Ruken Esra Demirdogen - Academia.edu (original) (raw)

Papers by Ruken Esra Demirdogen

Procedia - Social and Behavioral Sciences, 2009

In a globalization world, where all the boundaries are removed and shifted through the inter-and ... more In a globalization world, where all the boundaries are removed and shifted through the inter-and intraconnectedness and guidance provided by (nano) technological, internet, and ICT and through development of novel intelligence technologies, the enormous rate at which information and knowledge is created, distributed and disseminated renders protection and security of these work and the minds creating them to have utmost importance. The purpose of this study is to assess the gathering storm, which is threatening the economy as well as technology integration for socioeconomic growth in both countries. In this context, this work intends to identify and suggest various policies, procedures and certain standards necessary for securing intellectual assets and technological awareness. In this study, the current technology innovation initiatives are analyzed and a framework for securing intellectual assets is proposed. For this purpose a comparative study is carried out among Turkey, Pakistan and the developed countries. The study also assesses how technology intervening helps improve quality of knowledge and research, achieve excellence in education and knowledge management via cultivating the pathway for interdisciplinary work of actors in education vis a vis examining the case in Turkey, Pakistan and in the developed societies.

Phosphorus, Sulfur, and Silicon and the Related Elements

Journal of Molecular Structure

Biological Trace Element Research

Aluminum (Al) is the most common and widely used element in nature, which cause many health probl... more Aluminum (Al) is the most common and widely used element in nature, which cause many health problems and toxic effects. The accumulation of aluminum in the brain, which easily crosses the blood-brain barrier, causes neurodegenerative diseases such as Alzheimer's and dementia, especially diseases associated with free radicals. Reduced glutathione (GSH) is an intracellular tripeptide with low molecular weight, hydrophilic properties, and strong antioxidant effects. This study aimed to investigate the role of reduced glutathione on the activity of adenosine deaminase, antioxidative system, aluminum and zinc levels in aluminum toxicity. In this study, Sprague Dawley rats (n=32) were used. The rats were divided into four equal groups. Group I received 0.5 mL intraperitoneal injection of 0.9 % saline solution (NaCI), Group II received single-dose AlCI3 , Group III was given GSH for seven days, Group IV was given AlCI3 single dose and at the same time 100 mg/kg GSH was given for seven ...

Nutraceutical is a food or part of a food that provides health benefits. Boron is an essential mi... more Nutraceutical is a food or part of a food that provides health benefits. Boron is an essential micronutrient and neutraceutical for many life functions such as reproduction and embryogenesis, eye development, immune response and inflammation. The main sources of boron are vegetables, fruits, nuts and legumes. Recent studies are about the relation of boron with bone metabolism. Therefore, in this review we aimed to give information about the possible effects of boron on bone metabolism as a nutraceutical.

Online Submission, May 1, 2007

This paper is about a study carried out at a chemical production facility in Izmir, Turkey during... more This paper is about a study carried out at a chemical production facility in Izmir, Turkey during 2005/6 using CNC Learning environment and Kolb cycle. The system has been tested with 12 chemists working in this factory. The training course was carried on in a web-based environment and also routine meetings with the instructors were held. The target was to increase competency and compatibility to new technological advances through creating a continuous learning and experimenting environment for all faculty members and especially for adults. It was observed that this method of learning and training was successful in enabling individuals at any age to become informed, capable and creative enough to cope with the demands of new economy and era. Hence, it can be concluded that using an CNC environment for LLL with a collaborative tool advances the performance and efficiency.

Online Submission, Jan 4, 2007

This paper is about a study, which has been carried out at a chemical production facility in Izmi... more This paper is about a study, which has been carried out at a chemical production facility in Izmir, Turkey during the spring of 2006 using Participatory Action Research process in a training course exploiting Learning Management System. The system has been tested with 12 chemists working in this factory. The technical training course was carried on in a web-based environment and also routine meetings with the instructors were provided. While for one of the two test groups was expected to deal with problems encountered in the workplace as abstracts problems the other group was expected to bring solutions to the same problems in the factory production line. It was observed that the achievement of both groups was the same, but the work skill of the latter group was better. Hence, it can be concluded that the modes and methods used in education impact competencies of individuals and hence the society.

