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Papers by Rodolfo Castillo
Journal of investigational allergology & clinical immunology, 2007
The single-blind, placebo controlled oral challenge (SBPCOC) is the definitive way to diagnosis n... more The single-blind, placebo controlled oral challenge (SBPCOC) is the definitive way to diagnosis nonsteroidal anti-inflammatory drug (NSAID)-induced reactions. To evaluate 223 NSAID-sensitive patients by means of SBPCOC, and to describe the main clinical patterns found. A prospective study was carried out, including 2 patient groups with case histories consistent with NSAID-induced reactions. Of the 223 patients, 174 were diagnosed on the basis of a positive SBPCOC. The second group consisted of 49 patients who were referred because of a documented history of anaphylaxis after taking NSAIDs, and these underwent SBPCOC with potent cyclooxygenase (COX)-1/COX-2 inhibitors, except those reported as being responsible for the reaction. The type of SBPCOC reaction, the NSAID reactivity pattern, and the associated diseases were the main classification criteria. Two broad categories of NSAID-induced reactions were identified: the cross-reactive and selective syndromes. The 150 patients who sh...
CHEST Journal, 2002
To study the existence of bronchial disease among rhinitis patients. To evaluate the laboratory t... more To study the existence of bronchial disease among rhinitis patients. To evaluate the laboratory test or set of tests (ie, symptoms, exposure, and sensitization to the allergen, and the provocative dose of methacholine [Mth] causing a 20% fall in FEV 1 [PD 20 ] and the maximal response plateau [MRP] to Mth) that best identifies a case of mild asthma. Design: Cross-sectional analysis in 52 Dermatophagoides pteronyssinus-monosensitized patients who were consulting a physician for perennial rhinitis.
Revista de Oncología, 2002
Journal of investigational allergology & clinical immunology, 2007
The single-blind, placebo controlled oral challenge (SBPCOC) is the definitive way to diagnosis n... more The single-blind, placebo controlled oral challenge (SBPCOC) is the definitive way to diagnosis nonsteroidal anti-inflammatory drug (NSAID)-induced reactions. To evaluate 223 NSAID-sensitive patients by means of SBPCOC, and to describe the main clinical patterns found. A prospective study was carried out, including 2 patient groups with case histories consistent with NSAID-induced reactions. Of the 223 patients, 174 were diagnosed on the basis of a positive SBPCOC. The second group consisted of 49 patients who were referred because of a documented history of anaphylaxis after taking NSAIDs, and these underwent SBPCOC with potent cyclooxygenase (COX)-1/COX-2 inhibitors, except those reported as being responsible for the reaction. The type of SBPCOC reaction, the NSAID reactivity pattern, and the associated diseases were the main classification criteria. Two broad categories of NSAID-induced reactions were identified: the cross-reactive and selective syndromes. The 150 patients who sh...
CHEST Journal, 2002
To study the existence of bronchial disease among rhinitis patients. To evaluate the laboratory t... more To study the existence of bronchial disease among rhinitis patients. To evaluate the laboratory test or set of tests (ie, symptoms, exposure, and sensitization to the allergen, and the provocative dose of methacholine [Mth] causing a 20% fall in FEV 1 [PD 20 ] and the maximal response plateau [MRP] to Mth) that best identifies a case of mild asthma. Design: Cross-sectional analysis in 52 Dermatophagoides pteronyssinus-monosensitized patients who were consulting a physician for perennial rhinitis.
Revista de Oncología, 2002