Rosiane Costa - Academia.edu (original) (raw)

Papers by Rosiane Costa

Journal of Agricultural and Food Chemistry

Regional Studies in Marine Science

It has been reported in the literature that hypertensive individuals who exercise autonomously do... more It has been reported in the literature that hypertensive individuals who exercise autonomously do not have a significant reduction in blood pressure. However, if they are inserted in a program with the accompaniment of Physical Education teachers, the same phenomenon also happens, it was still something unknown. The aim of this article was to analyze the blood pressure response of hypertensive patients regarding the exercise performed with monitoring by Physical Education professionals during three months of observation. This is an observational, quantitative study, from which this study was derived with a transversal cut. Ten hypertensive patients participated, five of whom were female, middle-aged between 45 and 59 years old, who practiced physical exercise at the Academia da Melhor Idade (AMI). Blood pressure was recorded daily in April, May and June 2018. One-way ANOVA was used. As a result, hypertensive patients did not show a significant reduction in systolic and diastolic blo...

Educación Física y Ciencia

Introdução: Na Academia da Cidade os hipertensos realizam exercício físico diariamente, mas pouco... more Introdução: Na Academia da Cidade os hipertensos realizam exercício físico diariamente, mas pouco trabalhos tratam sobre o comportamento da pressão arterial (PA) nesses espaços. Outra lacuna refere-se aos fatores preditores da resposta pressórica. Objetivo: investigar o comportamento da pressão arterial e analisar os fatores preditores durante o exercício físico. Métodos: estudo observacional, realizado de dezembro de 2018, janeiro e fevereiro de 2019. Dezesseis hipertensos (58.8±15.3 anos), praticantes de exercício em Academia da Cidade. A PA e frequência cardíaca foram verificadas antes e depois de cada sessão de exercício. A variabilidade da frequência cardíaca foi avaliada em dezembro. Para análise foram usados ANOVA de uma via e regressão linear. Resultados: PA sistólica (PAS) de repouso não reduziu entre os meses de observação. PA diastólica (PAD) de repouso reduziu entre dezembro e janeiro (79.3±9.7mmHg para 73.0±7.1mmHg, p=0.02, D de Cohen=0.77). Em dezembro, para a PAS pós-...

Bioactive Materials, 2022

Multifunctional scaffolds with host defense peptides designed for regenerative endodontics are de... more Multifunctional scaffolds with host defense peptides designed for regenerative endodontics are desirable nanobiotechnological tools for dentistry. Here, different scaffolds were tested for use during the pulp revascularization process, including poly(vinyl alcohol)-PVA hydrogels or resins, collagen hydrogels and poly(vinyl alcohol) PVA/Chitosan (PVA/CS) nanofibers. Based on time to degradation (21 days), nanofibers were chosen to be incorporated with ciprofloxacin and IDR-1002 (each at 50 mg/g). Nanofibers containing ciprofloxacin and IDR-1002 had anti-biofilm activity against Enterococcus faecalis, Staphylococcus aureus and a multispecies oral biofilm, besides anti-inflammatory activities. The in vivo subcutaneous tissue response to tooth fragments filled with nanofibers demonstrated a pulp-like tissue formation, when compared to empty teeth fragments. Thus, we designed a strong antimicrobial, immunomodulatory and regenerative candidate for pulp revascularization and regeneration procedures.

Resumo: Os transtornos mentais estao presentes na historia ha milenios, apresentando muitas conce... more Resumo: Os transtornos mentais estao presentes na historia ha milenios, apresentando muitas concepcoes e formas de tratamento. A Reforma Psiquiatrica representa um marco no campo da saude mental que redirecionou o modelo de assistencia as pessoas com transtornos mentais, no entanto, vivemos diante do contexto da ofensiva neoliberal que se torna um desafio para efetividade desse processo e suas acoes correspondentes, pois se fundamenta nos principios de privatizacao, sucateamento dos espacos publicos, supressao dos direitos sociais, entre outros aspectos desestruturantes. Este artigo traz algumas consideracoes acerca do processo da Reforma Psiquiatrica e da politica de Saude Mental no contexto contemporâneo.Palavras-chave: Reforma Psiquiatrica; Saude Mental; Neoliberalismo.

