Laura Roden - Academia.edu (original) (raw)

Papers by Laura Roden

Research paper thumbnail of The New Frontiers in Bone Tissue Engineering

Research paper thumbnail of Associations between self-reported sleep duration and cardiometabolic risk factors in young African-origin adults from the five-country modeling the epidemiologic transition study (METS)

Sleep Health, Aug 1, 2020

Publisher: Elsevier NOTICE: this is the author's version of a work that was accepted for publicat... more Publisher: Elsevier NOTICE: this is the author's version of a work that was accepted for publication in Sleep Health. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Sleep Health, 6:4, (2020)

Research paper thumbnail of Gene Regulatory Network Inference through Link Prediction using Graph Neural Network

Research paper thumbnail of 203 Covid-19 is associated with an increase in central and aortic augmentation index in women

Stable IHD/Prevention/Hypertension/Lipids

Research paper thumbnail of 9 Association between pulse wave velocity and measures of cardiac function in healthy individuals

Research paper thumbnail of Sleep characteristics associated with nocturnal blood pressure nondipping in healthy individuals: a systematic review

Blood Pressure Monitoring

Research paper thumbnail of Dim light melatonin onset following simulated eastward travel is earlier in young males genotyped as PER35/5 than PER34/4

Chronobiology International

Dim light melatonin onset following simulated eastward travel is earlier in young males genotyped... more Dim light melatonin onset following simulated eastward travel is earlier in young males genotyped as PER35/5 than PER34/4', Chronobiology International, vol. (In-Press), pp. (In-Press).

Research paper thumbnail of Red, blue or mix: choice of optimal light qualities for enhanced plant growth through in silico analysis

agriRxiv

In smart greenhouse farming, artificially adjustable light qualities (colours) play an important ... more In smart greenhouse farming, artificially adjustable light qualities (colours) play an important role to promote plant growth. While it is known that these light qualities have significant impacts on plant development, the suitable combinations enabling the plant to grow at its best are yet to be systematically identified. This study fills this gap by studying the effect of different properties of light qualities (i.e., photoperiod, light intensity, light ratio, light-dark order) on plant growth using a mathematical model of the model plant Arabidopsis thaliana , where days-to-flower (DTF) and hypocotyl (seedling stem) length are used as proxies for measuring plant growth. A comprehensive literature search is first conducted to establish a suitable range of each light property before they are systematically varied within that prescribed range to study their effect on plant growth. In comparison to a previous study using white light, monochromatic blue light with minimum intensity of...

Research paper thumbnail of Cardiovascular implications and physical activity in middle-aged and older adults with a history of COVID-19 (CV COVID): a protocol for a randomised controlled trial

Trials

Background The clinical manifestation of COVID-19 is associated with infection and inflammation o... more Background The clinical manifestation of COVID-19 is associated with infection and inflammation of the lungs, but there is evidence to suggest that COVID-19 may also affect the structure and function of the cardiovascular system. At present, it is not fully understood to what extent COVID-19 impacts cardiovascular function in the short- and long-term following infection. The aim of the present study is twofold: (i) to define the effect of COVID-19 on cardiovascular function (i.e. arterial stiffness, cardiac systolic and diastolic function) in otherwise healthy individuals and (ii) to evaluate the effect of a home-based physical activity intervention on cardiovascular function in people with a history of COVID-19. Methods This prospective, single-centre, observational study will recruit 120 COVID-19-vaccinated adult participants aged between 50 and 85 years, i.e. 80 with a history of COVID-19 and 40 healthy controls without a history of COVID-19. All participants will undergo baselin...

Research paper thumbnail of Table S1 from Circadian Oscillations Persist in Cervical and Esophageal Cancer Cells Displaying Decreased Expression of Tumor-Suppressing Circadian Clock Genes

Correlations between gene expression fold changes (R values are shown)

Research paper thumbnail of Figure S1 from Circadian Oscillations Persist in Cervical and Esophageal Cancer Cells Displaying Decreased Expression of Tumor-Suppressing Circadian Clock Genes

Microarray analysis showing significant downregulation of circadian clock gene, PER2, in cervical... more Microarray analysis showing significant downregulation of circadian clock gene, PER2, in cervical cancer tissue specimens (n = 16) compared to normal cervical epithelium (n = 8); *p < 0.0005.

