Debendra Roy - Academia.edu (original) (raw)

Papers by Debendra Roy

PLOS ONE

Background and aims Vaccination is the most powerful public health intervention proven to be safe... more Background and aims Vaccination is the most powerful public health intervention proven to be safe and effective in the battle against the coronavirus disease-2019 (COVID-19) pandemic. Despite the potential therapeutic benefits of primer vaccine dosage regimens, public perceptions of COVID-19 vaccine booster dose (VBD) acceptance and hesitancy vary among various sub-group populations. This study investigates COVID-19 vaccine booster dose acceptance and compares the multi-dimensional potential factors influencing VBD acceptance and hesitancy among university teachers and the student community in Bangladesh. Methods This web-based cross-sectional study employed an anonymous, validated, and self-administered questionnaire. The questionnaire items were adopted from a theoretical analysis of the recent relevant literature. The questionnaire was deployed in an on-line-enabled format (Google form) and conveniently distributed to 685 teachers and 990 students between 15th June, 2022 and 15th...

PLOS ONE, 2022

Background and aims Although vaccines are considered the most effective and fundamental therapeut... more Background and aims Although vaccines are considered the most effective and fundamental therapeutic tools for consistently preventing the COVID-19 disease, worldwide vaccine hesitancy has become a widespread public health issue for successful immunization. The aim of this review was to identify an up-to-date and concise assessment of potential factors influencing COVID-19 vaccine acceptance and refusal intention, and to outline the key message in order to organize these factors according to country count. Methods A systematic search of the peer-reviewed literature articles indexed in reputable databases, mainly Pub Med (MEDLINE), Elsevier, Science Direct, and Scopus, was performed between21stJune 2021 and10th July 2021. After obtaining the results via careful screening using a PRISMA flow diagram, 47 peer-reviewed articles met the inclusion criteria and formed the basic structure of the review. Results In total, 11 potential factors were identified, of which the greatest number of a...

Analgesics prescribing by physicians have gained due importance across the globe. The present stu... more Analgesics prescribing by physicians have gained due importance across the globe. The present study is aimed to evaluate the physicians prescribing pattern of analgesics, their usages by outpatients in three cities of Bangladesh. This cross sectional health survey was carried out with a self- designed standard questionnaire by manual data collection over a one month period (09-12-2015 to 10-01-2016) at three adjacent cities Jessore Sadar, Jhikargacha and Chowgacha upazila respectively. A total of 300 prescriptions were collected and 46 local pharmacies were selected for data collection about daily sales of analgesics. The highest prescribed analgesic groups were diclofenac (27%), aceclofenac (24%), ketorolac (16%), paracetamol (17%), naproxen (4%), ibuprofen (3%), etoricoxib (4%), indomethacin (1%) and others (4%). However, among the total prescriptions observed, 60% female patients and 30-45 years aged people were relaying completely on prescription to use analgesic medications. Ke...

International Journal of Phytopharmacy, 2015

Pleurotusosteratus (family: Pleurotaceae) and Ganodermalucidum (family: ganodermataceae) are comm... more Pleurotusosteratus (family: Pleurotaceae) and Ganodermalucidum (family: ganodermataceae) are common edible mushrooms in Bangladesh. Ethyl acetate extract of Pleurotusosteratus and Ganodermalucidum were used to find out their hypoglycaemicactivity in alloxan induced diabetic mice. Ethyl acetate extract of Pleurotusosteratus and Ganodermalucidum reduced blood glucose level of 39.56% and 43.27% respectively at 24 hours after intrapertitoneal administration (P<0.005) inalloxan induced diabeticmice.The possible mechanism of hypoglycemic action is due to the increased glucose uptake in liver cells because it markedly lowers the blood glucose levels in alloxan induced diabeticmice.

Although hospital pharmacists are recognized for its importance as health care provider in many d... more Although hospital pharmacists are recognized for its importance as health care provider in many developed countries, in most developing countries it is still underutilized. The aim of the present study was to summarize the current situation of pharmacy practices in five hospitals of Bangladesh and to identify the pharmacist’s roles in these seftap. The study was conducted through convenient sampling method using a well-designed 14-item questionnaire to collect the opinions from the respondents. The results showed that hospital pharmacy service, as a unique department of hospital, existed in 60% of the studied hospitals where activities were done by graduate pharmacists and they were also involved in different departments to provide clinical services to the patients. The rest 40% of the studied hospitals had no hospital pharmacy service. Only a retail drug store inside the hospital was present and there was no diploma or graduate or any pharmacy technician for providing patient care....

