Ruhul Amin - Academia.edu (original) (raw)

Papers by Ruhul Amin

Separations

Food, drugs, dyes, extracts, and minerals are all made up of complex elements, and utilizing unid... more Food, drugs, dyes, extracts, and minerals are all made up of complex elements, and utilizing unidimensional chromatography to separate them is inefficient and insensitive. This has sparked the invention of several linked chromatography methods, each of them with distinct separation principles and affinity for the analyte of interest. Multidimensional chromatography consists of the combination of multiple chromatography techniques, with great benefits at the level of efficiency, peak capacity, precision, and accuracy of the analysis, while reducing the time required for the analysis. Various coupled chromatography techniques have recently emerged, including liquid chromatography–gas chromatography (LC–GC), gas chromatography–gas chromatography (GC–GC), liquid chromatography–liquid chromatography (LC–LC), GCMS–MS, LCMS–MS, supercritical fluid techniques with chromatography techniques, and electro-driven multidimensional separation techniques. In this paper, the different coupled chrom...

International Journal of Applied Pharmaceutics, 2021

Objective: Shortages of medicinal products are complex global problems. Drug shortages remain a s... more Objective: Shortages of medicinal products are complex global problems. Drug shortages remain a significant public health issue. Global shortages of medical products have a potential effect on patient health and total healthcare costs. Countries worldwide, especially those affected by Coronavirus disease 2019 (COVID-19), is experiencing a rapid increase in drug shortage, which causes several complications for physicians, health care provider, patients, health institutes and health regulatory bodies. Methods: To carry out the study of shortages, several efforts have been taken by the regulators and industries. Prominent amongst these include FDA's research the needs and the reforms made in the regulations about shortages. We also searched for electronic databases (PubMed, Science direct, Web of Science) using the terms (COVID-19 and shortage) or (medicine and COVID-19) for articles in periods of 2019 to 2021. Results: On assessment based on the report, the number of shortage drug...

Evidence-Based Complementary and Alternative Medicine, 2022

Polyalthia suberosa (Roxb.) is a plant used to cure coughs, dysentery, fevers, joint aches, rheum... more Polyalthia suberosa (Roxb.) is a plant used to cure coughs, dysentery, fevers, joint aches, rheumatic pain, inflammation, and a variety of skin diseases. The aim of the study was to evaluate the ethyl acetate extract of Polyalthia suberosa (P. suberosa) leaves and their effects on mice for neuropharmacological, analgesic, and antidiarrheal activities. For neurological studies, the hole cross, hole board, open field, and thiopental sodium-induced sleep duration measurement methodologies were used. The castor oil-induced diarrhea inhibition test was used to assess antidiarrheal action, and the acetic acid-induced writhing inhibition test was used to determine analgesic effectiveness. The extract was given in doses of 250 and 500 mg kg−1 body weight. As a standard drug, diazepam at a dosage of 3 mg kg−1 was used. The extract was also given to groups, and sleep time was measured and recorded. The onset of the anxiolytic effect of the extract at both doses was found to be significant ( p...

BioMed Research International

Ondansetron tablets that are directly compressed using crospovidone and croscarmellose as a synth... more Ondansetron tablets that are directly compressed using crospovidone and croscarmellose as a synthetic super disintegrant are the subject of this investigation. A central composite, response surface, randomly quadratic, nonblock (version 13.0.9.0) 32 factorial design is used to optimize the formulation (two-factor three-level). To make things even more complicated, nine different formulation batches (designated as F1–F9) were created. There were three levels of crospovidone and croscarmellose (+1, 0, -1). In addition to that, pre- and postcompressional parameters were evaluated, and all evaluated parameters were found to be within acceptable range. Among all postcompressional parameter dispersion and disintegration time, in vitro drug release experiments (to quantify the amount of medication released from the tablet) and their percentage prediction error were shown to have a significant influence on three dependent variables. Various pre- and postcompression characteristics of each a...

Correspondence 1. Name of the registry: not applicable. 2. Unique identifying number or registrat... more Correspondence 1. Name of the registry: not applicable. 2. Unique identifying number or registration ID: not applicable. 3. Hyperlink to your specific registration (must be publicly accessible and will be checked): not applicable.

