Richard Mouy - Academia.edu (original) (raw)
Papers by Richard Mouy
Bulletins et mémoires de la Société médicale des hôpitaux de Paris, Nov 5, 1954
L’introduction des biotherapies en rhumatologie pediatrique a suivi de peu d’annees les 1ers essa... more L’introduction des biotherapies en rhumatologie pediatrique a suivi de peu d’annees les 1ers essais dans la polyarthrite rhumatoide de l’adulte. Ainsi, le recepteur soluble du TNF-α, etanercept, a ete introduit en pediatrie depuis une douzaine d’annees aux etats-Unis (1) et une dizaine d’annees en Europe (2, 3). De maniere encore plus remarquable, le canakinumab, l’anticorps monoclonal anti-IL-1, a fait l’objet d’etudes cliniques de maniere concomitante chez l’adulte et l’enfant. L’effi cacite et la bonne tolerance de ce traitement dans des maladies rares a debut pediatrique que sont le syndrome de Muckle-Wells (4) et la forme systemique d’arthrite juvenile idiopathique (FS-AJI) (ou maladie de Still pediatrique) a encourage des essais plus recents dans des maladies de l’adulte aussi frequentes que le diabete de type 2.
PubMed, Dec 1, 1985
Chronic granulomatous disease of childhood is a hereditary abnormality of phagocytic cells, frequ... more Chronic granulomatous disease of childhood is a hereditary abnormality of phagocytic cells, frequently associated with Aspergillus infections. From 1969 to 1984, 14 of 37 children with chronic granulomatous disease have presented with pulmonary (13 cases) and/or osteo-articular (1 case) aspergillosis. The paucity of symptoms was a characteristic of these infections. Lung lesions extending to the thoracic chest wall carried the bad prognosis. Neither the Aspergillus skin test nor the Aspergillus serology could definitely confirm the diagnosis. Only broncho-alveolar lavage and biopsy with isolation of Aspergillus could confirm the diagnosis. Long-term therapy with amphotericin B alone or associated with other antifungal agents is necessary. For the past 3 years, ketoconazole prophylaxis has been used in 23 children and none of these children has developed aspergillosis.
PubMed, May 1, 2001
Objective: Chronic arthritis in children represents a nonhomogeneous group of diseases with unkno... more Objective: Chronic arthritis in children represents a nonhomogeneous group of diseases with unknown etiology. To classify these patients in well defined diagnostic categories, a task force of the International League Against Rheumatism proposed a new classification with precise criteria. We analyzed the new criteria in children with chronic arthritis. Methods: A cohort of children was prospectively and sequentially examined in a pediatric rheumatology clinic from April to June 1997. Results: One hundred ninety-four children fulfilled the criteria of juvenile idiopathic arthritis and 80% of them (155 children) were classified in one of the 6 diagnostic categories. Seventeen children (9%) did not fit any other category and 22 (11%) could be classified in more than one category. The proportion of children fitting only one category was much lower for psoriatic arthritis and enthesitis related arthritis than for the other categories. Conclusion: Based on the results, we propose some modifications to the classification criteria. This new classification is an important tool for the diagnosis of chronic arthritis in children, but the criteria need further adjustments to improve the percentage of patients classified in one defined category.
