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Papers by Roman Rozencwaig

Research paper thumbnail of Editor's Mail

Postgraduate Medicine, 1982

Research paper thumbnail of Allergies: protective against cancer but predisposing to heart disease

Research paper thumbnail of Role of Melatonin in Curtailing Oxidative Stress during COVID-19

Medicine and clinical science, Dec 30, 2021

Several studies carried out during the ongoing COVID-19 pandemic revealed that oxidation stress i... more Several studies carried out during the ongoing COVID-19 pandemic revealed that oxidation stress is a major factor in the disease development, particularly in its severe complications, such as ALI and ARDS. It has been hypothesized that the well-known natural hormone melatonin may play a significant role in countering oxidative stress and consequently easing the progression of COVID-19. The present review summarizes available information on the contribution of oxidation stress during the pathogenesis of COVID-19 and several other diseases, and the rationale of their possible treatment with melatonin. This research direction will further expand our knowledge about melatonin beyond its role as the regulator of the circadian rhythm, and towards its application as an efficient adjuvant treatment for various diseases, including COVID-19 infection.

Research paper thumbnail of Melatonin in the Gastrointestinal Tract, Circadian Rhythms, Immunity and Microbiota in Health, Disease and Aging

Comprehensive Gut Microbiota, 2022

Research paper thumbnail of The melatonin and aging sourcebook

An authoritative text for every researcher and medical practitioner, this book summarizes researc... more An authoritative text for every researcher and medical practitioner, this book summarizes research on melatonin's application and effects.

Research paper thumbnail of Utilisation d'antagonistes de la sérotonine, notamment cyproheptadine, pour le traitement du cancer, de la maladie d'Alzheimer, du SIDA et de la multiple sclérose

Research paper thumbnail of Method of treatment of anemia with seratonin antagonists

Research paper thumbnail of Use of serotonin antagonists, particularly cyproheptadine, in the treatment of cancer, Alzheimer's disease, AIDS and multiple sclerosis

Research paper thumbnail of Method of medical treatment with serotonin antagonists

Research paper thumbnail of Allergy: a double edged sword?

Canadian family physician Médecin de famille canadien, 1982

Research paper thumbnail of The role of melatonin and serotonin in aging: Update Grad BR, Rozencwaig R (1993) Psychoneuroendocrinology 18(4):283–295

Psychoneuroendocrinology, 1993

It has been proposed that aging occurs because of a failure of the pineal gland to produce melato... more It has been proposed that aging occurs because of a failure of the pineal gland to produce melatonin from serotonin each day beginning at sunset and throughout the night. This lack leads to a nighttime deficiency of melatonin both absolutely and also relatively to serotonin. As melatonin has widespread integrative and regenerative effects, its lack may lead to disturbances normally associated with aging. The present paper reviews the pertinent literature which appeared since our first publication, but earlier articles are also included. Evidence is presented for a role of melatonin and serotonin in controlling the neuroendocrine and immune networks and in inhibiting the development of ischemic heart and Alzheimer's disease, tumor formation and other degenerative processes associated with aging. The possible role of melatonin in the favourable effects of dietary restriction on aging is also discussed. This paper provides additional evidence that a melatonin deficiency, especially in relation to serotonin, may be responsible for the promotion of aging in the organism.

Research paper thumbnail of The role of melatonin and serotonin in aging

Research paper thumbnail of Cyst Reduction by Melatonin in a Novel Drosophila Model of Polycystic Kidney Disease

Molecules, 2020

Autosomal dominant polycystic kidney disease (ADPKD) causes progressive cystic degeneration of th... more Autosomal dominant polycystic kidney disease (ADPKD) causes progressive cystic degeneration of the renal tubules, the nephrons, eventually severely compromising kidney function. ADPKD is incurable, with half of the patients eventually needing renal replacement. Treatments for ADPKD patients are limited and new effective therapeutics are needed. Melatonin, a central metabolic regulator conserved across all life kingdoms, exhibits oncostatic and oncoprotective activity and no detected toxicity. Here, we used the Bicaudal C (BicC) Drosophila model of polycystic kidney disease to test the cyst-reducing potential of melatonin. Significant cyst reduction was found in the renal (Malpighian) tubules upon melatonin administration and suggest mechanistic sophistication. Similar to vertebrate PKD, the BicC fly PKD model responds to the antiproliferative drugs rapamycin and mimics of the second mitochondria-derived activator of caspases (Smac). Melatonin appears to be a new cyst-reducing molecu...

Research paper thumbnail of Cyst Reduction by Melatonin in a Novel Drosophila Model of Polycystic Kidney Disease

Molecules, 2020

Autosomal dominant polycystic kidney disease (ADPKD) causes progressive cystic degeneration of th... more Autosomal dominant polycystic kidney disease (ADPKD) causes progressive cystic degeneration of the renal tubules, the nephrons, eventually severely compromising kidney function. ADPKD is incurable, with half of the patients eventually needing renal replacement. Treatments for ADPKD patients are limited and new effective therapeutics are needed. Melatonin, a central metabolic regulator conserved across all life kingdoms, exhibits oncostatic and oncoprotective activity and no detected toxicity. Here, we used the Bicaudal C (BicC) Drosophila model of polycystic kidney disease to test the cyst-reducing potential of melatonin. Significant cyst reduction was found in the renal (Malpighian) tubules upon melatonin administration and suggest mechanistic sophistication. Similar to vertebrate PKD, the BicC fly PKD model responds to the antiproliferative drugs rapamycin and mimics of the second mitochondria-derived activator of caspases (Smac). Melatonin appears to be a new cyst-reducing molecu...