Dear Editor, Langya virus is a Henipavirus that has been found in shrews, bats, rats, and other s... more Dear Editor, Langya virus is a Henipavirus that has been found in shrews, bats, rats, and other small animals. Some studies also reveal that animals such as dogs and goats have natural antibodies to the Langya virus [1]. Furthermore, when exposed to bat urine, the virus may spread to other species such as horses or infect pigs [2]. As a member of the RNA virus family Paramyxoviridae, the Langya henipavirus (LayV) has evolutionary ties with Nipah virus and Hendra virus [3]. Both the Nipah and Hendra viruses are emerging zoonotic diseases in the Asia-Pacific area. Despite their differences, these two RNA viruses have antigenic, serological, and ultrastructural features that place them in the same genus [4]. On 4 August, it was initially reported in The New England Journal of Medicine. Thirty-five persons in China's Shandong and Henan provinces contracted the LayV between December 2018 and May 2021 [5]. This indicates that the virus is not spreading among humans readily. There have also been no clusters of instances within the same family, like what may happen with coronavirus disease 2019, or clusters within a short amount of time or in close proximity to one another [4,6]. Contact tracing was performed on nine of the affected persons, and after contacting 15 close contacts of each patient, the researchers found no evidence of LayV infection [7]. This finding lends credence to the theory that the virus is transmitted not from person to person but from animal to human. To spread the Langya virus from person to person still needs a great deal of effort and direct physical contact. People with fever in eastern China who had just been exposed to animals led to the discovery of the virus. In the absence of a cure, problems may be treated with supportive care.

A 23-year-old woman presented to the hospital complaining weakness of lower limbs. On further inv... more A 23-year-old woman presented to the hospital complaining weakness of lower limbs. On further investigation, the patient revealed consumption of a mixed poison with intent to commit suicide, seven months ago.

Objectives: Extensive literature survey revealed that chronic obstructive pulmonary disease (COPD... more Objectives: Extensive literature survey revealed that chronic obstructive pulmonary disease (COPD) is one of the primary burdens for low-income countries like India. Out of around 30 million COPD patients in India, a considerable number of patients are uneducated about the basics of their disease prevention and medication. Patient information leaflets (PILs) are well accepted materials to educate patients/users about medications, disease and lifestyle modifications. Thus PILs printed in regional languages will certainly act as a valuable tool to disseminate and retain patient's information. Methods: PILs are developed in the English language by referring to various model leaflets that are available from different sources such as "Patient UK" , MICROMEDEX Database, GOLD guidelines. The content of the leaflet was validated by physicians. Cloze test was identified as a possible test for assessing the readability of leaflets in English, Kannada, Malayalam and in Hindi. A user-based Cloze test was performed on twenty COPD patients of in each language. Results: The FRE score achieved after the 5 th stage of modification was 77.3, and the FK-GL score achieved was 4.7, which is considered to be good readability of leaflets. User testing scores show significant improvement of knowledge after reading PILs. Conclusion: Present study strongly suggest that the development of patient information leaflet in regional language is likely to have a standard readability score and useful layout design. The prepared leaflet is easily readable and comes out to be user friendly for COPD patients.

Polyalthia suberosa (Roxb.) is a plant used to cure coughs, dysentery, fevers, joint aches, rheum... more Polyalthia suberosa (Roxb.) is a plant used to cure coughs, dysentery, fevers, joint aches, rheumatic pain, inflammation, and a variety of skin diseases. e aim of the study was to evaluate the ethyl acetate extract of Polyalthia suberosa (P. suberosa) leaves and their effects on mice for neuropharmacological, analgesic, and antidiarrheal activities. For neurological studies, the hole cross, hole board, open field, and thiopental sodium-induced sleep duration measurement methodologies were used. e castor oil-induced diarrhea inhibition test was used to assess antidiarrheal action, and the acetic acid-induced writhing inhibition test was used to determine analgesic effectiveness. e extract was given in doses of 250 and 500 mg kg −1 body weight. As a standard drug, diazepam at a dosage of 3 mg kg −1 was used. e extract was also given to groups, and sleep time was measured and recorded. e onset of the anxiolytic effect of the extract at both doses was found to be significant (p < 0.001), and sleep time increased to 273 minutes. For assessing analgesic activity, the extract along with standard diclofenac was administered and found to be 55.02 percent and 64.33 percent, respectively, for the extracts, and diclofenac was found to be 67.44 percent (p < 0.001). For antidiarrheal activity, it was compared with the standard drug, loperamide. e decrease for plant extracts was 50.07 percent and 70.06 percent at 250 mg kg −1 and 500 mg kg −1 , respectively, whereas it was 85.01 percent for loperamide (3 mg kg −1) (p < 0.00). In this study, it was found that ethyl acetate extract of Polyalthia suberosa leaves had strong CNS depressant, analgesic, and antidiarrheal activities, which indicates that it may be used in contemporary medicine.

