Rosario Megna - Academia.edu (original) (raw)
Papers by Rosario Megna
Astroparticle Physics, Nov 1, 2006
In 2005, the ANTARES Collaboration deployed and operated at a depth of 2500 m a so-called Mini In... more In 2005, the ANTARES Collaboration deployed and operated at a depth of 2500 m a so-called Mini Instrumentation Line equipped with Optical Modules (MILOM) at the ANTARES site. The various data acquired during the continuous operation from April to December 2005 of the MILOM confirm the satisfactory performance of the Optical Modules, their front-end electronics and readout system, as well as the calibration devices of the detector. The in-situ measurement of the Optical Module time response yields a resolution better than 0.5 ns. The performance of the acoustic positioning system, which enables the spatial reconstruction of the ANTARES detector with a precision of about 10 cm, is verified. These results demonstrate that with the full ANTARES neutrino telescope the design angular resolution of better than 0.3 • can be realistically achieved.
International Journal of Computer Assisted Radiology and Surgery, May 26, 2010
Computational and Mathematical Methods in Medicine
Traditional approach for predicting coronary artery disease (CAD) is based on demographic data, s... more Traditional approach for predicting coronary artery disease (CAD) is based on demographic data, symptoms such as chest pain and dyspnea, and comorbidity related to cardiovascular diseases. Usually, these variables are analyzed by logistic regression to quantifying their relationship with the outcome; nevertheless, their predictive value is limited. In the present study, we aimed to investigate the value of different machine learning (ML) techniques for the evaluation of suspected CAD; having as gold standard, the presence of stress-induced ischemia by 82Rb positron emission tomography/computed tomography (PET/CT) myocardial perfusion imaging (MPI) ML was chosen on their clinical use and on the fact that they are representative of different classes of algorithms, such as deterministic (Support vector machine and Naïve Bayes), adaptive (ADA and AdaBoost), and decision tree (Random Forest, rpart, and XGBoost). The study population included 2503 consecutive patients, who underwent MPI f...
Journal of Nuclear Cardiology
Background Cardiovascular risk models are based on traditional risk factors and investigations su... more Background Cardiovascular risk models are based on traditional risk factors and investigations such as imaging tests. External validation is important to determine reproducibility and generalizability of a prediction model. We performed an external validation of t the Japanese Assessment of Cardiac Events and Survival Study by Quantitative Gated SPECT (J-ACCESS) model, developed from a cohort of patients undergoing stress myocardial perfusion imaging. Methods We included 3623 patients with suspected or known coronary artery disease undergoing stress single-photon emission computer tomography (SPECT) myocardial perfusion imaging at our academic center between January 2001 and December 2019. Results In our study population, the J-ACCESS model underestimated the risk of major adverse cardiac events (cardiac death, nonfatal myocardial infarction, and severe heart failure requiring hospitalization) within three-year follow-up. The recalibrations and updated of the model slightly improved...
Applied Sciences
Coronary artery calcification and sarcopenia may have a relevant prognostic impact in oncological... more Coronary artery calcification and sarcopenia may have a relevant prognostic impact in oncological and non-oncological patients. The use of freeware software is promising for quantitative evaluation of these parameters after whole-body positron emission tomography (PET)/computed tomography (CT) and might be useful for one-stop shop risk stratification without additional radiation ionizing burden and further charges to health care costs. In this study, we compared two semiautomatic freeware software tools (Horos Medical Image software and LIFEx) for the assessment of coronary artery calcium (CAC) score and muscle mass in 40 patients undergoing whole-body PET/CT. The muscle areas obtained by the two software programs were comparable, showing high correlation with Lin’s concordance coefficient (0.9997; 95% confidence intervals: 0.9995–0.9999) and very good agreement with Bland–Altman analysis (mean difference = 0.41 cm2, lower limit = −1.06 cm2, upper limit = 1.89) was also found. For C...
