statistically significant improvement in both periods evaluated. In the evaluation of laterality, it was found that the individual is complete right-handed. It is concluded that motor stimulation acts positively on the motor skills of children with intellectual disabilities.

Research paper thumbnail of Effects of early aldosterone antagonism on cardiac remodeling in rats with aortic stenosis-induced pressure overload

International Journal of Cardiology, Nov 1, 2016

Aldosterone plays a pivotal role in the pathophysiology of systolic heart failure. However, wheth... more Aldosterone plays a pivotal role in the pathophysiology of systolic heart failure. However, whether early aldosterone antagonism improves cardiac remodeling during persistent pressure overload is unsettled. We evaluated the effects of aldosterone antagonist spironolactone on cardiac remodeling in rats with ascending aortic stenosis (AS). Methods: Three days after inducing AS, weaning rats were randomized to receive spironolactone (AS-SPR, 20 mg/kg/day) or no drug (AS) for 18 weeks, and compared with sham-operated rats. Myocardial function was studied in isolated left ventricular (LV) papillary muscles. Statistical analyses: ANOVA or Kruskal-Wallis tests.

Research paper thumbnail of O Karatê Como Agente Promotor De Melhoras Psicomotoras, Academicas, Sociais e Comportamentais No Ambiente Escolar

FIEP Bulletin On-line, 2018

Resumo: O karate, “o caminho das maos vazias”, surgiu nas ilhas de Okinawa no Japao por meio das ... more Resumo: O karate, “o caminho das maos vazias”, surgiu nas ilhas de Okinawa no Japao por meio das tecnicas epreceitos filosoficos de Gichin Funakoshi, permeia o ataque e defesa sem uso de armas e procura aperfeicoar os aspectosfisicos e mentais dos praticantes. O objetivo dessa pesquisa e verificar se estimulos ofertados por meio das aulas de karateexercem efeitos sobre os aspectos psicomotores, sociais, comportamentais e academicos em escolares do terceiro e quartoano do ensino fundamental I. Os responsaveis assinaram o Termo de Livre Consentimento Esclarecido (TCLE), foramrealizadas avaliacoes antropometricas. O peso foi aferido por uma balanca com capacidade de 300 1bs 130 kg, graduada de 21b. 1 kg, e fita metrica de 3 m por 10 ft FZ-Z19 mm. Como parâmetro para avalicao dos aspectos psicomotores foi utilizado aEscala de Desenvolvimento Motor (EDM)), em vista as habilidades sociais, comportamentais e academicas a Escalas deHabilidades Sociais, Comportamentos Problematicos e Competencia Academica (SSRS-BR). A comparacao das variaveisentre os momentos inicial e final foi realizada pelo teste t-student para amostras dependentes, sendo o nivel de significânciaadotado de 5%. Os resultados evidenciaram melhoras em todos os aspectos psicomotores. Considerando que em habilidadessociais e comportamentais foi significativo em relacao a visao dos alunos o autocontrole , para os pais hiperatividade, e para osprofessores o autocontrole, autodefesa , comportamento problematico externalizantes e responsabilidade/cooperacao ,assercao, cooperacao com pares, comportamento problematico internalizantes e melhoras no desempenho de aprendizagemde competencia academica. Os resultados evidenciam que a insercao da pratica do karate contribui para melhoras dos aspectospsicomotores, sociais, comportamentais e academicos da amostra estudada.

Research paper thumbnail of P2508Physical exercise improves diastolic function and attenuates type III collagen myocardial accumulation in aged rats

European Heart Journal, Oct 1, 2019

Background: Interstitial collagen matrix increase and left ventricular (LV) diastolic dysfunction... more Background: Interstitial collagen matrix increase and left ventricular (LV) diastolic dysfunction are the most frequent cardiac alterations during aging. Whether changes are part of the aging process or induced by a sedentary life style is not clear. Purpose: To evaluate the effects of aerobic exercise on functional capacity, cardiac and myocardial function, and interstitial collagen matrix of aging rats. Methods: Male Wistar rats were assigned into three groups: 1) sedentary six-month-old rats (W6, n=24); 2) sedentary 21-month-old rats (W21-Sed, n=25); and 3) exercised 21-month-old rats (W21-Ex, n=20). Physical exercise was by treadmill for 12 weeks. In vivo cardiac evaluation was performed by Doppler echocardiography. Myocardial function was assessed in LV papillary muscle preparation. Total and soluble myocardial collagen concentrations were evaluated by spectrophotometry. Protein expression was analyzed by Western blot. Statistical analysis: ANOVA and Bonferroni or Kruskal-Wallis and Dunn. Results: Body weight was greater in W21-Sed and W21-Ex than W6. Before exercise, functional capacity did not differ between aged groups. After training, W21-Ex group ran farther and longer in treadmill than W21-Sed e W6, and W21-Sed presented worse physical capacity than W6. LV diastolic posterior wall, interventricular septum, and relative wall thicknesses were greater in W21-Sed and W21-Ex than W6, and did not differ between aged groups. E wave was lower in both aged groups than W6. E/E' ratio was lower in W21-Ex than W21-Sed. Isolated papillary muscle developed tension was higher in W21-Sed than W6; W21-Ex values did not differ from both W6 and W21-Sed groups. Time to peak tension was higher in W21-Sed and W21-Ex than W6 and did not differ between aged groups. The same results were observed after positive inotropic stimulation. Total collagen concentration was higher in W21-Sed and W21-Ex than W6 and did not differ between aged groups. Soluble collagen did not differ between groups. Type III collagen expression was higher in W21-Sed than W6; the W21-Ex group presented intermediary values that did not differ from W21-Sed or W6 groups. Type I collagen was similar between groups. Conclusion: Regular physical aerobic training improves functional capacity and left ventricular diastolic function and attenuates type III collagen myocardial accumulation in aged rats.