Research paper thumbnail of Figure S2 from Circadian Oscillations Persist in Cervical and Esophageal Cancer Cells Displaying Decreased Expression of Tumor-Suppressing Circadian Clock Genes

Relative circadian clock gene expression in normal and cancer tissue, as calculated based on data... more Relative circadian clock gene expression in normal and cancer tissue, as calculated based on data generated by the TCGA Research Network (https://www.cancer.gov/tcga) and The Genotype Tissue Expression (GTEx) project (https://www.gtexportal.org/home/). A. Circadian clock gene expression in normal cervical epithelium vs cervical cancer tissue. B. Expression of KI67 and p16, known to be upregulated in cervical cancer. C. Circadian clock gene expression in normal oesophageal epithelium vs oesophageal cancer tissue. D. Expression of KI67 and KPNα2, known to be upregulated in oesophageal cancer (*p<0.05).

Research paper thumbnail of Figure S5 from Circadian Oscillations Persist in Cervical and Esophageal Cancer Cells Displaying Decreased Expression of Tumor-Suppressing Circadian Clock Genes

CpG island prediction software, MethPrimer (www.urogene.org), identifies CpG islands in the 5&#39... more CpG island prediction software, MethPrimer (www.urogene.org), identifies CpG islands in the 5' regulatory sequences of circadian clock genes, CLOCK, RORα, CRY1 and PER2. The regions from -2000 to +2000 were analysed, relative to the transcription start site of +1. In the linear scale depicted, 0 refers to 2000 bases upstream and 4000 refers to 2000 bases downstream of the transcription start site.

Research paper thumbnail of New frontiers in bone tissue engineering

Clinics in Plastic Surgery, 2003

No single scientific field can generate the ideal method of engineering bone. However, through co... more No single scientific field can generate the ideal method of engineering bone. However, through collaboration and expansion of programs in bone tissue engineering, the right combination of materials, cells, growth factors, and methodology will come together for each clinical situation such that harvesting bone grafts will become obsolete. This article reviews the need for engineered bone and provides a historical perspective of bone engineering research, current research efforts, and the future direction of this work.

Research paper thumbnail of Chronotype distribution in professional rugby players: Evidence for the environment hypothesis?

Chronobiology international, 2017

Individual sport athletes have been shown to comprise unusually high proportions of morning-types... more Individual sport athletes have been shown to comprise unusually high proportions of morning-types (MTs) coupled with a higher prevalence of the morningness-associated PERIOD3 variable number tandem repeat (VNTR) allele, PER3(5). The degree to which type of sport selected is influenced by either chronotype or genotype, or the extent to which sporting environment contributes to chronotype is unclear. The aim of this study was to assess chronotype and PER3 VNTR polymorphism frequencies in team sport players and non-athletic controls. South African male Super Rugby players (RUG, n = 120) and a control population of males with habitually low levels of physical activity (defined as exercise no more than twice a week; CON, n = 117) took part in this study. Participants completed the Horne-Östberg morningness-eveningness questionnaire to determine chronotype and donated buccal cell or blood samples from which PER3 VNTR genotype was established. There were more MTs in the RUG (47%) than CON ...

Research paper thumbnail of Comparison between an African town and a neighbouring village shows delayed, but not decreased, sleep during the early stages of urbanisation

Scientific reports, Jan 18, 2017

The well-established negative health outcomes of sleep deprivation, and the suggestion that avail... more The well-established negative health outcomes of sleep deprivation, and the suggestion that availability of electricity may enable later bed times without compensating sleep extension in the morning, have stimulated interest in studying communities whose sleep pattern may resemble a pre-industrial state. Here, we describe sleep and activity in two neighbouring communities, one urban (Milange) and one rural (Tengua), in a region of Mozambique where urbanisation is an ongoing process. The two communities differ in the amount and timing of daily activity and of light exposure, with later bedtimes (≈1 h) associated with more evening and less daytime light exposure seen in the town of Milange. In contrast to previous reports comparing communities with and without electricity, sleep duration did not differ between Milange (7.28 h) and Tengua (7.23 h). Notably, calculated sleep quality was significantly poorer in rural Tengua than in Milange, and poor sleep quality was associated with a nu...