The present article analyzes in the counterreform process in the Brazilian health policy, the pri... more The present article analyzes in the counterreform process in the Brazilian health policy, the private devices of hegemony. In this process, the so-called private hegemony devices disseminate ideologies, conceptions and formulate propositions that favor the interests of private capital in the health sector, which weakens and focuses health policy of a public and universal character.

O artigo apresenta mediações entre os Direitos Humanos e a Política Nacional de Saúde Mental. Eme... more O artigo apresenta mediações entre os Direitos Humanos e a Política Nacional de Saúde Mental. Emerge de uma pesquisa que problematiza as ações ocorridas no governo de Michel Temer e as primeiras iniciativas do governo Bolsonaro ao promover um recrudescimento na área da saúde através de medidas neoliberais ortodoxas, reverberando na desestruturação da Rede de Atenção Psicossocial. O estudo realizou-se através de pesquisa documental com enfoque nas legislações pertinentes ao tema. Desse modo, as recentes mudanças resultam num retrocesso de 30 anos, quando predominava a barbárie no tratamento. Aquele governo e o atual traçaram estratégias neoconservadoras para violar os Direitos Humanos conquistados pela classe trabalhadora, a exemplo do retorno do uso dos hospitais psiquiátricos, representando um distanciamento de toda a luta antimanicomial.

Durante a construcao de um objeto digital de aprendizagem e imprescindivel representar corretamen... more Durante a construcao de um objeto digital de aprendizagem e imprescindivel representar corretamente todos os conceitos expostos, a fim de que estes nao ‘distorcam’ sua finalidade. Com o intuito de representar corretamente os comportamentos de associacao dos atomos em reacoes quimicas reversiveis oriundas tendendo ao equilibrio quimico, buscamos por um metodo de simples implementacao e que calcule a distância entre um dado atomo(A) e quaisquer outros atomos(B) contidos em uma lista. Realizamos um levantamento sobre “distância entre dois pontos” no escopo “geometria plana” e considerando que a distância entre dois pontos (euclidiana), e dada conforme a equacao , implementamos esta como uma funcao javascript , que e executada durante as iteracoes da lista, de modo a conhecer a menor distância entre o atomo(A) e algum atomo(B) contido na lista. Dessa forma, por questoes fisicas e quimicas, na animacao a todo o momento que um dado atomo(A) se associa a um atomo(B), deve buscar o atomo (B...

Frontiers in Marine Science, 2021

Oceanic environments are one of the largest sources of bioactive molecules, due to the high degre... more Oceanic environments are one of the largest sources of bioactive molecules, due to the high degree of biodiversity and the innumerable ecological relationships established between macro and microorganisms found in the different ecosystems of these complex environments. Marine organisms are being studied increasingly because they are considered important producers of biologically active peptides. Peptides extracted from marine sources have different functions and structures, when compared to peptides isolated from terrestrial sources, considering the different adaptive pressures undergone by these organisms throughout the evolutionary process. Most bioactive compounds isolated from marine environments are obtained from symbiont microorganisms. Of these microorganisms, bacteria are an important source of bioactive peptides, isolated by metagenomic studies from complex gene networks expressed under marine conditions. Several peptides have been shown to have biotechnological properties ...

Brazilian Journal of Microbiology, 2021

Paenibacillus elgii AC13 produces antimicrobial lipopeptides of agricultural and pharmaceutical i... more Paenibacillus elgii AC13 produces antimicrobial lipopeptides of agricultural and pharmaceutical importance. It secretes four cyclic lipopeptides named pelgipeptins, previously characterized in P. elgii B69. These lipopeptides result from the expression of a nonribosomal peptide gene cluster. P. elgii AC13 also produced two linear lipopeptides with ratios of [M + H] + 1105 and 1119 m/z. These compounds were previously observed in Paenibacillus sp. strain OSY-N, but due to purification difficulties, their characterization was executed using synthetically produced linear pelgipeptins. In the present study, purification was achieved from the supernatants of cultures from three complex media by high-performance liquid chromatography. The partial characterization of linear pelgipeptins revealed the similar antimicrobial activity and cytotoxicity of their synthetically produced counterparts, known as paenipeptins. Cyclic forms were highly stable to changes in pH, temperature, and organic extraction with n-butanol as shown by mass spectrometry (MALDI-TOF); therefore, these steps did not cause the hydrolysis of pelgipeptins. A low-activity thioesterase could also generate the linear isoforms observed; this enzyme catalyzes the cyclization process and is coded in the same gene cluster. Alternatively, the cyclic forms were hydrolyzed by an unknown protease produced during growth in the complex medium used in the present study. Although culture conditions are known to produce pelgipeptins with different yields and amino acid compositions, the occurrence of linear and cyclic forms simultaneously has not yet been reported. A mixture of cyclic and linear pelgipeptins presents a potential advantage of the higher antimicrobial activity of cyclic forms combined with the lower cytotoxicity of linear isoforms.