Procedia - Social and Behavioral Sciences, 2009

Engineering profession proposed a road map by directly putting the impact on economic growth thro... more Engineering profession proposed a road map by directly putting the impact on economic growth through various means such as technology, learning, access and quality. It is envisaged that to maintain quality human resource in professional engineering, accreditation and assessment of engineering education requires focusing. This would foster engineering education for socioeconomic development at all levels. Accreditation and assessment at regional/national level is based on monitoring of educational programs like curriculum, teaching and learning, equipment/laboratory facilities, student performance, etc., rather than outcomesbased assessments. Moreover, assessment is also vital to identify and realize achievements and goals through the engineering profession and to attain student learning outcomes in accordance with both institutional and professional criteria. One of the major concerns for assessment and accreditation of engineering profession is that in the developing countries (i.e., Pakistan) the accredited bodies constituted at the regional/national level are striving hard to set out uniform, transparent and precise accreditation models. However, in order to gain global acceptance, there is a great need to explore possibility of mutual recognition and global mobility of engineers. In this study, accredited bodies for engineering profession, how engineering programs intervening help to improve quality of education as well as outcomes in the economic development are assessed in an environment of continuous development. A uniform model for global recognition of this profession is proposed. The current auditing of the engineering programs in Pakistan and in Turkey are analyzed and the trends are presented in a comparative assessment study vis a vis their global status. This paper presents an insight for policy makers in higher education sector to redesign, upgrade and modify the existing initiatives in developing nations through the case study made for Pakistan and Turkey.

Journal of the Turkish Chemical Society Section A: Chemistry, 2019

Water pollution is a global concern. Inorganic and organic pollutants constitute primary pollutan... more Water pollution is a global concern. Inorganic and organic pollutants constitute primary pollutants in water resources. Therefore, it is of great concern to develop advanced sorbent materials for effective and efficient removal of metals and oil from water. In this study, synthesis of new LDH composites which would be used for sorption of heavy metals and oils from polluted water. For this purpose, MgAlOH- ɣ-Fe2O3-MoS2 composite was prepared and characterized were made via FT-IR and XRD. The XRD powder pattern of the composite showed that it contained g-Fe2O3 (PDF card no:00-002-1047), MgAl(OH)14.XH2O (PDF card no:00-043-0072) and MoS2 (PDF card no:00-037-4492). Thermal stability of the composite was investigated via DTA/TG technique. MgAlOH-ɣ-Fe2O3-MoS2 composite was shows highly efficient sorption for vegetable oil up to 418% times its own weight. The ablity of MgAlOH- ɣ-Fe2O3-MoS2 composite for removing Pb2+ ions from aqueous solution. Pb2+ analysis was made by ICP-OES. The effec...

Journal of Molecular Structure

Eskişehir Technical University Journal of Science and Technology A - Applied Sciences and Engineering, 2019

World Health Organization projected the number of deaths due to cancer alone to be ~13.1 million ... more World Health Organization projected the number of deaths due to cancer alone to be ~13.1 million by 2030. To a certain extent conventional chemotherapy has been successful, but poor bioavailability, high-dose requirements, adverse side effects, low therapeutic indices, development of multiple drug resistance, and non-specific targeting have been severe limitations to its success. These limitations can be overcome via “theranostics” as it is precision medicine providing simultaneous diagnosis, targeted treatment and monitoring. Here the major actor is the drug –the therapeutic compound. It is importance to develop new green chemistries and technologies to produce supramolecular nanomedicines by employing appropriate inorganic and organic structures as theranostic platforms. SrMoO4:Eu3+- MCM-41-ɣ-Fe2O3 composite was synthesized and characterized via FT-IR and XRD techniques. XRD pattern of SrMoO4:Eu3+- MCM-41-ɣ-Fe2O3 composite shows the presence of SrMoO4 (PDF card No: 01-075-4312), γ...