Research paper thumbnail of One night of partial sleep deprivation impairs recovery from a single exercise training session

European journal of applied physiology, Jan 28, 2017

The effects of sleep deprivation on physical performance are well documented, but data on the con... more The effects of sleep deprivation on physical performance are well documented, but data on the consequence of sleep deprivation on recovery from exercise are limited. The aim was to compare cyclists' recovery from a single bout of high-intensity interval training (HIIT) after which they were given either a normal night of sleep (CON, 7.56 ± 0.63 h) or half of their usual time in bed (DEP, 3.83 ± 0.33 h). In this randomized cross-over intervention study, 16 trained male cyclists (age 32 ± 7 years), relative peak power output (PPO 4.6 ± 0.7 W kg(-1)) performed a HIIT session at ±18:00 followed by either the CON or DEP sleep condition. Recovery from the HIIT session was assessed the following day by comparing pre-HIIT variables to those measured 12 and 24 h after the session. Following a 2-week washout, cyclists repeated the trial, but under the alternate sleep condition. PPO was reduced more 24 h after the HIIT session in the DEP (ΔPPO -0.22 ± 0.22 W kg(-1); range -0.75 to 0.1 W kg...

Research paper thumbnail of Sleep: a serious contender for the prevention of obesity and non-communicable diseases

Journal of Endocrinology, Metabolism and Diabetes of South Africa, 2016

Research paper thumbnail of Chronotype of South African adults is affected by solar entrainment

Chronobiology International, 2016

Our daily lives are influenced by three different daily timers: the solar clock, our endogenous c... more Our daily lives are influenced by three different daily timers: the solar clock, our endogenous circadian clock and the societal clock. The way an individual&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s endogenous clock synchronises to the solar clock, through either advances or delays relative to sunrise and sunset, results in a phenomenon known as diurnal preference or chronotype. South Africa uses just one time zone, but in the most easterly regions of the country, the sun rises and sets up to an hour earlier than in the most westerly regions throughout the year. It was hypothesised first that South Africans living in the east of the country may have a greater preference for mornings (more morning chronotypes) than those living in the west; and second, that this difference would not be due to genetic differences in the populations, particularly a genetic polymorphism previously shown to influence chronotype. Here, we describe and compare the distribution of chorotype and PERIOD3 variable number tandem repeat (VNTR) polymorphism frequency in eastern (n = 129) and western (n = 175) sample populations. Using the Horne-Östberg Morningness, Eveningness Questionnaire we found that there was a significantly higher proportion of morning-types in the eastern population (56.6%) than in the western population (39.4%), and there were higher proportions of neither-types and evening-types in the western population (51.4% and 9.1%, respectively) than in the eastern population (37.2% and 6.2%, respectively) (p = 0.009). There were no significant differences in distribution of the PER3 genotype (p = 0.895) and allele (p = 0.636) frequencies. Although previous studies have shown associations between chronotype and PER3 VNTR genotypes, no significant associations were observed in either the eastern (p = 0.695) or the western (p = 0.630) populations. These findings indicate that, in South African populations, longitude influences chronotype independently of PER3 genotype. The impacts of the differences in chronotype whilst maintaining the same societal temporal organisation in the eastern and western regions were not assessed.

Research paper thumbnail of Jasmonate signalling drives time-of-day differences in susceptibility of Arabidopsis to the fungal pathogen Botrytis cinerea

The Plant Journal, 2015

The circadian clock, an internal time-keeping mechanism, allows plants to anticipate regular chan... more The circadian clock, an internal time-keeping mechanism, allows plants to anticipate regular changes in the environment, such as light and dark, and biotic challenges such as pathogens and herbivores. Here, we demonstrate that the plant circadian clock influences susceptibility to the necrotrophic fungal pathogen, Botrytis cinerea. Arabidopsis plants show differential susceptibility to B. cinerea depending on the time of day of inoculation. Decreased susceptibility after inoculation at dawn compared with night persists under constant light conditions and is disrupted in dysfunctional clock mutants, demonstrating the role of the plant clock in driving time-of-day susceptibility to B. cinerea. The decreased susceptibility to B. cinerea following inoculation at subjective dawn was associated with faster transcriptional reprogramming of the defence response with gating of infection-responsive genes apparent. Direct target genes of core clock regulators were enriched among the transcription factors that responded more rapidly to infection at subjective dawn than subjective night, suggesting an influence of the clock on the defence-signalling network. In addition, jasmonate signalling plays a crucial role in the rhythmic susceptibility of Arabidopsis to B. cinerea with the enhanced susceptibility to this pathogen at subjective night lost in a jaz6 mutant.