Pleurotus osteratus (family: Pleurotaceae) and Ganoderma lucidum (family: ganodermataceae) are co... more Pleurotus osteratus (family: Pleurotaceae) and Ganoderma lucidum (family: ganodermataceae) are common edible mushrooms in Bangladesh. Ethyl acetate extract of Pleurotus osteratus and Ganoderma lucidum were used to find out their hypolipidemic and hepatoprotective activity in alloxan induced diabetic mice and normal mice. Lipid profile namely LDL, TG and TC level significantly reduced after 24 hours by the intraperitoneal administration of these extracts in normal and diabetic mice whereas equipotently increased HLD level in both cases. Further, diabetic condition increases alanine aminotransferase ALT/SGPT and aspartate aminotransferase AST/SGOT enzyme level in liver. Present treatment also showed that both the oyster and reishi has significantly inhibited the rise of both serum liver enzymes in the treated mice compared to controls.

International Journal of Medicinal and Aromatic Plants, 2013

The aim of the present study was to conduct an ethnobotanical survey on medicinal plants used by ... more The aim of the present study was to conduct an ethnobotanical survey on medicinal plants used by local m e- dicinal plants practitioner for the treatment of snake bite and sexual dysfunction in Jessore and Bagerhat district of Ban g- ladesh. It was found that a total of 35 plant species distributed in to 29 families are used for the ailment of diseases in which six plants are used in the treatment of snake bite and 29 plants are used in the treatment of sexual dysfunction. The plant parts used in their formulations were roots, seeds, fruits, flowers, rhizomes , decoctions, leaves, whole plants, wood and ash among which roots were 25.71% of total use, seeds were 28.57%, flowers were 11.43%, fruits were 5.71%, rh i- zomes were 5.71, decoctions were 5.71%, leaves, wood and ash were 2.86% followed by whole plant at 5. 71%. Among ailments treated were erectile dysfunction, libido, low sperm count, night pollution, premature ejaculation, orgasm, coitus power and duration, spermatorrhoea a...

International journal of biomedical research, 2016

Objectives: The objective of this study was to evaluate the level of lipid profile and serum crea... more Objectives: The objective of this study was to evaluate the level of lipid profile and serum creatinine in patients with diabetes mellitus to correlate the lipid profile abnormalities with serum creatinine levels in diabetic patients. Methods: This cross sectional health survey was carried out with a self-designed standard questionnaire by manual data collection over a six months period (12.09.2015 to 10.04.2016) at three adjacent cities Jessore Sadar, Jhikargacha and Chowgacha upazila respectively. The data were collected from the patients prescription, diagnostic reports and by directly interviewing the patients who were treated as either type 1 or type 2 diabetic 235 fasting patients during the study period. Descriptive statistics were applied to the collected data and analyzed using Microsoft Excel software. Results: In our current survey, the average levels of HDL, LDL, TC, TG and Serum creatinine of investigated patients were observed with respect to their individual groups as...

Journal of Applied Pharmaceutical Science, 2016

Proton pump inhibitors (PPIs) are the most widely prescribed class of gastrointestinal drugs as t... more Proton pump inhibitors (PPIs) are the most widely prescribed class of gastrointestinal drugs as they have minimal side effects and few significant drug interactions, and are generally considered safe for long-term treatment. The proton pump inhibitors such as omeprazole, esomeprazole, pantoprazole, lansoprazole and rabeprazole have quite similar efficacy and potency. Current study was carried out at Jessore district in Bangladesh to investigate the current status of most commonly prescribed PPIs in terms of their generation, gender variation, age categorization and their preferred route of administration as well. However, esomeprazole was used by top most 70% patients, followed by 20%, 6%, 3% and 1% for omeprazole, pantoprazole, rabeprazole and dexlansoprazole respectively. 75% prescriptions were prescribed for oral route of administration. 55% male and 35% of 35-50 years aged patients are suffering from peptic ulcer diseases and uses PPIs for healing process. During proton pump inhibitor therapy, it was observed to have nausea of 30% and vomiting for 28% patients as a major side effect. This study reveals that the new generation PPIs becomes more popular for the treatment of gastric disorders among people of Jessore city, Bangladesh.

Annals of Clinical Microbiology and Antimicrobials, 2014

F1000Research

Background: Examining the prevalence of coronavirus disease (COVID-19) vaccine hesitancy and unde... more Background: Examining the prevalence of coronavirus disease (COVID-19) vaccine hesitancy and understanding what motivates students to accept or reject a newly promoted vaccine has the potential in preventing rapid spread of infection and optimizing country-wide mass vaccination programs. This systematic review aimed to examine global COVID-19 vaccine hesitancy among students, and to identify an up-to-date and concise assessment of most common factors influencing vaccine acceptance and hesitancy around the world. Methods: A systematic search of peer-reviewed literatures indexed in reputable databases was performed. After obtaining the results via screening using PRISMA flow diagram, a total of 35 articles met the inclusion criteria and formed the basic structure of the study objectives. Results: The results revealed that, the worldwide pooled COVID-19 vaccine hesitancy rate was (x̅%)=29.8% (95% CI 23.37–36.23) among students. According to the country count assessment, the pooled vacc...