Journal of the Turkish Chemical Society Section A: Chemistry, 2019

Mesoporous 2-Chlorobenzoylthiourea-modified MCM-41 was prepared and loaded with ibuprofen in a su... more Mesoporous 2-Chlorobenzoylthiourea-modified MCM-41 was prepared and loaded with ibuprofen in a supercritical carbon dioxide (sC-CO2) environment. 2-chloro-benzoythiourea modified MCM-41 was prepared and also characterized via XRD, FT-IR, SEM and BET techniques. The (100) and (110) reflections observed at low angle XRD show the mesoporous SiO2 structure. The paticule size of non-uniform spheres were observed at a range of 250-305 nm. BET surface areas were calculated as 1506 m2 / g for MCM-41 and 306 m2/g 2-chloro-benzoythiourea modified MCM-4, respectively. The absorption and releasing studies of ibuprofen were caried out in simulated body fluid. The result revealed that high adsorption capacity for drug with 2-chloro-benzoythiourea modified MCM-41 and slower drug release rate was achieved.

Eskişehir Technical University Journal of Science and Technology A - Applied Sciences and Engineering, 2021

Sr2SiO4:%3Nd 3+ was synthesized and its structural characterization was made via XRD technique. T... more Sr2SiO4:%3Nd 3+ was synthesized and its structural characterization was made via XRD technique. The results indicated that Sr2SiO4:%3Nd 3+ had Pmma (62) space group (PDF: 00-039-1256) in the orthorhombic crystal system. Luminescence and thermoluminescence (TL) properties of Sr2SiO4:%3Nd 3 was investigated in detail. Computerized glow curve deconvolution methods was used for to determine the kinetic properties of Sr2SiO4:%3Nd 3+. The TL results showed that Sr2SiO4:Nd 3+ consisted of seven TL glow peaks.

Journal of Thermal Analysis and Calorimetry, 2019

Pyridine-derived platinum(II) complexes with the general formula [PtCl 2 L 2 ] (L 1 : 3,5-dimethy... more Pyridine-derived platinum(II) complexes with the general formula [PtCl 2 L 2 ] (L 1 : 3,5-dimethylpyridine, L 2 : 2-amino-5bromopyridine, L 3 : 4-(4-nitrobenzyl)pyridine) were synthesized. Characterization of the synthesized complexes was made via FT-IR, UV-Vis, 1 H-NMR and 13 C-NMR techniques. While the thermal behavior of the complexes was investigated via DTA/TG combined system, their kinetic parameters were investigated by using Flynn-Wall-Ozawa (FWO) and Kissinger-Akahira-Sunose (KAS) methods. The activation energy of the decomposition kinetics of the complexes was calculated to be 196.5-31.7 kJ mol-1 for FWO and 203.4-29.2 kJ mol-1 for KAS. The cytotoxic effect of the complexes against the colon cancer cell line (DLD-1), which is one of the most common types of cancer observed both in humans and animals, was investigated. The complexes showed high cytotoxicity on DLD-1. In particular, [PtCl 2 L 2 1 ] complex was found to be the most effective compounds against colon cancer cell line during the 24 h incubation period. According to these results, the pyridine-derived platinum(II) complexes would contribute to oncologic treatment as chemotherapeutic agents.

Journal of the Turkish Chemical Society, Section A: Chemistry, 2018

The extraction of Lavandula Officinalis (lavender) and Hypericum Perforatum (centaury) plants gro... more The extraction of Lavandula Officinalis (lavender) and Hypericum Perforatum (centaury) plants grown in Mersin region were extracted by supercritical carbon dioxide extraction system (P=100 bar, T=40 o C). The chemical compositions of the lavender and centaury extracts were analyzed by Gas Chromatography-Mass Spectrometry (GC-MS). For antioxidant activity experiments, 1,1-diphenyl-2picrylhidrazine (DPPH) radical was used in radical effect tests. For antimicrobial activity studies, Bacillus subtilis, Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Streptococcus pneumoniae with Nutrient Agar Broth (NA) and Eosin Methylene-blue lactose sucrose agar (EMB) broth were used. For determining antimicrobial effect of plant extracts, diffusion method was used. Antibacterial and antioxidant properties of the obtained extracts were examined and have been determined that the resulting extracts have significant antioxidant and antimicrobial effects. The extracts were also used in cosmetic cream formulas as protectives. Effective results have also been determined in antibacterial activity studies of creams after 6 months.

