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Papers by Maria del Carmen Rubio

Research paper thumbnail of Pulmonary arterial hypertension in congenital cardiac disease – the need for refinement of the Evian-Venice classification

Cardiology in the Young, 2008

Research paper thumbnail of Need for palliative, corrective, and second–corrective surgery in adult patients with congenital cardiopathy classified according to disease complexity

International Journal of Scientific Research, Nov 1, 2014

The prevalence of adult congenital heart disease has increased with advances in endovascular surg... more The prevalence of adult congenital heart disease has increased with advances in endovascular surgery and treatments. It is therefore essential to determine the need for surgery in these patients throughout their lives. Based on a multi-center database on Grown-up congenital heart disease (GUTI-GUCH), an observational study was performed to assess the need for palliative, corrective, and second-corrective surgery, in patients with adult congenital heart disease. Patients were classified as having MILD, MODERATE, or SEVERE anomalies. The association between need for surgery and severity of cardiopathy was analyzed using Kaplan Meier analysis.

Research paper thumbnail of Tratamiento periodontal intensivo en pacientes con enfermedad coronaria

Rev Fundac Juan Jose Carraro, Oct 1, 2012

Research paper thumbnail of Comparative study of changes in arterial pressure and heart rate during dental treatment under local anesthesia in hypertensive patients versus normotensive patients

Acta odontológica latinoamericana : AOL, 2012

The aim of this study was to determine changes in arterial pressure (AP) and heart rate (HR) duri... more The aim of this study was to determine changes in arterial pressure (AP) and heart rate (HR) during dental treatment under local infiltration anesthesia (LIA) in patients with controlled arterial hypertension (AHT) versus normotensive patients. A longitudinal comparative study involving repeated measurements in well-controlled hypertensive (cases) and normotensive patients (controls) was conducted. All patients received standardized preventive periodontal treatment under LIA (1.8 ml of 4% articaine with 1:100000 L-Adrenaline). AP and HR were determined at 5 different phases of treatment. The study comprised 82 patients, 46.3% of whom were hypertensive, 61% were female. Systolic (SAP) and diastolic (DAP) arterial pressure and HR increased as the procedure advanced and then returned to initial values in both groups. Average HR values were lower in normotensive than in hypertensive patients (p < 0.001). Significant differences in AP and HR were observed among initial, mid-procedure,...

Research paper thumbnail of Oxidative stress assessed in saliva from patients with acute myocardial infarction. A preliminary study

Acta odontológica latinoamericana : AOL, 2013

There is evidence that acute myocardial infarction (AMI) is associated with increasing production... more There is evidence that acute myocardial infarction (AMI) is associated with increasing production of reactive oxygen species and tissue injury. The aim of this study was to assess the presence of oxidative stress indices in saliva 24 and 48h after AMI. We designed a prospective study comparing salivary levels of biomarkers of oxidative stress in patients with AMI with elevation of the ST segment in electrocardiogram versus clinically healthy subjects. Oxidative stress indices including the rate of oxidation of 2'7' dichlorohydrofluorescein diacetate (DCFH-DA) and the activity of the antioxidant enzyme catalase (CAT) were evaluated in saliva from patients with AMI at 24 and 48 hours. At each sampling time, blood was drawn for serum markers of myocardial infarction. This study included ten patients with acute ST-segment elevation myocardial infarction and ten clinically healthy controls. Mean age was 67.8 +/- 11.1 vs. 48.7 +/- 4.1 years (p < 0.001) and gender was 60% male v...

Research paper thumbnail of Effect of Oral Hygiene and 0.12% Chlorhexidine Gluconate Oral Rinse in Preventing Ventilator-Associated Pneumonia After Cardiovascular Surgery