F1000Research

Background: In the wake of COVID-19 prevention, a growing attention has been devoted to administe... more Background: In the wake of COVID-19 prevention, a growing attention has been devoted to administering vaccines among various sub-group populations including community health care providers. As a community health worker pharmacists and pharmacy students played a crucial role in patient-centered services for managing COVID-19. Examining pharmacy students’ vaccine acceptance intent has great potential in understanding how pharmacists’ perception impacts community people. This study investigated COVID-19 vaccine acceptance among pharmacy students in Bangladesh and identified the potential factors associated with their vaccine acceptance and hesitancy. Methods: An anonymous questionnaire was deployed online using Google forms in English and conveniently sent to 1190 pharmacy students at different universities between 15th October 2021 and 15th December 2021. The convenience sampling consisted of 1034 student pharmacists (response rate 86.9%) who participated in this study. Binary logisti...

Epidemiology and Infection

This study investigated COVID-19 vaccine acceptance, and compared the potential factors influenci... more This study investigated COVID-19 vaccine acceptance, and compared the potential factors influencing vaccine acceptance and hesitancy between public university (PuU) and private university (PrU) students in Bangladesh. An anonymous, self-administered questionnaire was sent to 640 PuU and 660 PrU students in Google Form between 25th September and 22nd November 2021, which resulted in the participation of 1034 (461 PuU vs. 573 PrU) respondents (response rate: 72.03% vs. 86.81%). The pooled vaccine acceptance rates among PuU and PrU students were almost similar (88.1%, 95% CI 85.1─91.1 vs. 87.6%, 95% CI 84.6─90.6). Employing binary logistic regression to assess the association between various potential factors and vaccine acceptance, the study revealed that out of 10 predictors, "safety" and "efficacy" had highly significant positive associations with vaccine acceptance in both cohorts (p=0.000 ,p=0.005). "Political roles" was found to have varied effects─ a significant (p=0.02) negative and a significant positive (p=0.002) association with vaccine acceptance in PuU and PrU students, respectively. Additionally, "communication" (p=0.003) and "trust" (p=0.01) were found to have significant positive associations in PrU students while "rumors" (p=0.03) had negative association in PuU students. The odds of accepting the COVID-19 vaccine were 1.5 vs. 0.9 in PuU and PrU students. Although chi-square analysis did not show any significant association between gender and vaccine acceptance, discrepancies were found in the factors that potentially affect vaccine uptake decision between PuU and PrU students. COVID-19 vaccine uptake may be improved if vaccine-related information becomes available and is communicated to large numbers of people effectively. The implementation of multidisciplinary interventional educational programs may also be considered as a preferred approach to improve student's engagement in pandemic awareness and vaccine readiness.

The Journal of Phytopharmacology, 2015

In this study we have evaluated the nutritional analysisand mineral content of two varieties of m... more In this study we have evaluated the nutritional analysisand mineral content of two varieties of mushroom species include oyster (Pleurotus ostreatus) and Reshii (Ganoderma lucidum). The mushroom varieties were harvested and dried, then taken to the laboratory for proximate and mineral analysis by standard assay methods. For both mushrooms the nutritional composition was analyzed namely pH, moisture content, crude fibre, ash, water soluble protein, total lipid, total soluble sugar, reducing sugar, non-reducing sugar and starch content. However ten mineral elements were analyzed: potassium, calcium, magnesium, sodium, phosphorus, sulfur, cupper, iron, manganese and zinc having no significance difference in values of both mushroom species. Based on the result these mushrooms have high nutrient potentials hence it will serve as a good means of reducing the incidence and high prevalence of malnutrition in Bangladesh since it is a cheap food source that is within the reach of the poor.

Journal of Pharmacognosy and Phytochemistry, 2016

In the present study the methanolic extract of Borassus flabellifer L. (MBF) was evaluated for th... more In the present study the methanolic extract of Borassus flabellifer L. (MBF) was evaluated for the safety along with neuropharmacological activity by using OECD guidelines, y-maze, elevated plus-maze and open field test respectively. Mortality, sign of any toxicity or behavioral changes were not noticed up to the dose as high as 4000mg/kg. Moreover, in y-maze test, MBF 200 mg/kg and MBF 400 mg/kg exhibited anti-depressive and depressive activities. Again, every extract including both lower and higher doses elicited depressive, antidepressive and anxiolytic activities in elevated plus maze test. Later, in open field test, significant (p<0.05, vs. control) CNS depressive activities were found by both MBF 200 mg/kg and MBF 400 mg/kg. The results obtained in the present study demonstrated that MBF can be the possible sources of CNS depressant, antidepressant and anxiolytic agents. But further investigation is needed for the identification of the active compounds as well as confirmati...

