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Papers by Ruchita Badekar

International Journal of Pharmacy and Pharmaceutical Sciences, Apr 1, 2024

The pharmaceutical sector is looking for new ways to deliver drugs, and one such way is through t... more The pharmaceutical sector is looking for new ways to deliver drugs, and one such way is through thin films. It has been said that thin films offer an alternative to traditional dosage forms. They offer rapid, local, or systemic effects and are a very flexible platform. Furthermore, patients with dysphagia, elderly, paediatrics, or bedridden patients, as well as those who have difficulty accessing water, can easily utilize these systems on their own. There are several ways to administer these drug delivery systems, including transdermally, ocularly, buccally, sublingually, and orally. One of the most creative and patient-focused novel drug delivery systems is Orodispersible Thin Films (OTF). Numerous pharmaceutical companies and academic experts worldwide are currently investigating the potential of these films for delivering drugs derived from both synthetic and natural sources. The beauty of this special drug delivery method is that, as we can see from the subjects' consumption of conventional dosage forms (tablets, capsules), they don't require water to be consumed. Furthermore, these delivery methods do a great job of encouraging patient compliance in general, especially in the case of both older and pediatric patients. This review shows a detailed review of oral thin film its applications and method of preparation; mainly focus of this research is thin film introduction to researchers and last 10 y of research on thin film with drugs and polymers used in research.

PULSATILE DRUG DELIVERY, 2024

Oral pulsatile drug delivery systems (PDDS) are intended to induce programmable lag phases before... more Oral pulsatile drug delivery systems (PDDS) are intended to induce programmable lag phases before a quick and quantifiable, repeated, or prolonged medication release. As a result, they are gaining popularity due to their inherent suitability for achieving chronotherapeutic goals, which have just been highlighted concerning several prevalent chronic illnesses characterized by typical night or early-morning recurring symptoms (e. g. bronchial asthma, heart attack, rheumatoid arthritis, early-morningawakening). Furthermore, time-based colonic release is possible when pulsatile delivery devices are correctly modified to overcome unexpected gastric emptying and give delay periods that roughly match the small intestine transit time. Oral pulsatile administration is accomplished using several release platforms, including reservoir, capsular, and osmotic devices. The current review article addressed the topics that followed: the reason pulsatile drug delivery systems have been invented; diseases for which pulsatile release is necessary; classification, advantages and disadvantages; methods used in the current systems; the situation nowadays and its potential for the future; recent advancements, and especially, the previous five to ten years of research on pulsatile drug delivery conducted by researchers using a variety of drugs for a variety of diseases.

Research & Review: Drugs and Drugs Development

Whenever the body has inadequate amounts of healthy red blood cells that supply oxygen to the bod... more Whenever the body has inadequate amounts of healthy red blood cells that supply oxygen to the body's organs, anaemia develops. Anaemia patients experience coldness, fatigue, and weakness. Iron deficiency anaemia is the most prevalent kind of anaemia. Red blood cells use a protein called haemoglobin, which iron creates, to deliver oxygen. Iron can be added to food to ease it. Anaemia brought on by inflammations brought on by infections, autoimmune disorders, cancer, and chronic kidney diseases is the second most common type of anaemia. In this type of anaemia, the blood iron level is low despite the body having a normal or even increasing quantity of iron stored in body tissues. One of the most common dangerous diseases, especially in women, pregnant women, children, and adults, is anaemia deficiency. According to the World Health Organisation (2007), anaemia affects 30% to 50% of children and other groups as a result of iron deficiency. Out of the worldwide 1.6 billion anaemic p...

REVIEW ON SEPSIVAC INJECTION (MYCOBACTERIUM W) AN EMERGENCY MEDICATION, 2023

The mycobacterium w (Mw) has improved outcomes for individuals with severe sepsis by acting as an... more The mycobacterium w (Mw) has improved outcomes for individuals with severe sepsis by acting as an
immunomodulator. Mw is typically administered intradermally (ID), with a maximum injection volume of 0.1
millilitres (mL). The intradermal approach can be substituted with the intravenous (IV) route. Sepsis is a
potentially fatal infection that is treated with sepsivac.It employs a two-pronged strategy that increases innate
immunity and reduces the body's inflammatory response. Immunity is both inherent and learned in humans. A
person's natural immunity is activated by sepsivac. Traditional vaccinations or acquired immunity function
through antibodies. Comparing Sepsivac to a typical vaccination is not appropriate. It prevents inflammatory
cytokines like IL6 from attacking the organs. Body's intrinsic immunity will kick in if organ damage is contained.
Sepsivac, an immunomodulator used to treat leprosy, has been given the go-ahead to be used in the Philippines
to treat Covid-19. According to a corporate representative, the Food and Drug Administration of the Philippines
approved on September 15.

