Ruth Bulger - Academia.edu (original) (raw)
Papers by Ruth Bulger
Virchows Archiv B Cell Pathology, 1977
Studies were undertaken to determine whether a hypotensive episode under variable conditions is c... more Studies were undertaken to determine whether a hypotensive episode under variable conditions is capable of inducing experimental acute renal failure in rats. Animals were subjected to hypovolemic shock by withdrawing volumes of blood necessary to maintain a systolic pressure of 30-40 mm Hg for 105-110 min. The blood was then reinfusedand the animal was allowed to recover for 48 h prior to sacrifice. In an attempt to increase the injury, a second group of animals was salt-depleted prior to injury, a third group was volume-depleted by being deprived of H20 for 72 h prior to injury, a fourth group received 7.5 mg/kg indomethacin 30 min prior to injury, and a fifth group had 30% of the blood which was removed to produce shock hemolyzed and returned following the injury.
Download hundreds of free books in PDF • Read thousands of books online for free • Explore our in... more Download hundreds of free books in PDF • Read thousands of books online for free • Explore our innovative research tools -try the "Research Dashboard" now! • Sign up to be notified when new books are published • Purchase printed books and selected PDF files Thank you for downloading this PDF. If you have comments, questions or just want more information about the books published by the National Academies Press, you may contact our customer service department tollfree at 888-624-8373, visit us online, or send an email to feedback@nap.edu. This book plus thousands more are available at http://www.nap.edu.
J Cell Biol, 1981
... RUTH ELLEN BULGER, REINIER BEEUWKES III, and ALBERT J .SAUBERMANN Department of Pathology and... more ... RUTH ELLEN BULGER, REINIER BEEUWKES III, and ALBERT J .SAUBERMANN Department of Pathology and Laboratory Medicine, University of Texas Medical School at Houston ... papilla was mounted under liquid nitrogen in a precooled vise-type copper three-point holder. ...
American Journal of Anatomy, Apr 1, 1974
Virchows Archiv B Cell Pathology, Aug 1, 1975
... Sciences, 2nd ed. This is the second edition of an acclaimed textbook on the ... a stimulatin... more ... Sciences, 2nd ed. This is the second edition of an acclaimed textbook on the ... a stimulating resource for anyone involved in biological research." The Lancet " This book will ... use in graduate ethics courses for the biological scientist." Doodv's Health Sciences Book Review Annual ...
Kidney Int, 1987
... J Cell Biol 88:268273, 1981; Beck F, Dorge A, Mason J, Rick R, Thurau K: Element concentrati... more ... J Cell Biol 88:268273, 1981; Beck F, Dorge A, Mason J, Rick R, Thurau K: Element concentrations of renal and hepatic cells under ... 474475, 1985; Grantham JJ, Lowe CM, Dellasega M, Cole BR: Effect of hypotonic medium on K and Na content of proximal renal tubules. ...
NATIONAL ACADEMY PRESS 2101 Constitution Avenue, NW Washington, DC 20418 NOTICE: The project th... more NATIONAL ACADEMY PRESS 2101 Constitution Avenue, NW Washington, DC 20418 NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the Na- ...
Academic Medicine, Oct 1, 1993
The authors describe their experiences in developing and introducing a course on responsible cond... more The authors describe their experiences in developing and introducing a course on responsible conduct at the Graduate School of Biological Sciences at the University of Texas Health Science Center at Houston. The paper covers issues involved with course faculty, course content and format, and evaluation. At least half of the course time focused on general or case-study discussions of the students and faculty about ethical problems raised in course readings or the students' research experiences. An important issue for institutions trying to encourage students to recognize, reason about, and understand ethical concerns is how the institution itself becomes aware of the ethical implications of its own unconsciously or explicitly stated policies. Such reflection among institutional leaders is critical to fostering the public trust necessary for a profession to sustain its right to self-regulation and its claim of authenticity.
