Riki Nova - Academia.edu (original) (raw)

Papers by Riki Nova

Research paper thumbnail of Edukasi Komplikasi Terjadinya Hipertensi Dan Peranan Konsumsi Obat Hipertensi Pada Penderita Diabetes Melitus Usia Lansia DI Puskesmas Lubuk Buaya Tahun 2021

Kumawula: Jurnal Pengabdian Kepada Masyarakat

Diabetes Melitus (DM) merupakan suatu penyakit peningkatan kadar glukosa darah di atas nilai norm... more Diabetes Melitus (DM) merupakan suatu penyakit peningkatan kadar glukosa darah di atas nilai normal. Dinas Kesehatan Kota Padang pada tahun 2019 melaporkan penderita DM di Kota Padang sebanyak 17.018 dan mayoritas berkunjung ke puskesmas. Penyakit DM ini dapat menimbulkan kondisi hiperglikemia yang dapat memicu peningkatan volume cairan tubuh dan resistensi pembuluh darah perifer sehingga dapat meningkatkan risiko terjadinya hipertensi. Saat ini terdapat 40-80% pasien diabetes dengan hipertensi, diketahui risiko penderita diabetes mengalami hipertensi 2 kali lipat lebih berisiko dibanding orang tidak diabetes. Pasien diabetes melitus yang tidak terkontrol kadar glukosa darahnya memerlukan pengobatan komprehensif sebagai upaya pencegahan komplikasi. Masih banyak lansia penyandang DM dengan komorbid hipertensi yang belum paham mengenai bagaimana cara konsumsi obat anti hipertensi. Perlu dilakukan suatu penyuluhan untuk memberikan informasi tentang hipertensi sebagai komplikasi diabete...

Research paper thumbnail of Management of Acute Hypertensive Emergencies on CKD

Science Midwifery

Hypertensive emergencies in acute CKD are clinical manifestations of kidney failure which if not ... more Hypertensive emergencies in acute CKD are clinical manifestations of kidney failure which if not treated immediately can result in damage to various internal organs that can be life threatening. One of them is the appearance of symptoms of anasarca edema, which is a serious disease that should not be ignored. Your body experiences swelling, even causing pulmonary edema. Severe anasarca edema can make the body weak and feel uncomfortable. Administration of furosemide iv up to the maximum dose is one of the treatments to avoid damage to other organs.

Research paper thumbnail of Association between C1236T Genetic Variant of ABCB1 Gene and Molecular Response to Imatinib in Indonesian Chronic Myeloid Patients

Asian Pacific Journal of Cancer Prevention, 2019

Research paper thumbnail of Mutation Analysis of ABL1 Gene and its Relation to the Achievement of Major Molecular Response in Indonesian Chronic Myeloid Leukemia Patients

Current Pharmacogenomics and Personalized Medicine, 2019

Background: Imatinib mesylate is the first tyrosine kinase inhibitor approved for chronic myeloid... more Background: Imatinib mesylate is the first tyrosine kinase inhibitor approved for chronic myeloid leukemia (CML) therapy. Imatinib is an effective drug. However, previous studies had shown that about 20-30% of patients eventually would develop resistance to imatinib. Approximately 40% of imatinib resistance is associated with BCR-ABL kinase domain mutation. One of the most common and serious variations accounts for imatinib response is T315I of ABL1 gene. Objective: To examine the association of T315I mutation in the ABL1 gene and its relation to major molecular response (MMR) achievement in CML patients. This study also examined other mutations adjacent to T315I, i.e., F311I, F317L, and different possible variations in the ABL1 gene. Methods: This was a cross-sectional study on Indonesian CML patients in chronic phase. We analyzed 120 blood samples from patients in chronic phase who have received imatinib mesylate (IM) for ≥12 months. Results: There are no T315I, F311I, and F317L m...