Clinical & Biomedical Research, 2018

Acid sensing ion channels (ASIC) are Na+ channels activa ed by ex ernal pro ons. Number of neurol... more Acid sensing ion channels (ASIC) are Na+ channels activa ed by ex ernal pro ons. Number of neurological (pa hological pain, expression of fear, anxie y, depression, and neurodegeneration after ischemic s roke e c) and non -neurological (brain umor, cardiovascular mechanosensation, hypoxia induced hyper ension, glaucoma, e c.) disorders are implica ed by various ASICs sub ypes. Due o heir known and po ential roles in many disease pa hologies, i is very au hentic o explore he impor ance of new and selective small molecule inhibi ors and even activa ors of ASICs as a research ool in clinical uses for reating hese diseases pa hogenesis. This review is aimed o find ou he herapeutic po entialities of ASICs arge ed novel drugs in con ex of heir pa hophysiological role in human body. Fluorescen dyes and optical sensors as a means of fas and efficien screening approaches would cer ainly be used o improve he discovery echnology of ASICs modula ed drugs.

International journal of biomedical research, 2018

Background and Objectives: Hypertension (HTN) or high blood pressure is a chronic medical conditi... more Background and Objectives: Hypertension (HTN) or high blood pressure is a chronic medical condition in which the blood pressure in the arteries is elevated. Blood pressure is summarized by two measurements, systolic and diastolic, which depend on whether the heart muscle is contracting (systole) or relaxed between beats (diastole). Our survey based study is carried out to estimate the current consequences of HTN among the populations of southern cities in Bangladesh. Methods: We have conducted our research in context on population’s age, gender, family history, addictive probability with type of drug habit, age of onset of respondents. We have compared systolic value with diastolic regarding these parameters by the help of self-designed standard questionnaire relevant with hypertension by manual data collection over six month’s period. Total 350 subject respondents were investigated by majorly visiting at their home, work places and hospitals. Descriptive statistics were applied to ...

INDONESIAN JOURNAL OF PHARMACY, 2013

The different fractions of crude ethanol extract of leaf and stem of S. caseolaris (Linn.) (Sonne... more The different fractions of crude ethanol extract of leaf and stem of S. caseolaris (Linn.) (Sonneratiaceae) were screened for its analgesic and antidiarrhoeal activities. The different fraction of crude extract was obtained by using four different solvent systems. The different fractions of crude extract produced significant writhing inhibition in acetic acid induced writhing in mice at dose of 250 and 500mg/kg BW comparable to the standard drug diclofenac sodium at the dose of 25mg/kg BW. When tested for its antidiarrhoeal effects on castor oil induced diarrhea in mice, it increased mean latent period and decreased the frequency of defecation significantly at the dose of 250 and 500mg/kg BW comparable to the standard drug loperamide at the dose of 50mg/kg BW. The overall results tend to suggest the analgesic and antidiarrhoeal activities of the different fractions of crude extract. Both ethyl acetate fraction of stem and chloroform fraction of leaf have significant analgesic activi...

International Journal of Basic and Clinical Pharmacology, 2016

Background: Radioisotope tomography is a form of medical imaging of the kidneys that uses radiola... more Background: Radioisotope tomography is a form of medical imaging of the kidneys that uses radiolabelling. The two most common radiolabelled pharmaceutical agents used are Tc99m-MAG3 (MAG3 is also called mercaptoacetyltriglycine) and Tc-99m-DTPA (diethylenetriaminepentacetate). Tc-99m-DTPA is filtered by the glomerulus and used to measure the glomerular filtration rate and is the second most commonly used renal radiopharmaceutical, primarily because it is the least expensive. The main objective of the present study was to obtain the bio-kinetic data of organ activity as well as organ absorbed dose of Tc99m-DTPA for single photon emitters. Methods: We have carried out a method to obtain accurate organ activity with single photon emission computed tomography (SPECT). Tc-99m-DTPA radiopharmaceutical medicine was used as single photon emitters and we have demonstrated effective decay method and conventional method to obtain accurate organ (seven) activity with single photon emission computed SPECT. The observed organ activity is due to the Tc99m-DTPA is obtained and the data is compared among male, female and ICRP (international committee for radiation protection)-53 recommended data as well. Results: The outcome of study revealed that, dose absorbed power of male is greater than female, so in nuclear medicine centre absorbed doses should be estimated separately both for male and female for more proper treatment opportunity. It is also observed that there is no good agreement of absorbed dose values among male, female and ICRP-53 recommended data. Conclusions: Our achieved result is due to the extreme variation in food values and fundamental needed elements are certainly different between Bangladeshi peoples and foreigners. In case of foreigner's it is almost equal for male and female, whereas for Bangladeshi male and female it is certainly different.