Research paper thumbnail of The New Frontiers in Bone Tissue Engineering

Research paper thumbnail of Associations between self-reported sleep duration and cardiometabolic risk factors in young African-origin adults from the five-country modeling the epidemiologic transition study (METS)

Sleep Health, Aug 1, 2020

Publisher: Elsevier NOTICE: this is the author's version of a work that was accepted for publicat... more Publisher: Elsevier NOTICE: this is the author's version of a work that was accepted for publication in Sleep Health. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Sleep Health, 6:4, (2020)

Research paper thumbnail of Gene Regulatory Network Inference through Link Prediction using Graph Neural Network

Research paper thumbnail of 203 Covid-19 is associated with an increase in central and aortic augmentation index in women

Stable IHD/Prevention/Hypertension/Lipids

Research paper thumbnail of 9 Association between pulse wave velocity and measures of cardiac function in healthy individuals

Research paper thumbnail of Sleep characteristics associated with nocturnal blood pressure nondipping in healthy individuals: a systematic review

Blood Pressure Monitoring

Research paper thumbnail of Dim light melatonin onset following simulated eastward travel is earlier in young males genotyped as PER35/5 than PER34/4

Chronobiology International

Dim light melatonin onset following simulated eastward travel is earlier in young males genotyped... more Dim light melatonin onset following simulated eastward travel is earlier in young males genotyped as PER35/5 than PER34/4', Chronobiology International, vol. (In-Press), pp. (In-Press).

Research paper thumbnail of Red, blue or mix: choice of optimal light qualities for enhanced plant growth through in silico analysis

agriRxiv

In smart greenhouse farming, artificially adjustable light qualities (colours) play an important ... more In smart greenhouse farming, artificially adjustable light qualities (colours) play an important role to promote plant growth. While it is known that these light qualities have significant impacts on plant development, the suitable combinations enabling the plant to grow at its best are yet to be systematically identified. This study fills this gap by studying the effect of different properties of light qualities (i.e., photoperiod, light intensity, light ratio, light-dark order) on plant growth using a mathematical model of the model plant Arabidopsis thaliana , where days-to-flower (DTF) and hypocotyl (seedling stem) length are used as proxies for measuring plant growth. A comprehensive literature search is first conducted to establish a suitable range of each light property before they are systematically varied within that prescribed range to study their effect on plant growth. In comparison to a previous study using white light, monochromatic blue light with minimum intensity of...

Research paper thumbnail of Cardiovascular implications and physical activity in middle-aged and older adults with a history of COVID-19 (CV COVID): a protocol for a randomised controlled trial

Trials

Background The clinical manifestation of COVID-19 is associated with infection and inflammation o... more Background The clinical manifestation of COVID-19 is associated with infection and inflammation of the lungs, but there is evidence to suggest that COVID-19 may also affect the structure and function of the cardiovascular system. At present, it is not fully understood to what extent COVID-19 impacts cardiovascular function in the short- and long-term following infection. The aim of the present study is twofold: (i) to define the effect of COVID-19 on cardiovascular function (i.e. arterial stiffness, cardiac systolic and diastolic function) in otherwise healthy individuals and (ii) to evaluate the effect of a home-based physical activity intervention on cardiovascular function in people with a history of COVID-19. Methods This prospective, single-centre, observational study will recruit 120 COVID-19-vaccinated adult participants aged between 50 and 85 years, i.e. 80 with a history of COVID-19 and 40 healthy controls without a history of COVID-19. All participants will undergo baselin...

Research paper thumbnail of Table S1 from Circadian Oscillations Persist in Cervical and Esophageal Cancer Cells Displaying Decreased Expression of Tumor-Suppressing Circadian Clock Genes

Correlations between gene expression fold changes (R values are shown)

Research paper thumbnail of Figure S1 from Circadian Oscillations Persist in Cervical and Esophageal Cancer Cells Displaying Decreased Expression of Tumor-Suppressing Circadian Clock Genes

Microarray analysis showing significant downregulation of circadian clock gene, PER2, in cervical... more Microarray analysis showing significant downregulation of circadian clock gene, PER2, in cervical cancer tissue specimens (n = 16) compared to normal cervical epithelium (n = 8); *p < 0.0005.