Japanese Journal of Radiology
Purpose To compare texture feature estimates obtained from 18 F-FDG-PET images using three differ... more Purpose To compare texture feature estimates obtained from 18 F-FDG-PET images using three different software packages. Methods PET images from 15 patients with head and neck cancer were processed with three different freeware software: CGITA, LIFEx, and Metavol. For each lesion, 38 texture features were extracted from each software package. To evaluate the statistical agreement among the features across packages a non-parametric Kruskal–Wallis test was used. Differences in the features between each couple of software were assessed using a subsequent Dunn test. Correlation between texture features was evaluated via the Spearman coefficient. Results Twenty-three of 38 features showed a significant agreement across the three software ( P < 0.05). The agreement was better between LIFEx vs. Metavol (36 of 38) and worse between CGITA and Metavol (24 of 38), and CGITA vs. LIFEx (23 of 38). All features resulted correlated ( ρ > = 0.70, P < 0.001) in comparing LIFEx vs. Metavol. Seven of 38 features were found not in agreement and slightly or not correlated ( ρ < 0.70, P < 0.001) in comparing CGITA vs. LIFEx, and CGITA vs. Metavol. Conclusion Some texture discrepancies across software packages exist. Our findings reinforce the need to continue the standardization process, and to succeed in building a reference dataset to be used for comparisons.
International Journal of Computer Assisted Radiology and Surgery, 2010
Purpose Conventional chest X-ray is still the most common radiological imaging to detect pulmonar... more Purpose Conventional chest X-ray is still the most common radiological imaging to detect pulmonary metastases and nodules. The detection rate of such nodules, however, is limited due to different experiences of the radiologists and depends furthermore critically on the image quality. The role of conventional X-ray as a screening tool is critically discussed [1]. The enhanced and automated detection of pulmonary nodules but also the automated detection of other alterations of the lung including fibrotic and emphysematic structures is, thus of essential importance. In order to achieve a reliable and accurate analysis computer-based image analysis quality might offer additional help. Currently available CAD-solutions will shortly be discussed within this invited lecture with special focus on clinical results and further needs of development. Methods Recently established CAD-solutions offer the opportunity of an automated detection of pulmonary nodules, there is no software-based limita...
Journal of Nuclear Cardiology, 2021
Prevention and development of diagnostic and therapeutic techniques reduced morbidity and mortali... more Prevention and development of diagnostic and therapeutic techniques reduced morbidity and mortality for coronary artery disease (CAD). In this context, the cardiovascular risk assessment for major adverse cardiac events (MACE) at 2-year (CRAX2MACE) model for prediction of 2-year major adverse cardiac events was developed. We performed an external validation of this model. We included 1003 patients with suspected CAD undergoing stress-rest single-photon emission computed tomography myocardial perfusion imaging at our academic center between March 2015 and April 2019. Considering the occurrence of MACE (death from any cause, acute myocardial infarction, or late coronary revascularization), for the CRAX2MACE model the area under the receiver operating characteristic curve was 0.612 and the Brier score was 0.061. The Hosmer–Lemeshow test estimated a non-optimal fit (χ2 28, P < .001). Considering only hard events (cardiac death, acute myocardial infarction), the external validation of the CRAX2MACE model revealed a Brier score of 0.053 and an area under the receiver operating characteristic curve of 0.621. Hosmer–Lemeshow test was calculated by deciles and showed a poor fit (χ2 31, P < .001). CRAX2MACE model had a limited value for predicting 2-year major adverse cardiovascular events in an external validation cohort of patients with suspected CAD.
Biomedical Journal of Scientific & Technical Research, 2019
International Journal of Radiation Oncology*Biology*Physics, 2016
income quartile (HR Z 0.92, 95% CI Z 0.88 to 0.95). Compared to patients who did not undergo surg... more income quartile (HR Z 0.92, 95% CI Z 0.88 to 0.95). Compared to patients who did not undergo surgery or receive definitive RT, surgery and RT combined was associated with a larger decrease in mortality (HR Z 0.60, 95% CI Z 0.53 to 0.69) than surgery alone (HR Z 0.75, 95% CI Z 0.71 to 0.80) or RT alone (HR Z 0.74, 95% CI Z 0.62 to 0.88). Patients with higher Charlson co-morbidity score, Medicaid/Medicare insurance (compared to private insurance), and non-epithelial histology had decreased survival. Conclusion: The rate of definitive radiation therapy utilization for nonmetastatic malignant pleural mesothelioma has remained low over the past decade. Patients who received definitive RT had improved OS compared to patients who did not in this retrospective national cancer registry-based analysis, suggesting a role for increased utilization of this modality, especially in the advent of improved radiation treatment delivery techniques. Surgical resection, receipt of chemotherapy, and treatment at an academic facility were also associated with improved survival.