Revue du Rhumatisme, Nov 1, 2016
Communications posters électroniques / Revue du Rhumatisme 83S (2016) A163-A304 A176 physaire bil... more Communications posters électroniques / Revue du Rhumatisme 83S (2016) A163-A304 A176 physaire bilatérale L2-L3 avec aspect d'épidurite postérieure en regard. Dans l'attente des résultats des prélèvements bactériologiques, un traitement par colchicine était initié. Une apyrexie, une diminution des douleurs périphériques et axiales et une quasi négativation du syndrome inflammatoire étaient observées. À 6 semaines, l'IRM montrait une nette régression des remaniements inflammatoires et le scanner bi-énergie montrait des dépôts d'urate de sodium au niveau articulaire postérieur. À 4 mois, sous colchicine et allopurinol, l'évolution clinicobiologique était favorable. Discussion.-Ces 2 patients présentaient une goutte tophacée sous allopurinol dont le suivi et l'observance étaient aléatoires. À leur admission, une spondylodiscite associée à une goutte polyarticulaire était suspectée et, dans l'attente d'une documentation bactériologique, un traitement par colchicine était mis en place. Aucune antibiothérapie n'était finalement débutée en raison de l'évolution favorable sur le plan clinique, biologique et d'imagerie. Le scanner bi-énergie confirmait la présence d'urate de sodium au niveau des lésions inflammatoires rachidiennes, donnant un argument supplémentaire à l'hypothèse d'une goutte rachidienne. Conclusion.-Les gouttes polyarticulaires et tophacées mal contrôlées peuvent se présenter sous forme de tableaux atypiques et trompeurs dont des atteintes rachidiennes. Le scanner bi-énergie peut, dans ces situations, apporter une aide diagnostique et limiter les procédures invasives de ponctions articulaires postérieures ou discovertébrales. Conflit d'intérêt.-aucun PE.Di-023
Archives De Pediatrie, 1996
Le ~mrd de crols.~3nc~ £1 I'ost~me toni d~' .. ~L~.~-cre~ majcurs du wonosll¢ 4 long tcrme dcs lo... more Le ~mrd de crols.~3nc~ £1 I'ost~me toni d~' .. ~L~.~-cre~ majcurs du wonosll¢ 4 long tcrme dcs lo/'~ s~*t~aiq'u~ d'arthr;~c chr~q.c jm~nilc (AC. I) CC sont ~gaI~+l d~ cot~iml:O~ d. llaitm l TM i~lliCold~l dlP, m,P,d dalts 1,1 pc'tile
Research Square (Research Square), Jan 26, 2021
Pediatric Rheumatology, Dec 1, 2013
Human & Experimental Toxicology, 1990
1 The toxicokinetics of paraquat were studied in 18 cases of acute human poisoning using a specif... more 1 The toxicokinetics of paraquat were studied in 18 cases of acute human poisoning using a specific radioimmunoassay. Plasma paraquat concentration exhibited a mean distribution half-life ( t½ α) of 5 h and a mean elimination half-life ( t½ β) of 84 h. Cardiovascular collapse supervened early during the course of the intoxication and was associated with the distribution phase. Death related to pulmonary fibrosis occurred late and was associated with the elimination phase. 2 Pharmacokinetic analysis of urine paraquat excretion confirmed the biphasic decline of paraquat. Moreover, renal paraquat and creatinine clearances were not correlated but renal paraquat clearance was never higher than the renal creatinine clearance. 3 Tissue paraquat distribution was ubiquitous with an apparent volume of distribution ranging from 1.2 to 1.6 l/kg. Muscle could represent an important reservoir explaining the long persistence of paraquat in plasma and urine for several weeks or months after poisoning.
Pediatric Rheumatology, Dec 1, 2013
PubMed, Mar 1, 1989
The case of a young girl, born to a woman who was a vegetarian for 18 years, is presented. She ha... more The case of a young girl, born to a woman who was a vegetarian for 18 years, is presented. She had been exclusively breast-fed until the age of 6 months when a severe anemia was discovered with an extremely low hemoglobin level (1.9 g/100 ml). Her physical growth and psychomotor development had been normal until 3 months of age. Bone marrow showed megaloblastosis and the serum B12 level was low (45 ng/l). B12 levels were also decreased in both parents (110 and 105 ng/l) and in the mother's milk (12 ng/l). Treatment with parenteral B12 was successful. The importance of a careful dietetic inquiry in the case of an infant with megaloblastic anemia is stressed and likewise, as a preventive measure during all normal pregnancies.
Archives De Pediatrie, Feb 1, 2019
on behalf of the French Network of rare autoimmune, autoinflammatory diseases FAI2R
Background: Some patients with systemic juvenile idiopathic arthritis (SJIA) and severe, refracto... more Background: Some patients with systemic juvenile idiopathic arthritis (SJIA) and severe, refractory disease achieved remission through intensive immunosuppressive treatment followed by autologous hematopoietic stem cell transplantation (HSCT). However, disease relapsed in most cases. More recently selected SJIA patients received allogenic HSCT from a HLA-identical sibling or a HLA matched unrelated donor. While most transplanted patients achieved sustained SJIA remission off-treatment, the procedure-related morbidity was high.Case report: A girl presented SJIA since the age of 15 months with a severe disease course. She was refractory to the combination of methotrexate and steroids to anti-interleukin (IL)-1, then anti-IL-6, tumor necrosis factor alpha inhibitors, and thalidomide. Therefore, allogenic HSCT was considered. In the absence of any possible HLA matched donor, a multidisciplinary team carefully assessed risks and benefits of a transplant procedure with an alternative dono...