Journal of Molecular Structure, 2017

A novel thiourea derivative, N-((2-chloropyridin-3-yl)carbamothioyl) thiophene-2carboxamide,C 11 ... more A novel thiourea derivative, N-((2-chloropyridin-3-yl)carbamothioyl) thiophene-2carboxamide,C 11 H 8 ClN 3 OS 2 (HL) and its Co(II), Ni(II) and Cu(II) complexes (ML 2 type) were prepared and characterized by elemental analysis, FT-IR , 1 H-NMR and HR-MS methods. The crystal structure of HL was also investigated by single crystal X-ray diffraction study. The HL crystallizes in the orthorhombic crystal system with P 2 1 2 1 2 1 space group, Z=4, a=3.8875(3) Å, b=14.6442(13) Å, c=21.8950(19) Å. The [ML 2 ] complex structures were optimized by using B97D/TZVP level. Molecular orbitals of HL ligand were calculated at the same level. Thermal and electrochemical behaviors of the complexes were investigated. Anticancer and antioxidant activities of the complexes were also investigated. Antioxidant activities were determined by using DPPH (2,2-diphenyl-1-picrylhydrazyl) and ABTS (2,2′azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) assays. Anticancer activities were studied via MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay in MCF-7 (Michigan Cancer Foundation-7) breast cancer cells.

International Journal of Biological Macromolecules, 2017

Nanotechnology for Synthesis and characterization of poly(3-hydroxybutyrate-co-3hydroxyhexanoate)... more Nanotechnology for Synthesis and characterization of poly(3-hydroxybutyrate-co-3hydroxyhexanoate) nanoparticles for sustained bortezomib release using supercritical CO2 assisted particle formation combined with electrodeposition, International Journal of Biological Macromoleculeshttp://dx.

Journal of the Turkish Chemical Society, Section A: Chemistry, 2016

The target of this study is to determine the interrelation among serum Li level on bone metabolis... more The target of this study is to determine the interrelation among serum Li level on bone metabolism (Ca, P, Parathormone, and Vitamin-D), sex and metabolic hormones (estrogen, FSH, LH and TSH), and some biochemical parameters in premenopausal and postmenopausal women. The study is carried out with 10 women, 5 of which is in the premenopausal period. The serum Li levels, bone metabolism indicators (i.e., ALP, Ca, P, Mg, Cu, and Zn) and some biochemical parameters such as serum triglyceride, alkalene phosphatase, total cholesterol, HDL, LDL, and cholesterol levels were determined. The estrogen blood level of women in menopause period was found to be lower than that of women in pre-menopause period (p<0.01) and the FSH level was found to be higher (p<0.01). In the lipid profile, the triglyceride level in the post-menopause period was found to be low (p<0.05) and HDL (p<0.001), LDL (p<0.001) and the cholesterol levels were found to be high (p<0.001). The alkalene phosphatase (p<0.001) and Vitamin-D levels (p<0.001) were found to decrease. When the mineral levels were investigated, no meaningful difference was observed in the serum magnesium and copper levels while zinc (p<0.01) and phosphorus (p<0.005) levels were observed to increase, the calcium levels (p<0.05) decreased and Li levels considerably decreased (p<0.0001). According to the results obtained it was determined for the first time that Li deficiency can be related with menopause and the related diseases and thus Li therapy can be used in developing new treatment protocols of menopause as an alternative method.

Academic Platform Journal of Engineering and Science, 2014

A high-skilled workforce is conditio sine qua non for a high quality of life and economic growth ... more A high-skilled workforce is conditio sine qua non for a high quality of life and economic growth in an ever competitive environment. Vocational education and training institutes often apply teaching methodologies which are outdated or lack relevance for the labor market needs. The paper analysis how innovative processes can improve the quality of vocational training services. The culture of an organization impacts the degree to which creative, innovative solutions to problems are encouraged and implemented. Promising tools are the support for "innovation teams" and failure-tolerance as well as recruiting trainers with practical, cross-cultural background and skills. Innovative delivery of vocational education and training is also needed to forge stronger linkages between VET and private industries.