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Objective: Shortages of medicinal products are complex global problems. Drug shortages remain a s... more Objective: Shortages of medicinal products are complex global problems. Drug shortages remain a significant public health issue. Global shortages of medical products have a potential effect on patient health and total healthcare costs. Countries worldwide, especially those affected by Coronavirus disease 2019 (COVID-19), is experiencing a rapid increase in drug shortage, which causes several complications for physicians, health care provider, patients, health institutes and health regulatory bodies. Methods: To carry out the study of shortages, several efforts have been taken by the regulators and industries. Prominent amongst these include FDA's research the needs and the reforms made in the regulations about shortages. We also searched for electronic databases (PubMed, Science direct, Web of Science) using the terms (COVID-19 and shortage) or (medicine and COVID-19) for articles in periods of 2019 to 2021. Results: On assessment based on the report, the number of shortage drugs in 2020 is 835; Anesthesia drugs are highest during the COVID-19 outbreak data indicate the number of shortages is 143 in USA. It was found that generic products were mostly in short supply, with antimicrobial agents (63%) topping the list of therapeutic categories of medicines with interrupted supply, followed by oncology medicines (47%) and then anesthetic agents (38%) during COVID-19 pandemic. Conclusion: Many steps have been taken to reduce the impact of a shortage of health care. Agencies like the United States Food and Drug Administration (US FDA) and European Medicines Agency (EMA) has established guidelines and works with manufacturers and other partners to help prevent shortages. This article aims to the analysis the root cause of medicinal product shortages, their effects on the patient outcome, medication error, which occurs due to the substitution safe and effective therapies with alternative treatments, identify possible solutions and policies established to manage medicinal product shortages.

Separations

Food, drugs, dyes, extracts, and minerals are all made up of complex elements, and utilizing unid... more Food, drugs, dyes, extracts, and minerals are all made up of complex elements, and utilizing unidimensional chromatography to separate them is inefficient and insensitive. This has sparked the invention of several linked chromatography methods, each of them with distinct separation principles and affinity for the analyte of interest. Multidimensional chromatography consists of the combination of multiple chromatography techniques, with great benefits at the level of efficiency, peak capacity, precision, and accuracy of the analysis, while reducing the time required for the analysis. Various coupled chromatography techniques have recently emerged, including liquid chromatography–gas chromatography (LC–GC), gas chromatography–gas chromatography (GC–GC), liquid chromatography–liquid chromatography (LC–LC), GCMS–MS, LCMS–MS, supercritical fluid techniques with chromatography techniques, and electro-driven multidimensional separation techniques. In this paper, the different coupled chrom...

International Journal of Applied Pharmaceutics, 2021

Objective: Shortages of medicinal products are complex global problems. Drug shortages remain a s... more Objective: Shortages of medicinal products are complex global problems. Drug shortages remain a significant public health issue. Global shortages of medical products have a potential effect on patient health and total healthcare costs. Countries worldwide, especially those affected by Coronavirus disease 2019 (COVID-19), is experiencing a rapid increase in drug shortage, which causes several complications for physicians, health care provider, patients, health institutes and health regulatory bodies. Methods: To carry out the study of shortages, several efforts have been taken by the regulators and industries. Prominent amongst these include FDA's research the needs and the reforms made in the regulations about shortages. We also searched for electronic databases (PubMed, Science direct, Web of Science) using the terms (COVID-19 and shortage) or (medicine and COVID-19) for articles in periods of 2019 to 2021. Results: On assessment based on the report, the number of shortage drug...

