Rubaiya Tabassum - Academia.edu (original) (raw)
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Papers by Rubaiya Tabassum
Dla takich miast jak Szczecin, Koszalin, Słupsk czy Kołobrzeg wyraźny wpływ „szkoły berlińskiej”,... more Dla takich miast jak Szczecin, Koszalin, Słupsk czy Kołobrzeg wyraźny wpływ „szkoły berlińskiej”, eksperymentów Ernesta Maya i Brunona Tauta z oczywistych powodów skończył się defi nitywnie wraz z upadkiem III Rzeszy i przyłączeniem tzw. „Ziem Zachodnich” do Polski w 1945 roku. Dla zasiedlających te tereny przesiedlonych z Kresów Wschodnich, ale i szukających tu swego nowego miejsca zamieszkania, przybywających z terenów centralnej Polski nowych mieszkańców „niemiecka przeszłość” stanowiła całkowitą tabula rasa. Okres powojenny oznaczał też dla architektury tych ziem, a szczególnie dla terenu Pomorza Zachodniego „nowe otwarcie” pozbawione ‘naturalnej’ ciągłości tradycji i sentymentów. Przed pierwszymi, wykształconymi już w utworzonej w Szczecinie w 1947 roku Wyższej Szkole Inżynierskiej absolwentami skupionymi w oddziale szczecińskiego „Miastoprojektu” otwarły się praktycznie nieograniczone wprost możliwości wprowadzenia w życie wyniesionych z ukończonych trzyletnich studiów idei, g...
Anatomy & Cell Biology, 2019
Microarray technology has become an indispensable tool for monitoring the levels of gene expressi... more Microarray technology has become an indispensable tool for monitoring the levels of gene expression in a given organism through organization, analysis, interpretation, and utilization of biological sequences. Importantly, preliminary microarray gene expression differs from experimentally validated gene expression. Generally, microarray analysis of gene expression in microglial cells is used to identify genes in the brain and spinal cord that are responsible for the onset of neurodegenerative diseases; these genes are either upregulated or downregulated. In the present study, 770 genes identified in prior publications, including experimental studies, were analyzed to determine whether these genes encode novel disease genes. Among the genes published, 340 genes were matched among multiple publications, whereas 430 genes were mismatched; the matched genes were presumed to have the greatest likelihood of contributing to neurodegenerative diseases and thus to be potentially useful target genes for treatment of neurodegenerative diseases. In protein and mRNA expression studies, matched and mismatched genes showed 99% and 97% potentiality, respectively. In addition, some genes identified in microarray analyses were significantly different from those in experimentally validated expression patterns. This study identified novel genes in microglial cells through comparative analysis of published microarray and experimental data on neurodegenerative diseases.
Neural Regeneration Research, 2020
Hydrogen sulfide (H 2 S) is a gasotransmitter that acts as an antioxidant and exhibits a wide var... more Hydrogen sulfide (H 2 S) is a gasotransmitter that acts as an antioxidant and exhibits a wide variety of cytoprotective and physiological functions in age-associated diseases. One of the major causes of age-related diseases is oxidative stress. In recent years, the importance of H 2 S has become clear, although its antioxidant function has not yet been fully explored. The enzymes cystathionine β-synthase, cystathionine γ-lya-se, and 3-mercaptopyruvate sulfurtransferase are involved in the enzymatic production of H 2 S. Previously, H 2 S was considered a neuromodulator, given its role in long-term hippocampal potentiation, but it is now also recognized as an antioxidant in age-related neurodegeneration. Due to aerobic metabolism, the central nervous system is vulnerable to oxidative stress in brain aging, resulting in age-associated degenerative diseases. H 2 S exerts its antioxidant effect by limiting free radical reactions through the activation of antioxidant enzymes, including superoxide dismutase, catalase, and glutathione peroxidase, which protect against the effects of aging by regulating apoptosis-related genes, including p53, Bax, and Bcl-2. This review explores the implications and mechanisms of H 2 S as an antioxidant in age-associated neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and Down syndrome.
International Journal of Medical Sciences, 2019
Oxidative phosphorylation is a source of energy production by which many cells satisfy their ener... more Oxidative phosphorylation is a source of energy production by which many cells satisfy their energy requirements. Endogenous reactive oxygen species (ROS) are by-products of oxidative phosphorylation. ROS are formed due to the inefficiency of oxidative phosphorylation, and lead to oxidative stress that affects mitochondrial metabolism. Chronic oxidative stress contributes to the onset of neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS). The immediate consequences of oxidative stress include lipid peroxidation, protein oxidation, and mitochondrial deoxyribonucleic acid (mtDNA) mutation, which induce neuronal cell death. Mitochondrial binding of amyloid-β (Aβ) protein has been identified as a contributing factor in AD. In PD and HD, respectively, α-synuclein (α-syn) and huntingtin (Htt) gene mutations have been reported to exacerbate the effects of oxidative stress. Similarly, abnormalities in mitochondrial dynamics and the respiratory chain occur in ALS due to dysregulation of mitochondrial complexes II and IV. However, oxidative stress-induced dysfunctions in neurodegenerative diseases can be mitigated by the antioxidant function of hydrogen sulfide (H 2 S), which also acts through the potassium (K ATP /K +) ion channel and calcium (Ca 2+) ion channels to increase glutathione (GSH) levels. The pharmacological activity of H 2 S is exerted by both inorganic and organic compounds. GSH, glutathione peroxidase (Gpx), and superoxide dismutase (SOD) neutralize H 2 O 2-induced oxidative damage in mitochondria. The main purpose of this review is to discuss specific causes and effects of mitochondrial oxidative stress in neurodegenerative diseases, and how these are impacted by the antioxidant functions of H 2 S to support the development of advancements in neurodegenerative disease treatment.