AIP Conference Proceedings, 2005
The ARGO-YBJ experiment, currently under construction at the YangBaJing Laboratory (Tibet, P.R. C... more The ARGO-YBJ experiment, currently under construction at the YangBaJing Laboratory (Tibet, P.R. China, 4300 m a.s.l.), could be upgraded with a large (∼ 2500 m 2) muon detector both to extend the sensitivity to γ-ray sources to energies greater than ∼ 20 TeV and to perform a cosmic ray primary composition study. In this paper we present an evaluation of the rejection power for proton-induced showers achievable with the upgraded ARGO-YBJ detector. Minimum detectable γ-ray fluxes are calculated for different experimental setups.
Astroparticle, Particle and Space Physics, Detectors and Medical Physics Applications, 2006
... in NEMO The" optical" timing calibration system will allow to measure the time dela... more ... in NEMO The" optical" timing calibration system will allow to measure the time delays between each FCM and the optical modules connected to it. The scheme of the system to be implemented on each floor of the towers is shown in Figure 1. In this scheme a blue light pulse is ...
Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2007
ANTARES is a neutrino telescope being deployed in the Mediterranean Sea. It consists of a three d... more ANTARES is a neutrino telescope being deployed in the Mediterranean Sea. It consists of a three dimensional array of photomultiplier tubes that can detect the Cherenkov light induced by charged particles produced in the interactions of neutrinos with the surrounding medium. High angular resolution can be achieved, in particular when a muon is produced, provided that the Cherenkov photons are detected with sufficient timing precision. Considerations of the intrinsic time uncertainties stemming from the transit time spread in the photomultiplier tubes and the mechanism of transmission of light in sea water lead to the conclusion that a relative time accuracy of the order of 0.5 ns is desirable. Accordingly, different time calibration systems have been developed for the ANTARES telescope. In this article, a system based on Optical Beacons, a set of external and well-controlled pulsed light sources located throughout the detector, is described. This calibration system takes into account the optical properties of sea water, which is used as the detection volume of the ANTARES telescope. The design, tests, construction and first results of the two types of beacons, LED and laser-based, are presented.
Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2007
The ANTARES neutrino telescope is being constructed in the Mediterranean Sea. It consists of a la... more The ANTARES neutrino telescope is being constructed in the Mediterranean Sea. It consists of a large three-dimensional array of photo-multiplier tubes. The data acquisition system of the detector takes care of the digitisation of the photo-multiplier tube signals, data transport, data filtering, and data storage. The detector is operated using a control program interfaced with all elements. The design and the implementation of the data acquisition system are described.
Nuclear Physics B - Proceedings Supplements, 2007
The activities towards the realization of a km 3 Cherenkov neutrino detector carried out by the N... more The activities towards the realization of a km 3 Cherenkov neutrino detector carried out by the NEMO Collaboration are described. Long-term exploration of a 3500 m deep-sea site close to the Sicilian coast has shown that it is optimal for the installation of the detector.
Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2008
The status of the activities towards the realization of a km3 Cherenkov neutrino detector carried... more The status of the activities towards the realization of a km3 Cherenkov neutrino detector carried out by the NEMO Collaboration is described. The realization of a Phase-1 project, which is under way, will validate the proposed technologies for the realization of the km3 detector on a Test Site at 2000m depth. The realization of a new infrastructure on the candidate
Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2009
... C. D&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#x27;Amato a , V. D&amp;... more ... C. D&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#x27;Amato a , V. D&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#x27;Amato a , G. De Bonis q , G. De Rosa g , G. De Ruvo b , R. De Vita e , C. Distefano a , E. Falchini p , V. Flaminio p , K ... a , C. Petta m , P. Piattelli a , D. Piombo e , F. Raffaelli p , G. Raia a , N. Randazzo d , S. Reito d , G. Ricco n , G. Riccobene a , M. Ripani e , A ...