Procedia - Social and Behavioral Sciences, 2009

In a globalization world, where all the boundaries are removed and shifted through the inter-and ... more In a globalization world, where all the boundaries are removed and shifted through the inter-and intraconnectedness and guidance provided by (nano) technological, internet, and ICT and through development of novel intelligence technologies, the enormous rate at which information and knowledge is created, distributed and disseminated renders protection and security of these work and the minds creating them to have utmost importance. The purpose of this study is to assess the gathering storm, which is threatening the economy as well as technology integration for socioeconomic growth in both countries. In this context, this work intends to identify and suggest various policies, procedures and certain standards necessary for securing intellectual assets and technological awareness. In this study, the current technology innovation initiatives are analyzed and a framework for securing intellectual assets is proposed. For this purpose a comparative study is carried out among Turkey, Pakistan and the developed countries. The study also assesses how technology intervening helps improve quality of knowledge and research, achieve excellence in education and knowledge management via cultivating the pathway for interdisciplinary work of actors in education vis a vis examining the case in Turkey, Pakistan and in the developed societies.

Phosphorus, Sulfur, and Silicon and the Related Elements

Journal of Molecular Structure

Biological Trace Element Research

Aluminum (Al) is the most common and widely used element in nature, which cause many health probl... more Aluminum (Al) is the most common and widely used element in nature, which cause many health problems and toxic effects. The accumulation of aluminum in the brain, which easily crosses the blood-brain barrier, causes neurodegenerative diseases such as Alzheimer's and dementia, especially diseases associated with free radicals. Reduced glutathione (GSH) is an intracellular tripeptide with low molecular weight, hydrophilic properties, and strong antioxidant effects. This study aimed to investigate the role of reduced glutathione on the activity of adenosine deaminase, antioxidative system, aluminum and zinc levels in aluminum toxicity. In this study, Sprague Dawley rats (n=32) were used. The rats were divided into four equal groups. Group I received 0.5 mL intraperitoneal injection of 0.9 % saline solution (NaCI), Group II received single-dose AlCI3 , Group III was given GSH for seven days, Group IV was given AlCI3 single dose and at the same time 100 mg/kg GSH was given for seven ...

Nutraceutical is a food or part of a food that provides health benefits. Boron is an essential mi... more Nutraceutical is a food or part of a food that provides health benefits. Boron is an essential micronutrient and neutraceutical for many life functions such as reproduction and embryogenesis, eye development, immune response and inflammation. The main sources of boron are vegetables, fruits, nuts and legumes. Recent studies are about the relation of boron with bone metabolism. Therefore, in this review we aimed to give information about the possible effects of boron on bone metabolism as a nutraceutical.

Online Submission, May 1, 2007

This paper is about a study carried out at a chemical production facility in Izmir, Turkey during... more This paper is about a study carried out at a chemical production facility in Izmir, Turkey during 2005/6 using CNC Learning environment and Kolb cycle. The system has been tested with 12 chemists working in this factory. The training course was carried on in a web-based environment and also routine meetings with the instructors were held. The target was to increase competency and compatibility to new technological advances through creating a continuous learning and experimenting environment for all faculty members and especially for adults. It was observed that this method of learning and training was successful in enabling individuals at any age to become informed, capable and creative enough to cope with the demands of new economy and era. Hence, it can be concluded that using an CNC environment for LLL with a collaborative tool advances the performance and efficiency.

Online Submission, Jan 4, 2007

This paper is about a study, which has been carried out at a chemical production facility in Izmi... more This paper is about a study, which has been carried out at a chemical production facility in Izmir, Turkey during the spring of 2006 using Participatory Action Research process in a training course exploiting Learning Management System. The system has been tested with 12 chemists working in this factory. The technical training course was carried on in a web-based environment and also routine meetings with the instructors were provided. While for one of the two test groups was expected to deal with problems encountered in the workplace as abstracts problems the other group was expected to bring solutions to the same problems in the factory production line. It was observed that the achievement of both groups was the same, but the work skill of the latter group was better. Hence, it can be concluded that the modes and methods used in education impact competencies of individuals and hence the society.