In pharmacy profession Pharmacovigilance (PV) is essential in the healthcare profession because t... more In pharmacy profession Pharmacovigilance (PV) is essential in the healthcare profession because this examines, monitors, and identifies medication interactions and their impacts on individuals. Biotechnological and pharmaceutical treatments are designed to treat, prevent, or cure diseases, but they come with risks, chief among them the potential for adverse drug reactions (ADRs), which can be significantly detrimental to patients. As a result, it is crucial to keep an eye on pharmaceutical adverse drug reactions (ADRs) for every medicine throughout the course of its development, including in early stages of substance development, clinical studies, and post-marketing surveillance. The identification, assessment, understanding, and avoidance of ADRs are all things that PV is concerned with. Ranitidine is a drug used to reduce the formation of stomach acid and is marketed under the brand nam es Zantac and others. [4] It is frequently employed in the treatment of Zollinger-Ellison syndrome, gastroesophageal reflux disease and peptic ulcer disease. [4] It can be administered orally, intravenously, or intramuscularly. Ranitidine products from several manufacturers were recalled in September 2019 after the possible carcinogenic N-nitroso dimethylamine (NDMA) was found in them.

Review on Hematinic Formulations Used in Anaemia Deficiency Disorders, 2023

Whenever the body has inadequate amounts of healthy red blood cells that supply oxygen to the bod... more Whenever the body has inadequate amounts of healthy red blood cells that supply oxygen to the body's organs, anaemia develops. Anaemia patients experience coldness, fatigue, and weakness. Iron deficiency anaemia is the most prevalent kind of anaemia. Red blood cells use a protein called haemoglobin, which iron creates, to deliver oxygen. Iron can be added to food to ease it. Anaemia brought on by inflammations brought on by infections, autoimmune disorders, cancer, and chronic kidney diseases is the second most common type of anaemia. In this type of anaemia, the blood iron level is low despite the body having a normal or even increasing quantity of iron stored in body tissues. One of the most common dangerous diseases, especially in women, pregnant women, children, and adults, is anaemia deficiency. According to the World Health Organisation (2007), anaemia affects 30% to 50% of children and other groups as a result of iron deficiency. Out of the worldwide 1.6 billion anaemic populations, several hundred million suffer from iron deficiency anaemia. Therefore, iron deficiency is the main contributing factor to anaemia worldwide. Iron deficiency anaemia affects a part of the two billion persons who are iron nutritionally deficient globally. This hematinic medication, such as (Dexorange, Orofer XT and Feronia XT) is a form of iron supplement used for the treatment or prevention of low iron levels in the blood, which can occur due to anaemia or pregnancy. For the body to create red blood cells and sustain its health, iron is a crucial mineral.

International Journal of Pharmacy and Pharmaceutical Sciences, Apr 1, 2024

The pharmaceutical sector is looking for new ways to deliver drugs, and one such way is through t... more The pharmaceutical sector is looking for new ways to deliver drugs, and one such way is through thin films. It has been said that thin films offer an alternative to traditional dosage forms. They offer rapid, local, or systemic effects and are a very flexible platform. Furthermore, patients with dysphagia, elderly, paediatrics, or bedridden patients, as well as those who have difficulty accessing water, can easily utilize these systems on their own. There are several ways to administer these drug delivery systems, including transdermally, ocularly, buccally, sublingually, and orally. One of the most creative and patient-focused novel drug delivery systems is Orodispersible Thin Films (OTF). Numerous pharmaceutical companies and academic experts worldwide are currently investigating the potential of these films for delivering drugs derived from both synthetic and natural sources. The beauty of this special drug delivery method is that, as we can see from the subjects' consumption of conventional dosage forms (tablets, capsules), they don't require water to be consumed. Furthermore, these delivery methods do a great job of encouraging patient compliance in general, especially in the case of both older and pediatric patients. This review shows a detailed review of oral thin film its applications and method of preparation; mainly focus of this research is thin film introduction to researchers and last 10 y of research on thin film with drugs and polymers used in research.

PULSATILE DRUG DELIVERY, 2024

Oral pulsatile drug delivery systems (PDDS) are intended to induce programmable lag phases before... more Oral pulsatile drug delivery systems (PDDS) are intended to induce programmable lag phases before a quick and quantifiable, repeated, or prolonged medication release. As a result, they are gaining popularity due to their inherent suitability for achieving chronotherapeutic goals, which have just been highlighted concerning several prevalent chronic illnesses characterized by typical night or early-morning recurring symptoms (e. g. bronchial asthma, heart attack, rheumatoid arthritis, early-morningawakening). Furthermore, time-based colonic release is possible when pulsatile delivery devices are correctly modified to overcome unexpected gastric emptying and give delay periods that roughly match the small intestine transit time. Oral pulsatile administration is accomplished using several release platforms, including reservoir, capsular, and osmotic devices. The current review article addressed the topics that followed: the reason pulsatile drug delivery systems have been invented; diseases for which pulsatile release is necessary; classification, advantages and disadvantages; methods used in the current systems; the situation nowadays and its potential for the future; recent advancements, and especially, the previous five to ten years of research on pulsatile drug delivery conducted by researchers using a variety of drugs for a variety of diseases.