Evidence-Based Complementary and Alternative Medicine, 2022

Polyalthia suberosa (Roxb.) is a plant used to cure coughs, dysentery, fevers, joint aches, rheum... more Polyalthia suberosa (Roxb.) is a plant used to cure coughs, dysentery, fevers, joint aches, rheumatic pain, inflammation, and a variety of skin diseases. The aim of the study was to evaluate the ethyl acetate extract of Polyalthia suberosa (P. suberosa) leaves and their effects on mice for neuropharmacological, analgesic, and antidiarrheal activities. For neurological studies, the hole cross, hole board, open field, and thiopental sodium-induced sleep duration measurement methodologies were used. The castor oil-induced diarrhea inhibition test was used to assess antidiarrheal action, and the acetic acid-induced writhing inhibition test was used to determine analgesic effectiveness. The extract was given in doses of 250 and 500 mg kg−1 body weight. As a standard drug, diazepam at a dosage of 3 mg kg−1 was used. The extract was also given to groups, and sleep time was measured and recorded. The onset of the anxiolytic effect of the extract at both doses was found to be significant ( p...

BioMed Research International

Ondansetron tablets that are directly compressed using crospovidone and croscarmellose as a synth... more Ondansetron tablets that are directly compressed using crospovidone and croscarmellose as a synthetic super disintegrant are the subject of this investigation. A central composite, response surface, randomly quadratic, nonblock (version 13.0.9.0) 32 factorial design is used to optimize the formulation (two-factor three-level). To make things even more complicated, nine different formulation batches (designated as F1–F9) were created. There were three levels of crospovidone and croscarmellose (+1, 0, -1). In addition to that, pre- and postcompressional parameters were evaluated, and all evaluated parameters were found to be within acceptable range. Among all postcompressional parameter dispersion and disintegration time, in vitro drug release experiments (to quantify the amount of medication released from the tablet) and their percentage prediction error were shown to have a significant influence on three dependent variables. Various pre- and postcompression characteristics of each a...

Correspondence 1. Name of the registry: not applicable. 2. Unique identifying number or registrat... more Correspondence 1. Name of the registry: not applicable. 2. Unique identifying number or registration ID: not applicable. 3. Hyperlink to your specific registration (must be publicly accessible and will be checked): not applicable.

Dear Editor, Langya virus is a Henipavirus that has been found in shrews, bats, rats, and other s... more Dear Editor, Langya virus is a Henipavirus that has been found in shrews, bats, rats, and other small animals. Some studies also reveal that animals such as dogs and goats have natural antibodies to the Langya virus [1]. Furthermore, when exposed to bat urine, the virus may spread to other species such as horses or infect pigs [2]. As a member of the RNA virus family Paramyxoviridae, the Langya henipavirus (LayV) has evolutionary ties with Nipah virus and Hendra virus [3]. Both the Nipah and Hendra viruses are emerging zoonotic diseases in the Asia-Pacific area. Despite their differences, these two RNA viruses have antigenic, serological, and ultrastructural features that place them in the same genus [4]. On 4 August, it was initially reported in The New England Journal of Medicine. Thirty-five persons in China's Shandong and Henan provinces contracted the LayV between December 2018 and May 2021 [5]. This indicates that the virus is not spreading among humans readily. There have also been no clusters of instances within the same family, like what may happen with coronavirus disease 2019, or clusters within a short amount of time or in close proximity to one another [4,6]. Contact tracing was performed on nine of the affected persons, and after contacting 15 close contacts of each patient, the researchers found no evidence of LayV infection [7]. This finding lends credence to the theory that the virus is transmitted not from person to person but from animal to human. To spread the Langya virus from person to person still needs a great deal of effort and direct physical contact. People with fever in eastern China who had just been exposed to animals led to the discovery of the virus. In the absence of a cure, problems may be treated with supportive care.

A 23-year-old woman presented to the hospital complaining weakness of lower limbs. On further inv... more A 23-year-old woman presented to the hospital complaining weakness of lower limbs. On further investigation, the patient revealed consumption of a mixed poison with intent to commit suicide, seven months ago.

