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Papers by Ries Robinson
Clinical Chemistry, 1992
Noninvasive monitoring of blood/tissue glucose concentrations has been successfully accomplished ... more Noninvasive monitoring of blood/tissue glucose concentrations has been successfully accomplished in individual diabetic subjects by using near-infrared (NIR) spectroscopy coupled with chemometric methods. Three different spectrometer configurations were tested: a) a Fourier-transform infrared spectrometer with an indium antimonide detector; b) a grating monochromator equipped with a silicon (Si) array detector, without fiber optics; and c) a grating monochromator equipped with an Si detector, with fiber-optic sampling. NIR spectra were obtained from diabetic subjects by transmission through the finger during a meal-tolerance test. The maximum range of observed plasma glucose concentrations obtained from the blood samples was 2.5-27 mmol/L. The NIR spectra were processed by using the chemometric multivariate calibration methods of partial least squares and principal component regression. The best calibration yielded a cross-validated average absolute error in glucose concentration of...
L'invention concerne des procedes et un appareil de verification non effractive de l'iden... more L'invention concerne des procedes et un appareil de verification non effractive de l'identite d'etres humains par spectroscopie dans le proche infrarouge. Des spectres de tissu dans le proche infrarouge peuvent etre obtenus par projection de rayonnements proche infrarouge dans la peau du dessous des avant-bras humains et par capture de la lumiere reflechie par et a travers le tissu. Le spectre de tissu recueilli comprend, de preference, la lumiere reflechie a diffusion preponderante en provenance du derme interne. Des spectres et des identites de tissu multiples peuvent etre recueillis chez les individus pour lesquels il peut etre souhaitable par la suite de proceder a une verification d'identite. Les spectres du tissu de chaque individu peuvent etre analyses par un ordinateur puis agglomeres ou classifies au moyen d'outils tels qu'une analyse discriminante lineaire. Un individu cible desirant une verification d'identite peut soumettre une identite preten...
L'invention concerne l'utilisation d'un dispositif optique ou d'un autre disposit... more L'invention concerne l'utilisation d'un dispositif optique ou d'un autre dispositif de mesure dans un systeme d'acces au sang, permettant la determination d'un echantillon de fluide approprie pour des mesures en temps reel. Cette information peut etre utilisee pour commander le systeme d'acces au sang ainsi que les procedes de mesure associes. La determination peut etre fondee, par exemple, sur au moins l'un des parametres parmi lesquels: la densite optique, la diffusion optique, le niveau d'analyte, la temperature, l'horizontale absolue de l'un quelconque de ces parametres, ou la valeur de l'un quelconque de ces parametres par rapport a une autre determination. La determination peut etre realisee au moyen, par exemple, d'au moins l'un des elements parmi lesquels: un capteur electrochimique, une electrode specifique des ions, la mesure de capacite, la mesure d'impedance, la mesure d'inductance, la mesure de connectivite...
Applied Spectroscopy, Mar 1, 1998
Near-infrared spectra (1300–2500 nm) collected from lysed blood solutions were shown to correlate... more Near-infrared spectra (1300–2500 nm) collected from lysed blood solutions were shown to correlate with the pH of the solutions measured potentiometrically. Cross-validated partial least-squares (PLS) models were developed from these spectral data, which provided standard error of prediction (SEP) values below 0.05 pH units for a pH range of 1.0 (6.8–7.8). Experiments were designed to eliminate possible correlation between pH and other components in the blood in order to ensure that variations in the spectral data correlated to pH were due to hydrogen ion changes only. Further work was performed to discern the primary source of pH information in the lysed blood spectra by using spectra collected from plasma and histidine solutions. The blood, plasma, and histidine data sets were compared with the use of loading vectors from principal component analysis (PCA). These loading vectors show that variations in the spectra of the titrated amino acid histidine mimic those seen in lysed blood, but not those seen in plasma. These results suggest that histidine residues of hemoglobin are providing the spectral variation necessary for pH modeling in the lysed blood solutions. It is further shown that the observed pH-sensitive histidine bands do not arise from the exchangeable proton on the imidazole ring of histidine; rather they arise from the variation in the C–H bonds of the C2 and/or the C4 carbons of the imidazole ring as they are influenced by the titration of the nitrogen-bound proton of the imidazole ring.