Research paper thumbnail of Editor's Mail

Postgraduate Medicine, 1982

Research paper thumbnail of Allergies: protective against cancer but predisposing to heart disease

Research paper thumbnail of Role of Melatonin in Curtailing Oxidative Stress during COVID-19

Medicine and clinical science, Dec 30, 2021

Several studies carried out during the ongoing COVID-19 pandemic revealed that oxidation stress i... more Several studies carried out during the ongoing COVID-19 pandemic revealed that oxidation stress is a major factor in the disease development, particularly in its severe complications, such as ALI and ARDS. It has been hypothesized that the well-known natural hormone melatonin may play a significant role in countering oxidative stress and consequently easing the progression of COVID-19. The present review summarizes available information on the contribution of oxidation stress during the pathogenesis of COVID-19 and several other diseases, and the rationale of their possible treatment with melatonin. This research direction will further expand our knowledge about melatonin beyond its role as the regulator of the circadian rhythm, and towards its application as an efficient adjuvant treatment for various diseases, including COVID-19 infection.

Research paper thumbnail of Melatonin in the Gastrointestinal Tract, Circadian Rhythms, Immunity and Microbiota in Health, Disease and Aging

Comprehensive Gut Microbiota, 2022

Research paper thumbnail of The melatonin and aging sourcebook

An authoritative text for every researcher and medical practitioner, this book summarizes researc... more An authoritative text for every researcher and medical practitioner, this book summarizes research on melatonin's application and effects.

Research paper thumbnail of Utilisation d'antagonistes de la sérotonine, notamment cyproheptadine, pour le traitement du cancer, de la maladie d'Alzheimer, du SIDA et de la multiple sclérose

Research paper thumbnail of Method of treatment of anemia with seratonin antagonists

Research paper thumbnail of Use of serotonin antagonists, particularly cyproheptadine, in the treatment of cancer, Alzheimer's disease, AIDS and multiple sclerosis

Research paper thumbnail of Method of medical treatment with serotonin antagonists

Research paper thumbnail of Allergy: a double edged sword?

Canadian family physician Médecin de famille canadien, 1982

Research paper thumbnail of The role of melatonin and serotonin in aging: Update Grad BR, Rozencwaig R (1993) Psychoneuroendocrinology 18(4):283–295

Psychoneuroendocrinology, 1993

It has been proposed that aging occurs because of a failure of the pineal gland to produce melato... more It has been proposed that aging occurs because of a failure of the pineal gland to produce melatonin from serotonin each day beginning at sunset and throughout the night. This lack leads to a nighttime deficiency of melatonin both absolutely and also relatively to serotonin. As melatonin has widespread integrative and regenerative effects, its lack may lead to disturbances normally associated with aging. The present paper reviews the pertinent literature which appeared since our first publication, but earlier articles are also included. Evidence is presented for a role of melatonin and serotonin in controlling the neuroendocrine and immune networks and in inhibiting the development of ischemic heart and Alzheimer's disease, tumor formation and other degenerative processes associated with aging. The possible role of melatonin in the favourable effects of dietary restriction on aging is also discussed. This paper provides additional evidence that a melatonin deficiency, especially in relation to serotonin, may be responsible for the promotion of aging in the organism.

Research paper thumbnail of The role of melatonin and serotonin in aging

Research paper thumbnail of Cyst Reduction by Melatonin in a Novel Drosophila Model of Polycystic Kidney Disease

Molecules, 2020

Autosomal dominant polycystic kidney disease (ADPKD) causes progressive cystic degeneration of th... more Autosomal dominant polycystic kidney disease (ADPKD) causes progressive cystic degeneration of the renal tubules, the nephrons, eventually severely compromising kidney function. ADPKD is incurable, with half of the patients eventually needing renal replacement. Treatments for ADPKD patients are limited and new effective therapeutics are needed. Melatonin, a central metabolic regulator conserved across all life kingdoms, exhibits oncostatic and oncoprotective activity and no detected toxicity. Here, we used the Bicaudal C (BicC) Drosophila model of polycystic kidney disease to test the cyst-reducing potential of melatonin. Significant cyst reduction was found in the renal (Malpighian) tubules upon melatonin administration and suggest mechanistic sophistication. Similar to vertebrate PKD, the BicC fly PKD model responds to the antiproliferative drugs rapamycin and mimics of the second mitochondria-derived activator of caspases (Smac). Melatonin appears to be a new cyst-reducing molecu...

Research paper thumbnail of Cyst Reduction by Melatonin in a Novel Drosophila Model of Polycystic Kidney Disease

Molecules, 2020

Autosomal dominant polycystic kidney disease (ADPKD) causes progressive cystic degeneration of th... more Autosomal dominant polycystic kidney disease (ADPKD) causes progressive cystic degeneration of the renal tubules, the nephrons, eventually severely compromising kidney function. ADPKD is incurable, with half of the patients eventually needing renal replacement. Treatments for ADPKD patients are limited and new effective therapeutics are needed. Melatonin, a central metabolic regulator conserved across all life kingdoms, exhibits oncostatic and oncoprotective activity and no detected toxicity. Here, we used the Bicaudal C (BicC) Drosophila model of polycystic kidney disease to test the cyst-reducing potential of melatonin. Significant cyst reduction was found in the renal (Malpighian) tubules upon melatonin administration and suggest mechanistic sophistication. Similar to vertebrate PKD, the BicC fly PKD model responds to the antiproliferative drugs rapamycin and mimics of the second mitochondria-derived activator of caspases (Smac). Melatonin appears to be a new cyst-reducing molecu...