Objectives: Extensive literature survey revealed that chronic obstructive pulmonary disease (COPD... more Objectives: Extensive literature survey revealed that chronic obstructive pulmonary disease (COPD) is one of the primary burdens for low-income countries like India. Out of around 30 million COPD patients in India, a considerable number of patients are uneducated about the basics of their disease prevention and medication. Patient information leaflets (PILs) are well accepted materials to educate patients/users about medications, disease and lifestyle modifications. Thus PILs printed in regional languages will certainly act as a valuable tool to disseminate and retain patient's information. Methods: PILs are developed in the English language by referring to various model leaflets that are available from different sources such as "Patient UK" , MICROMEDEX Database, GOLD guidelines. The content of the leaflet was validated by physicians. Cloze test was identified as a possible test for assessing the readability of leaflets in English, Kannada, Malayalam and in Hindi. A user-based Cloze test was performed on twenty COPD patients of in each language. Results: The FRE score achieved after the 5 th stage of modification was 77.3, and the FK-GL score achieved was 4.7, which is considered to be good readability of leaflets. User testing scores show significant improvement of knowledge after reading PILs. Conclusion: Present study strongly suggest that the development of patient information leaflet in regional language is likely to have a standard readability score and useful layout design. The prepared leaflet is easily readable and comes out to be user friendly for COPD patients.

Polyalthia suberosa (Roxb.) is a plant used to cure coughs, dysentery, fevers, joint aches, rheum... more Polyalthia suberosa (Roxb.) is a plant used to cure coughs, dysentery, fevers, joint aches, rheumatic pain, inflammation, and a variety of skin diseases. e aim of the study was to evaluate the ethyl acetate extract of Polyalthia suberosa (P. suberosa) leaves and their effects on mice for neuropharmacological, analgesic, and antidiarrheal activities. For neurological studies, the hole cross, hole board, open field, and thiopental sodium-induced sleep duration measurement methodologies were used. e castor oil-induced diarrhea inhibition test was used to assess antidiarrheal action, and the acetic acid-induced writhing inhibition test was used to determine analgesic effectiveness. e extract was given in doses of 250 and 500 mg kg −1 body weight. As a standard drug, diazepam at a dosage of 3 mg kg −1 was used. e extract was also given to groups, and sleep time was measured and recorded. e onset of the anxiolytic effect of the extract at both doses was found to be significant (p < 0.001), and sleep time increased to 273 minutes. For assessing analgesic activity, the extract along with standard diclofenac was administered and found to be 55.02 percent and 64.33 percent, respectively, for the extracts, and diclofenac was found to be 67.44 percent (p < 0.001). For antidiarrheal activity, it was compared with the standard drug, loperamide. e decrease for plant extracts was 50.07 percent and 70.06 percent at 250 mg kg −1 and 500 mg kg −1 , respectively, whereas it was 85.01 percent for loperamide (3 mg kg −1) (p < 0.00). In this study, it was found that ethyl acetate extract of Polyalthia suberosa leaves had strong CNS depressant, analgesic, and antidiarrheal activities, which indicates that it may be used in contemporary medicine.

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Objective: Shortages of medicinal products are complex global problems. Drug shortages remain a s... more Objective: Shortages of medicinal products are complex global problems. Drug shortages remain a significant public health issue. Global shortages of medical products have a potential effect on patient health and total healthcare costs. Countries worldwide, especially those affected by Coronavirus disease 2019 (COVID-19), is experiencing a rapid increase in drug shortage, which causes several complications for physicians, health care provider, patients, health institutes and health regulatory bodies. Methods: To carry out the study of shortages, several efforts have been taken by the regulators and industries. Prominent amongst these include FDA's research the needs and the reforms made in the regulations about shortages. We also searched for electronic databases (PubMed, Science direct, Web of Science) using the terms (COVID-19 and shortage) or (medicine and COVID-19) for articles in periods of 2019 to 2021. Results: On assessment based on the report, the number of shortage drugs in 2020 is 835; Anesthesia drugs are highest during the COVID-19 outbreak data indicate the number of shortages is 143 in USA. It was found that generic products were mostly in short supply, with antimicrobial agents (63%) topping the list of therapeutic categories of medicines with interrupted supply, followed by oncology medicines (47%) and then anesthetic agents (38%) during COVID-19 pandemic. Conclusion: Many steps have been taken to reduce the impact of a shortage of health care. Agencies like the United States Food and Drug Administration (US FDA) and European Medicines Agency (EMA) has established guidelines and works with manufacturers and other partners to help prevent shortages. This article aims to the analysis the root cause of medicinal product shortages, their effects on the patient outcome, medication error, which occurs due to the substitution safe and effective therapies with alternative treatments, identify possible solutions and policies established to manage medicinal product shortages.