Clinical Chemistry, 1992
Noninvasive monitoring of blood/tissue glucose concentrations has been successfully accomplished ... more Noninvasive monitoring of blood/tissue glucose concentrations has been successfully accomplished in individual diabetic subjects by using near-infrared (NIR) spectroscopy coupled with chemometric methods. Three different spectrometer configurations were tested: a) a Fourier-transform infrared spectrometer with an indium antimonide detector; b) a grating monochromator equipped with a silicon (Si) array detector, without fiber optics; and c) a grating monochromator equipped with an Si detector, with fiber-optic sampling. NIR spectra were obtained from diabetic subjects by transmission through the finger during a meal-tolerance test. The maximum range of observed plasma glucose concentrations obtained from the blood samples was 2.5-27 mmol/L. The NIR spectra were processed by using the chemometric multivariate calibration methods of partial least squares and principal component regression. The best calibration yielded a cross-validated average absolute error in glucose concentration of...
L'invention concerne des procedes et un appareil de verification non effractive de l'iden... more L'invention concerne des procedes et un appareil de verification non effractive de l'identite d'etres humains par spectroscopie dans le proche infrarouge. Des spectres de tissu dans le proche infrarouge peuvent etre obtenus par projection de rayonnements proche infrarouge dans la peau du dessous des avant-bras humains et par capture de la lumiere reflechie par et a travers le tissu. Le spectre de tissu recueilli comprend, de preference, la lumiere reflechie a diffusion preponderante en provenance du derme interne. Des spectres et des identites de tissu multiples peuvent etre recueillis chez les individus pour lesquels il peut etre souhaitable par la suite de proceder a une verification d'identite. Les spectres du tissu de chaque individu peuvent etre analyses par un ordinateur puis agglomeres ou classifies au moyen d'outils tels qu'une analyse discriminante lineaire. Un individu cible desirant une verification d'identite peut soumettre une identite preten...
L'invention concerne l'utilisation d'un dispositif optique ou d'un autre disposit... more L'invention concerne l'utilisation d'un dispositif optique ou d'un autre dispositif de mesure dans un systeme d'acces au sang, permettant la determination d'un echantillon de fluide approprie pour des mesures en temps reel. Cette information peut etre utilisee pour commander le systeme d'acces au sang ainsi que les procedes de mesure associes. La determination peut etre fondee, par exemple, sur au moins l'un des parametres parmi lesquels: la densite optique, la diffusion optique, le niveau d'analyte, la temperature, l'horizontale absolue de l'un quelconque de ces parametres, ou la valeur de l'un quelconque de ces parametres par rapport a une autre determination. La determination peut etre realisee au moyen, par exemple, d'au moins l'un des elements parmi lesquels: un capteur electrochimique, une electrode specifique des ions, la mesure de capacite, la mesure d'impedance, la mesure d'inductance, la mesure de connectivite...
Applied Spectroscopy, Mar 1, 1998
Near-infrared spectra (1300–2500 nm) collected from lysed blood solutions were shown to correlate... more Near-infrared spectra (1300–2500 nm) collected from lysed blood solutions were shown to correlate with the pH of the solutions measured potentiometrically. Cross-validated partial least-squares (PLS) models were developed from these spectral data, which provided standard error of prediction (SEP) values below 0.05 pH units for a pH range of 1.0 (6.8–7.8). Experiments were designed to eliminate possible correlation between pH and other components in the blood in order to ensure that variations in the spectral data correlated to pH were due to hydrogen ion changes only. Further work was performed to discern the primary source of pH information in the lysed blood spectra by using spectra collected from plasma and histidine solutions. The blood, plasma, and histidine data sets were compared with the use of loading vectors from principal component analysis (PCA). These loading vectors show that variations in the spectra of the titrated amino acid histidine mimic those seen in lysed blood, but not those seen in plasma. These results suggest that histidine residues of hemoglobin are providing the spectral variation necessary for pH modeling in the lysed blood solutions. It is further shown that the observed pH-sensitive histidine bands do not arise from the exchangeable proton on the imidazole ring of histidine; rather they arise from the variation in the C–H bonds of the C2 and/or the C4 carbons of the imidazole ring as they are influenced by the titration of the nitrogen-bound proton of the imidazole ring.