Astroparticle Physics, Nov 1, 2006
In 2005, the ANTARES Collaboration deployed and operated at a depth of 2500 m a so-called Mini In... more In 2005, the ANTARES Collaboration deployed and operated at a depth of 2500 m a so-called Mini Instrumentation Line equipped with Optical Modules (MILOM) at the ANTARES site. The various data acquired during the continuous operation from April to December 2005 of the MILOM confirm the satisfactory performance of the Optical Modules, their front-end electronics and readout system, as well as the calibration devices of the detector. The in-situ measurement of the Optical Module time response yields a resolution better than 0.5 ns. The performance of the acoustic positioning system, which enables the spatial reconstruction of the ANTARES detector with a precision of about 10 cm, is verified. These results demonstrate that with the full ANTARES neutrino telescope the design angular resolution of better than 0.3 • can be realistically achieved.
International Journal of Computer Assisted Radiology and Surgery, May 26, 2010
Computational and Mathematical Methods in Medicine
Traditional approach for predicting coronary artery disease (CAD) is based on demographic data, s... more Traditional approach for predicting coronary artery disease (CAD) is based on demographic data, symptoms such as chest pain and dyspnea, and comorbidity related to cardiovascular diseases. Usually, these variables are analyzed by logistic regression to quantifying their relationship with the outcome; nevertheless, their predictive value is limited. In the present study, we aimed to investigate the value of different machine learning (ML) techniques for the evaluation of suspected CAD; having as gold standard, the presence of stress-induced ischemia by 82Rb positron emission tomography/computed tomography (PET/CT) myocardial perfusion imaging (MPI) ML was chosen on their clinical use and on the fact that they are representative of different classes of algorithms, such as deterministic (Support vector machine and Naïve Bayes), adaptive (ADA and AdaBoost), and decision tree (Random Forest, rpart, and XGBoost). The study population included 2503 consecutive patients, who underwent MPI f...
Journal of Nuclear Cardiology
Background Cardiovascular risk models are based on traditional risk factors and investigations su... more Background Cardiovascular risk models are based on traditional risk factors and investigations such as imaging tests. External validation is important to determine reproducibility and generalizability of a prediction model. We performed an external validation of t the Japanese Assessment of Cardiac Events and Survival Study by Quantitative Gated SPECT (J-ACCESS) model, developed from a cohort of patients undergoing stress myocardial perfusion imaging. Methods We included 3623 patients with suspected or known coronary artery disease undergoing stress single-photon emission computer tomography (SPECT) myocardial perfusion imaging at our academic center between January 2001 and December 2019. Results In our study population, the J-ACCESS model underestimated the risk of major adverse cardiac events (cardiac death, nonfatal myocardial infarction, and severe heart failure requiring hospitalization) within three-year follow-up. The recalibrations and updated of the model slightly improved...
Applied Sciences
Coronary artery calcification and sarcopenia may have a relevant prognostic impact in oncological... more Coronary artery calcification and sarcopenia may have a relevant prognostic impact in oncological and non-oncological patients. The use of freeware software is promising for quantitative evaluation of these parameters after whole-body positron emission tomography (PET)/computed tomography (CT) and might be useful for one-stop shop risk stratification without additional radiation ionizing burden and further charges to health care costs. In this study, we compared two semiautomatic freeware software tools (Horos Medical Image software and LIFEx) for the assessment of coronary artery calcium (CAC) score and muscle mass in 40 patients undergoing whole-body PET/CT. The muscle areas obtained by the two software programs were comparable, showing high correlation with Lin’s concordance coefficient (0.9997; 95% confidence intervals: 0.9995–0.9999) and very good agreement with Bland–Altman analysis (mean difference = 0.41 cm2, lower limit = −1.06 cm2, upper limit = 1.89) was also found. For C...