PLOS ONE

Background and aims Vaccination is the most powerful public health intervention proven to be safe... more Background and aims Vaccination is the most powerful public health intervention proven to be safe and effective in the battle against the coronavirus disease-2019 (COVID-19) pandemic. Despite the potential therapeutic benefits of primer vaccine dosage regimens, public perceptions of COVID-19 vaccine booster dose (VBD) acceptance and hesitancy vary among various sub-group populations. This study investigates COVID-19 vaccine booster dose acceptance and compares the multi-dimensional potential factors influencing VBD acceptance and hesitancy among university teachers and the student community in Bangladesh. Methods This web-based cross-sectional study employed an anonymous, validated, and self-administered questionnaire. The questionnaire items were adopted from a theoretical analysis of the recent relevant literature. The questionnaire was deployed in an on-line-enabled format (Google form) and conveniently distributed to 685 teachers and 990 students between 15th June, 2022 and 15th...

PLOS ONE, 2022

Background and aims Although vaccines are considered the most effective and fundamental therapeut... more Background and aims Although vaccines are considered the most effective and fundamental therapeutic tools for consistently preventing the COVID-19 disease, worldwide vaccine hesitancy has become a widespread public health issue for successful immunization. The aim of this review was to identify an up-to-date and concise assessment of potential factors influencing COVID-19 vaccine acceptance and refusal intention, and to outline the key message in order to organize these factors according to country count. Methods A systematic search of the peer-reviewed literature articles indexed in reputable databases, mainly Pub Med (MEDLINE), Elsevier, Science Direct, and Scopus, was performed between21stJune 2021 and10th July 2021. After obtaining the results via careful screening using a PRISMA flow diagram, 47 peer-reviewed articles met the inclusion criteria and formed the basic structure of the review. Results In total, 11 potential factors were identified, of which the greatest number of a...

Analgesics prescribing by physicians have gained due importance across the globe. The present stu... more Analgesics prescribing by physicians have gained due importance across the globe. The present study is aimed to evaluate the physicians prescribing pattern of analgesics, their usages by outpatients in three cities of Bangladesh. This cross sectional health survey was carried out with a self- designed standard questionnaire by manual data collection over a one month period (09-12-2015 to 10-01-2016) at three adjacent cities Jessore Sadar, Jhikargacha and Chowgacha upazila respectively. A total of 300 prescriptions were collected and 46 local pharmacies were selected for data collection about daily sales of analgesics. The highest prescribed analgesic groups were diclofenac (27%), aceclofenac (24%), ketorolac (16%), paracetamol (17%), naproxen (4%), ibuprofen (3%), etoricoxib (4%), indomethacin (1%) and others (4%). However, among the total prescriptions observed, 60% female patients and 30-45 years aged people were relaying completely on prescription to use analgesic medications. Ke...

International Journal of Phytopharmacy, 2015

Pleurotusosteratus (family: Pleurotaceae) and Ganodermalucidum (family: ganodermataceae) are comm... more Pleurotusosteratus (family: Pleurotaceae) and Ganodermalucidum (family: ganodermataceae) are common edible mushrooms in Bangladesh. Ethyl acetate extract of Pleurotusosteratus and Ganodermalucidum were used to find out their hypoglycaemicactivity in alloxan induced diabetic mice. Ethyl acetate extract of Pleurotusosteratus and Ganodermalucidum reduced blood glucose level of 39.56% and 43.27% respectively at 24 hours after intrapertitoneal administration (P<0.005) inalloxan induced diabeticmice.The possible mechanism of hypoglycemic action is due to the increased glucose uptake in liver cells because it markedly lowers the blood glucose levels in alloxan induced diabeticmice.

Although hospital pharmacists are recognized for its importance as health care provider in many d... more Although hospital pharmacists are recognized for its importance as health care provider in many developed countries, in most developing countries it is still underutilized. The aim of the present study was to summarize the current situation of pharmacy practices in five hospitals of Bangladesh and to identify the pharmacist’s roles in these seftap. The study was conducted through convenient sampling method using a well-designed 14-item questionnaire to collect the opinions from the respondents. The results showed that hospital pharmacy service, as a unique department of hospital, existed in 60% of the studied hospitals where activities were done by graduate pharmacists and they were also involved in different departments to provide clinical services to the patients. The rest 40% of the studied hospitals had no hospital pharmacy service. Only a retail drug store inside the hospital was present and there was no diploma or graduate or any pharmacy technician for providing patient care....