Research paper thumbnail of Recreational Practices in Development of a Student's Motor with Adhd

FIEP Bulletin On-line, 2019

In addition, the realization of recreational activities is important for the individual in a warm... more In addition, the realization of recreational activities is important for the individual in a warm, fun and full of possibilities, as well as the accomplishment of a series of tasks, stimulating a self-confidence and softening the feeling of incapacity (TINTORI; BAST; PITTA, 2010). During the KTK test, the equilibrium and single-leg jumps tasks were observed for the dynamic balance and strength abilities of dominant or non-dominant lower limbs. In the lateral jumps task the velocity of the performer was observed in alternating the jumps realized with the feet together. The lateral transfer task sought to evaluate the laterality and spatial notion (SILVA JUNIOR, 2012; GORLA; ARAUJO; RODRIGUES, 2014). The aim of this study was to verify if the development of recreational practices could improve the motor development in ADHD patients. The values presented in the motor quotients (QM) originated from the absolute values obtained in the accomplishment of each task of the KTK test. Furthermore, these values were related to the reference table of the original KTK test, which takes into account the performance obtained in the tasks and the age of the performer. The present study is a case report of a 14-year-old student with Attention Deficit Hyperactivity Disorder accompanied by the Multidisciplinary Pedagogical Support Center (CEAPEM) in the city of Itapeva-SP. Recreation is an indispensable tool that explores motor skills during play, manipulation of objects and participation in games without any learning process, providing benefits for the individual with ADHD, such as cooperation, interaction with the group, respect for rules, and establishment of interpersonal, motor perceptive, cognitive, social and academic relationships (TINTORI; BAST; PITTA, 2010; SILVA, DAMATTO, 2018). Attention Deficit Hyperactivity Disorder (ADHD) is a neurobehavioral disorder that results in attenuation of attention, characterized as a neuropsychiatric syndrome leading to inattention, hyperactivity and impulsivity to the various environments and the daily action of the subject for less (AMERICAN PSYCHIATRIC ASSOCIATION, 2013). The DSC-V (DSM-V) is a type of diagnosis for the type of association that falls within the first six symptoms of the syndrome and may vary the intensity of the disorder from individual to individual (AMERICAN PSYCHIATRIC ASSOCIATION,

Research paper thumbnail of Determination of the Use of Ergogenics in Bodybuilding Practice

FIEP Bulletin On-line, 2019

Daily the number of people looking for gyms to aid in the search for the desired aesthetic standa... more Daily the number of people looking for gyms to aid in the search for the desired aesthetic standard increases. With theincreasing demand for bodybuilding, the use of ergogenics has also increased, aiming to maintain health or even improve sportsperformance. The objective of the present study was to verify the incidence of ergogenic use and to characterize the bodybuildingindividuals who use ergogenic substances and to verify which professional is prescribing these substances. A total of 164bodybuilders were evaluated. The participants answered a questionnaire elaborated in Google Docs with the theme about theuse of ergogenic substances. The questions applied followed objective and multiple choice. Based on the data presented, it isconcluded that the use of steroids is not so common among bodybuilders, but their prescription does not happen due to the factthat in no case was there a medical prescription. With regard to supplements, its use is very common, for the various objectives,however, it is not frequent the indication made by a nutritionist. From the analysis of the data, it is noticed that there is even theintervention of Physical Education Professionals, which is not in accordance with the functions they must exercise, emphasizingthat each professional should act in the area in which he is responsible formation.

Research paper thumbnail of N-Acetylcysteine Influence on Oxidative Stress and Cardiac Remodeling in Rats with Persistent Pressure Overload