The Hastings Center Report, Sep 1, 2005
Kidney Int, 1978
The present study investigated the protective effect of acute volume expansion (25%) with isotoni... more The present study investigated the protective effect of acute volume expansion (25%) with isotonic saline, isotonic mannitol, and hypertonic mannitol in a model of unilateral norepinephrine-induced acute renal failure (ARF). Three hours following a 40-min intrarenal infusion of norepinephrine (NE) (0.75 microgram/kg/min), inulin clearance had fallen from a control value of 54.1 +/- 6.5 to 1.3 +/- 1.3 ml/min in untreated dogs and fell similarly (P = NS) to 3.3 +/- 1.5 ml/min in animals preexpanded with 0.9% saline (0.75 ml/kg/min). In contrast, as compared to the untreated animals, inulin clearance 3 hr post NE infusion was significantly greater in dogs preexpanded with 5% mannitol (9.2 +/- 2.5 ml/min, P less than 0.01), or 20% mannitol (16.6 +/- 3.9 ml/min, P less than 0.01). The protective effects of 5% and 20% mannitol were not statistically different from each other. Recovery of renal excretory function in all groups, expressed as 3-hr post NE inulin clearance, correlated with the magnitude of pre NE solute excretion rate (r = 0.612, P less than 0.001) and osmolar clearance rate (r=0.593, P less than 0.001), but not with pre insult inulin clearance (r = 0.233, P = NS) or renal blood flow (r = 0.249, P = NS). In the presence of a profound fall in inulin clearance, proximal tubular (PT) pressures in untreated dogs 3 hr post NE infusion achieved a value equal to control (26 +/- 11 vs. 25 +/- 2 mm Hg). In contrast, pretreatment with isotonic mannitol produced a rise in PT pressure both before (45 +/- 4 mm Hg, P less than 0.05) and 3 hr post NE infusion (38 +/- 5 mm Hg, P less than 0.05). In all groups of animals, at both 3 and 24 hr post NE, tubular injury was observed but glomerular architecture remained normal by light and electron microscopy. Conclusion. the protective effect of mannitol in this reversible model of ARF did not correlate with inulin clearance, renal blood flow, extracellular fluid (ECF) volume, ECF hypertonicity, or renal histologic changes but did correlate with the solute excretion rate. The increased PT pressures with mannitol both before and after the NE insult could contribute to the protective effect of attenuating any relative intratubular obstruction.
Virchows Archiv B Cell Pathology, 1977
Studies were undertaken to determine whether a hypotensive episode under variable conditions is c... more Studies were undertaken to determine whether a hypotensive episode under variable conditions is capable of inducing experimental acute renal failure in rats. Animals were subjected to hypovolemic shock by withdrawing volumes of blood necessary to maintain a systolic pressure of 30-40 mm Hg for 105-110 min. The blood was then reinfusedand the animal was allowed to recover for 48 h prior to sacrifice. In an attempt to increase the injury, a second group of animals was salt-depleted prior to injury, a third group was volume-depleted by being deprived of H20 for 72 h prior to injury, a fourth group received 7.5 mg/kg indomethacin 30 min prior to injury, and a fifth group had 30% of the blood which was removed to produce shock hemolyzed and returned following the injury.
Download hundreds of free books in PDF • Read thousands of books online for free • Explore our in... more Download hundreds of free books in PDF • Read thousands of books online for free • Explore our innovative research tools -try the "Research Dashboard" now! • Sign up to be notified when new books are published • Purchase printed books and selected PDF files Thank you for downloading this PDF. If you have comments, questions or just want more information about the books published by the National Academies Press, you may contact our customer service department tollfree at 888-624-8373, visit us online, or send an email to feedback@nap.edu. This book plus thousands more are available at http://www.nap.edu.
J Cell Biol, 1981
... RUTH ELLEN BULGER, REINIER BEEUWKES III, and ALBERT J .SAUBERMANN Department of Pathology and... more ... RUTH ELLEN BULGER, REINIER BEEUWKES III, and ALBERT J .SAUBERMANN Department of Pathology and Laboratory Medicine, University of Texas Medical School at Houston ... papilla was mounted under liquid nitrogen in a precooled vise-type copper three-point holder. ...