Pleurotus osteratus (family: Pleurotaceae) and Ganoderma lucidum (family: ganodermataceae) are co... more Pleurotus osteratus (family: Pleurotaceae) and Ganoderma lucidum (family: ganodermataceae) are common edible mushrooms in Bangladesh. Ethyl acetate extract of Pleurotus osteratus and Ganoderma lucidum were used to find out their hypolipidemic and hepatoprotective activity in alloxan induced diabetic mice and normal mice. Lipid profile namely LDL, TG and TC level significantly reduced after 24 hours by the intraperitoneal administration of these extracts in normal and diabetic mice whereas equipotently increased HLD level in both cases. Further, diabetic condition increases alanine aminotransferase ALT/SGPT and aspartate aminotransferase AST/SGOT enzyme level in liver. Present treatment also showed that both the oyster and reishi has significantly inhibited the rise of both serum liver enzymes in the treated mice compared to controls.

International Journal of Medicinal and Aromatic Plants, 2013

The aim of the present study was to conduct an ethnobotanical survey on medicinal plants used by ... more The aim of the present study was to conduct an ethnobotanical survey on medicinal plants used by local m e- dicinal plants practitioner for the treatment of snake bite and sexual dysfunction in Jessore and Bagerhat district of Ban g- ladesh. It was found that a total of 35 plant species distributed in to 29 families are used for the ailment of diseases in which six plants are used in the treatment of snake bite and 29 plants are used in the treatment of sexual dysfunction. The plant parts used in their formulations were roots, seeds, fruits, flowers, rhizomes , decoctions, leaves, whole plants, wood and ash among which roots were 25.71% of total use, seeds were 28.57%, flowers were 11.43%, fruits were 5.71%, rh i- zomes were 5.71, decoctions were 5.71%, leaves, wood and ash were 2.86% followed by whole plant at 5. 71%. Among ailments treated were erectile dysfunction, libido, low sperm count, night pollution, premature ejaculation, orgasm, coitus power and duration, spermatorrhoea a...

International journal of biomedical research, 2016

Objectives: The objective of this study was to evaluate the level of lipid profile and serum crea... more Objectives: The objective of this study was to evaluate the level of lipid profile and serum creatinine in patients with diabetes mellitus to correlate the lipid profile abnormalities with serum creatinine levels in diabetic patients. Methods: This cross sectional health survey was carried out with a self-designed standard questionnaire by manual data collection over a six months period (12.09.2015 to 10.04.2016) at three adjacent cities Jessore Sadar, Jhikargacha and Chowgacha upazila respectively. The data were collected from the patients prescription, diagnostic reports and by directly interviewing the patients who were treated as either type 1 or type 2 diabetic 235 fasting patients during the study period. Descriptive statistics were applied to the collected data and analyzed using Microsoft Excel software. Results: In our current survey, the average levels of HDL, LDL, TC, TG and Serum creatinine of investigated patients were observed with respect to their individual groups as...

Journal of Applied Pharmaceutical Science, 2016

Proton pump inhibitors (PPIs) are the most widely prescribed class of gastrointestinal drugs as t... more Proton pump inhibitors (PPIs) are the most widely prescribed class of gastrointestinal drugs as they have minimal side effects and few significant drug interactions, and are generally considered safe for long-term treatment. The proton pump inhibitors such as omeprazole, esomeprazole, pantoprazole, lansoprazole and rabeprazole have quite similar efficacy and potency. Current study was carried out at Jessore district in Bangladesh to investigate the current status of most commonly prescribed PPIs in terms of their generation, gender variation, age categorization and their preferred route of administration as well. However, esomeprazole was used by top most 70% patients, followed by 20%, 6%, 3% and 1% for omeprazole, pantoprazole, rabeprazole and dexlansoprazole respectively. 75% prescriptions were prescribed for oral route of administration. 55% male and 35% of 35-50 years aged patients are suffering from peptic ulcer diseases and uses PPIs for healing process. During proton pump inhibitor therapy, it was observed to have nausea of 30% and vomiting for 28% patients as a major side effect. This study reveals that the new generation PPIs becomes more popular for the treatment of gastric disorders among people of Jessore city, Bangladesh.

Annals of Clinical Microbiology and Antimicrobials, 2014

F1000Research

Background: Examining the prevalence of coronavirus disease (COVID-19) vaccine hesitancy and unde... more Background: Examining the prevalence of coronavirus disease (COVID-19) vaccine hesitancy and understanding what motivates students to accept or reject a newly promoted vaccine has the potential in preventing rapid spread of infection and optimizing country-wide mass vaccination programs. This systematic review aimed to examine global COVID-19 vaccine hesitancy among students, and to identify an up-to-date and concise assessment of most common factors influencing vaccine acceptance and hesitancy around the world. Methods: A systematic search of peer-reviewed literatures indexed in reputable databases was performed. After obtaining the results via screening using PRISMA flow diagram, a total of 35 articles met the inclusion criteria and formed the basic structure of the study objectives. Results: The results revealed that, the worldwide pooled COVID-19 vaccine hesitancy rate was (x̅%)=29.8% (95% CI 23.37–36.23) among students. According to the country count assessment, the pooled vacc...