Japanese Journal of Radiology
Purpose To compare texture feature estimates obtained from 18 F-FDG-PET images using three differ... more Purpose To compare texture feature estimates obtained from 18 F-FDG-PET images using three different software packages. Methods PET images from 15 patients with head and neck cancer were processed with three different freeware software: CGITA, LIFEx, and Metavol. For each lesion, 38 texture features were extracted from each software package. To evaluate the statistical agreement among the features across packages a non-parametric Kruskal–Wallis test was used. Differences in the features between each couple of software were assessed using a subsequent Dunn test. Correlation between texture features was evaluated via the Spearman coefficient. Results Twenty-three of 38 features showed a significant agreement across the three software ( P < 0.05). The agreement was better between LIFEx vs. Metavol (36 of 38) and worse between CGITA and Metavol (24 of 38), and CGITA vs. LIFEx (23 of 38). All features resulted correlated ( ρ > = 0.70, P < 0.001) in comparing LIFEx vs. Metavol. Seven of 38 features were found not in agreement and slightly or not correlated ( ρ < 0.70, P < 0.001) in comparing CGITA vs. LIFEx, and CGITA vs. Metavol. Conclusion Some texture discrepancies across software packages exist. Our findings reinforce the need to continue the standardization process, and to succeed in building a reference dataset to be used for comparisons.
International Journal of Computer Assisted Radiology and Surgery, 2010
Purpose Conventional chest X-ray is still the most common radiological imaging to detect pulmonar... more Purpose Conventional chest X-ray is still the most common radiological imaging to detect pulmonary metastases and nodules. The detection rate of such nodules, however, is limited due to different experiences of the radiologists and depends furthermore critically on the image quality. The role of conventional X-ray as a screening tool is critically discussed [1]. The enhanced and automated detection of pulmonary nodules but also the automated detection of other alterations of the lung including fibrotic and emphysematic structures is, thus of essential importance. In order to achieve a reliable and accurate analysis computer-based image analysis quality might offer additional help. Currently available CAD-solutions will shortly be discussed within this invited lecture with special focus on clinical results and further needs of development. Methods Recently established CAD-solutions offer the opportunity of an automated detection of pulmonary nodules, there is no software-based limita...
Journal of Nuclear Cardiology, 2021
Prevention and development of diagnostic and therapeutic techniques reduced morbidity and mortali... more Prevention and development of diagnostic and therapeutic techniques reduced morbidity and mortality for coronary artery disease (CAD). In this context, the cardiovascular risk assessment for major adverse cardiac events (MACE) at 2-year (CRAX2MACE) model for prediction of 2-year major adverse cardiac events was developed. We performed an external validation of this model. We included 1003 patients with suspected CAD undergoing stress-rest single-photon emission computed tomography myocardial perfusion imaging at our academic center between March 2015 and April 2019. Considering the occurrence of MACE (death from any cause, acute myocardial infarction, or late coronary revascularization), for the CRAX2MACE model the area under the receiver operating characteristic curve was 0.612 and the Brier score was 0.061. The Hosmer–Lemeshow test estimated a non-optimal fit (χ2 28, P < .001). Considering only hard events (cardiac death, acute myocardial infarction), the external validation of the CRAX2MACE model revealed a Brier score of 0.053 and an area under the receiver operating characteristic curve of 0.621. Hosmer–Lemeshow test was calculated by deciles and showed a poor fit (χ2 31, P < .001). CRAX2MACE model had a limited value for predicting 2-year major adverse cardiovascular events in an external validation cohort of patients with suspected CAD.
Biomedical Journal of Scientific & Technical Research, 2019
International Journal of Radiation Oncology*Biology*Physics, 2016
income quartile (HR Z 0.92, 95% CI Z 0.88 to 0.95). Compared to patients who did not undergo surg... more income quartile (HR Z 0.92, 95% CI Z 0.88 to 0.95). Compared to patients who did not undergo surgery or receive definitive RT, surgery and RT combined was associated with a larger decrease in mortality (HR Z 0.60, 95% CI Z 0.53 to 0.69) than surgery alone (HR Z 0.75, 95% CI Z 0.71 to 0.80) or RT alone (HR Z 0.74, 95% CI Z 0.62 to 0.88). Patients with higher Charlson co-morbidity score, Medicaid/Medicare insurance (compared to private insurance), and non-epithelial histology had decreased survival. Conclusion: The rate of definitive radiation therapy utilization for nonmetastatic malignant pleural mesothelioma has remained low over the past decade. Patients who received definitive RT had improved OS compared to patients who did not in this retrospective national cancer registry-based analysis, suggesting a role for increased utilization of this modality, especially in the advent of improved radiation treatment delivery techniques. Surgical resection, receipt of chemotherapy, and treatment at an academic facility were also associated with improved survival.