Neural Regeneration Research, 2020
Dla takich miast jak Szczecin, Koszalin, Słupsk czy Kołobrzeg wyraźny wpływ „szkoły berlińskiej”,... more Dla takich miast jak Szczecin, Koszalin, Słupsk czy Kołobrzeg wyraźny wpływ „szkoły berlińskiej”, eksperymentów Ernesta Maya i Brunona Tauta z oczywistych powodów skończył się defi nitywnie wraz z upadkiem III Rzeszy i przyłączeniem tzw. „Ziem Zachodnich” do Polski w 1945 roku. Dla zasiedlających te tereny przesiedlonych z Kresów Wschodnich, ale i szukających tu swego nowego miejsca zamieszkania, przybywających z terenów centralnej Polski nowych mieszkańców „niemiecka przeszłość” stanowiła całkowitą tabula rasa. Okres powojenny oznaczał też dla architektury tych ziem, a szczególnie dla terenu Pomorza Zachodniego „nowe otwarcie” pozbawione ‘naturalnej’ ciągłości tradycji i sentymentów. Przed pierwszymi, wykształconymi już w utworzonej w Szczecinie w 1947 roku Wyższej Szkole Inżynierskiej absolwentami skupionymi w oddziale szczecińskiego „Miastoprojektu” otwarły się praktycznie nieograniczone wprost możliwości wprowadzenia w życie wyniesionych z ukończonych trzyletnich studiów idei, g...
Anatomy & Cell Biology, 2019
Microarray technology has become an indispensable tool for monitoring the levels of gene expressi... more Microarray technology has become an indispensable tool for monitoring the levels of gene expression in a given organism through organization, analysis, interpretation, and utilization of biological sequences. Importantly, preliminary microarray gene expression differs from experimentally validated gene expression. Generally, microarray analysis of gene expression in microglial cells is used to identify genes in the brain and spinal cord that are responsible for the onset of neurodegenerative diseases; these genes are either upregulated or downregulated. In the present study, 770 genes identified in prior publications, including experimental studies, were analyzed to determine whether these genes encode novel disease genes. Among the genes published, 340 genes were matched among multiple publications, whereas 430 genes were mismatched; the matched genes were presumed to have the greatest likelihood of contributing to neurodegenerative diseases and thus to be potentially useful target genes for treatment of neurodegenerative diseases. In protein and mRNA expression studies, matched and mismatched genes showed 99% and 97% potentiality, respectively. In addition, some genes identified in microarray analyses were significantly different from those in experimentally validated expression patterns. This study identified novel genes in microglial cells through comparative analysis of published microarray and experimental data on neurodegenerative diseases.
Neural Regeneration Research, 2020
Hydrogen sulfide (H 2 S) is a gasotransmitter that acts as an antioxidant and exhibits a wide var... more Hydrogen sulfide (H 2 S) is a gasotransmitter that acts as an antioxidant and exhibits a wide variety of cytoprotective and physiological functions in age-associated diseases. One of the major causes of age-related diseases is oxidative stress. In recent years, the importance of H 2 S has become clear, although its antioxidant function has not yet been fully explored. The enzymes cystathionine β-synthase, cystathionine γ-lya-se, and 3-mercaptopyruvate sulfurtransferase are involved in the enzymatic production of H 2 S. Previously, H 2 S was considered a neuromodulator, given its role in long-term hippocampal potentiation, but it is now also recognized as an antioxidant in age-related neurodegeneration. Due to aerobic metabolism, the central nervous system is vulnerable to oxidative stress in brain aging, resulting in age-associated degenerative diseases. H 2 S exerts its antioxidant effect by limiting free radical reactions through the activation of antioxidant enzymes, including superoxide dismutase, catalase, and glutathione peroxidase, which protect against the effects of aging by regulating apoptosis-related genes, including p53, Bax, and Bcl-2. This review explores the implications and mechanisms of H 2 S as an antioxidant in age-associated neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and Down syndrome.
International Journal of Medical Sciences, 2019
Oxidative phosphorylation is a source of energy production by which many cells satisfy their ener... more Oxidative phosphorylation is a source of energy production by which many cells satisfy their energy requirements. Endogenous reactive oxygen species (ROS) are by-products of oxidative phosphorylation. ROS are formed due to the inefficiency of oxidative phosphorylation, and lead to oxidative stress that affects mitochondrial metabolism. Chronic oxidative stress contributes to the onset of neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS). The immediate consequences of oxidative stress include lipid peroxidation, protein oxidation, and mitochondrial deoxyribonucleic acid (mtDNA) mutation, which induce neuronal cell death. Mitochondrial binding of amyloid-β (Aβ) protein has been identified as a contributing factor in AD. In PD and HD, respectively, α-synuclein (α-syn) and huntingtin (Htt) gene mutations have been reported to exacerbate the effects of oxidative stress. Similarly, abnormalities in mitochondrial dynamics and the respiratory chain occur in ALS due to dysregulation of mitochondrial complexes II and IV. However, oxidative stress-induced dysfunctions in neurodegenerative diseases can be mitigated by the antioxidant function of hydrogen sulfide (H 2 S), which also acts through the potassium (K ATP /K +) ion channel and calcium (Ca 2+) ion channels to increase glutathione (GSH) levels. The pharmacological activity of H 2 S is exerted by both inorganic and organic compounds. GSH, glutathione peroxidase (Gpx), and superoxide dismutase (SOD) neutralize H 2 O 2-induced oxidative damage in mitochondria. The main purpose of this review is to discuss specific causes and effects of mitochondrial oxidative stress in neurodegenerative diseases, and how these are impacted by the antioxidant functions of H 2 S to support the development of advancements in neurodegenerative disease treatment.
Neural Regeneration Research, 2020