Procedia - Social and Behavioral Sciences, 2009

Engineering profession proposed a road map by directly putting the impact on economic growth thro... more Engineering profession proposed a road map by directly putting the impact on economic growth through various means such as technology, learning, access and quality. It is envisaged that to maintain quality human resource in professional engineering, accreditation and assessment of engineering education requires focusing. This would foster engineering education for socioeconomic development at all levels. Accreditation and assessment at regional/national level is based on monitoring of educational programs like curriculum, teaching and learning, equipment/laboratory facilities, student performance, etc., rather than outcomesbased assessments. Moreover, assessment is also vital to identify and realize achievements and goals through the engineering profession and to attain student learning outcomes in accordance with both institutional and professional criteria. One of the major concerns for assessment and accreditation of engineering profession is that in the developing countries (i.e., Pakistan) the accredited bodies constituted at the regional/national level are striving hard to set out uniform, transparent and precise accreditation models. However, in order to gain global acceptance, there is a great need to explore possibility of mutual recognition and global mobility of engineers. In this study, accredited bodies for engineering profession, how engineering programs intervening help to improve quality of education as well as outcomes in the economic development are assessed in an environment of continuous development. A uniform model for global recognition of this profession is proposed. The current auditing of the engineering programs in Pakistan and in Turkey are analyzed and the trends are presented in a comparative assessment study vis a vis their global status. This paper presents an insight for policy makers in higher education sector to redesign, upgrade and modify the existing initiatives in developing nations through the case study made for Pakistan and Turkey.

Journal of the Turkish Chemical Society Section A: Chemistry, 2019

Water pollution is a global concern. Inorganic and organic pollutants constitute primary pollutan... more Water pollution is a global concern. Inorganic and organic pollutants constitute primary pollutants in water resources. Therefore, it is of great concern to develop advanced sorbent materials for effective and efficient removal of metals and oil from water. In this study, synthesis of new LDH composites which would be used for sorption of heavy metals and oils from polluted water. For this purpose, MgAlOH- ɣ-Fe2O3-MoS2 composite was prepared and characterized were made via FT-IR and XRD. The XRD powder pattern of the composite showed that it contained g-Fe2O3 (PDF card no:00-002-1047), MgAl(OH)14.XH2O (PDF card no:00-043-0072) and MoS2 (PDF card no:00-037-4492). Thermal stability of the composite was investigated via DTA/TG technique. MgAlOH-ɣ-Fe2O3-MoS2 composite was shows highly efficient sorption for vegetable oil up to 418% times its own weight. The ablity of MgAlOH- ɣ-Fe2O3-MoS2 composite for removing Pb2+ ions from aqueous solution. Pb2+ analysis was made by ICP-OES. The effec...

Journal of Molecular Structure

Eskişehir Technical University Journal of Science and Technology A - Applied Sciences and Engineering, 2019

World Health Organization projected the number of deaths due to cancer alone to be ~13.1 million ... more World Health Organization projected the number of deaths due to cancer alone to be ~13.1 million by 2030. To a certain extent conventional chemotherapy has been successful, but poor bioavailability, high-dose requirements, adverse side effects, low therapeutic indices, development of multiple drug resistance, and non-specific targeting have been severe limitations to its success. These limitations can be overcome via “theranostics” as it is precision medicine providing simultaneous diagnosis, targeted treatment and monitoring. Here the major actor is the drug –the therapeutic compound. It is importance to develop new green chemistries and technologies to produce supramolecular nanomedicines by employing appropriate inorganic and organic structures as theranostic platforms. SrMoO4:Eu3+- MCM-41-ɣ-Fe2O3 composite was synthesized and characterized via FT-IR and XRD techniques. XRD pattern of SrMoO4:Eu3+- MCM-41-ɣ-Fe2O3 composite shows the presence of SrMoO4 (PDF card No: 01-075-4312), γ...