Objectives: To assess dosing, preliminary safety, and efficacy of canakinumab, a fully human anti... more Objectives: To assess dosing, preliminary safety, and efficacy of canakinumab, a fully human anti-interleukin-1β (IL-1β) antibody, in children with systemic juvenile idiopathic arthritis (sJIA) and active systemic features. Methods: In this open-label, dose-escalation, phase II study, children with sJIA who were ≥ 4 years of age, with fever, and receiving ≤ 0.4 mg/kg/d of corticosteroids, were administered a single subcutaneous (sc) dose of canakinumab, 0.5–9 mg/kg and were re-dosed upon relapse. Response was assessed according to adapted American College of Rheumatology (ACR) pediatric criteria. Results: 23 Children (aged 4–19 years) with active disease were enrolled; 1 patient was excluded and 3 re-enrolled patients were included twice in the efficacy analysis. By day 15 of the first treatment cycle, 15/25 (60%) of patients achieved an adapted ACR ped 50 with 4 of them achieving inactive disease status. Response was sustained over time with 11/13 patients able to maintain response...
ABSTRACTAmong immune cells, activated monocytes play a detrimental role in chronic and viral-indu... more ABSTRACTAmong immune cells, activated monocytes play a detrimental role in chronic and viral-induced inflammatory pathologies. The uncontrolled activation of monocytes and the subsequent excessive production of inflammatory factors damage bone-cartilage joints in Juvenile Idiopathic Arthritis (JIA), a childhood rheumatoid arthritis (RA) disease. Inflammatory monocytes also exert a critical role in the cytokine storm induced by SARS-CoV2 infection in severe COVID-19 patients. The moderate beneficial effect of current therapies and clinical trials highlights the need of alternative strategies targeting monocytes to treat RA and COVID-19 pathologies. Here, we show that targeting CXCR4 with small amino compound such as the histamine analogue clobenpropit (CB) inhibits spontaneous and induced-production of a set of key inflammatory cytokines by monocytes isolated from blood and synovial fluids of JIA patients. Moreover, daily intraperitoneal CB treatment of arthritic mice results in sign...
Archives de Pédiatrie, 2019
on behalf of the French Network of rare autoimmune, autoinflammatory diseases FAI2R
Pediatric Rheumatology, 2017
Introduction: In 2015 the historic Jones criteria for the diagnosis of Acute Rheumatic Fever (ARF... more Introduction: In 2015 the historic Jones criteria for the diagnosis of Acute Rheumatic Fever (ARF) were revised introducing two different sets of criteria for low-risk and for moderate/high-risk populations (according to ARF incidence). In Italy the exact ARF incidence is unknown but small regional or local reports suggest an incidence of 2-5/100.000 per year, suggesting that our population might be considered at moderate risk for ARF. Objectives: To evaluate the performance of the revised Jones criteria in a retrospective population and to compare it with the performance of the previous version of Jones criteria. Methods: We conducted a retrospective study on 288 patients with ARF (108 female; median age 8.5 years, IQR 7.1-10.3) diagnosed from 2001 to 2015 in a Pediatric Rheumatology Division by pediatric rheumatologists, discharged with an ICD 9 code consistent with ARF. We retrospectively applied the two sets (for low-risk and for moderate/high-risk) of the 2015 revised Jones criteria and the 1992 version of the Jones criteria. Results: Of 288 patients, 253 (87.8%) met the 1992 version of the Jones criteria, 237 (82.3%) met the revised criteria for low-risk populations and 259 (89.9%) for moderate/high-risk populations. None of these differences was significant. Prevalence of major and minor criteria is shown in Table. With the exception of difference in arthritis, the 1992 version and the 2015 revised version did not show major differences. Of the 288 patients with a clinical diagnosis of ARF 29 did not meet any version of the Jones criteria. Patients in this group presented with isolated chorea or silent carditis without other manifestations. Prevalence of the clinical characteristics and comparison among the 1992 version of Jones criteria and the 2015 revised Jones criteria (low risk and moderate-high risk populations): Values are expressed in Number (percentage). *p value (Fisher Exact test) Conclusion: The revised Jones criteria for low-risk populations are slightly more sensitive than the 1992 version of Jones criteria, while the revised Jones criteria for moderate/high populations are slightly less sensitive than the 1992 version. In this population, the revised criteria did not substantially modify the diagnosis of ARF. Approximately 10% of patients presented with isolated chorea or silent carditis.