Research & Review: Drugs and Drugs Development

Whenever the body has inadequate amounts of healthy red blood cells that supply oxygen to the bod... more Whenever the body has inadequate amounts of healthy red blood cells that supply oxygen to the body's organs, anaemia develops. Anaemia patients experience coldness, fatigue, and weakness. Iron deficiency anaemia is the most prevalent kind of anaemia. Red blood cells use a protein called haemoglobin, which iron creates, to deliver oxygen. Iron can be added to food to ease it. Anaemia brought on by inflammations brought on by infections, autoimmune disorders, cancer, and chronic kidney diseases is the second most common type of anaemia. In this type of anaemia, the blood iron level is low despite the body having a normal or even increasing quantity of iron stored in body tissues. One of the most common dangerous diseases, especially in women, pregnant women, children, and adults, is anaemia deficiency. According to the World Health Organisation (2007), anaemia affects 30% to 50% of children and other groups as a result of iron deficiency. Out of the worldwide 1.6 billion anaemic p...

REVIEW ON SEPSIVAC INJECTION (MYCOBACTERIUM W) AN EMERGENCY MEDICATION, 2023

The mycobacterium w (Mw) has improved outcomes for individuals with severe sepsis by acting as an... more The mycobacterium w (Mw) has improved outcomes for individuals with severe sepsis by acting as an
immunomodulator. Mw is typically administered intradermally (ID), with a maximum injection volume of 0.1
millilitres (mL). The intradermal approach can be substituted with the intravenous (IV) route. Sepsis is a
potentially fatal infection that is treated with sepsivac.It employs a two-pronged strategy that increases innate
immunity and reduces the body's inflammatory response. Immunity is both inherent and learned in humans. A
person's natural immunity is activated by sepsivac. Traditional vaccinations or acquired immunity function
through antibodies. Comparing Sepsivac to a typical vaccination is not appropriate. It prevents inflammatory
cytokines like IL6 from attacking the organs. Body's intrinsic immunity will kick in if organ damage is contained.
Sepsivac, an immunomodulator used to treat leprosy, has been given the go-ahead to be used in the Philippines
to treat Covid-19. According to a corporate representative, the Food and Drug Administration of the Philippines
approved on September 15.

In pharmacy profession Pharmacovigilance (PV) is essential in the healthcare profession because t... more In pharmacy profession Pharmacovigilance (PV) is essential in the healthcare profession because this examines, monitors, and identifies medication interactions and their impacts on individuals. Biotechnological and pharmaceutical treatments are designed to treat, prevent, or cure diseases, but they come with risks, chief among them the potential for adverse drug reactions (ADRs), which can be significantly detrimental to patients. As a result, it is crucial to keep an eye on pharmaceutical adverse drug reactions (ADRs) for every medicine throughout the course of its development, including in early stages of substance development, clinical studies, and post-marketing surveillance. The identification, assessment, understanding, and avoidance of ADRs are all things that PV is concerned with. Ranitidine is a drug used to reduce the formation of stomach acid and is marketed under the brand nam es Zantac and others. [4] It is frequently employed in the treatment of Zollinger-Ellison syndrome, gastroesophageal reflux disease and peptic ulcer disease. [4] It can be administered orally, intravenously, or intramuscularly. Ranitidine products from several manufacturers were recalled in September 2019 after the possible carcinogenic N-nitroso dimethylamine (NDMA) was found in them.

Review on Hematinic Formulations Used in Anaemia Deficiency Disorders, 2023

Whenever the body has inadequate amounts of healthy red blood cells that supply oxygen to the bod... more Whenever the body has inadequate amounts of healthy red blood cells that supply oxygen to the body's organs, anaemia develops. Anaemia patients experience coldness, fatigue, and weakness. Iron deficiency anaemia is the most prevalent kind of anaemia. Red blood cells use a protein called haemoglobin, which iron creates, to deliver oxygen. Iron can be added to food to ease it. Anaemia brought on by inflammations brought on by infections, autoimmune disorders, cancer, and chronic kidney diseases is the second most common type of anaemia. In this type of anaemia, the blood iron level is low despite the body having a normal or even increasing quantity of iron stored in body tissues. One of the most common dangerous diseases, especially in women, pregnant women, children, and adults, is anaemia deficiency. According to the World Health Organisation (2007), anaemia affects 30% to 50% of children and other groups as a result of iron deficiency. Out of the worldwide 1.6 billion anaemic populations, several hundred million suffer from iron deficiency anaemia. Therefore, iron deficiency is the main contributing factor to anaemia worldwide. Iron deficiency anaemia affects a part of the two billion persons who are iron nutritionally deficient globally. This hematinic medication, such as (Dexorange, Orofer XT and Feronia XT) is a form of iron supplement used for the treatment or prevention of low iron levels in the blood, which can occur due to anaemia or pregnancy. For the body to create red blood cells and sustain its health, iron is a crucial mineral.