Research paper thumbnail of Figure S2 from Circadian Oscillations Persist in Cervical and Esophageal Cancer Cells Displaying Decreased Expression of Tumor-Suppressing Circadian Clock Genes

Relative circadian clock gene expression in normal and cancer tissue, as calculated based on data... more Relative circadian clock gene expression in normal and cancer tissue, as calculated based on data generated by the TCGA Research Network (https://www.cancer.gov/tcga) and The Genotype Tissue Expression (GTEx) project (https://www.gtexportal.org/home/). A. Circadian clock gene expression in normal cervical epithelium vs cervical cancer tissue. B. Expression of KI67 and p16, known to be upregulated in cervical cancer. C. Circadian clock gene expression in normal oesophageal epithelium vs oesophageal cancer tissue. D. Expression of KI67 and KPNα2, known to be upregulated in oesophageal cancer (*p<0.05).

Research paper thumbnail of Figure S5 from Circadian Oscillations Persist in Cervical and Esophageal Cancer Cells Displaying Decreased Expression of Tumor-Suppressing Circadian Clock Genes

CpG island prediction software, MethPrimer (www.urogene.org), identifies CpG islands in the 5&#39... more CpG island prediction software, MethPrimer (www.urogene.org), identifies CpG islands in the 5' regulatory sequences of circadian clock genes, CLOCK, RORα, CRY1 and PER2. The regions from -2000 to +2000 were analysed, relative to the transcription start site of +1. In the linear scale depicted, 0 refers to 2000 bases upstream and 4000 refers to 2000 bases downstream of the transcription start site.

Research paper thumbnail of New frontiers in bone tissue engineering

Clinics in Plastic Surgery, 2003

No single scientific field can generate the ideal method of engineering bone. However, through co... more No single scientific field can generate the ideal method of engineering bone. However, through collaboration and expansion of programs in bone tissue engineering, the right combination of materials, cells, growth factors, and methodology will come together for each clinical situation such that harvesting bone grafts will become obsolete. This article reviews the need for engineered bone and provides a historical perspective of bone engineering research, current research efforts, and the future direction of this work.

Research paper thumbnail of Chronotype distribution in professional rugby players: Evidence for the environment hypothesis?

Chronobiology international, 2017

Individual sport athletes have been shown to comprise unusually high proportions of morning-types... more Individual sport athletes have been shown to comprise unusually high proportions of morning-types (MTs) coupled with a higher prevalence of the morningness-associated PERIOD3 variable number tandem repeat (VNTR) allele, PER3(5). The degree to which type of sport selected is influenced by either chronotype or genotype, or the extent to which sporting environment contributes to chronotype is unclear. The aim of this study was to assess chronotype and PER3 VNTR polymorphism frequencies in team sport players and non-athletic controls. South African male Super Rugby players (RUG, n = 120) and a control population of males with habitually low levels of physical activity (defined as exercise no more than twice a week; CON, n = 117) took part in this study. Participants completed the Horne-Östberg morningness-eveningness questionnaire to determine chronotype and donated buccal cell or blood samples from which PER3 VNTR genotype was established. There were more MTs in the RUG (47%) than CON ...

Research paper thumbnail of Comparison between an African town and a neighbouring village shows delayed, but not decreased, sleep during the early stages of urbanisation

Scientific reports, Jan 18, 2017

The well-established negative health outcomes of sleep deprivation, and the suggestion that avail... more The well-established negative health outcomes of sleep deprivation, and the suggestion that availability of electricity may enable later bed times without compensating sleep extension in the morning, have stimulated interest in studying communities whose sleep pattern may resemble a pre-industrial state. Here, we describe sleep and activity in two neighbouring communities, one urban (Milange) and one rural (Tengua), in a region of Mozambique where urbanisation is an ongoing process. The two communities differ in the amount and timing of daily activity and of light exposure, with later bedtimes (≈1 h) associated with more evening and less daytime light exposure seen in the town of Milange. In contrast to previous reports comparing communities with and without electricity, sleep duration did not differ between Milange (7.28 h) and Tengua (7.23 h). Notably, calculated sleep quality was significantly poorer in rural Tengua than in Milange, and poor sleep quality was associated with a nu...