The FASEB Journal, Apr 1, 2017

Background/Aims: To evaluate the effects of the antioxidant N-acetylcysteine (NAC) on cardiac str... more Background/Aims: To evaluate the effects of the antioxidant N-acetylcysteine (NAC) on cardiac structure and function in rats with long-term ascending aortic stenosis (AS). Methods: Four months after inducing AS, Wistar rats were assigned into the groups Sham, AS, and AS treated with NAC (AS-NAC) and followed for eight weeks. Cardiac structure and function were evaluated by echocardiogram. Myocardial antioxidant enzymes activity was measured by spectrophotometry and malondialdehyde serum concentration by HPLC. Gene expression of NADPH oxidase subunits NOX2, NOX4, p22 phox, and p47 phox was assessed by real time RT-PCR and protein expression of MAPK proteins by Western blot. Statistical analyzes were performed with Goodman and ANOVA or Mann-Whitney Results: NAC restored myocardial total glutathione (Sham 20.8±3.00; AS 12.6±2.92; AS-NAC 17.6±2.45 nmol/g tissue; p<0.05 AS vs Sham and AS-NAC). Malondialdehyde serum concentration was lower in AS-NAC and myocardial lipid hydroperoxide was higher in AS (Sham 199±48.1; AS 301±36.0; AS-NAC 181±41.3 nmol/g tissue). Glutathione peroxidase activity was lower in AS than Sham. Echocardiogram showed LV concentric hypertrophy with systolic and diastolic dysfunction before and after treatment; no differences were observed between AS-NAC and AS groups. NAC reduced p-ERK and p-JNK protein expression, attenuated myocardial fibrosis, and decreased the frequency of right ventricular hypertrophy. Conclusion: N-acetylcysteine restores myocardial total glutathione, reduces systemic and myocardial oxidative stress, improves MAPK signaling, and attenuates myocardial fibrosis in aortic stenosis rats.

Research paper thumbnail of Prenatal Stress: Molecular Mechanisms and Cardiovascular Disease

Arquivos Brasileiros De Cardiologia, 2018

Research paper thumbnail of Renin‐angiotensin‐aldosterone system blockade ameliorates myocardial and ventricular function of rats with diabetes mellitus

The FASEB Journal, Apr 1, 2015

Research paper thumbnail of Fundamento: A Tolerância ao Esforço Físico (TEF) é uma medida de condicionamento cardiorrespiratório. A capacidade aeróbica é reduzida na Insuficiência Cardíaca (IC), embora não haja dados disponíveis sobre esse parâmetro em animais com disfunção ventricular e sem sinais de IC. Objetivo: Avaliar ...

Fundamento: A Tolerância ao Esforço Físico (TEF) é uma medida de condicionamento cardiorrespirató... more Fundamento: A Tolerância ao Esforço Físico (TEF) é uma medida de condicionamento cardiorrespiratório. A capacidade aeróbica é reduzida na Insuficiência Cardíaca (IC), embora não haja dados disponíveis sobre esse parâmetro em animais com disfunção ventricular e sem sinais de IC. Objetivo: Avaliar a TEF em ratos com disfunção ventricular diastólica isolada ou associada com disfunção sistólica induzida pela Estenose da Aorta ascendente (EAo). Métodos: Ratos Wistar machos jovens (20-30 dias de idade) foram divididos em Grupo Controle (GC, n = 11) e Grupo EAo (n = 12). Os animais foram avaliados em 6 e 18 semanas após a cirurgia para EAo. O teste ergométrico foi feito até a exaustão e foram avaliadas a velocidade da esteira e a concentração de lactato [LAC] no limiar de lactato, velocidade da esteira e [LAC] na exaustão, e tempo total do teste. Resultados: Dados ecocardiográficos revelaram remodelação do átrio esquerdo e hipertrofia concêntrica ventricular esquerda em 6 e 18 semanas. A fração de encurtamento endocárdico mostrou-se maior no grupo EAo do que no GC em 6 e 18 semanas. A fração de encurtamento da parede média mostrou-se maior no grupo EAo do que no GC em 6 semanas. O índice cardíaco mostrou-se semelhante no GC e no grupo EAo em 6 e 18 semanas, tendo diminuído entre 6-18 semanas em ambos os grupos. A razão entre a onda E a onda A foi maior no GC do que no grupo EAo em ambos os períodos e não se alterou em ambos os grupos entre a semana 6 e a semana 18. Os parâmetros do teste de esforço na esteira foram semelhantes nos dois grupos tanto na semana 6 quanto na semana 18. Conclusão: Embora a EAo promova a disfunção diastólica isolada ou associada à disfunção sistólica, em 6 ou 18 semanas, ela não é suficiente para alterar a tolerância ao esforço físico. (Arq Bras Cardiol. 2012; [online].ahead print, PP.0-0) Palavras-chave: Ratos; Exercício; Estenose da Valva Aórtica; Disfunção Ventricular.

Research paper thumbnail of Growth Hormone Administration Alters Protein Expression in Skeletal Muscle of Rats with Aortic Stenosis‐Induced Heart Failure

Research paper thumbnail of Moderate intensity exercise does not modulate myostatin and follistatin gene expression in the gastrocnemius muscle of spontaneously hypertensive rats with heart failure

The FASEB Journal

The myostatin/follistatin pathway modulates skeletal muscle trophism. Physical exercise has an im... more The myostatin/follistatin pathway modulates skeletal muscle trophism. Physical exercise has an important role in the heart failure treatment. In this study we evaluated the effects of moderate aerobic physical training on myostatin and follistatin gene expression and trophism in the gastrocnemius of spontaneously hypertensive rats with heart failure. Sixteen‐month‐old SHRs and normotensive Wistar‐Kyoto (WKY) rats were assigned to sedentary or trained groups. Exercise was performed on treadmill, 30 min/day, 5 days/week, 12 m/min for 4 months. Transthoracic echocardiogram was performed at the end of experiment. Gene expression was evaluated by real time RT‐PCR. Fiber cross‐sectional area was measured in HE‐stained histological sections.Statistical analysistwo‐way ANOVA and Tukey.ResultsEchocardiography showed left cardiac chambers dilation and left ventricular systolic and diastolic dysfunction in both SHR groups compared to the WKY groups. Gene expression of myostatin and follistatin...