Research paper thumbnail of Potential of herbal medicines in cancer therapy

The Indonesia Journal of Cancer Control, 2021

Herbal medicines have long been used for traditional treatment of diseases. Our ancestors used pl... more Herbal medicines have long been used for traditional treatment of diseases. Our ancestors used plants empirically as treatment and for the maintenance of health inherited from generation to generation. At present, most of the research and development of drugs is still focused on a single compound as the main compound against the treatment target. It is difficult to get a single compound chemical with high selectivity and potential but low toxicity to the target of the disease. Empiric treatment with medicinal plants is particularly a concern in cancer treatment, where treatment is currently done with chemotherapy, radiotherapy, and surgery. The active compound of herbal plants is one alternative in searching for a new anti-cancer because it is believed to have minimal side effects. Therefore, the design and development of anti-cancer drug candidate from herbal plants are increasingly in demand.

Research paper thumbnail of Antiviral treatment of COVID-19: a clinical pharmacology narrative review

Medical Journal of Indonesia

The outbreak of coronavirus disease 2019 (COVID-19) in December 2019 in China, has become a pande... more The outbreak of coronavirus disease 2019 (COVID-19) in December 2019 in China, has become a pandemic in March 2020. Repurposing old and relatively safe drugs becomes an advantageous option to obtain the urgently needed effective treatment. Repurposing chloroquine, hydroxychloroquine, oseltamivir, lopinavir/ritonavir, andfavipiravir, and the use of investigational drug remdesivir for treatment of COVID-19, are reviewed from the clinical pharmacology perspective, particularly its efficacy and safety. Limited clinical studies of chloroquine, hydroxychloroquine, favipiravir, and remdesivir showed some efficacy in COVID-19 treatment with tolerable adverse effects. Potential serious adverse effect of chloroquine and hydroxychloroquine is cardiac arrhythmia. Oseltamivir has no documented activity against SARS-CoV-2, while lopinavir/ritonavir showed limited efficacy in COVID-19. Currently, there is no sufficient evidence to recommend any specific anti-COVID-19 treatment. The decision to use...

Research paper thumbnail of Edukasi Komplikasi Terjadinya Hipertensi Dan Peranan Konsumsi Obat Hipertensi Pada Penderita Diabetes Melitus Usia Lansia DI Puskesmas Lubuk Buaya Tahun 2021

Kumawula: Jurnal Pengabdian Kepada Masyarakat

Diabetes Melitus (DM) merupakan suatu penyakit peningkatan kadar glukosa darah di atas nilai norm... more Diabetes Melitus (DM) merupakan suatu penyakit peningkatan kadar glukosa darah di atas nilai normal. Dinas Kesehatan Kota Padang pada tahun 2019 melaporkan penderita DM di Kota Padang sebanyak 17.018 dan mayoritas berkunjung ke puskesmas. Penyakit DM ini dapat menimbulkan kondisi hiperglikemia yang dapat memicu peningkatan volume cairan tubuh dan resistensi pembuluh darah perifer sehingga dapat meningkatkan risiko terjadinya hipertensi. Saat ini terdapat 40-80% pasien diabetes dengan hipertensi, diketahui risiko penderita diabetes mengalami hipertensi 2 kali lipat lebih berisiko dibanding orang tidak diabetes. Pasien diabetes melitus yang tidak terkontrol kadar glukosa darahnya memerlukan pengobatan komprehensif sebagai upaya pencegahan komplikasi. Masih banyak lansia penyandang DM dengan komorbid hipertensi yang belum paham mengenai bagaimana cara konsumsi obat anti hipertensi. Perlu dilakukan suatu penyuluhan untuk memberikan informasi tentang hipertensi sebagai komplikasi diabete...

