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Research paper thumbnail of Riboflavin operon of Bacillus subtilis : unusual symmetric arrangement of the regulatory region

Molecular and General Genetics, 1992

Seventeen cis-dominant mutations leading to riboflavin overproduction in Bacillus subtilis were l... more Seventeen cis-dominant mutations leading to riboflavin overproduction in Bacillus subtilis were localized to the region between nucleotides + 37 and + 159 relative to the transcription initiation site of the riboflavin operon. This region displays an unusual structure for regulatory sequences. The main part of it represents clusters of A/T and G/Grich sequences that symmetrically blank a short inverted repeat.

Research paper thumbnail of Sensing Small Molecules by Nascent RNA

Cell, 2002

Thiamin and riboflavin are precursors of essential coenzymes—thiamin pyrophosphate (TPP) and flav... more Thiamin and riboflavin are precursors of essential coenzymes—thiamin pyrophosphate (TPP) and flavin mononucleotide (FMN)/flavin adenine dinucleotide (FAD), respectively. In Bacillus spp, genes responsible for thiamin and riboflavin biosynthesis are organized in tightly controllable operons. Here, we demonstrate that the feedback regulation of riboflavin and thiamin genes relies on a novel transcription attenuation mechanism. A unique feature of this mechanism is

Research paper thumbnail of Genetic mapping of regulatory mutations of Bacillus subtilis riboflavin operon

Molecular and General Genetics, 1990

Seven mutations leading to riboflavin overproduction inBacillus subtilis were found to be linked ... more Seven mutations leading to riboflavin overproduction inBacillus subtilis were found to be linked to the markerdnaF133 (145° on theB. subtilis genetic map) by transformation. Cotransfer indexes (42.5%–61.7%) suggest that theribC mutations are alleles of the same locus. Results of transduction and transformation crosses suggest the following order of markers:pyrD26 −ts-6 −dnaF133 −ribC −recA1.

Research paper thumbnail of Riboflavin operon of Bacillus subtilis : unusual symmetric arrangement of the regulatory region

Molecular and General Genetics, 1992

Seventeen cis-dominant mutations leading to riboflavin overproduction in Bacillus subtilis were l... more Seventeen cis-dominant mutations leading to riboflavin overproduction in Bacillus subtilis were localized to the region between nucleotides + 37 and + 159 relative to the transcription initiation site of the riboflavin operon. This region displays an unusual structure for regulatory sequences. The main part of it represents clusters of A/T and G/Grich sequences that symmetrically blank a short inverted repeat.

Research paper thumbnail of Sensing Small Molecules by Nascent RNA

Cell, 2002

Thiamin and riboflavin are precursors of essential coenzymes—thiamin pyrophosphate (TPP) and flav... more Thiamin and riboflavin are precursors of essential coenzymes—thiamin pyrophosphate (TPP) and flavin mononucleotide (FMN)/flavin adenine dinucleotide (FAD), respectively. In Bacillus spp, genes responsible for thiamin and riboflavin biosynthesis are organized in tightly controllable operons. Here, we demonstrate that the feedback regulation of riboflavin and thiamin genes relies on a novel transcription attenuation mechanism. A unique feature of this mechanism is

Research paper thumbnail of Genetic mapping of regulatory mutations of Bacillus subtilis riboflavin operon

Molecular and General Genetics, 1990

Seven mutations leading to riboflavin overproduction inBacillus subtilis were found to be linked ... more Seven mutations leading to riboflavin overproduction inBacillus subtilis were found to be linked to the markerdnaF133 (145° on theB. subtilis genetic map) by transformation. Cotransfer indexes (42.5%–61.7%) suggest that theribC mutations are alleles of the same locus. Results of transduction and transformation crosses suggest the following order of markers:pyrD26 −ts-6 −dnaF133 −ribC −recA1.

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