Rosephine Enadeghe - Academia.edu (original) (raw)

Uploads

Papers by Rosephine Enadeghe

Research paper thumbnail of Investigation of the Subchronic Toxicity of Graded Doses of Extracts of Dialium guineense Stem Bark in Rats

International journal of research and scientific innovation, 2024

Research paper thumbnail of FUDMA Journal of Sciences ANTI-NOCICEPTIVE EFFECT OF ACTIVATED CHARCOAL OF TERMINALIA CATAPPA STEM BARK ON ACETIC ACID-INDUCED PAIN IN WISTAR ALBINO RATS

Fudma Journal of Sciences, Jun 30, 2024

Research paper thumbnail of Nutritional, Elemental, and Gas Chromatography-Mass Spectrometry Analysis of Honey Samples from Selected Apiaries in Edo and Osun State

Pharmacology and Texicology of Natural Medicines, Dec 19, 2023

Research paper thumbnail of NUTRITIONAL COMPOSITION AND GAS CHROMATOGRAPHY-MASS SPECTROMETRY (GC-MS) ANALYSIS OF METHANOL LEAF EXTRACT OF Terminalia ivorensis

FUDMA JOURNAL OF SCIENCES, Dec 29, 2023

Research paper thumbnail of Neuroprotective (Antioxidant, Antiamyloidogenic, and Antiexcitatory) Effects of TrévoTM against Cadmium Chloride Neurotoxicity in Adult Male Wistar Rats

OBM Neurobiology

Cadmium (Cd) is a heavy metal that is deleterious to brain development as it increases brain agin... more Cadmium (Cd) is a heavy metal that is deleterious to brain development as it increases brain aging. Trévo is a multi-herbal supplement that provides various health benefits, including boosting the immune system and detoxification. In this study, we investigated the neuroprotective effects of Trévo against the neurotoxic effects of cadmium chloride (CdCl2). Thirty male Wistar rats were equally divided into three groups: Group I (normal control), Group II (administered CdCl2), and Group III (administered Trévo and CdCl2), and were used in the experiments. Animals were pretreated with 2 mL/kg of Trévo for five days and injected with Cd intraperitoneally 3 h later. Cd significantly increased the production of malondialdehyde (MDA), amyloidogenesis, activation of caspase 3 and 9, and the production of p53 and glutamate. It also inhibited the activity of Na+/K+ ATPase, glutamate dehydrogenase, catalase, superoxide dismutase, and glutathione-S-transferase. The administration of Trévo revea...

Research paper thumbnail of Investigation of the Subchronic Toxicity of Graded Doses of Extracts of Dialium guineense Stem Bark in Rats

International journal of research and scientific innovation, 2024

Research paper thumbnail of FUDMA Journal of Sciences ANTI-NOCICEPTIVE EFFECT OF ACTIVATED CHARCOAL OF TERMINALIA CATAPPA STEM BARK ON ACETIC ACID-INDUCED PAIN IN WISTAR ALBINO RATS

Fudma Journal of Sciences, Jun 30, 2024

Research paper thumbnail of Nutritional, Elemental, and Gas Chromatography-Mass Spectrometry Analysis of Honey Samples from Selected Apiaries in Edo and Osun State

Pharmacology and Texicology of Natural Medicines, Dec 19, 2023

Research paper thumbnail of NUTRITIONAL COMPOSITION AND GAS CHROMATOGRAPHY-MASS SPECTROMETRY (GC-MS) ANALYSIS OF METHANOL LEAF EXTRACT OF Terminalia ivorensis

FUDMA JOURNAL OF SCIENCES, Dec 29, 2023

Research paper thumbnail of Neuroprotective (Antioxidant, Antiamyloidogenic, and Antiexcitatory) Effects of TrévoTM against Cadmium Chloride Neurotoxicity in Adult Male Wistar Rats

OBM Neurobiology

Cadmium (Cd) is a heavy metal that is deleterious to brain development as it increases brain agin... more Cadmium (Cd) is a heavy metal that is deleterious to brain development as it increases brain aging. Trévo is a multi-herbal supplement that provides various health benefits, including boosting the immune system and detoxification. In this study, we investigated the neuroprotective effects of Trévo against the neurotoxic effects of cadmium chloride (CdCl2). Thirty male Wistar rats were equally divided into three groups: Group I (normal control), Group II (administered CdCl2), and Group III (administered Trévo and CdCl2), and were used in the experiments. Animals were pretreated with 2 mL/kg of Trévo for five days and injected with Cd intraperitoneally 3 h later. Cd significantly increased the production of malondialdehyde (MDA), amyloidogenesis, activation of caspase 3 and 9, and the production of p53 and glutamate. It also inhibited the activity of Na+/K+ ATPase, glutamate dehydrogenase, catalase, superoxide dismutase, and glutathione-S-transferase. The administration of Trévo revea...

Log In