Journal of the Turkish Chemical Society Section A: Chemistry, 2019

Mesoporous 2-Chlorobenzoylthiourea-modified MCM-41 was prepared and loaded with ibuprofen in a su... more Mesoporous 2-Chlorobenzoylthiourea-modified MCM-41 was prepared and loaded with ibuprofen in a supercritical carbon dioxide (sC-CO2) environment. 2-chloro-benzoythiourea modified MCM-41 was prepared and also characterized via XRD, FT-IR, SEM and BET techniques. The (100) and (110) reflections observed at low angle XRD show the mesoporous SiO2 structure. The paticule size of non-uniform spheres were observed at a range of 250-305 nm. BET surface areas were calculated as 1506 m2 / g for MCM-41 and 306 m2/g 2-chloro-benzoythiourea modified MCM-4, respectively. The absorption and releasing studies of ibuprofen were caried out in simulated body fluid. The result revealed that high adsorption capacity for drug with 2-chloro-benzoythiourea modified MCM-41 and slower drug release rate was achieved.

Eskişehir Technical University Journal of Science and Technology A - Applied Sciences and Engineering, 2021

Sr2SiO4:%3Nd 3+ was synthesized and its structural characterization was made via XRD technique. T... more Sr2SiO4:%3Nd 3+ was synthesized and its structural characterization was made via XRD technique. The results indicated that Sr2SiO4:%3Nd 3+ had Pmma (62) space group (PDF: 00-039-1256) in the orthorhombic crystal system. Luminescence and thermoluminescence (TL) properties of Sr2SiO4:%3Nd 3 was investigated in detail. Computerized glow curve deconvolution methods was used for to determine the kinetic properties of Sr2SiO4:%3Nd 3+. The TL results showed that Sr2SiO4:Nd 3+ consisted of seven TL glow peaks.

Journal of Thermal Analysis and Calorimetry, 2019

Pyridine-derived platinum(II) complexes with the general formula [PtCl 2 L 2 ] (L 1 : 3,5-dimethy... more Pyridine-derived platinum(II) complexes with the general formula [PtCl 2 L 2 ] (L 1 : 3,5-dimethylpyridine, L 2 : 2-amino-5bromopyridine, L 3 : 4-(4-nitrobenzyl)pyridine) were synthesized. Characterization of the synthesized complexes was made via FT-IR, UV-Vis, 1 H-NMR and 13 C-NMR techniques. While the thermal behavior of the complexes was investigated via DTA/TG combined system, their kinetic parameters were investigated by using Flynn-Wall-Ozawa (FWO) and Kissinger-Akahira-Sunose (KAS) methods. The activation energy of the decomposition kinetics of the complexes was calculated to be 196.5-31.7 kJ mol-1 for FWO and 203.4-29.2 kJ mol-1 for KAS. The cytotoxic effect of the complexes against the colon cancer cell line (DLD-1), which is one of the most common types of cancer observed both in humans and animals, was investigated. The complexes showed high cytotoxicity on DLD-1. In particular, [PtCl 2 L 2 1 ] complex was found to be the most effective compounds against colon cancer cell line during the 24 h incubation period. According to these results, the pyridine-derived platinum(II) complexes would contribute to oncologic treatment as chemotherapeutic agents.

Journal of the Turkish Chemical Society, Section A: Chemistry, 2018

The extraction of Lavandula Officinalis (lavender) and Hypericum Perforatum (centaury) plants gro... more The extraction of Lavandula Officinalis (lavender) and Hypericum Perforatum (centaury) plants grown in Mersin region were extracted by supercritical carbon dioxide extraction system (P=100 bar, T=40 o C). The chemical compositions of the lavender and centaury extracts were analyzed by Gas Chromatography-Mass Spectrometry (GC-MS). For antioxidant activity experiments, 1,1-diphenyl-2picrylhidrazine (DPPH) radical was used in radical effect tests. For antimicrobial activity studies, Bacillus subtilis, Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Streptococcus pneumoniae with Nutrient Agar Broth (NA) and Eosin Methylene-blue lactose sucrose agar (EMB) broth were used. For determining antimicrobial effect of plant extracts, diffusion method was used. Antibacterial and antioxidant properties of the obtained extracts were examined and have been determined that the resulting extracts have significant antioxidant and antimicrobial effects. The extracts were also used in cosmetic cream formulas as protectives. Effective results have also been determined in antibacterial activity studies of creams after 6 months.