Research paper thumbnail of Aerobic Exercise During Advance Stage of Uncontrolled Arterial Hypertension

Frontiers in Physiology

AimTo evaluate the influence of physical training on myocardial function, oxidative stress, energ... more AimTo evaluate the influence of physical training on myocardial function, oxidative stress, energy metabolism, and MAPKs and NF-κB signaling pathways in spontaneously hypertensive rats (SHR), at advanced stage of arterial hypertension, which precedes heart failure development.MethodsWe studied four experimental groups: normotensive Wistar rats (W, n = 27), trained W (W-EX, n = 31), SHR (n = 27), and exercised SHR (SHR-EX, n = 32). At 13 months old, the exercise groups underwent treadmill exercise 5 days a week for 4 months. In vitro myocardial function was analyzed in left ventricular (LV) papillary muscle preparations. Antioxidant enzyme activity and energy metabolism were assessed by spectrophotometry. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity was analyzed by lucigenin reduction and protein expression by Western blot. Statistical analyzes: ANOVA and Tukey or Kruskal–Wallis and Dunn tests.ResultsSHR-EX had a lower frequency of heart failure features than ...

Research paper thumbnail of Influence of N ‐Acetylcysteine on Apoptosis in White‐Gastrocnemius Muscle of Rats With Chronic Heart Failure

Research paper thumbnail of Growth Hormone Administration Influence on Soleus Muscle of Heart Failure Rats

Research paper thumbnail of Growth hormone influences atrophy pathways in skeletal muscle of heart failure rats (1163.3)

Research paper thumbnail of Protein expression of myostatin and follistatin in the myocardium of spontaneously hypertensive rats with heart failure

Research paper thumbnail of Influência Do Treinamento Intervalado Realizado Em Diferentes Superfícies No Desempenho De Atletas Mirins De Futsal

FIEP Bulletin On-line, 2018

O futsal, e uma das modalidades que mais cresce no cenario esportivo nos ultimos anos, com isso, ... more O futsal, e uma das modalidades que mais cresce no cenario esportivo nos ultimos anos, com isso, torna-senecessario conhecer as caracteristicas deste esporte, para a estruturacao de programas eficazes de treinamento. O atleta esubmetido a varias situacoes de alta intensidade e curta duracao durante o jogo, portanto o treinamento intervalado e ummetodo bastante indicado para treinadores. O objetivo deste estudo foi comparar o desempenho em atletas de futsal apostreinamento intervalado realizado em quadra e areia. Participaram da pesquisa 27 atletas de futsal com idade entre 13 e 16anos, que inicialmente foram submetidos a uma avaliacao antropometrica, e em seguida pelos testes de salto vertical e depotencia anaerobia. Posteriormente foram divididos em dois grupos: grupo Quadra (GQ, n= 14), que executou todos os treinosna quadra, e grupo areia (GA, n= 13), que executou treinamento intervalado na areia. Durante oito semanas, com duas sessoessemanais, os atletas desenvolviam como parte ...

Research paper thumbnail of Effects of Growth Hormone Administration on Cardiac Remodeling Process in Rats with Aortic Stenosis‐Induced Heart Failure

The FASEB Journal

ObjectiveTo evaluate the growth hormone (GH) administration influence on cardiac structures and f... more ObjectiveTo evaluate the growth hormone (GH) administration influence on cardiac structures and function in aortic stenosis‐induced chronic heart failure rats.MethodsMale wistar rats were submitted to surgery to induce aortic stenosis. After heart failure findings detection, rats cardiac structures and ventricular function were assessed by transthoracic echocardiogram. Aortic stenosis group (EAo) animals were randomly subdivided in two groups, EAo GH treated group (EAo‐GH, n=10) and EAo without treatment group (EAo, n=15). Sham group was also constituted(n=18). After the treatment period, all animals were yet submitted to echocardiogram.ResultsGH administration preserved body weight (BW) (Sham 484±42; EAo 415±31; EAo‐GH 476±58 g; p<0.05 EAo vs Sham and EAo‐GH). Left ventricular diastolic diameter/BW was higher in EAo group than Sham; EAo‐GH and Sham groups were similar (Sham 15.5±1.5; EAo18.5±3.2; EAo‐GH 16.5±3.6 mm/kg; p<0.05 EAo vs. Sham). Left ventricular posterior wall thi...

Research paper thumbnail of Signaling pathways involved in skeletal muscle response to oxidative stress in rats with heart failure

The FASEB Journal

This study examined whether mitogen‐activated protein kinases (MAPK) and nuclear factor‐kappaB (N... more This study examined whether mitogen‐activated protein kinases (MAPK) and nuclear factor‐kappaB (NF‐κB) pathways participate in skeletal muscle response to oxidative stress in heart failure rats.MethodsMyocardial infarction (MI) was induced by left coronary occlusion. Four months later, rats were assigned to three groups: Sham (n=8), MI without treatment (n=8), and MI/NAC (MI treated with the antioxidant N‐acetylcysteine, 120 mg/kg/day, n=8). Rats with small MI were excluded. Six months after surgery, total and phosphorylated forms of MAPK (JNK and p38) and NF‐κB proteins were analyzed by Westen blot in soleus muscle.ResultsMI size did not differ between MI and MI/NAC groups (P>0.05; Student's t test). Total JNK, p‐p38 and p‐NF‐κB did not differ among the groups. Table shows the other Western blot results.ConclusionSkeletal muscle response to oxidative stress is combined with JNK and NF‐κB protein expression changes in rats with heart failure. Support: FAPESP, CNPq, and Fundun...