Pediatric Rheumatology, 2013
New England Journal of Medicine, 1991
... Margolis DM, Melnick DA, Alling DW, Gallin JI. ... Julien Beauté, Gaëlle Obenga, Loïc Le Mign... more ... Margolis DM, Melnick DA, Alling DW, Gallin JI. ... Julien Beauté, Gaëlle Obenga, Loïc Le Mignot, Nizar Mahlaoui, Marie-Elisabeth Bougnoux, Richard Mouy, Marie-Anne Gougerot-Pocidalo, Vincent Barlogis, Felipe Suarez, Fanny Lanternier, Olivier Hermine, Marc Lecuit, Stéphane ...
Human & Experimental Toxicology, 1990
1 The toxicokinetics of paraquat were studied in 18 cases of acute human poisoning using a specif... more 1 The toxicokinetics of paraquat were studied in 18 cases of acute human poisoning using a specific radioimmunoassay. Plasma paraquat concentration exhibited a mean distribution half-life ( t½ α) of 5 h and a mean elimination half-life ( t½ β) of 84 h. Cardiovascular collapse supervened early during the course of the intoxication and was associated with the distribution phase. Death related to pulmonary fibrosis occurred late and was associated with the elimination phase. 2 Pharmacokinetic analysis of urine paraquat excretion confirmed the biphasic decline of paraquat. Moreover, renal paraquat and creatinine clearances were not correlated but renal paraquat clearance was never higher than the renal creatinine clearance. 3 Tissue paraquat distribution was ubiquitous with an apparent volume of distribution ranging from 1.2 to 1.6 l/kg. Muscle could represent an important reservoir explaining the long persistence of paraquat in plasma and urine for several weeks or months after poisoning.
Bulletins et mémoires de la Société médicale des hôpitaux de Paris, Nov 5, 1954
L’introduction des biotherapies en rhumatologie pediatrique a suivi de peu d’annees les 1ers essa... more L’introduction des biotherapies en rhumatologie pediatrique a suivi de peu d’annees les 1ers essais dans la polyarthrite rhumatoide de l’adulte. Ainsi, le recepteur soluble du TNF-α, etanercept, a ete introduit en pediatrie depuis une douzaine d’annees aux etats-Unis (1) et une dizaine d’annees en Europe (2, 3). De maniere encore plus remarquable, le canakinumab, l’anticorps monoclonal anti-IL-1, a fait l’objet d’etudes cliniques de maniere concomitante chez l’adulte et l’enfant. L’effi cacite et la bonne tolerance de ce traitement dans des maladies rares a debut pediatrique que sont le syndrome de Muckle-Wells (4) et la forme systemique d’arthrite juvenile idiopathique (FS-AJI) (ou maladie de Still pediatrique) a encourage des essais plus recents dans des maladies de l’adulte aussi frequentes que le diabete de type 2.
PubMed, Dec 1, 1985
Chronic granulomatous disease of childhood is a hereditary abnormality of phagocytic cells, frequ... more Chronic granulomatous disease of childhood is a hereditary abnormality of phagocytic cells, frequently associated with Aspergillus infections. From 1969 to 1984, 14 of 37 children with chronic granulomatous disease have presented with pulmonary (13 cases) and/or osteo-articular (1 case) aspergillosis. The paucity of symptoms was a characteristic of these infections. Lung lesions extending to the thoracic chest wall carried the bad prognosis. Neither the Aspergillus skin test nor the Aspergillus serology could definitely confirm the diagnosis. Only broncho-alveolar lavage and biopsy with isolation of Aspergillus could confirm the diagnosis. Long-term therapy with amphotericin B alone or associated with other antifungal agents is necessary. For the past 3 years, ketoconazole prophylaxis has been used in 23 children and none of these children has developed aspergillosis.