AIMS Microbiology, 2021

Systemic mycoses have become a major cause of morbidity and mortality, particularly among immunoc... more Systemic mycoses have become a major cause of morbidity and mortality, particularly among immunocompromised hosts and long-term hospitalized patients. Conventional antifungal agents are limited because of not only their costs and toxicity but also the rise of resistant strains. Lipopeptides from Paenibacillus species exhibit antimicrobial activity against a wide range of human and plant bacterial pathogens. However, the antifungal potential of these compounds against important human pathogens has not yet been fully evaluated, except for Candida albicans. Paenibacillus elgii produces a family of lipopeptides named pelgipeptins, which are synthesized by a non-ribosomal pathway, such as polymyxin. The present study aimed to evaluate the activity of pelgipeptins produced by P. elgii AC13 against Cryptococcus neoformans, Paracoccidioides brasiliensis, and Candida spp. Pelgipeptins were purified from P. elgii AC13 cultures and characterized by high-performance liquid chromatography (HPLC) and mass spectrometry (MALDI-TOF MS). The in vitro antifugal activity of pelgipeptins was evaluated against C. neoformans H99, P. brasiliensis PB18, C. albicans SC 5314, Candida glabrata ATCC 90030, and C. albicans biofilms. Furthermore, the minimal inhibitory concentration (MIC) was determined according to the CLSI microdilution method. Fluconazole and amphotericin B were also used as a positive control. Pelgipeptins A to D inhibited the formation and development of C. albicans biofilms and presented activity against all tested microorganisms. The minimum inhibitory concentration values ranged 29

Microbial Ecology, 2020

Metagenomic studies revealed the prevalence of Acidobacteria in soils, but the physiological and ... more Metagenomic studies revealed the prevalence of Acidobacteria in soils, but the physiological and ecological reasons for their success are not well understood. Many Acidobacteria exhibit carotenoid-related pigments, which may be involved in their tolerance of environmental stress. The aim of this work was to investigate the role of the orange pigments produced by Acidobacteria strain AB23 isolated from a savannah-like soil and to identify putative carotenoid genes in Acidobacteria genomes. Phylogenetic analysis revealed that strain AB23 belongs to the Occallatibacter genus from the class Acidobacteriia (subdivision 1). Strain AB23 produced carotenoids in the presence of light and vitamins; however, the growth rate and biomass decreased when cells were exposed to light. The presence of carotenoids resulted in tolerance to hydrogen peroxide. Comparative genomics revealed that all members of Acidobacteriia with available genomes possess the complete gene cluster for phytoene production. Some Acidobacteriia members have an additional gene cluster that may be involved in the production of colored carotenoids. Both colored and colorless carotenoids are involved in tolerance to oxidative stress. These results show that the presence of carotenoid genes is widespread among Acidobacteriia. Light and atmospheric oxygen stimulate carotenoid synthesis, but there are other natural sources of oxidative stress in soils. Tolerance to environmental oxidative stress provided by carotenoids may offer a competitive advantage for Acidobacteria in soils.

Expert Review of Clinical Pharmacology, 2020

Introduction: The need to develop new drugs for the control of pathogenic microorganisms has redo... more Introduction: The need to develop new drugs for the control of pathogenic microorganisms has redoubled efforts to prospect for antimicrobial peptides (AMPs) from natural sources and to characterize its structure and function. These molecules present a broad spectrum of action against different microorganisms and frequently present promiscuous action, with anticancer and immunomodulatory activities. Furthermore, AMPs can be used as biopharmaceuticals in the treatment of hospital-acquired infections and other serious diseases with relevant social and economic impacts. Areas covered: The low yield and the therefore difficult extraction and purification process in AMPs are problems that limit their industrial application and scientific research. Thus, optimized heterologous expression systems were developed to significantly boost AMP yields, allow high efficiency in purification and structural optimization for the increase of therapeutic activity. Expert opinion: This review provides an update on recent developments in the recombinant production of ribosomal and non-ribosomal synthesis of AMPs and on strategies to increase the expression of genes encoding AMPs at the transcriptional and translational levels and regulation of the post-translational modifications. Moreover, there are detailed reports of AMPs that have already reached marketable status or are in the pipeline under advanced stages of preclinical testing.