American Journal of Anatomy, Apr 1, 1974
Virchows Archiv B Cell Pathology, Aug 1, 1975
... Sciences, 2nd ed. This is the second edition of an acclaimed textbook on the ... a stimulatin... more ... Sciences, 2nd ed. This is the second edition of an acclaimed textbook on the ... a stimulating resource for anyone involved in biological research." The Lancet " This book will ... use in graduate ethics courses for the biological scientist." Doodv's Health Sciences Book Review Annual ...
Kidney Int, 1987
... J Cell Biol 88:268273, 1981; Beck F, Dorge A, Mason J, Rick R, Thurau K: Element concentrati... more ... J Cell Biol 88:268273, 1981; Beck F, Dorge A, Mason J, Rick R, Thurau K: Element concentrations of renal and hepatic cells under ... 474475, 1985; Grantham JJ, Lowe CM, Dellasega M, Cole BR: Effect of hypotonic medium on K and Na content of proximal renal tubules. ...
NATIONAL ACADEMY PRESS 2101 Constitution Avenue, NW Washington, DC 20418 NOTICE: The project th... more NATIONAL ACADEMY PRESS 2101 Constitution Avenue, NW Washington, DC 20418 NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the Na- ...
Academic Medicine, Oct 1, 1993
The authors describe their experiences in developing and introducing a course on responsible cond... more The authors describe their experiences in developing and introducing a course on responsible conduct at the Graduate School of Biological Sciences at the University of Texas Health Science Center at Houston. The paper covers issues involved with course faculty, course content and format, and evaluation. At least half of the course time focused on general or case-study discussions of the students and faculty about ethical problems raised in course readings or the students' research experiences. An important issue for institutions trying to encourage students to recognize, reason about, and understand ethical concerns is how the institution itself becomes aware of the ethical implications of its own unconsciously or explicitly stated policies. Such reflection among institutional leaders is critical to fostering the public trust necessary for a profession to sustain its right to self-regulation and its claim of authenticity.
The Hastings Center Report, Sep 1, 2005
Kidney Int, 1978
The present study investigated the protective effect of acute volume expansion (25%) with isotoni... more The present study investigated the protective effect of acute volume expansion (25%) with isotonic saline, isotonic mannitol, and hypertonic mannitol in a model of unilateral norepinephrine-induced acute renal failure (ARF). Three hours following a 40-min intrarenal infusion of norepinephrine (NE) (0.75 microgram/kg/min), inulin clearance had fallen from a control value of 54.1 +/- 6.5 to 1.3 +/- 1.3 ml/min in untreated dogs and fell similarly (P = NS) to 3.3 +/- 1.5 ml/min in animals preexpanded with 0.9% saline (0.75 ml/kg/min). In contrast, as compared to the untreated animals, inulin clearance 3 hr post NE infusion was significantly greater in dogs preexpanded with 5% mannitol (9.2 +/- 2.5 ml/min, P less than 0.01), or 20% mannitol (16.6 +/- 3.9 ml/min, P less than 0.01). The protective effects of 5% and 20% mannitol were not statistically different from each other. Recovery of renal excretory function in all groups, expressed as 3-hr post NE inulin clearance, correlated with the magnitude of pre NE solute excretion rate (r = 0.612, P less than 0.001) and osmolar clearance rate (r=0.593, P less than 0.001), but not with pre insult inulin clearance (r = 0.233, P = NS) or renal blood flow (r = 0.249, P = NS). In the presence of a profound fall in inulin clearance, proximal tubular (PT) pressures in untreated dogs 3 hr post NE infusion achieved a value equal to control (26 +/- 11 vs. 25 +/- 2 mm Hg). In contrast, pretreatment with isotonic mannitol produced a rise in PT pressure both before (45 +/- 4 mm Hg, P less than 0.05) and 3 hr post NE infusion (38 +/- 5 mm Hg, P less than 0.05). In all groups of animals, at both 3 and 24 hr post NE, tubular injury was observed but glomerular architecture remained normal by light and electron microscopy. Conclusion. the protective effect of mannitol in this reversible model of ARF did not correlate with inulin clearance, renal blood flow, extracellular fluid (ECF) volume, ECF hypertonicity, or renal histologic changes but did correlate with the solute excretion rate. The increased PT pressures with mannitol both before and after the NE insult could contribute to the protective effect of attenuating any relative intratubular obstruction.