PubMed, May 1, 2001
Objective: Chronic arthritis in children represents a nonhomogeneous group of diseases with unkno... more Objective: Chronic arthritis in children represents a nonhomogeneous group of diseases with unknown etiology. To classify these patients in well defined diagnostic categories, a task force of the International League Against Rheumatism proposed a new classification with precise criteria. We analyzed the new criteria in children with chronic arthritis. Methods: A cohort of children was prospectively and sequentially examined in a pediatric rheumatology clinic from April to June 1997. Results: One hundred ninety-four children fulfilled the criteria of juvenile idiopathic arthritis and 80% of them (155 children) were classified in one of the 6 diagnostic categories. Seventeen children (9%) did not fit any other category and 22 (11%) could be classified in more than one category. The proportion of children fitting only one category was much lower for psoriatic arthritis and enthesitis related arthritis than for the other categories. Conclusion: Based on the results, we propose some modifications to the classification criteria. This new classification is an important tool for the diagnosis of chronic arthritis in children, but the criteria need further adjustments to improve the percentage of patients classified in one defined category.
Revue du Rhumatisme, Nov 1, 2016
Communications posters électroniques / Revue du Rhumatisme 83S (2016) A163-A304 A176 physaire bil... more Communications posters électroniques / Revue du Rhumatisme 83S (2016) A163-A304 A176 physaire bilatérale L2-L3 avec aspect d'épidurite postérieure en regard. Dans l'attente des résultats des prélèvements bactériologiques, un traitement par colchicine était initié. Une apyrexie, une diminution des douleurs périphériques et axiales et une quasi négativation du syndrome inflammatoire étaient observées. À 6 semaines, l'IRM montrait une nette régression des remaniements inflammatoires et le scanner bi-énergie montrait des dépôts d'urate de sodium au niveau articulaire postérieur. À 4 mois, sous colchicine et allopurinol, l'évolution clinicobiologique était favorable. Discussion.-Ces 2 patients présentaient une goutte tophacée sous allopurinol dont le suivi et l'observance étaient aléatoires. À leur admission, une spondylodiscite associée à une goutte polyarticulaire était suspectée et, dans l'attente d'une documentation bactériologique, un traitement par colchicine était mis en place. Aucune antibiothérapie n'était finalement débutée en raison de l'évolution favorable sur le plan clinique, biologique et d'imagerie. Le scanner bi-énergie confirmait la présence d'urate de sodium au niveau des lésions inflammatoires rachidiennes, donnant un argument supplémentaire à l'hypothèse d'une goutte rachidienne. Conclusion.-Les gouttes polyarticulaires et tophacées mal contrôlées peuvent se présenter sous forme de tableaux atypiques et trompeurs dont des atteintes rachidiennes. Le scanner bi-énergie peut, dans ces situations, apporter une aide diagnostique et limiter les procédures invasives de ponctions articulaires postérieures ou discovertébrales. Conflit d'intérêt.-aucun PE.Di-023
Archives De Pediatrie, 1996
Le ~mrd de crols.~3nc~ £1 I'ost~me toni d~' .. ~L~.~-cre~ majcurs du wonosll¢ 4 long tcrme dcs lo... more Le ~mrd de crols.~3nc~ £1 I'ost~me toni d~' .. ~L~.~-cre~ majcurs du wonosll¢ 4 long tcrme dcs lo/'~ s~*t~aiq'u~ d'arthr;~c chr~q.c jm~nilc (AC. I) CC sont ~gaI~+l d~ cot~iml:O~ d. llaitm l TM i~lliCold~l dlP, m,P,d dalts 1,1 pc'tile
Research Square (Research Square), Jan 26, 2021
Pediatric Rheumatology, Dec 1, 2013
Human & Experimental Toxicology, 1990
1 The toxicokinetics of paraquat were studied in 18 cases of acute human poisoning using a specif... more 1 The toxicokinetics of paraquat were studied in 18 cases of acute human poisoning using a specific radioimmunoassay. Plasma paraquat concentration exhibited a mean distribution half-life ( t½ α) of 5 h and a mean elimination half-life ( t½ β) of 84 h. Cardiovascular collapse supervened early during the course of the intoxication and was associated with the distribution phase. Death related to pulmonary fibrosis occurred late and was associated with the elimination phase. 2 Pharmacokinetic analysis of urine paraquat excretion confirmed the biphasic decline of paraquat. Moreover, renal paraquat and creatinine clearances were not correlated but renal paraquat clearance was never higher than the renal creatinine clearance. 3 Tissue paraquat distribution was ubiquitous with an apparent volume of distribution ranging from 1.2 to 1.6 l/kg. Muscle could represent an important reservoir explaining the long persistence of paraquat in plasma and urine for several weeks or months after poisoning.
