Robert Miller - Academia.edu (original) (raw)

Papers by Robert Miller

European Journal of Immunology, 1990

Any immune response is characterized by its idiotypic profile.Two different kinds of idiotype (Id... more Any immune response is characterized by its idiotypic profile.Two different kinds of idiotype (Id) have been described. Private Id are restricted to a few individuals from a species while recurrent Id appear in a large majority of individuals from the same species immunized with the same antigen. We describe, in this report, an experimental model whereby a private Id can become recurrent through genetic recombination. The immune response of A mice against the hapten arsonate is characterized by a recurrent Id called cross-reactive idiotype A (CRIA). A strongly CRI, called CRIA-like, can be occasionally detected in some BALBk mice (5% to 10%) immunized with arsonate. Molecular studies show that CRIA and CRIA-like antibodies have highly homologous D segments and identical light chains. By contrast, their VH segments are vastly dissimilar. We have examined the anti-arsonate response of inbred strains of mice whose Igh loci are recombinant between those of A/He and BALB/c. Interestingly, we have observed that the CRIA-like Id which is private in BALB/c becomes recurrent in the AXC-1 strain which harbors theVH genes from BALBk, the DH and CH genes from A/He. Structural studies demonstrate that highly homologous,VH,VL and D segments are used in BAL,B/c and AXC-lmice. The basis for this differential expression of highly similar genes could be linked to the DH locus. However, F1 mice stemming from the cross between AXC-1 and BALBk do not express the Id. The backcross analysis shows that the non-expression of the Id in F1 mice depends on genes unlinked to the Igh locus. * The Laboratoire de Physiologie Animale is supported by grants from the Belgian State (ARC). Recipient of a doctoral fellowship from IRSIA.

International Journal of Critical Infrastructure Protection, 2011

The government "owns" the entire US airspace-it can install radar systems, enforce nofly zones an... more The government "owns" the entire US airspace-it can install radar systems, enforce nofly zones and interdict hostile aircraft. Since the critical infrastructure and the associated cyberspace are just as vital to national security, could the US government protect major assets-including privately-owned assets-by positioning sensors and defensive systems? This paper discusses the legal issues related to the government's deployment of sensors in privately owned assets to gain broad situational awareness of foreign threats. This paper does not necessarily advocate pervasive government monitoring of the critical infrastructure; rather, it attempts to analyze the legal principles that would permit or preclude various forms of monitoring.

The Journal of Comparative Neurology, 1975

Commissural, cortico-cortical and corticocaudate neurons have been investigated in the primary se... more Commissural, cortico-cortical and corticocaudate neurons have been investigated in the primary sensorimotor cortex of the cat, using antidromic stimulation techniques, and histological identification of recording sites. These neurons are to be found in all cortical laminae except the first; commissural and cortico-cortical neumns were found to be commonest in laminae 111 and VI, whilst corticocaudate neurons were most abundant on the border between laminae I11 and V, in motor areas. In sensory areas topographically identified as representing distal parts of limbs, commissural neurons are very rare, confirming neuroanatomical studies on the origin and termination of callosal fibres. The intracerebral neuronal Projections investigated in this study had slow conduction velocities (less than 1 m/sec, up to about 10 m/sec). It was found that projections from area 6, whether commissural, cortico-caudate, or corticopeduncular have slower conduction velocities than their counterparts from area 4. It is suggested that this is related to the type of motor control in which these two areas are involved (slowly-responding postural movements, as opposed to more rapid distal limb movements). No neurons were found which had both commissural (or corticocortical), and cortico-fugal projections.

Human Brain Mapping, 2013

Stress is a constant characteristic of everyday life in our society, playing a role in triggering... more Stress is a constant characteristic of everyday life in our society, playing a role in triggering several chronic disorders. Therefore, there is an ongoing need to develop new methods in order to manage stress reactions. The regulatory function of right medial-prefrontal cortex (mPFC) is frequently reported by imaging studies during psychosocial stress situations. Here, we examined the effects of inhibitory and excitatory preconditioning stimulation via cathodal and anodal transcranial direct current stimulation (tDCS) on psychosocial stress related behavioral indicators and physiological factors, including the cortisol level in the saliva and changes in brain perfusion. Twenty minutes real or sham tDCS was applied over the right mPFC of healthy subjects before the performance of the Trier Social Stress Test (TSST). Regional cerebral blood flow (rCBF) was measured during stimulation and after TSST, using pseudo-continuous arterial spin labeling (pCASL). Comparing the effect of the different stimulation conditions, during anodal stimulation we found higher rCBF in the right mPFC, compared to the sham and in the right amygdala, superior PFC compared to the cathodal condition. Salivary cortisol levels showed a decrease in the anodal and increase in cathodal groups after completion of the TSST. The behavioral stress indicators indicated the increase of stress level, however, did not show any significant differences among groups. In this study we provide the first insights into the neuronal mechanisms mediating psychosocial stress responses by prefrontal tDCS.

Biological Psychology, 2010

Previous studies have demonstrated that the serotonin transporter gene-linked polymorphic region ... more Previous studies have demonstrated that the serotonin transporter gene-linked polymorphic region (5-HTTLPR) affects the recognition of facial expressions and attention to them. However, the relationship between 5-HTTLPR and the perceptual detection of others' facial expressions, the process which takes place prior to emotional labeling (i.e., recognition), is not clear. To examine whether the perceptual detection of emotional facial expressions is influenced by the allelic variation (short/long) of 5-HTTLPR, happy and sad facial expressions were presented at weak and mid intensities (25% and 50%). Ninety-eight participants, genotyped for 5-HTTLPR, judged whether emotion in images of faces was present. Participants with short alleles showed higher sensitivity (d9) to happy than to sad expressions, while participants with long allele(s) showed no such positivity advantage. This effect of 5-HTTLPR was found at different facial expression intensities among males and females. The results suggest that at the perceptual stage, a short allele enhances the processing of positive facial expressions rather than that of negative facial expressions.