Sébastien Le Mevel - Academia.edu (original) (raw)

Uploads

Papers by Sébastien Le Mevel

Research paper thumbnail of Unliganded thyroid hormone receptor is essential for Xenopus laevis eye development

Research paper thumbnail of Implication of bax in Xenopus laevis tail regression at metamorphosis

Developmental Dynamics, 2004

Apoptosis is fundamental to normal vertebrate development. A dramatic example of postembryonic de... more Apoptosis is fundamental to normal vertebrate development. A dramatic example of postembryonic development involving apoptosis is tail regression during amphibian metamorphosis. Earlier studies led us to propose a functional role for the pro-apoptotic protein Bax in tadpole tail regression. However, its physiological relevance has never been analyzed. We have now cloned a cDNA encoding Xenopus laevis bax (xlbax) and used in vivo gene transfer in tail muscle to analyze the effects of xlbax overexpression. Furthermore, by using an antisense strategy in a similar experimental paradigm, xlbax antisense mRNA was shown to block the apoptotic effects of xlbax and protect against apoptosis in metamorphosing tadpoles. Our results suggest that xlbax is a regulator of muscle fiber death in the regressing tail during metamorphosis. Developmental Dynamics 231: 671-682, 2004.

Research paper thumbnail of Specific Histone Lysine 4 Methylation Patterns Define TR-Binding Capacity and Differentiate Direct T 3 Responses

Molecular Endocrinology, 2011

Research paper thumbnail of Unliganded thyroid hormone receptor is essential for Xenopus laevis eye development

Research paper thumbnail of Implication of bax in Xenopus laevis tail regression at metamorphosis

Developmental Dynamics, 2004

Apoptosis is fundamental to normal vertebrate development. A dramatic example of postembryonic de... more Apoptosis is fundamental to normal vertebrate development. A dramatic example of postembryonic development involving apoptosis is tail regression during amphibian metamorphosis. Earlier studies led us to propose a functional role for the pro-apoptotic protein Bax in tadpole tail regression. However, its physiological relevance has never been analyzed. We have now cloned a cDNA encoding Xenopus laevis bax (xlbax) and used in vivo gene transfer in tail muscle to analyze the effects of xlbax overexpression. Furthermore, by using an antisense strategy in a similar experimental paradigm, xlbax antisense mRNA was shown to block the apoptotic effects of xlbax and protect against apoptosis in metamorphosing tadpoles. Our results suggest that xlbax is a regulator of muscle fiber death in the regressing tail during metamorphosis. Developmental Dynamics 231: 671-682, 2004.

Research paper thumbnail of Specific Histone Lysine 4 Methylation Patterns Define TR-Binding Capacity and Differentiate Direct T 3 Responses

Molecular Endocrinology, 2011

Log In