Journal of Molecular Structure, 2017

A novel thiourea derivative, N-((2-chloropyridin-3-yl)carbamothioyl) thiophene-2carboxamide,C 11 ... more A novel thiourea derivative, N-((2-chloropyridin-3-yl)carbamothioyl) thiophene-2carboxamide,C 11 H 8 ClN 3 OS 2 (HL) and its Co(II), Ni(II) and Cu(II) complexes (ML 2 type) were prepared and characterized by elemental analysis, FT-IR , 1 H-NMR and HR-MS methods. The crystal structure of HL was also investigated by single crystal X-ray diffraction study. The HL crystallizes in the orthorhombic crystal system with P 2 1 2 1 2 1 space group, Z=4, a=3.8875(3) Å, b=14.6442(13) Å, c=21.8950(19) Å. The [ML 2 ] complex structures were optimized by using B97D/TZVP level. Molecular orbitals of HL ligand were calculated at the same level. Thermal and electrochemical behaviors of the complexes were investigated. Anticancer and antioxidant activities of the complexes were also investigated. Antioxidant activities were determined by using DPPH (2,2-diphenyl-1-picrylhydrazyl) and ABTS (2,2′azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) assays. Anticancer activities were studied via MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay in MCF-7 (Michigan Cancer Foundation-7) breast cancer cells.

International Journal of Biological Macromolecules, 2017

Nanotechnology for Synthesis and characterization of poly(3-hydroxybutyrate-co-3hydroxyhexanoate)... more Nanotechnology for Synthesis and characterization of poly(3-hydroxybutyrate-co-3hydroxyhexanoate) nanoparticles for sustained bortezomib release using supercritical CO2 assisted particle formation combined with electrodeposition, International Journal of Biological Macromoleculeshttp://dx.

Journal of the Turkish Chemical Society, Section A: Chemistry, 2016

The target of this study is to determine the interrelation among serum Li level on bone metabolis... more The target of this study is to determine the interrelation among serum Li level on bone metabolism (Ca, P, Parathormone, and Vitamin-D), sex and metabolic hormones (estrogen, FSH, LH and TSH), and some biochemical parameters in premenopausal and postmenopausal women. The study is carried out with 10 women, 5 of which is in the premenopausal period. The serum Li levels, bone metabolism indicators (i.e., ALP, Ca, P, Mg, Cu, and Zn) and some biochemical parameters such as serum triglyceride, alkalene phosphatase, total cholesterol, HDL, LDL, and cholesterol levels were determined. The estrogen blood level of women in menopause period was found to be lower than that of women in pre-menopause period (p<0.01) and the FSH level was found to be higher (p<0.01). In the lipid profile, the triglyceride level in the post-menopause period was found to be low (p<0.05) and HDL (p<0.001), LDL (p<0.001) and the cholesterol levels were found to be high (p<0.001). The alkalene phosphatase (p<0.001) and Vitamin-D levels (p<0.001) were found to decrease. When the mineral levels were investigated, no meaningful difference was observed in the serum magnesium and copper levels while zinc (p<0.01) and phosphorus (p<0.005) levels were observed to increase, the calcium levels (p<0.05) decreased and Li levels considerably decreased (p<0.0001). According to the results obtained it was determined for the first time that Li deficiency can be related with menopause and the related diseases and thus Li therapy can be used in developing new treatment protocols of menopause as an alternative method.

Academic Platform Journal of Engineering and Science, 2014

A high-skilled workforce is conditio sine qua non for a high quality of life and economic growth ... more A high-skilled workforce is conditio sine qua non for a high quality of life and economic growth in an ever competitive environment. Vocational education and training institutes often apply teaching methodologies which are outdated or lack relevance for the labor market needs. The paper analysis how innovative processes can improve the quality of vocational training services. The culture of an organization impacts the degree to which creative, innovative solutions to problems are encouraged and implemented. Promising tools are the support for "innovation teams" and failure-tolerance as well as recruiting trainers with practical, cross-cultural background and skills. Innovative delivery of vocational education and training is also needed to forge stronger linkages between VET and private industries.