Rodrigo Abbud Canova - Academia.edu (original) (raw)
Papers by Rodrigo Abbud Canova
Deep venous thrombosis occurs in 50% 70% of patients submitted to acute fixation of proximal femu... more Deep venous thrombosis occurs in 50% 70% of patients submitted to acute fixation of proximal femur fractures, in multiple fractured patients, and in those presenting with spinal cord trauma, when no prophylactic measure is performed (1). Thrombosis may occur in any vessel of the body, but it is often found in lower limbs. This is the most important kind of thrombosis, both in terms of frequency and severity. There are some factors that may increase the risk of deep venous thrombosis, such as: age above 40 years old, extended rest periods, extensive surgeries, surgical complications, general anesthesia, immobility, trauma etc. (2). Therefore, prophylactic measures are performed in patients at a higher risk of deep venous thrombosis, if submitted to those conditions. THE EFFECTS OF LOW-MOLECULAR-WEIGHT HEPARIN (ENOXAPARIN) ON BONY CALLUS FORMATION IN RATS’ FEMURS – AN EXPERIMENTAL STUDY
Objective: To realize a case-control study, comparing the clinical outcomes of tongue fractures o... more Objective: To realize a case-control study, comparing the clinical outcomes of tongue fractures of the calcaneus treated by two techniques: open reduction and internal fixation or percutaneous fixation. Methods: Between January 2005 and December 2007, 15 patients were treated by the percutaneous reduction and fixation (Group A). These patients were compared to other 15, treated by open reduction and internal fixation with plate (Group B). The groups were similar in age, sex, side of fracture, type of fracture, initial displace and initime between the injury and the surgery. Results: Minimal follow-up was ten months. More early (p=0.005) and late (p=0.004) complications occurred in Group B. There were more patients with AOFAS score considered good/excellent (>80) in the Group A than in the Group B, but with no statistical significance (p=0.2557). The mean AOFAS score of Group A was slightly better than Group B, but with no statistical significance too (p=0.1224). When the groups w...
Acta Ortopedica Brasileira, Dec 1, 2005
Cardiovascular Radiation Medicine, 2001
Background: It has been shown that irradiation with either beta and gamma sources inhibit neointi... more Background: It has been shown that irradiation with either beta and gamma sources inhibit neointimal formation. Samarium-153 (153 Sm) is an isotope with 0.8 MeV, subdivided in three different beta energies and 103 keV of gamma energy. This compound has been tested and used in humans for palliation of pain from bone metastases. The aim of the present study was to evaluate the feasibility and efficacy of brachytherapy with 153 Sm-filled balloon to inhibit neointimal formation in rabbits after balloon overstretch injury. Methods: Nineteen rabbits underwent balloon injury in their iliac arteries. In 12 animals (control), oversized balloons filled with saline solution were inflated up to 5 atm for a period of 5 min. In 7 rabbits, the same procedure was performed but using balloons filled with 153 Sm. In all cases, both iliac arteries were treated. The prescribed radiation dose was 15 Gy at 1 mm depth. After 30 days, the animals were sacrificed and their arterial segments were analyzed. Radiation exposure at the animal chest to the table and at a distance of 1 m from the table was measured. Results: Histopathologic analysis showed a striking reduction in the amount of neointima in the irradiated arteries compared with control vessels (0.36 0.21 vs. 1.07 0.56 mm 2 , P < .01). The dose delivered to the animal chest was 21.5 mR/h, whereas only 1.9 mR/h was measured at the table and virtually no radiation could be detected at a distance of 1 m from the table. Conclusions: Brachytherapy with 153 Sm was feasible with minimal personnel exposure radiation and effectively inhibited neointimal formation in this experimental model. These results warrant further experimental and clinical investigations.
Deep venous thrombosis occurs in 50% 70% of patients submitted to acute fixation of proximal femu... more Deep venous thrombosis occurs in 50% 70% of patients submitted to acute fixation of proximal femur fractures, in multiple fractured patients, and in those presenting with spinal cord trauma, when no prophylactic measure is performed (1). Thrombosis may occur in any vessel of the body, but it is often found in lower limbs. This is the most important kind of thrombosis, both in terms of frequency and severity. There are some factors that may increase the risk of deep venous thrombosis, such as: age above 40 years old, extended rest periods, extensive surgeries, surgical complications, general anesthesia, immobility, trauma etc. (2). Therefore, prophylactic measures are performed in patients at a higher risk of deep venous thrombosis, if submitted to those conditions. THE EFFECTS OF LOW-MOLECULAR-WEIGHT HEPARIN (ENOXAPARIN) ON BONY CALLUS FORMATION IN RATS’ FEMURS – AN EXPERIMENTAL STUDY
Objective: To realize a case-control study, comparing the clinical outcomes of tongue fractures o... more Objective: To realize a case-control study, comparing the clinical outcomes of tongue fractures of the calcaneus treated by two techniques: open reduction and internal fixation or percutaneous fixation. Methods: Between January 2005 and December 2007, 15 patients were treated by the percutaneous reduction and fixation (Group A). These patients were compared to other 15, treated by open reduction and internal fixation with plate (Group B). The groups were similar in age, sex, side of fracture, type of fracture, initial displace and initime between the injury and the surgery. Results: Minimal follow-up was ten months. More early (p=0.005) and late (p=0.004) complications occurred in Group B. There were more patients with AOFAS score considered good/excellent (>80) in the Group A than in the Group B, but with no statistical significance (p=0.2557). The mean AOFAS score of Group A was slightly better than Group B, but with no statistical significance too (p=0.1224). When the groups w...
Acta Ortopedica Brasileira, Dec 1, 2005
Cardiovascular Radiation Medicine, 2001
Background: It has been shown that irradiation with either beta and gamma sources inhibit neointi... more Background: It has been shown that irradiation with either beta and gamma sources inhibit neointimal formation. Samarium-153 (153 Sm) is an isotope with 0.8 MeV, subdivided in three different beta energies and 103 keV of gamma energy. This compound has been tested and used in humans for palliation of pain from bone metastases. The aim of the present study was to evaluate the feasibility and efficacy of brachytherapy with 153 Sm-filled balloon to inhibit neointimal formation in rabbits after balloon overstretch injury. Methods: Nineteen rabbits underwent balloon injury in their iliac arteries. In 12 animals (control), oversized balloons filled with saline solution were inflated up to 5 atm for a period of 5 min. In 7 rabbits, the same procedure was performed but using balloons filled with 153 Sm. In all cases, both iliac arteries were treated. The prescribed radiation dose was 15 Gy at 1 mm depth. After 30 days, the animals were sacrificed and their arterial segments were analyzed. Radiation exposure at the animal chest to the table and at a distance of 1 m from the table was measured. Results: Histopathologic analysis showed a striking reduction in the amount of neointima in the irradiated arteries compared with control vessels (0.36 0.21 vs. 1.07 0.56 mm 2 , P < .01). The dose delivered to the animal chest was 21.5 mR/h, whereas only 1.9 mR/h was measured at the table and virtually no radiation could be detected at a distance of 1 m from the table. Conclusions: Brachytherapy with 153 Sm was feasible with minimal personnel exposure radiation and effectively inhibited neointimal formation in this experimental model. These results warrant further experimental and clinical investigations.