Research paper thumbnail of Inclusion of an Intellectual Disability Student in Physical Education Classes

FIEP Bulletin On-line, 2020

Neurodevelopmental Disorders is a set of changes that has its onset in the child's developmen... more Neurodevelopmental Disorders is a set of changes that has its onset in the child's developmental period. One of the manifestations of this disorder is Intellectual Disability, which occurs during the child's development, causing motor, speech and social failures. The stimuli are extremely important to have an evolution in the cognitive, motor, affective and social development, besides promoting inclusion. Objective of this study was to identify the effectiveness of motor stimulation in a student with intellectual disabilities in physical education classes. The present study is a case report that developed in a 15 years old with intellectual disability Intellectual Development Disorder. The Francisco Rosa Neto Motor Development Scale was used as an assessment instrument. The tests were applied in 50-minute sections to apply all the tests in the manual, namely fine motor skills, overall motor skills, balance, body scheme, organization. spatial, temporal organization and laterality. After initial evaluation, two further evaluations were performed during the 10-week stimulation period, one on the 5th and the 10th week. Having some evolutions in certain abilities such as fine motor coordination, balance, body schema, temporal organization, being verified statistically significant improvement already in the 5th week of stimulation, the spatial organization showed statistically significant improvement in the 10th week and the body schema skills, temporal organization presented statistically significant improvement on week 5 and 10, indicating that there was a statistically significant improvement in both periods evaluated. In the evaluation of laterality, it was found that the individual is complete right-handed. It is concluded that motor stimulation acts positively on the motor skills of children with intellectual disabilities.

Research paper thumbnail of Effects of early aldosterone antagonism on cardiac remodeling in rats with aortic stenosis-induced pressure overload

International Journal of Cardiology, Nov 1, 2016

Aldosterone plays a pivotal role in the pathophysiology of systolic heart failure. However, wheth... more Aldosterone plays a pivotal role in the pathophysiology of systolic heart failure. However, whether early aldosterone antagonism improves cardiac remodeling during persistent pressure overload is unsettled. We evaluated the effects of aldosterone antagonist spironolactone on cardiac remodeling in rats with ascending aortic stenosis (AS). Methods: Three days after inducing AS, weaning rats were randomized to receive spironolactone (AS-SPR, 20 mg/kg/day) or no drug (AS) for 18 weeks, and compared with sham-operated rats. Myocardial function was studied in isolated left ventricular (LV) papillary muscles. Statistical analyses: ANOVA or Kruskal-Wallis tests.

Research paper thumbnail of O Karatê Como Agente Promotor De Melhoras Psicomotoras, Academicas, Sociais e Comportamentais No Ambiente Escolar

FIEP Bulletin On-line, 2018

Resumo: O karate, “o caminho das maos vazias”, surgiu nas ilhas de Okinawa no Japao por meio das ... more Resumo: O karate, “o caminho das maos vazias”, surgiu nas ilhas de Okinawa no Japao por meio das tecnicas epreceitos filosoficos de Gichin Funakoshi, permeia o ataque e defesa sem uso de armas e procura aperfeicoar os aspectosfisicos e mentais dos praticantes. O objetivo dessa pesquisa e verificar se estimulos ofertados por meio das aulas de karateexercem efeitos sobre os aspectos psicomotores, sociais, comportamentais e academicos em escolares do terceiro e quartoano do ensino fundamental I. Os responsaveis assinaram o Termo de Livre Consentimento Esclarecido (TCLE), foramrealizadas avaliacoes antropometricas. O peso foi aferido por uma balanca com capacidade de 300 1bs 130 kg, graduada de 21b. 1 kg, e fita metrica de 3 m por 10 ft FZ-Z19 mm. Como parâmetro para avalicao dos aspectos psicomotores foi utilizado aEscala de Desenvolvimento Motor (EDM)), em vista as habilidades sociais, comportamentais e academicas a Escalas deHabilidades Sociais, Comportamentos Problematicos e Competencia Academica (SSRS-BR). A comparacao das variaveisentre os momentos inicial e final foi realizada pelo teste t-student para amostras dependentes, sendo o nivel de significânciaadotado de 5%. Os resultados evidenciaram melhoras em todos os aspectos psicomotores. Considerando que em habilidadessociais e comportamentais foi significativo em relacao a visao dos alunos o autocontrole , para os pais hiperatividade, e para osprofessores o autocontrole, autodefesa , comportamento problematico externalizantes e responsabilidade/cooperacao ,assercao, cooperacao com pares, comportamento problematico internalizantes e melhoras no desempenho de aprendizagemde competencia academica. Os resultados evidenciam que a insercao da pratica do karate contribui para melhoras dos aspectospsicomotores, sociais, comportamentais e academicos da amostra estudada.