AIP Conference Proceedings, 2005
The ARGO-YBJ experiment, currently under construction at the YangBaJing Laboratory (Tibet, P.R. C... more The ARGO-YBJ experiment, currently under construction at the YangBaJing Laboratory (Tibet, P.R. China, 4300 m a.s.l.), could be upgraded with a large (∼ 2500 m 2) muon detector both to extend the sensitivity to γ-ray sources to energies greater than ∼ 20 TeV and to perform a cosmic ray primary composition study. In this paper we present an evaluation of the rejection power for proton-induced showers achievable with the upgraded ARGO-YBJ detector. Minimum detectable γ-ray fluxes are calculated for different experimental setups.
Astroparticle, Particle and Space Physics, Detectors and Medical Physics Applications, 2006
... in NEMO The" optical" timing calibration system will allow to measure the time dela... more ... in NEMO The" optical" timing calibration system will allow to measure the time delays between each FCM and the optical modules connected to it. The scheme of the system to be implemented on each floor of the towers is shown in Figure 1. In this scheme a blue light pulse is ...
Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2007
ANTARES is a neutrino telescope being deployed in the Mediterranean Sea. It consists of a three d... more ANTARES is a neutrino telescope being deployed in the Mediterranean Sea. It consists of a three dimensional array of photomultiplier tubes that can detect the Cherenkov light induced by charged particles produced in the interactions of neutrinos with the surrounding medium. High angular resolution can be achieved, in particular when a muon is produced, provided that the Cherenkov photons are detected with sufficient timing precision. Considerations of the intrinsic time uncertainties stemming from the transit time spread in the photomultiplier tubes and the mechanism of transmission of light in sea water lead to the conclusion that a relative time accuracy of the order of 0.5 ns is desirable. Accordingly, different time calibration systems have been developed for the ANTARES telescope. In this article, a system based on Optical Beacons, a set of external and well-controlled pulsed light sources located throughout the detector, is described. This calibration system takes into account the optical properties of sea water, which is used as the detection volume of the ANTARES telescope. The design, tests, construction and first results of the two types of beacons, LED and laser-based, are presented.
Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2007
The ANTARES neutrino telescope is being constructed in the Mediterranean Sea. It consists of a la... more The ANTARES neutrino telescope is being constructed in the Mediterranean Sea. It consists of a large three-dimensional array of photo-multiplier tubes. The data acquisition system of the detector takes care of the digitisation of the photo-multiplier tube signals, data transport, data filtering, and data storage. The detector is operated using a control program interfaced with all elements. The design and the implementation of the data acquisition system are described.
Nuclear Physics B - Proceedings Supplements, 2007
The activities towards the realization of a km 3 Cherenkov neutrino detector carried out by the N... more The activities towards the realization of a km 3 Cherenkov neutrino detector carried out by the NEMO Collaboration are described. Long-term exploration of a 3500 m deep-sea site close to the Sicilian coast has shown that it is optimal for the installation of the detector.
Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2008
The status of the activities towards the realization of a km3 Cherenkov neutrino detector carried... more The status of the activities towards the realization of a km3 Cherenkov neutrino detector carried out by the NEMO Collaboration is described. The realization of a Phase-1 project, which is under way, will validate the proposed technologies for the realization of the km3 detector on a Test Site at 2000m depth. The realization of a new infrastructure on the candidate
Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2009
... C. D&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#x27;Amato a , V. D&amp;... more ... C. D&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#x27;Amato a , V. D&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#x27;Amato a , G. De Bonis q , G. De Rosa g , G. De Ruvo b , R. De Vita e , C. Distefano a , E. Falchini p , V. Flaminio p , K ... a , C. Petta m , P. Piattelli a , D. Piombo e , F. Raffaelli p , G. Raia a , N. Randazzo d , S. Reito d , G. Ricco n , G. Riccobene a , M. Ripani e , A ...