Respiratory Care, 2013

BACKGROUND: Ventilator-associated pneumonia (VAP) is a nosocomial infection of multifactorial eti... more BACKGROUND: Ventilator-associated pneumonia (VAP) is a nosocomial infection of multifactorial etiology and has a negative influence on cardiovascular surgery (CVS) outcomes. OBJECTIVES: Determine the effect of toothbrushing plus 0.12% chlorhexidine gluconate oral rinse in preventing VAP after CVS. METHODS: In a quasi-experimental study, patients undergoing heart surgery were enrolled in a protocol for controlling dental biofilm by proper oral hygiene (toothbrushing) and oral rinses with 0.12% chlorhexidine gluconate (Group 1), and they were compared with a historical control group (Group 2), which included patients who underwent cardiac surgery between 2009 and 2010 and who received regular oral hygiene care. Seventy-two hours before surgery, a dentist provided instruction and supervised oral hygiene with toothbrushing and chlorhexidine oral rinses to patients in Group 1. RESULTS: Each group comprised 150 patients. A lower incidence of VAP (2.7% [95% CI 0.7-7.8] vs 8.7% [95% CI 4.9-14.7], P ‫؍‬ .04) and a shorter hospital stay (9 ؎ 3 d [95% CI 8.5-9.5] vs 10 ؎ 4 d [95% CI 9.4-10.7], P ‫؍‬ .01) were observed in Group 1. No significant differences in all-cause in-hospital death were observed between groups (5.3% vs 4.7%, P > .99). The risk for developing pneumonia after surgery was 3-fold higher in Group 2 (3.9, 95% CI 1.1-14.2). CONCLUSIONS: Oral hygiene and mouth rinses with chlorhexidine under supervision of a dentist proved effective in reducing the incidence of VAP.

Research paper thumbnail of Association between oral health and acute coronary syndrome in elderly people

Acta odontológica latinoamericana : AOL, 2011

With the aim of contributing information to help clarify the association between oral health, per... more With the aim of contributing information to help clarify the association between oral health, periodontal disease and ischemic cardiomyopathy, a comparative study was performed on hospitalized patients with and without acute coronary syndrome (ACS), evaluating atherogenic risk factors (ARF), level of oral hygiene and dental and periodontal health status. The study included patients in the coronary unit with ACS and patients in regular floor bed without evidence of cardiovascular pathology at Hospital Español, Buenos Aires, Argentina. The following ARFs were analyzed for all patients: hypertension, cholesterol, diabetes, obesity and smoking. The clinical dental examination included recording dental charts and variables related to oral hygiene, epidemiological indices and diagnosis of periodontal disease. The data collected were used to compare the ACS Group to the Control Group regarding prevalence of the ARFs and clinical dental variables studied. A total of 146 patients were studie...

Research paper thumbnail of Pulmonary arterial hypertension in congenital cardiac disease – the need for refinement of the Evian-Venice classification

Cardiology in the Young, 2008

Research paper thumbnail of Need for palliative, corrective, and second–corrective surgery in adult patients with congenital cardiopathy classified according to disease complexity

International Journal of Scientific Research, Nov 1, 2014

The prevalence of adult congenital heart disease has increased with advances in endovascular surg... more The prevalence of adult congenital heart disease has increased with advances in endovascular surgery and treatments. It is therefore essential to determine the need for surgery in these patients throughout their lives. Based on a multi-center database on Grown-up congenital heart disease (GUTI-GUCH), an observational study was performed to assess the need for palliative, corrective, and second-corrective surgery, in patients with adult congenital heart disease. Patients were classified as having MILD, MODERATE, or SEVERE anomalies. The association between need for surgery and severity of cardiopathy was analyzed using Kaplan Meier analysis.

Research paper thumbnail of Tratamiento periodontal intensivo en pacientes con enfermedad coronaria

Rev Fundac Juan Jose Carraro, Oct 1, 2012

Research paper thumbnail of Comparative study of changes in arterial pressure and heart rate during dental treatment under local anesthesia in hypertensive patients versus normotensive patients

Acta odontológica latinoamericana : AOL, 2012

The aim of this study was to determine changes in arterial pressure (AP) and heart rate (HR) duri... more The aim of this study was to determine changes in arterial pressure (AP) and heart rate (HR) during dental treatment under local infiltration anesthesia (LIA) in patients with controlled arterial hypertension (AHT) versus normotensive patients. A longitudinal comparative study involving repeated measurements in well-controlled hypertensive (cases) and normotensive patients (controls) was conducted. All patients received standardized preventive periodontal treatment under LIA (1.8 ml of 4% articaine with 1:100000 L-Adrenaline). AP and HR were determined at 5 different phases of treatment. The study comprised 82 patients, 46.3% of whom were hypertensive, 61% were female. Systolic (SAP) and diastolic (DAP) arterial pressure and HR increased as the procedure advanced and then returned to initial values in both groups. Average HR values were lower in normotensive than in hypertensive patients (p < 0.001). Significant differences in AP and HR were observed among initial, mid-procedure,...