Research paper thumbnail of P2508Physical exercise improves diastolic function and attenuates type III collagen myocardial accumulation in aged rats

European Heart Journal, Oct 1, 2019

Background: Interstitial collagen matrix increase and left ventricular (LV) diastolic dysfunction... more Background: Interstitial collagen matrix increase and left ventricular (LV) diastolic dysfunction are the most frequent cardiac alterations during aging. Whether changes are part of the aging process or induced by a sedentary life style is not clear. Purpose: To evaluate the effects of aerobic exercise on functional capacity, cardiac and myocardial function, and interstitial collagen matrix of aging rats. Methods: Male Wistar rats were assigned into three groups: 1) sedentary six-month-old rats (W6, n=24); 2) sedentary 21-month-old rats (W21-Sed, n=25); and 3) exercised 21-month-old rats (W21-Ex, n=20). Physical exercise was by treadmill for 12 weeks. In vivo cardiac evaluation was performed by Doppler echocardiography. Myocardial function was assessed in LV papillary muscle preparation. Total and soluble myocardial collagen concentrations were evaluated by spectrophotometry. Protein expression was analyzed by Western blot. Statistical analysis: ANOVA and Bonferroni or Kruskal-Wallis and Dunn. Results: Body weight was greater in W21-Sed and W21-Ex than W6. Before exercise, functional capacity did not differ between aged groups. After training, W21-Ex group ran farther and longer in treadmill than W21-Sed e W6, and W21-Sed presented worse physical capacity than W6. LV diastolic posterior wall, interventricular septum, and relative wall thicknesses were greater in W21-Sed and W21-Ex than W6, and did not differ between aged groups. E wave was lower in both aged groups than W6. E/E' ratio was lower in W21-Ex than W21-Sed. Isolated papillary muscle developed tension was higher in W21-Sed than W6; W21-Ex values did not differ from both W6 and W21-Sed groups. Time to peak tension was higher in W21-Sed and W21-Ex than W6 and did not differ between aged groups. The same results were observed after positive inotropic stimulation. Total collagen concentration was higher in W21-Sed and W21-Ex than W6 and did not differ between aged groups. Soluble collagen did not differ between groups. Type III collagen expression was higher in W21-Sed than W6; the W21-Ex group presented intermediary values that did not differ from W21-Sed or W6 groups. Type I collagen was similar between groups. Conclusion: Regular physical aerobic training improves functional capacity and left ventricular diastolic function and attenuates type III collagen myocardial accumulation in aged rats.

Research paper thumbnail of Recreational Practices in Development of a Student's Motor with Adhd

FIEP Bulletin On-line, 2019

In addition, the realization of recreational activities is important for the individual in a warm... more In addition, the realization of recreational activities is important for the individual in a warm, fun and full of possibilities, as well as the accomplishment of a series of tasks, stimulating a self-confidence and softening the feeling of incapacity (TINTORI; BAST; PITTA, 2010). During the KTK test, the equilibrium and single-leg jumps tasks were observed for the dynamic balance and strength abilities of dominant or non-dominant lower limbs. In the lateral jumps task the velocity of the performer was observed in alternating the jumps realized with the feet together. The lateral transfer task sought to evaluate the laterality and spatial notion (SILVA JUNIOR, 2012; GORLA; ARAUJO; RODRIGUES, 2014). The aim of this study was to verify if the development of recreational practices could improve the motor development in ADHD patients. The values presented in the motor quotients (QM) originated from the absolute values obtained in the accomplishment of each task of the KTK test. Furthermore, these values were related to the reference table of the original KTK test, which takes into account the performance obtained in the tasks and the age of the performer. The present study is a case report of a 14-year-old student with Attention Deficit Hyperactivity Disorder accompanied by the Multidisciplinary Pedagogical Support Center (CEAPEM) in the city of Itapeva-SP. Recreation is an indispensable tool that explores motor skills during play, manipulation of objects and participation in games without any learning process, providing benefits for the individual with ADHD, such as cooperation, interaction with the group, respect for rules, and establishment of interpersonal, motor perceptive, cognitive, social and academic relationships (TINTORI; BAST; PITTA, 2010; SILVA, DAMATTO, 2018). Attention Deficit Hyperactivity Disorder (ADHD) is a neurobehavioral disorder that results in attenuation of attention, characterized as a neuropsychiatric syndrome leading to inattention, hyperactivity and impulsivity to the various environments and the daily action of the subject for less (AMERICAN PSYCHIATRIC ASSOCIATION, 2013). The DSC-V (DSM-V) is a type of diagnosis for the type of association that falls within the first six symptoms of the syndrome and may vary the intensity of the disorder from individual to individual (AMERICAN PSYCHIATRIC ASSOCIATION,

Research paper thumbnail of Determination of the Use of Ergogenics in Bodybuilding Practice

