Rosa Xicohtencatl - Academia.edu (original) (raw)

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Papers by Rosa Xicohtencatl

Research paper thumbnail of Caprine prion gene polymorphisms are associated with decreased incidence of classical scrapie in goat herds in the United Kingdom

Veterinary Research, 2011

The application of genetic breeding programmes to eradicate transmissible spongiform encephalopat... more The application of genetic breeding programmes to eradicate transmissible spongiform encephalopathies in goats is an important aim for reasons of animal welfare as well as human food safety and food security. Based on the positive impact of Prnp genetics on sheep scrapie in Europe in the past decade, we have established caprine Prnp gene variation in more than 1100 goats from the United Kingdom and studied the association of Prnp alleles with disease phenotypes in 150 scrapie-positive goats. This investigation confirms the association of the Met142 encoding Prnp allele with increased resistance to preclinical and clinical scrapie. It reveals a novel association of the Ser127 encoding allele with a reduced probability to develop clinical signs of scrapie in goats that are already positive for the accumulation of disease-specific prion protein in brain or periphery. A United Kingdom survey of Prnp genotypes in eight common breeds revealed eleven alleles in over thirty genotypes. The M...

Research paper thumbnail of Prion protein gene (PRNP) polymorphisms in healthy Pelibuey sheep in Mexico

Research paper thumbnail of Novel polymorphisms of the PRNP gene in Mexican Creole goats

Research paper thumbnail of Caprine prion gene polymorphisms are associated with decreased incidence of classical scrapie in goat herds in the United Kingdom

Veterinary Research, 2011

The application of genetic breeding programmes to eradicate transmissible spongiform encephalopat... more The application of genetic breeding programmes to eradicate transmissible spongiform encephalopathies in goats is an important aim for reasons of animal welfare as well as human food safety and food security. Based on the positive impact of Prnp genetics on sheep scrapie in Europe in the past decade, we have established caprine Prnp gene variation in more than 1100 goats from the United Kingdom and studied the association of Prnp alleles with disease phenotypes in 150 scrapie-positive goats. This investigation confirms the association of the Met142 encoding Prnp allele with increased resistance to preclinical and clinical scrapie. It reveals a novel association of the Ser127 encoding allele with a reduced probability to develop clinical signs of scrapie in goats that are already positive for the accumulation of disease-specific prion protein in brain or periphery. A United Kingdom survey of Prnp genotypes in eight common breeds revealed eleven alleles in over thirty genotypes. The M...

Research paper thumbnail of Prion protein gene (PRNP) polymorphisms in healthy Pelibuey sheep in Mexico

Research paper thumbnail of Novel polymorphisms of the PRNP gene in Mexican Creole goats

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