Pediatric Rheumatology, Dec 1, 2013
PubMed, Mar 1, 1989
The case of a young girl, born to a woman who was a vegetarian for 18 years, is presented. She ha... more The case of a young girl, born to a woman who was a vegetarian for 18 years, is presented. She had been exclusively breast-fed until the age of 6 months when a severe anemia was discovered with an extremely low hemoglobin level (1.9 g/100 ml). Her physical growth and psychomotor development had been normal until 3 months of age. Bone marrow showed megaloblastosis and the serum B12 level was low (45 ng/l). B12 levels were also decreased in both parents (110 and 105 ng/l) and in the mother's milk (12 ng/l). Treatment with parenteral B12 was successful. The importance of a careful dietetic inquiry in the case of an infant with megaloblastic anemia is stressed and likewise, as a preventive measure during all normal pregnancies.
Archives De Pediatrie, Feb 1, 2019
on behalf of the French Network of rare autoimmune, autoinflammatory diseases FAI2R
Background: Some patients with systemic juvenile idiopathic arthritis (SJIA) and severe, refracto... more Background: Some patients with systemic juvenile idiopathic arthritis (SJIA) and severe, refractory disease achieved remission through intensive immunosuppressive treatment followed by autologous hematopoietic stem cell transplantation (HSCT). However, disease relapsed in most cases. More recently selected SJIA patients received allogenic HSCT from a HLA-identical sibling or a HLA matched unrelated donor. While most transplanted patients achieved sustained SJIA remission off-treatment, the procedure-related morbidity was high.Case report: A girl presented SJIA since the age of 15 months with a severe disease course. She was refractory to the combination of methotrexate and steroids to anti-interleukin (IL)-1, then anti-IL-6, tumor necrosis factor alpha inhibitors, and thalidomide. Therefore, allogenic HSCT was considered. In the absence of any possible HLA matched donor, a multidisciplinary team carefully assessed risks and benefits of a transplant procedure with an alternative dono...
Objectives: To assess dosing, preliminary safety, and efficacy of canakinumab, a fully human anti... more Objectives: To assess dosing, preliminary safety, and efficacy of canakinumab, a fully human anti-interleukin-1β (IL-1β) antibody, in children with systemic juvenile idiopathic arthritis (sJIA) and active systemic features. Methods: In this open-label, dose-escalation, phase II study, children with sJIA who were ≥ 4 years of age, with fever, and receiving ≤ 0.4 mg/kg/d of corticosteroids, were administered a single subcutaneous (sc) dose of canakinumab, 0.5–9 mg/kg and were re-dosed upon relapse. Response was assessed according to adapted American College of Rheumatology (ACR) pediatric criteria. Results: 23 Children (aged 4–19 years) with active disease were enrolled; 1 patient was excluded and 3 re-enrolled patients were included twice in the efficacy analysis. By day 15 of the first treatment cycle, 15/25 (60%) of patients achieved an adapted ACR ped 50 with 4 of them achieving inactive disease status. Response was sustained over time with 11/13 patients able to maintain response...
ABSTRACTAmong immune cells, activated monocytes play a detrimental role in chronic and viral-indu... more ABSTRACTAmong immune cells, activated monocytes play a detrimental role in chronic and viral-induced inflammatory pathologies. The uncontrolled activation of monocytes and the subsequent excessive production of inflammatory factors damage bone-cartilage joints in Juvenile Idiopathic Arthritis (JIA), a childhood rheumatoid arthritis (RA) disease. Inflammatory monocytes also exert a critical role in the cytokine storm induced by SARS-CoV2 infection in severe COVID-19 patients. The moderate beneficial effect of current therapies and clinical trials highlights the need of alternative strategies targeting monocytes to treat RA and COVID-19 pathologies. Here, we show that targeting CXCR4 with small amino compound such as the histamine analogue clobenpropit (CB) inhibits spontaneous and induced-production of a set of key inflammatory cytokines by monocytes isolated from blood and synovial fluids of JIA patients. Moreover, daily intraperitoneal CB treatment of arthritic mice results in sign...