Research paper thumbnail of Management of Acute Hypertensive Emergencies on CKD

Science Midwifery

Hypertensive emergencies in acute CKD are clinical manifestations of kidney failure which if not ... more Hypertensive emergencies in acute CKD are clinical manifestations of kidney failure which if not treated immediately can result in damage to various internal organs that can be life threatening. One of them is the appearance of symptoms of anasarca edema, which is a serious disease that should not be ignored. Your body experiences swelling, even causing pulmonary edema. Severe anasarca edema can make the body weak and feel uncomfortable. Administration of furosemide iv up to the maximum dose is one of the treatments to avoid damage to other organs.

Research paper thumbnail of Association between C1236T Genetic Variant of ABCB1 Gene and Molecular Response to Imatinib in Indonesian Chronic Myeloid Patients

Asian Pacific Journal of Cancer Prevention, 2019

Research paper thumbnail of Mutation Analysis of ABL1 Gene and its Relation to the Achievement of Major Molecular Response in Indonesian Chronic Myeloid Leukemia Patients

Current Pharmacogenomics and Personalized Medicine, 2019

Background: Imatinib mesylate is the first tyrosine kinase inhibitor approved for chronic myeloid... more Background: Imatinib mesylate is the first tyrosine kinase inhibitor approved for chronic myeloid leukemia (CML) therapy. Imatinib is an effective drug. However, previous studies had shown that about 20-30% of patients eventually would develop resistance to imatinib. Approximately 40% of imatinib resistance is associated with BCR-ABL kinase domain mutation. One of the most common and serious variations accounts for imatinib response is T315I of ABL1 gene. Objective: To examine the association of T315I mutation in the ABL1 gene and its relation to major molecular response (MMR) achievement in CML patients. This study also examined other mutations adjacent to T315I, i.e., F311I, F317L, and different possible variations in the ABL1 gene. Methods: This was a cross-sectional study on Indonesian CML patients in chronic phase. We analyzed 120 blood samples from patients in chronic phase who have received imatinib mesylate (IM) for ≥12 months. Results: There are no T315I, F311I, and F317L m...

Research paper thumbnail of Potential of herbal medicines in cancer therapy

The Indonesia Journal of Cancer Control, 2021

Herbal medicines have long been used for traditional treatment of diseases. Our ancestors used pl... more Herbal medicines have long been used for traditional treatment of diseases. Our ancestors used plants empirically as treatment and for the maintenance of health inherited from generation to generation. At present, most of the research and development of drugs is still focused on a single compound as the main compound against the treatment target. It is difficult to get a single compound chemical with high selectivity and potential but low toxicity to the target of the disease. Empiric treatment with medicinal plants is particularly a concern in cancer treatment, where treatment is currently done with chemotherapy, radiotherapy, and surgery. The active compound of herbal plants is one alternative in searching for a new anti-cancer because it is believed to have minimal side effects. Therefore, the design and development of anti-cancer drug candidate from herbal plants are increasingly in demand.

Research paper thumbnail of Antiviral treatment of COVID-19: a clinical pharmacology narrative review

Medical Journal of Indonesia

The outbreak of coronavirus disease 2019 (COVID-19) in December 2019 in China, has become a pande... more The outbreak of coronavirus disease 2019 (COVID-19) in December 2019 in China, has become a pandemic in March 2020. Repurposing old and relatively safe drugs becomes an advantageous option to obtain the urgently needed effective treatment. Repurposing chloroquine, hydroxychloroquine, oseltamivir, lopinavir/ritonavir, andfavipiravir, and the use of investigational drug remdesivir for treatment of COVID-19, are reviewed from the clinical pharmacology perspective, particularly its efficacy and safety. Limited clinical studies of chloroquine, hydroxychloroquine, favipiravir, and remdesivir showed some efficacy in COVID-19 treatment with tolerable adverse effects. Potential serious adverse effect of chloroquine and hydroxychloroquine is cardiac arrhythmia. Oseltamivir has no documented activity against SARS-CoV-2, while lopinavir/ritonavir showed limited efficacy in COVID-19. Currently, there is no sufficient evidence to recommend any specific anti-COVID-19 treatment. The decision to use...