Research paper thumbnail of One night of partial sleep deprivation impairs recovery from a single exercise training session

European journal of applied physiology, Jan 28, 2017

The effects of sleep deprivation on physical performance are well documented, but data on the con... more The effects of sleep deprivation on physical performance are well documented, but data on the consequence of sleep deprivation on recovery from exercise are limited. The aim was to compare cyclists' recovery from a single bout of high-intensity interval training (HIIT) after which they were given either a normal night of sleep (CON, 7.56 ± 0.63 h) or half of their usual time in bed (DEP, 3.83 ± 0.33 h). In this randomized cross-over intervention study, 16 trained male cyclists (age 32 ± 7 years), relative peak power output (PPO 4.6 ± 0.7 W kg(-1)) performed a HIIT session at ±18:00 followed by either the CON or DEP sleep condition. Recovery from the HIIT session was assessed the following day by comparing pre-HIIT variables to those measured 12 and 24 h after the session. Following a 2-week washout, cyclists repeated the trial, but under the alternate sleep condition. PPO was reduced more 24 h after the HIIT session in the DEP (ΔPPO -0.22 ± 0.22 W kg(-1); range -0.75 to 0.1 W kg...

Research paper thumbnail of Sleep: a serious contender for the prevention of obesity and non-communicable diseases

Journal of Endocrinology, Metabolism and Diabetes of South Africa, 2016

Research paper thumbnail of Chronotype of South African adults is affected by solar entrainment

Chronobiology International, 2016

Our daily lives are influenced by three different daily timers: the solar clock, our endogenous c... more Our daily lives are influenced by three different daily timers: the solar clock, our endogenous circadian clock and the societal clock. The way an individual&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s endogenous clock synchronises to the solar clock, through either advances or delays relative to sunrise and sunset, results in a phenomenon known as diurnal preference or chronotype. South Africa uses just one time zone, but in the most easterly regions of the country, the sun rises and sets up to an hour earlier than in the most westerly regions throughout the year. It was hypothesised first that South Africans living in the east of the country may have a greater preference for mornings (more morning chronotypes) than those living in the west; and second, that this difference would not be due to genetic differences in the populations, particularly a genetic polymorphism previously shown to influence chronotype. Here, we describe and compare the distribution of chorotype and PERIOD3 variable number tandem repeat (VNTR) polymorphism frequency in eastern (n = 129) and western (n = 175) sample populations. Using the Horne-Östberg Morningness, Eveningness Questionnaire we found that there was a significantly higher proportion of morning-types in the eastern population (56.6%) than in the western population (39.4%), and there were higher proportions of neither-types and evening-types in the western population (51.4% and 9.1%, respectively) than in the eastern population (37.2% and 6.2%, respectively) (p = 0.009). There were no significant differences in distribution of the PER3 genotype (p = 0.895) and allele (p = 0.636) frequencies. Although previous studies have shown associations between chronotype and PER3 VNTR genotypes, no significant associations were observed in either the eastern (p = 0.695) or the western (p = 0.630) populations. These findings indicate that, in South African populations, longitude influences chronotype independently of PER3 genotype. The impacts of the differences in chronotype whilst maintaining the same societal temporal organisation in the eastern and western regions were not assessed.

Research paper thumbnail of Jasmonate signalling drives time-of-day differences in susceptibility of Arabidopsis to the fungal pathogen Botrytis cinerea

The Plant Journal, 2015

The circadian clock, an internal time-keeping mechanism, allows plants to anticipate regular chan... more The circadian clock, an internal time-keeping mechanism, allows plants to anticipate regular changes in the environment, such as light and dark, and biotic challenges such as pathogens and herbivores. Here, we demonstrate that the plant circadian clock influences susceptibility to the necrotrophic fungal pathogen, Botrytis cinerea. Arabidopsis plants show differential susceptibility to B. cinerea depending on the time of day of inoculation. Decreased susceptibility after inoculation at dawn compared with night persists under constant light conditions and is disrupted in dysfunctional clock mutants, demonstrating the role of the plant clock in driving time-of-day susceptibility to B. cinerea. The decreased susceptibility to B. cinerea following inoculation at subjective dawn was associated with faster transcriptional reprogramming of the defence response with gating of infection-responsive genes apparent. Direct target genes of core clock regulators were enriched among the transcription factors that responded more rapidly to infection at subjective dawn than subjective night, suggesting an influence of the clock on the defence-signalling network. In addition, jasmonate signalling plays a crucial role in the rhythmic susceptibility of Arabidopsis to B. cinerea with the enhanced susceptibility to this pathogen at subjective night lost in a jaz6 mutant.