Expert Opinion on Drug Delivery, 2020

Introduction: Due to the complexity of different oral infections, new anti-infective nanotechnolo... more Introduction: Due to the complexity of different oral infections, new anti-infective nanotechnological approaches have been emerging for dentistry in recent years. These strategies may contribute to antimicrobial molecules delivery, tissue regeneration, and oral health maintenance by acting in a more specific site and not being cytotoxic. In this context, nanofibers appear as versatile structures and might act both in the release of antimicrobial molecules and as a scaffold for new tissue formation. Areas covered: This review addresses the application of different nanofibers as new strategies for the delivery of antimicrobial molecules for dentistry. Here, we present the main polymers used to construct nanofibers, methods of production and mainly their antimicrobial activity against microorganisms commonly responsible for the usual dental infections. These biomaterials may be associated to restorative materials, prostheses, and mucoadhesive structures. Besides, nanofibers can be used for endodontic or periodontal therapy, or even on implant surfaces. Expert opinion: A wide variety of studies report the potential application of anti-infective nanofibers in the oral cavity. Although there are still several barriers between in vitro and in vivo studies, these new formulations appear as promising new therapies for dentistry.

Chemical Papers, 2020

The visible thermochromism of crystalline CoMoO 4 was investigated in a temperature range from 30... more The visible thermochromism of crystalline CoMoO 4 was investigated in a temperature range from 300 to 1000 °C. The microcrystals were obtained by the coprecipitation method followed by calcination. Through spectroscopic techniques, it was possible to monitor the phase transition from samples in the β-phase to α-phase, which is associated with the color change of the material from purple (β) to green (α). The phase transition was irreversible and proceeded approximately at 550 °C. Both polymorphs belong to C2/m (#12) space group and crystallize in the monoclinic arrangement. The colorimetric parameters allowed to follow the color differences obtained in the material according to the applied temperature. The relationship between crystal structure, colorimetric parameters, and spectroscopic properties was described in detail and help the understood of the thermochromic behavior in cobalt molybdate. The increase in the temperature allowed the band-gap tuning from 2.8 to 1.5 eV due to the change of color from purple to green, confirming the promising potential of these materials for use as temperature indicators that can be observed by the naked eye.

Revista Ibero-Americana de Ciência da Informação, 2018

Apresenta-se resultado de pesquisa que objetivou analisar as estratégias de mediação da informaçã... more Apresenta-se resultado de pesquisa que objetivou analisar as estratégias de mediação da informação utilizadas pelos profissionais que trabalham na Biblioteca Pública Municipal Capistrano de Abreu, situada na cidade de Maranguape-Ceará, Brasil, a fim de compreender o exercício da prática mediadora e da informação como instrumento de transformação social. Utiliza-se quanto ao percurso metodológico a abordagem qualitativa e o método de pesquisa exploratória. Os dados foram coletados por meio de entrevista e da aplicação de questionários, sendo analisados pela técnica de análise de conteúdo de Bardin, com o estabelecimento de categorias. Os resultados demonstram as estratégias de aproximação e mediação ocorrem por meio da interação estabelecida entre usuários, profissionais e biblioteca, quando os usuários são motivados a participar do planejamento dos serviços oferecidos. Conclui-se que, a biblioteca deve manter o foco em planejar e realizar ações de mediação que favoreçam a apropriaçã...

Temporalis, 2019

O presente estudo sintetiza algumas reflexões sobre a relação entre direitos humanos e o serviço ... more O presente estudo sintetiza algumas reflexões sobre a relação entre direitos humanos e o serviço social. Nele objetivamos discorrer acerca dos direitos humanos na atualidade, tomando como pontos de análise o contexto de retirada de direitos advindos de um processo de avanço do neoliberalismo. Nessa conjuntura, se situa o trabalho profissional do/a assistente social, em um terreno movido por interesses contraditórios que impõe limites as respostas profissionais. Nesse sentido e tomando como base esses apontamentos introdutórios, desenvolvemos o estudo buscando apresentar, sinteticamente, o atual contexto de violação dos direitos humanos e as inflexões no exercício profissional do/a assistente social.