Archives de Pédiatrie, 2019
on behalf of the French Network of rare autoimmune, autoinflammatory diseases FAI2R
Pediatric Rheumatology, 2017
Introduction: In 2015 the historic Jones criteria for the diagnosis of Acute Rheumatic Fever (ARF... more Introduction: In 2015 the historic Jones criteria for the diagnosis of Acute Rheumatic Fever (ARF) were revised introducing two different sets of criteria for low-risk and for moderate/high-risk populations (according to ARF incidence). In Italy the exact ARF incidence is unknown but small regional or local reports suggest an incidence of 2-5/100.000 per year, suggesting that our population might be considered at moderate risk for ARF. Objectives: To evaluate the performance of the revised Jones criteria in a retrospective population and to compare it with the performance of the previous version of Jones criteria. Methods: We conducted a retrospective study on 288 patients with ARF (108 female; median age 8.5 years, IQR 7.1-10.3) diagnosed from 2001 to 2015 in a Pediatric Rheumatology Division by pediatric rheumatologists, discharged with an ICD 9 code consistent with ARF. We retrospectively applied the two sets (for low-risk and for moderate/high-risk) of the 2015 revised Jones criteria and the 1992 version of the Jones criteria. Results: Of 288 patients, 253 (87.8%) met the 1992 version of the Jones criteria, 237 (82.3%) met the revised criteria for low-risk populations and 259 (89.9%) for moderate/high-risk populations. None of these differences was significant. Prevalence of major and minor criteria is shown in Table. With the exception of difference in arthritis, the 1992 version and the 2015 revised version did not show major differences. Of the 288 patients with a clinical diagnosis of ARF 29 did not meet any version of the Jones criteria. Patients in this group presented with isolated chorea or silent carditis without other manifestations. Prevalence of the clinical characteristics and comparison among the 1992 version of Jones criteria and the 2015 revised Jones criteria (low risk and moderate-high risk populations): Values are expressed in Number (percentage). *p value (Fisher Exact test) Conclusion: The revised Jones criteria for low-risk populations are slightly more sensitive than the 1992 version of Jones criteria, while the revised Jones criteria for moderate/high populations are slightly less sensitive than the 1992 version. In this population, the revised criteria did not substantially modify the diagnosis of ARF. Approximately 10% of patients presented with isolated chorea or silent carditis.
Pediatric Rheumatology, 2013
New England Journal of Medicine, 1991
... Margolis DM, Melnick DA, Alling DW, Gallin JI. ... Julien Beauté, Gaëlle Obenga, Loïc Le Mign... more ... Margolis DM, Melnick DA, Alling DW, Gallin JI. ... Julien Beauté, Gaëlle Obenga, Loïc Le Mignot, Nizar Mahlaoui, Marie-Elisabeth Bougnoux, Richard Mouy, Marie-Anne Gougerot-Pocidalo, Vincent Barlogis, Felipe Suarez, Fanny Lanternier, Olivier Hermine, Marc Lecuit, Stéphane ...
Human & Experimental Toxicology, 1990
1 The toxicokinetics of paraquat were studied in 18 cases of acute human poisoning using a specif... more 1 The toxicokinetics of paraquat were studied in 18 cases of acute human poisoning using a specific radioimmunoassay. Plasma paraquat concentration exhibited a mean distribution half-life ( t½ α) of 5 h and a mean elimination half-life ( t½ β) of 84 h. Cardiovascular collapse supervened early during the course of the intoxication and was associated with the distribution phase. Death related to pulmonary fibrosis occurred late and was associated with the elimination phase. 2 Pharmacokinetic analysis of urine paraquat excretion confirmed the biphasic decline of paraquat. Moreover, renal paraquat and creatinine clearances were not correlated but renal paraquat clearance was never higher than the renal creatinine clearance. 3 Tissue paraquat distribution was ubiquitous with an apparent volume of distribution ranging from 1.2 to 1.6 l/kg. Muscle could represent an important reservoir explaining the long persistence of paraquat in plasma and urine for several weeks or months after poisoning.