FIEP Bulletin On-line, 2019

Daily the number of people looking for gyms to aid in the search for the desired aesthetic standa... more Daily the number of people looking for gyms to aid in the search for the desired aesthetic standard increases. With theincreasing demand for bodybuilding, the use of ergogenics has also increased, aiming to maintain health or even improve sportsperformance. The objective of the present study was to verify the incidence of ergogenic use and to characterize the bodybuildingindividuals who use ergogenic substances and to verify which professional is prescribing these substances. A total of 164bodybuilders were evaluated. The participants answered a questionnaire elaborated in Google Docs with the theme about theuse of ergogenic substances. The questions applied followed objective and multiple choice. Based on the data presented, it isconcluded that the use of steroids is not so common among bodybuilders, but their prescription does not happen due to the factthat in no case was there a medical prescription. With regard to supplements, its use is very common, for the various objectives,however, it is not frequent the indication made by a nutritionist. From the analysis of the data, it is noticed that there is even theintervention of Physical Education Professionals, which is not in accordance with the functions they must exercise, emphasizingthat each professional should act in the area in which he is responsible formation.

Research paper thumbnail of N-Acetylcysteine Influence on Oxidative Stress and Cardiac Remodeling in Rats with Persistent Pressure Overload

The FASEB Journal, Apr 1, 2017

Background/Aims: To evaluate the effects of the antioxidant N-acetylcysteine (NAC) on cardiac str... more Background/Aims: To evaluate the effects of the antioxidant N-acetylcysteine (NAC) on cardiac structure and function in rats with long-term ascending aortic stenosis (AS). Methods: Four months after inducing AS, Wistar rats were assigned into the groups Sham, AS, and AS treated with NAC (AS-NAC) and followed for eight weeks. Cardiac structure and function were evaluated by echocardiogram. Myocardial antioxidant enzymes activity was measured by spectrophotometry and malondialdehyde serum concentration by HPLC. Gene expression of NADPH oxidase subunits NOX2, NOX4, p22 phox, and p47 phox was assessed by real time RT-PCR and protein expression of MAPK proteins by Western blot. Statistical analyzes were performed with Goodman and ANOVA or Mann-Whitney Results: NAC restored myocardial total glutathione (Sham 20.8±3.00; AS 12.6±2.92; AS-NAC 17.6±2.45 nmol/g tissue; p<0.05 AS vs Sham and AS-NAC). Malondialdehyde serum concentration was lower in AS-NAC and myocardial lipid hydroperoxide was higher in AS (Sham 199±48.1; AS 301±36.0; AS-NAC 181±41.3 nmol/g tissue). Glutathione peroxidase activity was lower in AS than Sham. Echocardiogram showed LV concentric hypertrophy with systolic and diastolic dysfunction before and after treatment; no differences were observed between AS-NAC and AS groups. NAC reduced p-ERK and p-JNK protein expression, attenuated myocardial fibrosis, and decreased the frequency of right ventricular hypertrophy. Conclusion: N-acetylcysteine restores myocardial total glutathione, reduces systemic and myocardial oxidative stress, improves MAPK signaling, and attenuates myocardial fibrosis in aortic stenosis rats.

Research paper thumbnail of Prenatal Stress: Molecular Mechanisms and Cardiovascular Disease

Arquivos Brasileiros De Cardiologia, 2018

Research paper thumbnail of Renin‐angiotensin‐aldosterone system blockade ameliorates myocardial and ventricular function of rats with diabetes mellitus

The FASEB Journal, Apr 1, 2015

Research paper thumbnail of Fundamento: A Tolerância ao Esforço Físico (TEF) é uma medida de condicionamento cardiorrespiratório. A capacidade aeróbica é reduzida na Insuficiência Cardíaca (IC), embora não haja dados disponíveis sobre esse parâmetro em animais com disfunção ventricular e sem sinais de IC. Objetivo: Avaliar ...

Fundamento: A Tolerância ao Esforço Físico (TEF) é uma medida de condicionamento cardiorrespirató... more Fundamento: A Tolerância ao Esforço Físico (TEF) é uma medida de condicionamento cardiorrespiratório. A capacidade aeróbica é reduzida na Insuficiência Cardíaca (IC), embora não haja dados disponíveis sobre esse parâmetro em animais com disfunção ventricular e sem sinais de IC. Objetivo: Avaliar a TEF em ratos com disfunção ventricular diastólica isolada ou associada com disfunção sistólica induzida pela Estenose da Aorta ascendente (EAo). Métodos: Ratos Wistar machos jovens (20-30 dias de idade) foram divididos em Grupo Controle (GC, n = 11) e Grupo EAo (n = 12). Os animais foram avaliados em 6 e 18 semanas após a cirurgia para EAo. O teste ergométrico foi feito até a exaustão e foram avaliadas a velocidade da esteira e a concentração de lactato [LAC] no limiar de lactato, velocidade da esteira e [LAC] na exaustão, e tempo total do teste. Resultados: Dados ecocardiográficos revelaram remodelação do átrio esquerdo e hipertrofia concêntrica ventricular esquerda em 6 e 18 semanas. A fração de encurtamento endocárdico mostrou-se maior no grupo EAo do que no GC em 6 e 18 semanas. A fração de encurtamento da parede média mostrou-se maior no grupo EAo do que no GC em 6 semanas. O índice cardíaco mostrou-se semelhante no GC e no grupo EAo em 6 e 18 semanas, tendo diminuído entre 6-18 semanas em ambos os grupos. A razão entre a onda E a onda A foi maior no GC do que no grupo EAo em ambos os períodos e não se alterou em ambos os grupos entre a semana 6 e a semana 18. Os parâmetros do teste de esforço na esteira foram semelhantes nos dois grupos tanto na semana 6 quanto na semana 18. Conclusão: Embora a EAo promova a disfunção diastólica isolada ou associada à disfunção sistólica, em 6 ou 18 semanas, ela não é suficiente para alterar a tolerância ao esforço físico. (Arq Bras Cardiol. 2012; [online].ahead print, PP.0-0) Palavras-chave: Ratos; Exercício; Estenose da Valva Aórtica; Disfunção Ventricular.