F1000Research

Background: In the wake of COVID-19 prevention, a growing attention has been devoted to administe... more Background: In the wake of COVID-19 prevention, a growing attention has been devoted to administering vaccines among various sub-group populations including community health care providers. As a community health worker pharmacists and pharmacy students played a crucial role in patient-centered services for managing COVID-19. Examining pharmacy students’ vaccine acceptance intent has great potential in understanding how pharmacists’ perception impacts community people. This study investigated COVID-19 vaccine acceptance among pharmacy students in Bangladesh and identified the potential factors associated with their vaccine acceptance and hesitancy. Methods: An anonymous questionnaire was deployed online using Google forms in English and conveniently sent to 1190 pharmacy students at different universities between 15th October 2021 and 15th December 2021. The convenience sampling consisted of 1034 student pharmacists (response rate 86.9%) who participated in this study. Binary logisti...

Epidemiology and Infection

This study investigated COVID-19 vaccine acceptance, and compared the potential factors influenci... more This study investigated COVID-19 vaccine acceptance, and compared the potential factors influencing vaccine acceptance and hesitancy between public university (PuU) and private university (PrU) students in Bangladesh. An anonymous, self-administered questionnaire was sent to 640 PuU and 660 PrU students in Google Form between 25th September and 22nd November 2021, which resulted in the participation of 1034 (461 PuU vs. 573 PrU) respondents (response rate: 72.03% vs. 86.81%). The pooled vaccine acceptance rates among PuU and PrU students were almost similar (88.1%, 95% CI 85.1─91.1 vs. 87.6%, 95% CI 84.6─90.6). Employing binary logistic regression to assess the association between various potential factors and vaccine acceptance, the study revealed that out of 10 predictors, "safety" and "efficacy" had highly significant positive associations with vaccine acceptance in both cohorts (p=0.000 ,p=0.005). "Political roles" was found to have varied effects─ a significant (p=0.02) negative and a significant positive (p=0.002) association with vaccine acceptance in PuU and PrU students, respectively. Additionally, "communication" (p=0.003) and "trust" (p=0.01) were found to have significant positive associations in PrU students while "rumors" (p=0.03) had negative association in PuU students. The odds of accepting the COVID-19 vaccine were 1.5 vs. 0.9 in PuU and PrU students. Although chi-square analysis did not show any significant association between gender and vaccine acceptance, discrepancies were found in the factors that potentially affect vaccine uptake decision between PuU and PrU students. COVID-19 vaccine uptake may be improved if vaccine-related information becomes available and is communicated to large numbers of people effectively. The implementation of multidisciplinary interventional educational programs may also be considered as a preferred approach to improve student's engagement in pandemic awareness and vaccine readiness.

The Journal of Phytopharmacology, 2015

In this study we have evaluated the nutritional analysisand mineral content of two varieties of m... more In this study we have evaluated the nutritional analysisand mineral content of two varieties of mushroom species include oyster (Pleurotus ostreatus) and Reshii (Ganoderma lucidum). The mushroom varieties were harvested and dried, then taken to the laboratory for proximate and mineral analysis by standard assay methods. For both mushrooms the nutritional composition was analyzed namely pH, moisture content, crude fibre, ash, water soluble protein, total lipid, total soluble sugar, reducing sugar, non-reducing sugar and starch content. However ten mineral elements were analyzed: potassium, calcium, magnesium, sodium, phosphorus, sulfur, cupper, iron, manganese and zinc having no significance difference in values of both mushroom species. Based on the result these mushrooms have high nutrient potentials hence it will serve as a good means of reducing the incidence and high prevalence of malnutrition in Bangladesh since it is a cheap food source that is within the reach of the poor.

Journal of Pharmacognosy and Phytochemistry, 2016

In the present study the methanolic extract of Borassus flabellifer L. (MBF) was evaluated for th... more In the present study the methanolic extract of Borassus flabellifer L. (MBF) was evaluated for the safety along with neuropharmacological activity by using OECD guidelines, y-maze, elevated plus-maze and open field test respectively. Mortality, sign of any toxicity or behavioral changes were not noticed up to the dose as high as 4000mg/kg. Moreover, in y-maze test, MBF 200 mg/kg and MBF 400 mg/kg exhibited anti-depressive and depressive activities. Again, every extract including both lower and higher doses elicited depressive, antidepressive and anxiolytic activities in elevated plus maze test. Later, in open field test, significant (p<0.05, vs. control) CNS depressive activities were found by both MBF 200 mg/kg and MBF 400 mg/kg. The results obtained in the present study demonstrated that MBF can be the possible sources of CNS depressant, antidepressant and anxiolytic agents. But further investigation is needed for the identification of the active compounds as well as confirmati...

