Richard Brownlee - Academia.edu (original) (raw)

Papers by Richard Brownlee

Function and Morphology of the Canine Lung Two Years Following Immediate or Delayed Reimplantation

Chest, 1969

Annals of Thoracic Surgery, 1968

of the major practical problems which confronts the surgeon contemplating lung transplantation is... more of the major practical problems which confronts the surgeon contemplating lung transplantation is the meticulous main-0 tenance of pulmonary tissue viability prior to and during the transplantation procedure. It would appear that preservation, as judged by the gross and microscopic appearance of the lung, can be achieved by using profound hypothermia and a hyperbaric environment of 3 atmospheres absolute [2, 91. Initial flushing of the pulmonary vasculature, rapid cooling by perfusion, the use of a "physiological" perfusate, the use of hyperbaric oxygenation, and continuous perfusion with ventilation all appear to add to the maintenance of the structural and functional integrity of the lung used for transplantation [l, 6, 10, 111. Notwithstanding these, it seemed useful at this time to delineate some of the factors involved in the maintenance of viability in pulmonary autografts and to study the function of surviving pulmonary autografts following attempts at preservation for varying periods of time using hypothermia alone and hypothermia combined with hyperbaric oxygenation. In addition, ventilation combined with hyperbaric oxygenation was studied as an alternative method of providing preservation.

Annals of Thoracic Surgery, 1998

Background. The Mitroflow pericardial bioprosthesis (model 11), a second-generation pericardial p... more Background. The Mitroflow pericardial bioprosthesis (model 11), a second-generation pericardial prosthesis, has clinical performance assessment to 10 years. The authors previously recommended the prosthesis for aortic valve replacement in patients 70 years or older. The purpose of the current assessment is to report on performance in patients 60 years or older undergoing aortic valve replacement.

Annals of Thoracic Surgery, 1995


Thorax, 1971

A newly designed strut-supported 'frustum' fascia lata valve has been described for replacement o... more A newly designed strut-supported 'frustum' fascia lata valve has been described for replacement of the mitral valve. It offers the advantages of autologous tissue leaflets, ease of construction and insertion, central flow through an unobstructed mobile annulus, no ventricular outflow obstruction, and minimal intracardiac prosthetic material. Initial clinical trials which have been carried out suggest that the action of this valve allows a close approximation of the haemodynamics and movement of the normal mitral valve.

Function and Morphology of the Canine Lung Two Years Following Immediate or Delayed Reimplantation

Chest, 1969

Annals of Thoracic Surgery, 1968

of the major practical problems which confronts the surgeon contemplating lung transplantation is... more of the major practical problems which confronts the surgeon contemplating lung transplantation is the meticulous main-0 tenance of pulmonary tissue viability prior to and during the transplantation procedure. It would appear that preservation, as judged by the gross and microscopic appearance of the lung, can be achieved by using profound hypothermia and a hyperbaric environment of 3 atmospheres absolute [2, 91. Initial flushing of the pulmonary vasculature, rapid cooling by perfusion, the use of a "physiological" perfusate, the use of hyperbaric oxygenation, and continuous perfusion with ventilation all appear to add to the maintenance of the structural and functional integrity of the lung used for transplantation [l, 6, 10, 111. Notwithstanding these, it seemed useful at this time to delineate some of the factors involved in the maintenance of viability in pulmonary autografts and to study the function of surviving pulmonary autografts following attempts at preservation for varying periods of time using hypothermia alone and hypothermia combined with hyperbaric oxygenation. In addition, ventilation combined with hyperbaric oxygenation was studied as an alternative method of providing preservation.

Annals of Thoracic Surgery, 1998

Background. The Mitroflow pericardial bioprosthesis (model 11), a second-generation pericardial p... more Background. The Mitroflow pericardial bioprosthesis (model 11), a second-generation pericardial prosthesis, has clinical performance assessment to 10 years. The authors previously recommended the prosthesis for aortic valve replacement in patients 70 years or older. The purpose of the current assessment is to report on performance in patients 60 years or older undergoing aortic valve replacement.

Annals of Thoracic Surgery, 1995


Thorax, 1971

A newly designed strut-supported 'frustum' fascia lata valve has been described for replacement o... more A newly designed strut-supported 'frustum' fascia lata valve has been described for replacement of the mitral valve. It offers the advantages of autologous tissue leaflets, ease of construction and insertion, central flow through an unobstructed mobile annulus, no ventricular outflow obstruction, and minimal intracardiac prosthetic material. Initial clinical trials which have been carried out suggest that the action of this valve allows a close approximation of the haemodynamics and movement of the normal mitral valve.