Research paper thumbnail of Growth Hormone Administration Alters Protein Expression in Skeletal Muscle of Rats with Aortic Stenosis‐Induced Heart Failure

Research paper thumbnail of Moderate intensity exercise does not modulate myostatin and follistatin gene expression in the gastrocnemius muscle of spontaneously hypertensive rats with heart failure

The FASEB Journal

The myostatin/follistatin pathway modulates skeletal muscle trophism. Physical exercise has an im... more The myostatin/follistatin pathway modulates skeletal muscle trophism. Physical exercise has an important role in the heart failure treatment. In this study we evaluated the effects of moderate aerobic physical training on myostatin and follistatin gene expression and trophism in the gastrocnemius of spontaneously hypertensive rats with heart failure. Sixteen‐month‐old SHRs and normotensive Wistar‐Kyoto (WKY) rats were assigned to sedentary or trained groups. Exercise was performed on treadmill, 30 min/day, 5 days/week, 12 m/min for 4 months. Transthoracic echocardiogram was performed at the end of experiment. Gene expression was evaluated by real time RT‐PCR. Fiber cross‐sectional area was measured in HE‐stained histological sections.Statistical analysistwo‐way ANOVA and Tukey.ResultsEchocardiography showed left cardiac chambers dilation and left ventricular systolic and diastolic dysfunction in both SHR groups compared to the WKY groups. Gene expression of myostatin and follistatin...

Research paper thumbnail of Aerobic Exercise During Advance Stage of Uncontrolled Arterial Hypertension

Frontiers in Physiology

AimTo evaluate the influence of physical training on myocardial function, oxidative stress, energ... more AimTo evaluate the influence of physical training on myocardial function, oxidative stress, energy metabolism, and MAPKs and NF-κB signaling pathways in spontaneously hypertensive rats (SHR), at advanced stage of arterial hypertension, which precedes heart failure development.MethodsWe studied four experimental groups: normotensive Wistar rats (W, n = 27), trained W (W-EX, n = 31), SHR (n = 27), and exercised SHR (SHR-EX, n = 32). At 13 months old, the exercise groups underwent treadmill exercise 5 days a week for 4 months. In vitro myocardial function was analyzed in left ventricular (LV) papillary muscle preparations. Antioxidant enzyme activity and energy metabolism were assessed by spectrophotometry. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity was analyzed by lucigenin reduction and protein expression by Western blot. Statistical analyzes: ANOVA and Tukey or Kruskal–Wallis and Dunn tests.ResultsSHR-EX had a lower frequency of heart failure features than ...

Research paper thumbnail of Influence of N ‐Acetylcysteine on Apoptosis in White‐Gastrocnemius Muscle of Rats With Chronic Heart Failure

Research paper thumbnail of Growth Hormone Administration Influence on Soleus Muscle of Heart Failure Rats

Research paper thumbnail of Growth hormone influences atrophy pathways in skeletal muscle of heart failure rats (1163.3)

Research paper thumbnail of Protein expression of myostatin and follistatin in the myocardium of spontaneously hypertensive rats with heart failure

Research paper thumbnail of Influência Do Treinamento Intervalado Realizado Em Diferentes Superfícies No Desempenho De Atletas Mirins De Futsal

FIEP Bulletin On-line, 2018

O futsal, e uma das modalidades que mais cresce no cenario esportivo nos ultimos anos, com isso, ... more O futsal, e uma das modalidades que mais cresce no cenario esportivo nos ultimos anos, com isso, torna-senecessario conhecer as caracteristicas deste esporte, para a estruturacao de programas eficazes de treinamento. O atleta esubmetido a varias situacoes de alta intensidade e curta duracao durante o jogo, portanto o treinamento intervalado e ummetodo bastante indicado para treinadores. O objetivo deste estudo foi comparar o desempenho em atletas de futsal apostreinamento intervalado realizado em quadra e areia. Participaram da pesquisa 27 atletas de futsal com idade entre 13 e 16anos, que inicialmente foram submetidos a uma avaliacao antropometrica, e em seguida pelos testes de salto vertical e depotencia anaerobia. Posteriormente foram divididos em dois grupos: grupo Quadra (GQ, n= 14), que executou todos os treinosna quadra, e grupo areia (GA, n= 13), que executou treinamento intervalado na areia. Durante oito semanas, com duas sessoessemanais, os atletas desenvolviam como parte ...