Clinical & Biomedical Research, 2018

Acid sensing ion channels (ASIC) are Na+ channels activa ed by ex ernal pro ons. Number of neurol... more Acid sensing ion channels (ASIC) are Na+ channels activa ed by ex ernal pro ons. Number of neurological (pa hological pain, expression of fear, anxie y, depression, and neurodegeneration after ischemic s roke e c) and non -neurological (brain umor, cardiovascular mechanosensation, hypoxia induced hyper ension, glaucoma, e c.) disorders are implica ed by various ASICs sub ypes. Due o heir known and po ential roles in many disease pa hologies, i is very au hentic o explore he impor ance of new and selective small molecule inhibi ors and even activa ors of ASICs as a research ool in clinical uses for reating hese diseases pa hogenesis. This review is aimed o find ou he herapeutic po entialities of ASICs arge ed novel drugs in con ex of heir pa hophysiological role in human body. Fluorescen dyes and optical sensors as a means of fas and efficien screening approaches would cer ainly be used o improve he discovery echnology of ASICs modula ed drugs.

International journal of biomedical research, 2018

Background and Objectives: Hypertension (HTN) or high blood pressure is a chronic medical conditi... more Background and Objectives: Hypertension (HTN) or high blood pressure is a chronic medical condition in which the blood pressure in the arteries is elevated. Blood pressure is summarized by two measurements, systolic and diastolic, which depend on whether the heart muscle is contracting (systole) or relaxed between beats (diastole). Our survey based study is carried out to estimate the current consequences of HTN among the populations of southern cities in Bangladesh. Methods: We have conducted our research in context on population’s age, gender, family history, addictive probability with type of drug habit, age of onset of respondents. We have compared systolic value with diastolic regarding these parameters by the help of self-designed standard questionnaire relevant with hypertension by manual data collection over six month’s period. Total 350 subject respondents were investigated by majorly visiting at their home, work places and hospitals. Descriptive statistics were applied to ...

INDONESIAN JOURNAL OF PHARMACY, 2013

The different fractions of crude ethanol extract of leaf and stem of S. caseolaris (Linn.) (Sonne... more The different fractions of crude ethanol extract of leaf and stem of S. caseolaris (Linn.) (Sonneratiaceae) were screened for its analgesic and antidiarrhoeal activities. The different fraction of crude extract was obtained by using four different solvent systems. The different fractions of crude extract produced significant writhing inhibition in acetic acid induced writhing in mice at dose of 250 and 500mg/kg BW comparable to the standard drug diclofenac sodium at the dose of 25mg/kg BW. When tested for its antidiarrhoeal effects on castor oil induced diarrhea in mice, it increased mean latent period and decreased the frequency of defecation significantly at the dose of 250 and 500mg/kg BW comparable to the standard drug loperamide at the dose of 50mg/kg BW. The overall results tend to suggest the analgesic and antidiarrhoeal activities of the different fractions of crude extract. Both ethyl acetate fraction of stem and chloroform fraction of leaf have significant analgesic activi...

International Journal of Basic and Clinical Pharmacology, 2016

Background: Radioisotope tomography is a form of medical imaging of the kidneys that uses radiola... more Background: Radioisotope tomography is a form of medical imaging of the kidneys that uses radiolabelling. The two most common radiolabelled pharmaceutical agents used are Tc99m-MAG3 (MAG3 is also called mercaptoacetyltriglycine) and Tc-99m-DTPA (diethylenetriaminepentacetate). Tc-99m-DTPA is filtered by the glomerulus and used to measure the glomerular filtration rate and is the second most commonly used renal radiopharmaceutical, primarily because it is the least expensive. The main objective of the present study was to obtain the bio-kinetic data of organ activity as well as organ absorbed dose of Tc99m-DTPA for single photon emitters. Methods: We have carried out a method to obtain accurate organ activity with single photon emission computed tomography (SPECT). Tc-99m-DTPA radiopharmaceutical medicine was used as single photon emitters and we have demonstrated effective decay method and conventional method to obtain accurate organ (seven) activity with single photon emission computed SPECT. The observed organ activity is due to the Tc99m-DTPA is obtained and the data is compared among male, female and ICRP (international committee for radiation protection)-53 recommended data as well. Results: The outcome of study revealed that, dose absorbed power of male is greater than female, so in nuclear medicine centre absorbed doses should be estimated separately both for male and female for more proper treatment opportunity. It is also observed that there is no good agreement of absorbed dose values among male, female and ICRP-53 recommended data. Conclusions: Our achieved result is due to the extreme variation in food values and fundamental needed elements are certainly different between Bangladeshi peoples and foreigners. In case of foreigner's it is almost equal for male and female, whereas for Bangladeshi male and female it is certainly different.