Research paper thumbnail of Oxidative stress assessed in saliva from patients with acute myocardial infarction. A preliminary study

Acta odontológica latinoamericana : AOL, 2013

There is evidence that acute myocardial infarction (AMI) is associated with increasing production... more There is evidence that acute myocardial infarction (AMI) is associated with increasing production of reactive oxygen species and tissue injury. The aim of this study was to assess the presence of oxidative stress indices in saliva 24 and 48h after AMI. We designed a prospective study comparing salivary levels of biomarkers of oxidative stress in patients with AMI with elevation of the ST segment in electrocardiogram versus clinically healthy subjects. Oxidative stress indices including the rate of oxidation of 2'7' dichlorohydrofluorescein diacetate (DCFH-DA) and the activity of the antioxidant enzyme catalase (CAT) were evaluated in saliva from patients with AMI at 24 and 48 hours. At each sampling time, blood was drawn for serum markers of myocardial infarction. This study included ten patients with acute ST-segment elevation myocardial infarction and ten clinically healthy controls. Mean age was 67.8 +/- 11.1 vs. 48.7 +/- 4.1 years (p < 0.001) and gender was 60% male v...

Research paper thumbnail of Effect of Oral Hygiene and 0.12% Chlorhexidine Gluconate Oral Rinse in Preventing Ventilator-Associated Pneumonia After Cardiovascular Surgery

Respiratory Care, 2013

BACKGROUND: Ventilator-associated pneumonia (VAP) is a nosocomial infection of multifactorial eti... more BACKGROUND: Ventilator-associated pneumonia (VAP) is a nosocomial infection of multifactorial etiology and has a negative influence on cardiovascular surgery (CVS) outcomes. OBJECTIVES: Determine the effect of toothbrushing plus 0.12% chlorhexidine gluconate oral rinse in preventing VAP after CVS. METHODS: In a quasi-experimental study, patients undergoing heart surgery were enrolled in a protocol for controlling dental biofilm by proper oral hygiene (toothbrushing) and oral rinses with 0.12% chlorhexidine gluconate (Group 1), and they were compared with a historical control group (Group 2), which included patients who underwent cardiac surgery between 2009 and 2010 and who received regular oral hygiene care. Seventy-two hours before surgery, a dentist provided instruction and supervised oral hygiene with toothbrushing and chlorhexidine oral rinses to patients in Group 1. RESULTS: Each group comprised 150 patients. A lower incidence of VAP (2.7% [95% CI 0.7-7.8] vs 8.7% [95% CI 4.9-14.7], P ‫؍‬ .04) and a shorter hospital stay (9 ؎ 3 d [95% CI 8.5-9.5] vs 10 ؎ 4 d [95% CI 9.4-10.7], P ‫؍‬ .01) were observed in Group 1. No significant differences in all-cause in-hospital death were observed between groups (5.3% vs 4.7%, P > .99). The risk for developing pneumonia after surgery was 3-fold higher in Group 2 (3.9, 95% CI 1.1-14.2). CONCLUSIONS: Oral hygiene and mouth rinses with chlorhexidine under supervision of a dentist proved effective in reducing the incidence of VAP.

Research paper thumbnail of Association between oral health and acute coronary syndrome in elderly people

Acta odontológica latinoamericana : AOL, 2011

With the aim of contributing information to help clarify the association between oral health, per... more With the aim of contributing information to help clarify the association between oral health, periodontal disease and ischemic cardiomyopathy, a comparative study was performed on hospitalized patients with and without acute coronary syndrome (ACS), evaluating atherogenic risk factors (ARF), level of oral hygiene and dental and periodontal health status. The study included patients in the coronary unit with ACS and patients in regular floor bed without evidence of cardiovascular pathology at Hospital Español, Buenos Aires, Argentina. The following ARFs were analyzed for all patients: hypertension, cholesterol, diabetes, obesity and smoking. The clinical dental examination included recording dental charts and variables related to oral hygiene, epidemiological indices and diagnosis of periodontal disease. The data collected were used to compare the ACS Group to the Control Group regarding prevalence of the ARFs and clinical dental variables studied. A total of 146 patients were studie...